BRPI0407658A - derivados de ácido aminofosfÈnico, seus sais e hidratos que atuam como moduladores de receptor de s1p e agente farmacêutico - Google Patents

derivados de ácido aminofosfÈnico, seus sais e hidratos que atuam como moduladores de receptor de s1p e agente farmacêutico

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Publication number
BRPI0407658A
BRPI0407658A BRPI0407658-3A BRPI0407658A BRPI0407658A BR PI0407658 A BRPI0407658 A BR PI0407658A BR PI0407658 A BRPI0407658 A BR PI0407658A BR PI0407658 A BRPI0407658 A BR PI0407658A
Authority
BR
Brazil
Prior art keywords
act
acid derivatives
receptor modulators
hydrates
salts
Prior art date
Application number
BRPI0407658-3A
Other languages
English (en)
Inventor
Yasushi Kohno
Kiyoaki Tanaka
Kazuhiko Kuriyama
Wataru Hori
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of BRPI0407658A publication Critical patent/BRPI0407658A/pt

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Abstract

"DERIVADOS DE áCIDO AMINOFOSFÈNICO, SEUS SAIS E HIDRATOS QUE ATUAM COMO MODULADORES DE RECEPTOR DE S1P E AGENTE FARMACêUTICO". Derivados de ácido aminofosfónico (como 2-amino-5-¢4-(3-benziloxifeniltio)-2-clorofenil!-2-metilpentilfosfonato monoéster) são representados pela seguinte fórmula geral (1): e que agem como eficazes moduladores de receptor de S1P ao mesmo tempo em que causam menos efeitos colaterais.
BRPI0407658-3A 2003-02-18 2004-02-18 derivados de ácido aminofosfÈnico, seus sais e hidratos que atuam como moduladores de receptor de s1p e agente farmacêutico BRPI0407658A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003039269 2003-02-18
PCT/JP2004/001783 WO2004074297A1 (ja) 2003-02-18 2004-02-18 アミノホスホン酸誘導体とその付加塩及びs1p受容体調節剤

Publications (1)

Publication Number Publication Date
BRPI0407658A true BRPI0407658A (pt) 2006-02-21

Family

ID=32905163

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0407658-3A BRPI0407658A (pt) 2003-02-18 2004-02-18 derivados de ácido aminofosfÈnico, seus sais e hidratos que atuam como moduladores de receptor de s1p e agente farmacêutico

Country Status (17)

Country Link
US (2) US7456157B2 (pt)
EP (2) EP1602660B1 (pt)
JP (1) JP4564918B2 (pt)
KR (1) KR101005171B1 (pt)
CN (1) CN100344638C (pt)
AT (1) ATE504590T1 (pt)
AU (1) AU2004213297B2 (pt)
BR (1) BRPI0407658A (pt)
CA (1) CA2515574C (pt)
CY (1) CY1111529T1 (pt)
DE (1) DE602004032118D1 (pt)
DK (1) DK1602660T3 (pt)
ES (1) ES2360394T3 (pt)
MX (1) MXPA05008760A (pt)
PT (1) PT1602660E (pt)
SI (1) SI1602660T1 (pt)
WO (1) WO2004074297A1 (pt)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4571497B2 (ja) * 2002-09-19 2010-10-27 杏林製薬株式会社 アミノアルコール誘導体とその付加塩及び免疫抑制剤
BRPI0407658A (pt) * 2003-02-18 2006-02-21 Kyorin Seiyaku Kk derivados de ácido aminofosfÈnico, seus sais e hidratos que atuam como moduladores de receptor de s1p e agente farmacêutico
US7638637B2 (en) 2003-11-03 2009-12-29 University Of Virginia Patent Foundation Orally available sphingosine 1-phosphate receptor agonists and antagonists
US7781617B2 (en) 2004-07-16 2010-08-24 Kyorin Pharmaceutical Co., Ltd Effective use method of medicaments and method of preventing expression of side effect
MX2007001661A (es) 2004-08-13 2007-04-23 Praecis Pharm Inc Metodos y composiciones para modular la actividad del receptor de esfingosina -1 fosfato (sip).
US20060223866A1 (en) * 2004-08-13 2006-10-05 Praecis Pharmaceuticals, Inc. Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity
EP1806338B1 (en) * 2004-10-12 2016-01-20 Kyorin Pharmaceutical Co., Ltd. Process for producing 2-amino-2-[2-[4-(3-benzyloxy-phenylthio)-2-chlorophenyl[ethyl]-1,3-propanediol hydrochloride and hydrates thereof. and intermediates the production thereof
WO2006063033A2 (en) 2004-12-06 2006-06-15 University Of Virginia Patent Foundation Aryl amide sphingosine 1-phosphate analogs
ES2529724T3 (es) * 2005-09-09 2015-02-25 Novartis Ag Tratamiento de enfermedades autoinmunes
PL1932522T3 (pl) * 2005-10-07 2012-09-28 Kyorin Seiyaku Kk Środek terapeutyczny do leczenia choroby wątroby zawierający jako składnik czynny pochodną 2-amino-1,3-propanodiolu
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