BRPI0407672A - processos para preparar imatinib e um sal de adição ácida deste, sais de adição ácida de imatinib, composição farmaceuticamente aceitável deste, imatinib e uso deste - Google Patents

processos para preparar imatinib e um sal de adição ácida deste, sais de adição ácida de imatinib, composição farmaceuticamente aceitável deste, imatinib e uso deste

Info

Publication number
BRPI0407672A
BRPI0407672A BRPI0407672-9A BRPI0407672A BRPI0407672A BR PI0407672 A BRPI0407672 A BR PI0407672A BR PI0407672 A BRPI0407672 A BR PI0407672A BR PI0407672 A BRPI0407672 A BR PI0407672A
Authority
BR
Brazil
Prior art keywords
imatinib
acid addition
addition salt
preparing
pharmaceutically acceptable
Prior art date
Application number
BRPI0407672-9A
Other languages
English (en)
Inventor
Rajendra Narayanrao Kankan
Dharmaraj Ramachandra Rao
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd filed Critical Cipla Ltd
Publication of BRPI0407672A publication Critical patent/BRPI0407672A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)

Abstract

"PROCESSOS PARA PREPARAR IMATINIB E UM SAL DE ADIçãO áCIDA DESTE, SAIS DE ADIçãO áCIDA DE IMATINIB, COMPOSIçãO FARMACEUTICAMENTE ACEITáVEL DESTE, IMATINIB E USO DESTE". A presente invenção refere-se a um processo para preparar imatinib, quer como base livre, quer como sal de adição ácida, o qual processo compreende reagir N-(2-metil-5aminofenil-4-(3-piridil)-2-pirimidina amina da fórmula (II) com haleto de 4-(4-metil-piperazino metil)benzoíla de fórmula (III) na presença de um solvente orgânico inerte, de maneira a produzir um sal de hidrohaleto de imatinib de fórmula (I) onde n representa 1, 2 ou 3 e Hal representa bromo, cloro, flúoro ou iodo, quer na forma anidra, quer na forma hidratada que pode, conforme desejado, opcionalmente ser adicionalmente convertido quer na base livre, quer em um sal de adição ácida adicional. A presente invenção também se refere ao imatinib preparado de acordo com o processo acima.
BRPI0407672-9A 2003-02-18 2004-01-08 processos para preparar imatinib e um sal de adição ácida deste, sais de adição ácida de imatinib, composição farmaceuticamente aceitável deste, imatinib e uso deste BRPI0407672A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0303730A GB2398565A (en) 2003-02-18 2003-02-18 Imatinib preparation and salts
PCT/GB2004/000018 WO2004074502A2 (en) 2003-02-18 2004-01-08 A process of preparing imatinib

Publications (1)

Publication Number Publication Date
BRPI0407672A true BRPI0407672A (pt) 2006-03-01

Family

ID=9953245

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0407672-9A BRPI0407672A (pt) 2003-02-18 2004-01-08 processos para preparar imatinib e um sal de adição ácida deste, sais de adição ácida de imatinib, composição farmaceuticamente aceitável deste, imatinib e uso deste

Country Status (12)

Country Link
US (1) US7638627B2 (pt)
EP (1) EP1599462B1 (pt)
JP (1) JP5064024B2 (pt)
KR (1) KR101086845B1 (pt)
AU (1) AU2004213616B2 (pt)
BR (1) BRPI0407672A (pt)
CA (1) CA2516370C (pt)
GB (1) GB2398565A (pt)
NZ (1) NZ542040A (pt)
PL (1) PL378128A1 (pt)
RU (1) RU2415849C2 (pt)
WO (1) WO2004074502A2 (pt)

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CN102250063B (zh) * 2010-05-19 2014-10-22 江苏豪森药业股份有限公司 甲磺酸伊马替尼的晶型及其制备方法
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CN101899035B (zh) * 2010-09-03 2012-09-05 天津市炜杰科技有限公司 一种高纯度伊马替尼的制备方法
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CN102816145B (zh) * 2011-06-11 2014-09-03 南京卡文迪许生物工程技术有限公司 甲磺酸伊马替尼多晶型物及其药用组合物
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JP6096205B2 (ja) 2011-11-01 2017-03-15 モッドジーン リミテッド ライアビリティ カンパニーＭｏｄｇｅｎｅ，Ｌｌｃ 低減されたタンパク質キナーゼ阻害を呈するイマチニブ誘導体の使用
CN102659762A (zh) * 2012-05-24 2012-09-12 石药集团中奇制药技术（石家庄）有限公司 一种甲磺酸伊马替尼晶型及其制备方法
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CN104163812A (zh) * 2013-05-17 2014-11-26 浙江九洲药业股份有限公司 一种无定型的伊马替尼甲磺酸盐及其制备方法
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CN103910711A (zh) * 2014-03-24 2014-07-09 福建天泉药业股份有限公司 一种伊马替尼游离碱晶型及其制备方法
CN104974133B (zh) * 2014-04-09 2018-04-27 石药集团中奇制药技术（石家庄）有限公司 一种甲磺酸伊马替尼晶型及其制备方法
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Also Published As

Publication number Publication date
PL378128A1 (pl) 2006-03-06
US7638627B2 (en) 2009-12-29
AU2004213616A1 (en) 2004-09-02
KR101086845B1 (ko) 2011-11-24
JP2006518360A (ja) 2006-08-10
GB0303730D0 (en) 2003-03-26
RU2415849C2 (ru) 2011-04-10
US20060173182A1 (en) 2006-08-03
EP1599462A2 (en) 2005-11-30
AU2004213616B2 (en) 2011-05-26
AU2004213616A2 (en) 2004-09-02
RU2005129100A (ru) 2006-06-10
WO2004074502A2 (en) 2004-09-02
NZ542040A (en) 2009-02-28
GB2398565A (en) 2004-08-25
EP1599462B1 (en) 2013-03-27
KR20050108358A (ko) 2005-11-16
WO2004074502A3 (en) 2004-10-28
JP5064024B2 (ja) 2012-10-31
CA2516370A1 (en) 2004-09-02
CA2516370C (en) 2012-08-21

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25G Requested change of headquarter approved

Owner name: CIPLA LIMITED (IN)

B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 13A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]