BRPI0412029A - formulações para microprojeções revestidas contendo contra-ìons não-voláteis - Google Patents

formulações para microprojeções revestidas contendo contra-ìons não-voláteis

Info

Publication number
BRPI0412029A
BRPI0412029A BRPI0412029-9A BRPI0412029A BRPI0412029A BR PI0412029 A BRPI0412029 A BR PI0412029A BR PI0412029 A BRPI0412029 A BR PI0412029A BR PI0412029 A BRPI0412029 A BR PI0412029A
Authority
BR
Brazil
Prior art keywords
formulations
counterions
coated microprojections
containing nonvolatile
microprojections containing
Prior art date
Application number
BRPI0412029-9A
Other languages
English (en)
Inventor
Mahmoud Ameri
Weiqi Lin
Michel J N Cormier
Yuh-Fun Maa
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of BRPI0412029A publication Critical patent/BRPI0412029A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electrotherapy Devices (AREA)

Abstract

"FORMULAçõES PARA MICROPROJEçõES REVESTIDAS CONTENDO CONTRA-ìONS NãO-VOLáTEIS". A invenção provê uma formulação para revestimento de uma ou mais microprojeções que reduzem ou minimizam a perda de contra-íons do revestimento, a fim de obter uma formulação de pH estabilizado.
BRPI0412029-9A 2003-06-30 2004-06-29 formulações para microprojeções revestidas contendo contra-ìons não-voláteis BRPI0412029A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48402003P 2003-06-30 2003-06-30
PCT/US2004/021004 WO2005004842A2 (en) 2003-06-30 2004-06-29 Formulations for coated microprojections containing non-volatile counterions

Publications (1)

Publication Number Publication Date
BRPI0412029A true BRPI0412029A (pt) 2006-09-05

Family

ID=34062010

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412029-9A BRPI0412029A (pt) 2003-06-30 2004-06-29 formulações para microprojeções revestidas contendo contra-ìons não-voláteis

Country Status (13)

Country Link
US (2) US7579013B2 (pt)
EP (1) EP1638523B8 (pt)
JP (1) JP5456234B2 (pt)
KR (1) KR20060038407A (pt)
CN (1) CN1842320B (pt)
AR (1) AR044964A1 (pt)
AU (1) AU2004255218A1 (pt)
BR (1) BRPI0412029A (pt)
CA (1) CA2530531A1 (pt)
ES (1) ES2437565T3 (pt)
MX (1) MXPA06000281A (pt)
TW (1) TW200518771A (pt)
WO (1) WO2005004842A2 (pt)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
ATE416692T1 (de) * 2000-10-13 2008-12-15 Alza Corp Mikronadelelementhalter für schlagapplikator
US7419481B2 (en) * 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
DE60138411D1 (de) * 2000-10-13 2009-05-28 Alza Corp Vorrichtung und verfahren zum durchstechen der haut mit micronadeln
NZ525551A (en) * 2000-10-26 2005-09-30 Alza Corp Transdermal drug delivery devices having coated microprotrusions
WO2002074173A1 (en) * 2001-03-16 2002-09-26 Alza Corporation Method and apparatus for coating skin piercing microprojections
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
PL1638468T3 (pl) * 2003-06-30 2008-01-31 Alza Corp Sposób powlekania mikrowystępów do przekłuwania skóry
KR20060038407A (ko) * 2003-06-30 2006-05-03 알자 코포레이션 비휘발성 반대이온을 포함하는 코팅된 미세돌출부용 제제
US20050123507A1 (en) 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
CN1845708A (zh) * 2003-07-02 2006-10-11 阿尔扎公司 微突出物阵列免疫贴剂和方法
JP2007501071A (ja) * 2003-08-04 2007-01-25 アルザ・コーポレーシヨン 経皮作用剤流率を向上させる方法および装置
US8524272B2 (en) 2003-08-15 2013-09-03 Mylan Technologies, Inc. Transdermal patch incorporating active agent migration barrier layer
US8961477B2 (en) 2003-08-25 2015-02-24 3M Innovative Properties Company Delivery of immune response modifier compounds
WO2005042702A2 (en) * 2003-10-23 2005-05-12 Alza Corporation Compositions of stabilized dna for coating microprojections
BRPI0415466A (pt) * 2003-10-24 2006-12-19 Alza Corp método e sistema de pré-tratamento para intensificar a distribuição transdérmica de fármacos
AU2004287412A1 (en) * 2003-10-28 2005-05-19 Alza Corporation Method and apparatus for reducing the incidence of tobacco use
ES2377647T3 (es) 2003-10-31 2012-03-29 Alza Corporation Aplicador auto-actuado para ordenamiento de microproyecciones
KR20070010115A (ko) * 2003-11-13 2007-01-22 알자 코포레이션 경피전달용 조성물 및 장치
CN101120101A (zh) * 2004-04-13 2008-02-06 阿尔扎公司 多联疫苗透皮释放的装置和方法
US7556821B2 (en) * 2004-05-13 2009-07-07 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
WO2006020841A2 (en) * 2004-08-11 2006-02-23 Alza Corporation Apparatus and method for transdermal delivery of natriuretic peptides
CA2593112A1 (en) * 2005-01-21 2006-07-27 Alza Corporation Therapeutic peptide formulations for coating microneedles with improved stability containing at least one counterion
WO2006081279A2 (en) * 2005-01-25 2006-08-03 Microchips, Inc. Control of drug release by transient modification of local microenvironments
JP2008530230A (ja) * 2005-02-16 2008-08-07 アルザ・コーポレーシヨン エリスロポエチンに基づく剤の経皮送達のための装置および方法
JP5438872B2 (ja) * 2005-06-02 2014-03-12 アルザ コーポレイション 経皮的送達デバイスの最終滅菌法
US20060275170A1 (en) * 2005-06-02 2006-12-07 Mahmoud Ameri Method for terminal sterilization of transdermal delivery devices
AU2006291157A1 (en) * 2005-09-12 2007-03-22 Alza Corporation Coatable transdermal delivery microprojection assembly
CA2629193C (en) * 2005-11-18 2016-03-29 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
US8554317B2 (en) * 2005-11-30 2013-10-08 3M Innovative Properties Company Microneedle arrays and methods of use thereof
US8632801B2 (en) * 2005-12-28 2014-01-21 Alza Corporation Stable therapeutic formulations
AU2007225056A1 (en) * 2006-03-15 2007-09-20 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents to prevent or treat osteopenia
US20070293816A1 (en) * 2006-04-25 2007-12-20 Alza Corporation Microprojection Array Application with Grouped Microprojections for High Drug Loading
US20070299388A1 (en) * 2006-04-25 2007-12-27 Alza Corporation Microprojection array application with multilayered microprojection member for high drug loading
US7771542B1 (en) 2006-05-30 2010-08-10 Stone Chemical Company Compositions and methods for removing lead from metal surfaces
CN102088991A (zh) 2008-05-13 2011-06-08 堪萨斯大学 金属提取肽标签和相关方法
HUE030072T2 (en) 2010-05-12 2017-04-28 Radius Health Inc Therapeutic prescriptions
EP2575845B1 (en) 2010-05-28 2017-02-15 3M Innovative Properties Company Aqueous formulations for coating microneedle arrays
US9133182B2 (en) 2010-09-28 2015-09-15 Radius Health, Inc. Selective androgen receptor modulators
WO2012071559A2 (en) * 2010-11-23 2012-05-31 Presage Biosciences, Inc. Therapeutic methods and compositions for solid delivery
CN102090904B (zh) * 2011-02-17 2013-04-03 中国中医科学院中医临床基础医学研究所 中药注射剂快速过敏皮试检测仪
US8512679B2 (en) 2011-03-04 2013-08-20 Elwha Llc Glassy compositions
NL2007382C2 (en) * 2011-09-09 2013-03-12 Univ Leiden Method to coat an active agent to a surface.
EP2771043A4 (en) 2011-10-28 2015-04-29 Presage Biosciences Inc ACTIVE RELEASE PROCEDURE
KR102143482B1 (ko) 2011-11-30 2020-08-11 쓰리엠 이노베이티브 프로퍼티즈 컴파니 펩티드 치료제 및 아미노산을 포함하는 마이크로니들 장치, 이의 제조 및 사용 방법
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity
US10980865B2 (en) 2012-08-10 2021-04-20 Aquavit Pharmaceuticals, Inc. Direct application system and method for the delivery of bioactive compositions and formulations
US9775799B2 (en) 2013-02-13 2017-10-03 Hisamitsu Pharmaceutical Co., Inc. Microneedle-coating composition and microneedle device
SG11201506326YA (en) 2013-02-13 2015-09-29 Hisamitsu Pharmaceutical Co Microneedle coating composition and microneedle device
WO2015027173A1 (en) * 2013-08-22 2015-02-26 Zp Opco, Inc. Stable glucagon peptide formulations
US9782344B2 (en) * 2013-08-22 2017-10-10 Zp Opco, Inc. Stable glucagon peptide formulations
ES3055185T3 (en) 2014-03-28 2026-02-10 Univ Duke Treatment of an estrogen receptor positive breast cancer using a selective estrogen receptor modulator
AU2016211916B2 (en) 2015-01-27 2018-10-18 3M Innovative Properties Company Alum-containing coating formulations for microneedle vaccine patches
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744239B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
KR20250152679A (ko) 2015-04-29 2025-10-23 래디어스 파마슈티컬스, 인코포레이티드 암을 치료하는 방법
WO2017062727A1 (en) * 2015-10-09 2017-04-13 3M Innovative Properties Company Zinc compositions for coated microneedle arrays
WO2017143345A1 (en) 2016-02-19 2017-08-24 Zp Opco, Inc. Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines
US10568937B2 (en) * 2016-04-18 2020-02-25 Radius Health, Inc. Formulations of abaloparatide, transdermal patches thereof, and uses thereof
MX389702B (es) 2016-06-22 2025-03-20 Ellipses Pharma Ltd Compuestos para usarse en el tratamiento de cancer de mama que expresa el receptor de androgenos (ar+).
AR109621A1 (es) * 2016-10-24 2018-12-26 Janssen Pharmaceuticals Inc Formulaciones de vacunas contra glucoconjugados de expec
JP7481115B2 (ja) 2017-01-05 2024-05-10 ラジウス ファーマシューティカルズ，インコーポレイテッド Ｒａｄ１９０１－２ｈｃｌの多形性形態
US11660264B2 (en) 2017-08-23 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
SG10201800072YA (en) * 2018-01-03 2019-08-27 Micropoint Tech Pte Ltd Microneedle Patches Comprising Corticosteroid
US11660265B2 (en) 2018-06-28 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
CN108721598B (zh) * 2018-07-03 2020-06-05 北京市新里程医药科技有限公司 一种缩宫素原料的制备方法及其药物组合物和制剂
MX2020013713A (es) 2018-07-04 2021-03-02 Radius Pharmaceuticals Inc Formas polimorficas de rad1901-2hcl.
EP3924328A1 (en) 2019-02-12 2021-12-22 Radius Pharmaceuticals, Inc. Processes and compounds
JP2023523952A (ja) 2020-04-28 2023-06-08 ティコナ・エルエルシー マイクロニードルアセンブリ

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123212A (en) 1964-03-03 Multiple disposable intracutaneous injector package
USRE25637E (en) 1964-09-08 Means for vaccinating
GB179994A (en) 1921-02-02 1922-05-02 Achilee Macchioni Throttling of the exhaust in a two-stroke cycle internal combustion motor applied to a locomotive for the purpose of increasing the power of the said motor
US2619962A (en) 1948-02-19 1952-12-02 Res Foundation Vaccination appliance
US2893392A (en) 1958-01-08 1959-07-07 American Cyanamid Co Article of manufacture for intracutaneous injections
US3072122A (en) 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3136314A (en) 1960-08-01 1964-06-09 Kravitz Harvey Vaccinating devices
US3221739A (en) 1962-03-26 1965-12-07 Rosenthal Sol Roy Injection device
US3221740A (en) 1962-08-31 1965-12-07 Rosenthal Sol Roy Injection device
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
BE795384A (fr) 1972-02-14 1973-08-13 Ici Ltd Pansements
OA05448A (fr) 1975-10-16 1981-03-31 Manufrance Manufacture Francai Dispositif vaccinateur multipénétrant.
FR2474856A1 (fr) 1980-01-31 1981-08-07 Merieux Inst Dispositif scarificateur
SE8501990D0 (sv) 1985-04-24 1985-04-24 Pharmacia Ab Beleggningsforfarande
DE3722775A1 (de) 1987-07-09 1989-01-19 Lohmann Therapie Syst Lts Transdermales therapeutisches system
US5051132A (en) * 1989-06-15 1991-09-24 Nippon Kayaku Kabushiki Kaisha Lyophilized preparation of 6-(3-dimethylaminopropionyl)forskolin
CA2016900A1 (en) 1989-07-06 1991-01-06 Ronald J. Filipski Tines structure in clinical applicator
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
JPH04134033A (ja) * 1990-01-19 1992-05-07 Nippon Kayaku Co Ltd エトポシド−２−ジメチルアミノ体の凍結乾燥製剤
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
DE4242919A1 (de) * 1992-12-18 1994-06-23 Boehringer Mannheim Gmbh Verfahren zur Herstellung von lagerstabilen wässrigen pharmazeutischen Zubereitungen von G-CSF
DE4341444C2 (de) 1993-12-04 1996-03-14 Lohmann Therapie Syst Lts Wirkstoffhaltiges Pflaster und Verfahren zu seiner Herstellung
US5496801A (en) * 1993-12-23 1996-03-05 Allelix Biopharmaceuticals Inc. Parathyroid hormone formulation
US5487726A (en) 1994-06-16 1996-01-30 Ryder International Corporation Vaccine applicator system
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
ATE252373T1 (de) 1994-08-04 2003-11-15 Elan Drug Delivery Ltd Feste verabreichungssysteme zur gesteuerten freisetzung von darin eingebauten molekülen sowie verfahren zu deren herstellung
AU3758595A (en) 1994-09-30 1996-04-26 Rutgers, The State University Direct introduction of foreign materials into cells
JPH10510175A (ja) 1994-12-09 1998-10-06 ノバルティス アクチェンゲゼルシャフト 経皮システム
US5866536A (en) * 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
AU5869796A (en) 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
WO1996037155A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
CA2253549C (en) 1996-06-18 2005-10-25 Alza Corporation Device for enhancing transdermal agent delivery or sampling
ATE241405T1 (de) 1996-07-03 2003-06-15 Altea Therapeutics Corp Mehrfache mechanische mikroperforierung von haut oder schleimhäuten
US5916524A (en) 1997-07-23 1999-06-29 Bio-Dot, Inc. Dispensing apparatus having improved dynamic range
US5743960A (en) 1996-07-26 1998-04-28 Bio-Dot, Inc. Precision metered solenoid valve dispenser
US5741554A (en) 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
US5738728A (en) 1996-07-26 1998-04-14 Bio Dot, Inc. Precision metered aerosol dispensing apparatus
US5983136A (en) 1996-09-17 1999-11-09 Deka Products Limited Partnership System for delivery of drugs by transport
EP0957972B1 (en) 1996-12-20 2003-03-19 Alza Corporation Device and method for enhancing transdermal agent flux
DE19654391A1 (de) 1996-12-27 1998-07-02 Basf Ag Katalysator zur selektiven Herstellung von Propylen aus Propan
BR9714113A (pt) 1996-12-31 2000-03-21 Shell Int Research Plataforma de tirante
US6918901B1 (en) 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
CA2313698C (en) 1997-12-11 2008-04-15 Alza Corporation Device for enhancing transdermal agent flux
ES2314995T3 (es) 1997-12-11 2009-03-16 Alza Corporation Dispositivo para mejorar el flujo de agentes tansdermicos.
DE69806963T2 (de) 1997-12-11 2002-11-21 Alza Corp., Mountain View Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
CA2311530C (en) * 1998-01-30 2008-06-10 Novartis Consumer Health S.A. Nasal solutions
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
EP1086214B1 (en) 1998-06-10 2009-11-25 Georgia Tech Research Corporation Microneedle devices and methods of their manufacture
US6532386B2 (en) 1998-08-31 2003-03-11 Johnson & Johnson Consumer Companies, Inc. Electrotransort device comprising blades
JP3722268B2 (ja) 1998-09-03 2005-11-30 栗田工業株式会社 抗菌性組成物
SE9803517D0 (sv) * 1998-10-15 1998-10-15 Astra Ab Pharmaceutical preparation
JP2002532165A (ja) 1998-12-18 2002-10-02 メドトロニック ミニメド インコーポレイテッド 医療装置と共に使われる、微小突刺し部材を備える挿入セット及びそのような挿入セットの使用方法
AR022119A1 (es) * 1998-12-22 2002-09-04 Bausch & Lomb Composiciones que contienen feniramina y metodo para el tratamiento de las respuestas alergicas
GB9901253D0 (en) * 1999-01-20 1999-03-10 Isis Innovation Bis-terpyridine-platinum(II) complexes
EP1163024B1 (en) 1999-01-28 2003-12-17 Cyto Pulse Sciences, Inc. Delivery of macromolecules into cells
US6884427B1 (en) 1999-02-08 2005-04-26 Aderans Research Institute, Inc. Filamentary means for introducing agents into tissue of a living host
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
GB9916316D0 (en) * 1999-07-12 1999-09-15 Quadrant Holdings Cambridge Dry powder compositions
US6623457B1 (en) 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US20020095134A1 (en) 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
ES2253278T3 (es) * 1999-12-10 2006-06-01 Alza Corporation Dispositivo y procedimiento para mejorar la perforacion cutanea con microprotuberancias.
CH694730A5 (de) * 2000-02-09 2005-06-30 Sumitomo Chemical Co Verfahren zum Herstellen optisch aktiver Hemiester.
DE60132325T2 (de) 2000-05-17 2009-01-02 Senju Pharmaceutical Co., Ltd. Ophthalmische lösung
US20020061838A1 (en) * 2000-05-17 2002-05-23 Barton Holmquist Peptide pharmaceutical formulations
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US6537242B1 (en) 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US20050008683A1 (en) 2000-06-29 2005-01-13 Becton Dickinson And Company Method for delivering interferons to the intradermal compartment
US6589202B1 (en) 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
GB0016002D0 (en) * 2000-06-29 2000-08-23 Glaxo Group Ltd Novel process for preparing crystalline particles
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
JP5507030B2 (ja) * 2000-09-08 2014-05-28 アルザ・コーポレーシヨン 経路閉鎖を阻害することによる経皮的薬物流動の減少の抑制方法
PL360978A1 (en) 2000-10-13 2004-09-20 Alza Corporation Microblade array impact applicator
DE60138411D1 (de) 2000-10-13 2009-05-28 Alza Corp Vorrichtung und verfahren zum durchstechen der haut mit micronadeln
ATE416692T1 (de) 2000-10-13 2008-12-15 Alza Corp Mikronadelelementhalter für schlagapplikator
NZ525551A (en) * 2000-10-26 2005-09-30 Alza Corp Transdermal drug delivery devices having coated microprotrusions
EP1345646A2 (en) 2000-12-14 2003-09-24 Georgia Tech Research Corporation Microneedle devices and production thereof
WO2002074173A1 (en) 2001-03-16 2002-09-26 Alza Corporation Method and apparatus for coating skin piercing microprojections
ATE444773T1 (de) * 2001-04-20 2009-10-15 Alza Corp Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält
US20020193729A1 (en) 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
EP1469903A2 (en) 2001-09-28 2004-10-27 BioValve Technologies, Inc. Microneedle with membrane
US6689100B2 (en) 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
DE60230894D1 (pt) * 2001-10-29 2009-03-05 Becton Dickinson Co
US20030199810A1 (en) 2001-11-30 2003-10-23 Trautman Joseph Creagan Methods and apparatuses for forming microprojection arrays
WO2003053258A1 (en) 2001-12-20 2003-07-03 Alza Corporation Skin-piercing microprojections having piercing depth control
US7015262B2 (en) 2002-05-01 2006-03-21 Lifescan, Inc. Hydrophilic coatings for medical implements
AU2003279641B2 (en) 2002-06-28 2009-06-18 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
PL1638468T3 (pl) * 2003-06-30 2008-01-31 Alza Corp Sposób powlekania mikrowystępów do przekłuwania skóry
US20050123507A1 (en) 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
KR20060038407A (ko) * 2003-06-30 2006-05-03 알자 코포레이션 비휘발성 반대이온을 포함하는 코팅된 미세돌출부용 제제
CN1845708A (zh) * 2003-07-02 2006-10-11 阿尔扎公司 微突出物阵列免疫贴剂和方法
ES2377647T3 (es) 2003-10-31 2012-03-29 Alza Corporation Aplicador auto-actuado para ordenamiento de microproyecciones
KR20070010115A (ko) 2003-11-13 2007-01-22 알자 코포레이션 경피전달용 조성물 및 장치
CA2593112A1 (en) * 2005-01-21 2006-07-27 Alza Corporation Therapeutic peptide formulations for coating microneedles with improved stability containing at least one counterion
US9960402B2 (en) 2016-09-07 2018-05-01 Thunder Power New Energy Vehicle Development Company Limited Process of manufacturing a battery system assembly using the battery system assembly press

Also Published As

Publication number Publication date
ES2437565T3 (es) 2014-01-13
KR20060038407A (ko) 2006-05-03
MXPA06000281A (es) 2006-07-03
WO2005004842A2 (en) 2005-01-20
JP2007527392A (ja) 2007-09-27
WO2005004842A3 (en) 2005-04-21
US20100221305A1 (en) 2010-09-02
US20040265354A1 (en) 2004-12-30
CN1842320A (zh) 2006-10-04
CA2530531A1 (en) 2005-01-20
EP1638523A2 (en) 2006-03-29
TW200518771A (en) 2005-06-16
AU2004255218A1 (en) 2005-01-20
AR044964A1 (es) 2005-10-12
US7579013B2 (en) 2009-08-25
EP1638523B1 (en) 2013-10-30
JP5456234B2 (ja) 2014-03-26
US8920817B2 (en) 2014-12-30
EP1638523B8 (en) 2013-12-25
CN1842320B (zh) 2013-06-19

Similar Documents

Publication Publication Date Title
BRPI0412029A (pt) formulações para microprojeções revestidas contendo contra-ìons não-voláteis
SI1259218T1 (sl) Kozmetični sestavek za tretiranje starajoče se in ali obremenjene kože
DK1651728T3 (da) Tokomponent-coatingsystem til forsyning af glatte overflader med rengøringsvenlige egenskaber
AR020345A1 (es) Pirazol-carboxanilidas, procedimiento para su obtencion, composiciones, empleo de dichos compuestos y procedimiento para la lucha contra microorganismos indeseables, y procedimiento para la obtencion de dichas composiciones.
BRPI0407373A (pt) Espuma hidro-alcoólica formando espuma em filme
ECSP109852A (es) Uso de homo y copolímeros para la estabilización de formulaciones de principios activos
BRPI0509505A (pt) método e kit útil para branqueamento de uma superfìcie dental
BRPI0007487B8 (pt) difenil-uréias substituídas com w-carbóxi-arilas como inibidores de raf cinase
CY1108532T1 (el) Ενωσεις και συνθεσεις για την παροχη δραστικων παραγοντων
BRPI0408373A (pt) composições para tratamento de pele que aumentam e reparam a função de barreira da pele
NO20080002L (no) Formuleringer av konjugerte ostrogener og bazedoxifen
AR019503A1 (es) Utilizacion de derivados sustituidos en 3 del estilbeno como agentes activos desodorantes en las composiciones cosmeticas
BR0209649A (pt) Sistema de teor aquoso em duas partes para a coloração oxidatina capilar
BR0212386A (pt) Composto, formulação farmacêutica, e, uso de um composto
TW200635620A (en) Formulations for coated microprojections having controlled solubility
BRPI0412697A (pt) composições farmacêuticas que apresentam um revestimento expansìvel
FR2848116B1 (fr) Composition cosmetique comprenant un inhibiteur des metallo-proteinases et un lipopeptide.
ES2190082T3 (es) Concentrados estables de vitamina c.
BR0208813A (pt) Composições contendo imidazotriazinona para a aplicação nasal
BRPI0515721A (pt) uso de um inibidor de src cinase e um inibidor de bcr-abl, composição farmacêutica e combinação
AR020563A1 (es) Compuestos (poli)tia-alquinoicos y sus derivados, composiciones que los incluyen y su utilizacion
BRPI0408848A (pt) formulações orais de cladribine
BR0303912A (pt) Composição para o condicionamento, composição para o condicionamento durável, método para o condicionamento, método para o condicionamento durável, método para o cuidado ou tratamento e kit para o cuidado, tratamento, condicionamento ou condicionamento durável
BR0309923B1 (pt) Formulação aquosa de poliuretano, e, uso da mesma
UA87312C2 (ru) КОМПОЗИЦИЯ ДЛЯ АЭРОЗОЛЬНОЙ ИНГАЛЯЦИИ β-АГОНИСТОВ

Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A E 7A ANUIDADE(S)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.