BRPI0407519A - derivados de benzofurano - Google Patents

derivados de benzofurano

Info

Publication number
BRPI0407519A
BRPI0407519A BRPI0407519-6A BRPI0407519A BRPI0407519A BR PI0407519 A BRPI0407519 A BR PI0407519A BR PI0407519 A BRPI0407519 A BR PI0407519A BR PI0407519 A BRPI0407519 A BR PI0407519A
Authority
BR
Brazil
Prior art keywords
optionally substituted
compound
benzofuran derivatives
alkyl
dihydroxyalkyl
Prior art date
Application number
BRPI0407519-6A
Other languages
English (en)
Inventor
Seiichi Sato
Tomoyuki Koshi
Toshimi Mizogughi
Kyoko Yasuoka
Natsuyo Kumai
Junko Totsuka
Masahiro Tamura
Masao Ohkuchi
Original Assignee
Kowa Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co filed Critical Kowa Co
Publication of BRPI0407519A publication Critical patent/BRPI0407519A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE BENZOFURANO". Um composto representado pela fórmula (1) geral: (em que R¬ 1¬ representa alquila opcionalmente substituído ou alquenila opcionalmente substituído; e cada R¬ 2¬ e R¬ 3¬ representa hidrogênio, alquila, hidroxialquila, diidroxialquila, ou alquinila, desde que R¬ 2¬ e R¬ 3¬ possam formar um grupo heterocíclico saturado nitrogenado opcionalmente substituído em cooperação com o nitrogênio adjacente) e uma composição medicinal contendo o composto. O composto funciona para inibir a produção de um fator de necrose tumoral (TNF-<244>) e tem capacidade de absorção oral satisfatória.
BRPI0407519-6A 2003-03-07 2004-03-03 derivados de benzofurano BRPI0407519A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45256403P 2003-03-07 2003-03-07
PCT/JP2004/002633 WO2004078751A1 (ja) 2003-03-07 2004-03-03 ベンゾフラン誘導体

Publications (1)

Publication Number Publication Date
BRPI0407519A true BRPI0407519A (pt) 2006-02-14

Family

ID=32962732

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0407519-6A BRPI0407519A (pt) 2003-03-07 2004-03-03 derivados de benzofurano

Country Status (15)

Country Link
US (1) US7314877B2 (pt)
EP (1) EP1602655A4 (pt)
JP (1) JP4528722B2 (pt)
KR (1) KR20050105982A (pt)
CN (1) CN1326852C (pt)
AU (1) AU2004218161B9 (pt)
BR (1) BRPI0407519A (pt)
CA (1) CA2512280A1 (pt)
MX (1) MXPA05009500A (pt)
MY (1) MY137964A (pt)
NO (1) NO20053312L (pt)
NZ (1) NZ541064A (pt)
RU (1) RU2328495C2 (pt)
TW (1) TWI281397B (pt)
WO (1) WO2004078751A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0408359A (pt) 2003-03-18 2006-03-21 Kowa Co derivados de fenilpiridazina solúveis em água e medicamentos contendo os mesmos
EP1604988A1 (en) * 2004-05-18 2005-12-14 Sanofi-Aventis Deutschland GmbH Pyridazinone derivatives, methods for producing them and their use as pharmaceuticals
DE102005057924A1 (de) * 2005-12-05 2007-06-06 Merck Patent Gmbh Pyridazinonderivate
AU2007222135B2 (en) 2006-03-09 2012-02-02 Om Pharma Immunomodulatory compounds and treatment of diseases related to an overproduction of inflammatory cytokines
FR2941947B1 (fr) * 2009-02-12 2011-03-25 Sanofi Aventis Derives de 3-benzofuranyl-indol-2-one subtitues en 3, leur preparation et leur application en therapeutique
CN101845032B (zh) * 2010-06-03 2011-11-30 广东德鑫制药有限公司 一种酚类化合物及用途
CN103003270B (zh) 2010-07-22 2014-11-12 扶桑药品工业株式会社 苯并呋喃酮化合物以及含有该化合物的药物组合物
KR101882172B1 (ko) * 2011-01-14 2018-07-26 스페로 트리넴, 인코포레이티드 자이라제 및 토포이소머라제 ⅳ 억제제의 제조방법
CN103998123B (zh) 2011-10-31 2016-08-24 韩国电力公社 用在干燥二氧化碳的捕集方法中的含胺或其化合物的固体二氧化碳吸收剂及其制造方法
KR101652199B1 (ko) * 2015-06-03 2016-08-30 영남대학교 산학협력단 신규 벤조퓨란온 유도체 화합물, 이의 제조 방법 및 이를 유효성분으로 포함하는 염증성 장질환 예방 또는 치료용 조성물
KR20180006522A (ko) 2016-07-07 2018-01-18 삼성디스플레이 주식회사 액정 조성물 및 이를 포함하는 액정 표시 장치
CN108440468B (zh) * 2018-04-17 2022-09-23 南华大学 2-(苯并呋喃-5-基)苯酚及其作为抗癌药物的应用
WO2020097258A1 (en) * 2018-11-06 2020-05-14 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
SMT202300355T1 (it) 2018-11-06 2024-01-10 Edgewise Therapeutics Inc Composti di piridazinone e loro usi
KR102885525B1 (ko) 2018-11-06 2025-11-13 엣지와이즈 테라퓨틱스, 인크. 피리다지논 화합물 및 이의 용도
EP4473968A3 (en) 2020-05-13 2025-03-26 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9127430D0 (en) * 1991-12-27 1992-02-19 Scras Benzofuranylimidazole derivatives
JP3093507B2 (ja) 1993-02-15 2000-10-03 キヤノン株式会社 液晶性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示方法および表示装置
PT889889E (pt) * 1996-03-29 2007-01-31 Duphar Int Res Composto de piperazina e piperidina
ATE230740T1 (de) 1996-04-12 2003-01-15 Sumitomo Pharma Piperidinylpyrimidine derivate
JP3337992B2 (ja) * 1997-11-04 2002-10-28 ファイザー製薬株式会社 ５−置換ピコリン酸化合物及びその製造方法
BR9813998A (pt) 1997-11-19 2000-09-26 Kowa Co Novos derivados de piridazina e produtos medicinais contendo os mesmos como ingredientes efetivos
TWI241295B (en) 1998-03-02 2005-10-11 Kowa Co Pyridazine derivative and medicine containing the same as effect component
JP2000247959A (ja) 1999-02-26 2000-09-12 Kowa Co ピリダジン−３−オン誘導体及びこれを含有する医薬
JP2000290261A (ja) * 1999-04-01 2000-10-17 Mitsui Chemicals Inc ジヒドロピリダジノン誘導体およびそれを有効成分として含有する腫瘍壊死因子産生抑制剤
JP2003510278A (ja) * 1999-09-30 2003-03-18 スミスクライン・ビーチャム・コーポレイション カスパーゼおよびアポプトシス
JP4502435B2 (ja) 1999-11-30 2010-07-14 興和創薬株式会社 ４，５，６，７−テトラヒドロチエノ〔２，３−ｃ〕ピリジン系化合物
JP4548882B2 (ja) 1999-11-30 2010-09-22 興和創薬株式会社 ４，５，６，７−テトラヒドロチエノ〔２，３−ｃ〕ピリジン化合物
JP4548884B2 (ja) 1999-12-03 2010-09-22 興和創薬株式会社 ４，５，６，７−テトラヒドロチエノ〔２，３−ｃ〕ピリジン誘導体
IL150841A0 (en) 2000-02-09 2003-02-12 Hokuriku Pharmaceutical 1h-imidazopyridine derivatives
EP1261595A1 (en) 2000-02-21 2002-12-04 AstraZeneca AB Arylpiperazines and arylpiperidines and their use as metalloproteinase inhibiting agents
US20030134880A1 (en) 2000-02-24 2003-07-17 Gordon Bruton Novel cd23 inhibitors
CA2397661C (en) 2000-03-01 2012-01-03 Janssen Pharmaceutica N.V. 2,4-disubstituted thiazolyl derivatives
US6664256B1 (en) 2000-07-10 2003-12-16 Kowa Co., Ltd. Phenylpyridazine compounds and medicines containing the same
US6861428B2 (en) 2001-09-26 2005-03-01 Kowa Co., Ltd. Water-soluble phenylpyridazine compounds and compositions containing the same
US6869954B2 (en) 2001-09-26 2005-03-22 Kowa Co., Ltd. Water-soluble phenylpyridazine compounds and compositions containing the same
JP3774710B2 (ja) 2003-06-27 2006-05-17 横浜ゴム株式会社 空気入りタイヤ

Also Published As

Publication number Publication date
NO20053312D0 (no) 2005-07-06
US20060189621A1 (en) 2006-08-24
AU2004218161A1 (en) 2004-09-16
EP1602655A1 (en) 2005-12-07
MXPA05009500A (es) 2005-10-18
CN1326852C (zh) 2007-07-18
NO20053312L (no) 2005-10-04
JP4528722B2 (ja) 2010-08-18
CA2512280A1 (en) 2004-09-16
CN1756753A (zh) 2006-04-05
TWI281397B (en) 2007-05-21
TW200420292A (en) 2004-10-16
WO2004078751A1 (ja) 2004-09-16
KR20050105982A (ko) 2005-11-08
AU2004218161B9 (en) 2009-11-26
EP1602655A4 (en) 2010-06-09
MY137964A (en) 2009-04-30
US7314877B2 (en) 2008-01-01
JPWO2004078751A1 (ja) 2006-06-08
HK1087105A1 (en) 2006-10-06
RU2328495C2 (ru) 2008-07-10
AU2004218161B2 (en) 2009-10-29
NZ541064A (en) 2007-09-28
RU2005131018A (ru) 2006-02-10

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.