BRPI0406738A - Processo de preparação de ésteres e éteres de probucol e derivados desse - Google Patents

Processo de preparação de ésteres e éteres de probucol e derivados desse

Info

Publication number
BRPI0406738A
BRPI0406738A BR0406738-0A BRPI0406738A BRPI0406738A BR PI0406738 A BRPI0406738 A BR PI0406738A BR PI0406738 A BRPI0406738 A BR PI0406738A BR PI0406738 A BRPI0406738 A BR PI0406738A
Authority
BR
Brazil
Prior art keywords
probucol
derivative
derivatives
compound
ethers
Prior art date
Application number
BR0406738-0A
Other languages
English (en)
Inventor
M David Weingarten
James A Sikorski
Original Assignee
Atherogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atherogenics Inc filed Critical Atherogenics Inc
Publication of BRPI0406738A publication Critical patent/BRPI0406738A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PROCESSO DE PREPARAçãO DE éSTERES E éTERES DE PROBUCOL E DERIVADOS DESSE". Um probucol ou um derivado de probucol pode ser convertido de forma eficaz a um mono-éster ou mono-éter de probucol pela reação do probucol livre contendo hidroxil ou um derivado desse (pelo qual se entende um composto de probucol com pelo menos um substituinte que é diferente daquele na molécula de probucol parente mas que mantém os dois grupos hidroxil livres) com um reagente de Grignard ou um reagente de lìtio que produz um brometo de magnésio ou sal de lítio de probucol ou o derivado de probucol. O ânion do composto de probucol reage com um éster ou éter que forma o composto.
BR0406738-0A 2003-01-13 2004-01-13 Processo de preparação de ésteres e éteres de probucol e derivados desse BRPI0406738A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43966503P 2003-01-13 2003-01-13
PCT/US2004/000805 WO2004062622A2 (en) 2003-01-13 2004-01-13 Process of preparing esters and ethers of probucol and derivatives thereof

Publications (1)

Publication Number Publication Date
BRPI0406738A true BRPI0406738A (pt) 2005-12-20

Family

ID=32713499

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0406738-0A BRPI0406738A (pt) 2003-01-13 2004-01-13 Processo de preparação de ésteres e éteres de probucol e derivados desse

Country Status (11)

Country Link
US (2) US7273948B2 (pt)
EP (1) EP1594824A4 (pt)
JP (1) JP4550800B2 (pt)
CN (2) CN100548950C (pt)
AU (1) AU2004204824B2 (pt)
BR (1) BRPI0406738A (pt)
CA (1) CA2512980A1 (pt)
IL (1) IL169662A (pt)
MX (1) MXPA05007548A (pt)
SG (1) SG142207A1 (pt)
WO (1) WO2004062622A2 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003253887A1 (en) * 2002-07-12 2004-02-02 Atherogenics, Inc. Novel salt forms of poorly soluble probucol esters and ethers
BRPI0406738A (pt) * 2003-01-13 2005-12-20 Atherogenics Inc Processo de preparação de ésteres e éteres de probucol e derivados desse
US7294736B2 (en) * 2004-04-09 2007-11-13 Cambrex Charles City, Inc. Process for preparation of probucol derivatives
US7294737B2 (en) 2004-04-20 2007-11-13 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
AU2005262390B2 (en) * 2004-07-01 2011-09-22 Atherogenics, Inc. Compounds and methods for treating diabetic vascular diseases
US20060194981A1 (en) * 2005-02-26 2006-08-31 Jass Paul A Process for preparation of probucol derivatives
BRPI0610602A2 (pt) * 2005-04-21 2010-07-06 Atherogenics Inc processo para a separação de derivados de probucol
US20070275174A1 (en) * 2006-05-24 2007-11-29 Hanson Eric L Fishing fly and fly fishing line with fluorocarbon coating
CN105001129B (zh) * 2015-08-18 2017-06-16 齐鲁安替（临邑）制药有限公司 一种高收率普罗布考精制析晶方法
CN111434647A (zh) * 2019-01-14 2020-07-21 中国科学院上海药物研究所 普罗布考单琥珀酸酯的多晶型
CN116046913A (zh) * 2021-10-28 2023-05-02 中国石油化工股份有限公司 用于定量检测顺酐制丁二酸酐反应液的组合物及方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3576883A (en) * 1969-06-30 1971-04-27 Consolidation Coal Co Alkylidenedithiobisphenols
FR2130975A5 (en) 1971-03-29 1972-11-10 Aries Robert Bis(4-(phenoxyalkanoyloxy)-phenylthio)alkanes - hypolipemics hypocholesterolemics
FR2133024A5 (en) 1971-04-06 1972-11-24 Aries Robert Bis-(4-nicotinoyloxyphenylthio) propanes - with hypocholesterolaemic and hypolipaemic activity
FR2134810A5 (en) 1971-04-21 1972-12-08 Aries Robert Bis-(3-alkyl-5-t-alkyl-4-(thiazole-5-carboxy)phenylthio) alcanes - - with hypocholesterolaemic and hypolipaemic activity
FR2140771A5 (en) 1971-06-07 1973-01-19 Aries Robert Tetralinyl phenoxy alkanoic esters - of bis hydroxyphenylthio alkanes, hypolipemics etc
FR2140769A5 (en) 1971-06-07 1973-01-19 Aries Robert Benzofuryloxy alkanoic derivs of probucol - hypocholesterolemic and hypolipemic agents
FR2168137A1 (en) 1972-01-17 1973-08-31 Dynachim Sarl Bis 4-hydroxyphenylthioalkane esters - with hypocholesterolaemic and hypolipaemic activities
US3952064A (en) * 1973-03-12 1976-04-20 Crown Zellerbach Corporation Process for producing mercaptophenols
US4752616A (en) * 1987-06-29 1988-06-21 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, compositions containing same and method of use
JPH01283261A (ja) * 1988-05-07 1989-11-14 Sanshin Chem Ind Co Ltd アルキル化方法
DE3929913A1 (de) * 1989-09-08 1991-04-04 Hoechst Ag 4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate sowie vorprodukte
US5155250A (en) * 1990-07-05 1992-10-13 Merrell Dow Pharmaceuticals Inc. 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents
FR2666583B1 (fr) * 1990-09-06 1994-09-09 Adir Nouveaux derives du spiro [4.5] decane, leur procede de preparation et leurs compositions pharmaceutiques les renfermant.
US5262439A (en) * 1992-04-30 1993-11-16 The Regents Of The University Of California Soluble analogs of probucol
US5783596A (en) * 1992-10-30 1998-07-21 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
US5380747A (en) * 1992-10-30 1995-01-10 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
FR2704224B1 (fr) * 1993-04-20 1995-08-25 Adir Nouveaux acides et esters phénoxy isobutyriques substitués.
US5792787A (en) * 1995-06-07 1998-08-11 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
FR2738817B1 (fr) 1995-09-14 1997-10-17 Adir Nouveaux acides et esters 2,2-dimethyl-omega-phenoxy alcanoiques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
EA200800375A1 (ru) * 1997-05-14 2008-06-30 Атеродженикс, Инк. Соединения и способы ингибирования экспрессии vcam-1
US6670398B2 (en) * 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
WO1999024400A1 (en) * 1997-11-10 1999-05-20 Vyrex Corporation Probucol esters and uses thereof
JP3344331B2 (ja) 1998-09-30 2002-11-11 日本電気株式会社 不揮発性半導体記憶装置
WO2001070757A2 (en) 2000-03-21 2001-09-27 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of vcam-1
US6323359B1 (en) * 2000-05-02 2001-11-27 Salsbury Chemicals, Inc. Process for preparing probucol derivatives
WO2002087556A2 (en) * 2001-04-11 2002-11-07 Atherogenics, Inc. Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
US6806381B2 (en) * 2001-11-02 2004-10-19 Bristol-Myers Squibb Company Process for the preparation of aniline-derived thyroid receptor ligands
BRPI0406738A (pt) * 2003-01-13 2005-12-20 Atherogenics Inc Processo de preparação de ésteres e éteres de probucol e derivados desse
US20060025481A1 (en) * 2004-02-09 2006-02-02 Strange Matthew L Process for preparation of probucol derivatives and polymorphic forms thereof
US7294737B2 (en) * 2004-04-20 2007-11-13 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof

Also Published As

Publication number Publication date
AU2004204824B2 (en) 2010-12-23
WO2004062622A2 (en) 2004-07-29
WO2004062622A3 (en) 2004-12-02
CA2512980A1 (en) 2004-07-29
HK1090633A1 (zh) 2006-12-29
MXPA05007548A (es) 2005-10-20
EP1594824A2 (en) 2005-11-16
US7273948B2 (en) 2007-09-25
US20040204485A1 (en) 2004-10-14
CN101391972A (zh) 2009-03-25
CN1759084A (zh) 2006-04-12
JP4550800B2 (ja) 2010-09-22
IL169662A (en) 2011-10-31
US20080009642A1 (en) 2008-01-10
US7622604B2 (en) 2009-11-24
JP2006516569A (ja) 2006-07-06
EP1594824A4 (en) 2007-04-04
CN100548950C (zh) 2009-10-14
SG142207A1 (en) 2008-05-28
AU2004204824A1 (en) 2004-07-29

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014.