BRPI0408006A - uso de ácidos graxos Èmega -3 no tratamento de pacientes diabéticos - Google Patents

uso de ácidos graxos Èmega -3 no tratamento de pacientes diabéticos

Info

Publication number
BRPI0408006A
BRPI0408006A BRPI0408006-8A BRPI0408006A BRPI0408006A BR PI0408006 A BRPI0408006 A BR PI0408006A BR PI0408006 A BRPI0408006 A BR PI0408006A BR PI0408006 A BRPI0408006 A BR PI0408006A
Authority
BR
Brazil
Prior art keywords
fatty acids
omega
treatment
diabetic patients
ethyl ester
Prior art date
Application number
BRPI0408006-8A
Other languages
English (en)
Inventor
Rainer Oelze
Cees-Nico Verboom
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of BRPI0408006A publication Critical patent/BRPI0408006A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"USO DE áCIDOS GRAXOS ÈMEGA -3 NO TRATAMENTO DE PACIENTES DIABéTICOS". A presente invenção refere-se ao uso de ácidos graxos essenciais com um alto teor de éster de etila de ácido eicosapentenóico (EPA) ou de éster de etila de ácido docosahexaenóico (DHA) útil para evitar eventos cardiovasculares em pacientes com diabetes melito.
BRPI0408006-8A 2003-03-05 2004-03-02 uso de ácidos graxos Èmega -3 no tratamento de pacientes diabéticos BRPI0408006A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03004792 2003-03-05
PCT/EP2004/050238 WO2004078166A2 (en) 2003-03-05 2004-03-02 Use of omega-3-fatty acids in the treatment of diabetic patients

Publications (1)

Publication Number Publication Date
BRPI0408006A true BRPI0408006A (pt) 2006-02-14

Family

ID=32946844

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408006-8A BRPI0408006A (pt) 2003-03-05 2004-03-02 uso de ácidos graxos Èmega -3 no tratamento de pacientes diabéticos

Country Status (8)

Country Link
EP (1) EP1603551A2 (pt)
JP (1) JP2006519244A (pt)
CN (1) CN1756545A (pt)
AU (1) AU2004216856A1 (pt)
BR (1) BRPI0408006A (pt)
CA (1) CA2515328A1 (pt)
MX (1) MXPA05009432A (pt)
WO (1) WO2004078166A2 (pt)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9901809D0 (en) 1999-01-27 1999-03-17 Scarista Limited Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes
EP1834639B8 (en) 2005-01-04 2016-12-07 Mochida Pharmaceutical Co., Ltd. Remedial agent for fat toxicity
KR101255650B1 (ko) * 2005-05-04 2013-04-16 프로노바 바이오파마 너지 에이에스 새로운 ｄｈａ 유도체 및 약제로서의 용도
EP1888728A4 (en) 2005-05-04 2010-07-14 Pronova Biopharma Norge As Fatty acid analogues, D.H. DHA DERIVATIVES FOR USE AS A MEDICAMENT
CN101213281B (zh) * 2005-05-04 2013-03-13 普罗诺瓦生物医药挪威公司 新的dha衍生物及其作为药物的用途
RU2441061C2 (ru) * 2005-05-04 2012-01-27 Пронова Биофарма Норге Эс. Производные докозагексаеновой кислоты и их применение в качестве лекарственных средств
JP5134916B2 (ja) * 2005-07-08 2013-01-30 持田製薬株式会社 心血管イベント発症予防用組成物
KR101465715B1 (ko) * 2005-07-08 2014-11-27 모치다 세이야쿠 가부시키가이샤 심혈관 이벤트 발병 예방용 조성물
JP5552313B2 (ja) * 2006-11-01 2014-07-16 プロノヴァ・バイオファーマ・ノルゲ・アーエス 脂質化合物
JP2010508262A (ja) * 2006-11-01 2010-03-18 プロノヴァ バイオファーマ ノルゲ アーエス 組成物
RU2507193C2 (ru) * 2006-11-01 2014-02-20 Пронова Биофарма Норге А/С Альфа-замещенные омега-3 липиды, которые являются активаторами или модуляторами рецептора, активируемого пролифераторами пероксисом (ppar)
CN101646426A (zh) * 2006-11-03 2010-02-10 普罗诺瓦生物医药挪威公司 ω-3脂质化合物
JPWO2010018856A1 (ja) * 2008-08-13 2012-01-26 持田製薬株式会社 カンナビノイド受容体関連疾患の予防／改善または治療剤
EP4137128A1 (en) 2008-09-02 2023-02-22 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and a statin, and methods of using same
ES2768091T3 (es) 2009-02-10 2020-06-19 Amarin Pharmaceuticals Ie Ltd Uso del éster etílico del ácido eicosapentaenoico para tratar la hipertrigliceridemia
NZ720946A (en) 2009-04-29 2017-09-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
MX350088B (es) 2009-04-29 2017-08-25 Amarin Pharma Inc Composicion farmaceutica estable y metodos de uso de la misma.
CN108096209A (zh) 2009-06-15 2018-06-01 阿马里纳制药公司 在相伴他汀类疗法的对象中降低甘油三酯、没有增加ldl-c水平的组合物和方法
FR2949063B1 (fr) * 2009-08-11 2011-09-30 Pf Medicament Composition pharmaceutique comprenant un ester de dha destinee a etre administree par voie parenterale
US20110071176A1 (en) 2009-09-23 2011-03-24 Amarin Pharma, Inc. Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same
WO2012063820A1 (ja) * 2010-11-09 2012-05-18 持田製薬株式会社 血糖値上昇抑制剤
US11712429B2 (en) 2010-11-29 2023-08-01 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
NZ712068A (en) 2010-11-29 2017-03-31 Amarin Pharmaceuticals Ie Ltd Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
US11291643B2 (en) 2011-11-07 2022-04-05 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
US20130131170A1 (en) 2011-11-07 2013-05-23 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
ES2891473T3 (es) 2012-01-06 2022-01-28 Amarin Pharmaceuticals Ie Ltd Composiciones y métodos para reducir los niveles de alta sensibilidad (hs-CRP) en un sujeto
CA3067012C (en) 2012-06-29 2021-10-05 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
WO2014074552A2 (en) 2012-11-06 2014-05-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy
US9814733B2 (en) 2012-12-31 2017-11-14 A,arin Pharmaceuticals Ireland Limited Compositions comprising EPA and obeticholic acid and methods of use thereof
US20140187633A1 (en) 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
US9624492B2 (en) 2013-02-13 2017-04-18 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9662307B2 (en) 2013-02-19 2017-05-30 The Regents Of The University Of Colorado Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof
US9283201B2 (en) 2013-03-14 2016-03-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for treating or preventing obesity in a subject in need thereof
US20140271841A1 (en) 2013-03-15 2014-09-18 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
US10966968B2 (en) 2013-06-06 2021-04-06 Amarin Pharmaceuticals Ireland Limited Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
US20150065572A1 (en) 2013-09-04 2015-03-05 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing prostate cancer
US9585859B2 (en) 2013-10-10 2017-03-07 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
US10561631B2 (en) 2014-06-11 2020-02-18 Amarin Pharmaceuticals Ireland Limited Methods of reducing RLP-C
US10172818B2 (en) 2014-06-16 2019-01-08 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
US10406130B2 (en) 2016-03-15 2019-09-10 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
WO2018213663A1 (en) 2017-05-19 2018-11-22 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject having reduced kidney function
US11058661B2 (en) 2018-03-02 2021-07-13 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
MA51766A (fr) 2018-09-24 2020-12-16 Amarin Pharmaceuticals Ie Ltd Procédés de réduction du risque d'événements cardiovasculaires chez un sujet
BR112022009189A2 (pt) 2019-11-12 2022-07-26 Amarin Pharmaceuticals Ie Ltd Métodos para reduzir o risco de eventos cardiovasculares em um sujeito com fibrilação atrial e/ou palpitação atrial
US11986452B2 (en) 2021-04-21 2024-05-21 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of heart failure

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60248610A (ja) * 1984-05-23 1985-12-09 Nitsusui Seiyaku Kk 糖尿病合併症の予防および治療剤
GB2218904A (en) * 1988-05-27 1989-11-29 Renafield Limited Pharmaceutical composition based on high-concentration esters of docosahexaenoic acid
GB2223943A (en) * 1988-10-21 1990-04-25 Tillotts Pharma Ag Oral disage forms of omega-3 polyunsaturated acids

Also Published As

Publication number Publication date
WO2004078166A3 (en) 2004-10-28
JP2006519244A (ja) 2006-08-24
WO2004078166A2 (en) 2004-09-16
CA2515328A1 (en) 2004-09-16
CN1756545A (zh) 2006-04-05
EP1603551A2 (en) 2005-12-14
AU2004216856A1 (en) 2004-09-16
MXPA05009432A (es) 2005-11-23

Similar Documents

Publication Publication Date Title
WO2004078166A3 (en) Use of omega-3-fatty acids in the treatment of diabetic patients
BR0008153A (pt) Uso de ácidos graxos essenciais na prevenção de eventos cardiovasculares
TW200744463A (en) Nutritional supplement containing long-chain polyunsaturated fatty acids
US5198468A (en) Essential fatty acid composition
PT1310249E (pt) Utilizacao de acidos gordos poli-insaturados para prevencao primaria de eventos cardiovasculares graves
BRPI0418921A (pt) uso de ácidos graxos poliinsaturados, composição nutricional, e, uso de uma composição
WO2008018043A3 (en) Methods of improving bone health and muscle health
DE69622722D1 (de) Fette enthaltende Ernährungszusammensetzung zur Behandlung des Stoffwechselssyndroms
KR940018090A (ko) 트리글리세라이드
ATE449057T1 (de) Resolvine: biotemplate zur durchführung therapeutischer anwendungen
BR0112073A (pt) Combinações terapêuticas de ácidos graxos
MXPA05003346A (es) Control glicemico mejorado para prediabetes y/o diabetes tipo ii utilizando acido docosahexaenoico.
DE602005021668D1 (de) Pharmazeutische formulierung mit statinmikrokapseln in alkylestern mehrfach ungesättigter fettsäuren
WO2008036353A3 (en) Omega-3 diglyceride emulsions
YU59303A (sh) Esencijalne n-3 masne kiseline u lečenju srčane insuficijencije i manjkavosti rada srca
MX2010004820A (es) Mezcla lipidica para nutricion infantil.
CO6150156A2 (es) Esteres de dha y su utilizacion en el tratamiento y la prevencion de enfermedades cardiovasculares
EP1765324A4 (en) COMPOSITIONS BASED ON STABLE BIOACTIVE METABOLITES OF DOCOSAHEXANOIC (DHA) AND EICOSAPENTANOIC ACIDS (EPA)
BRPI0512528B8 (pt) uso de ácidos graxos poliinsaturados, composição nutricional, e, uso de uma composição
Hiratsuka et al. Effect of dietary docosahexaenoic acid connecting phospholipids on the lipid peroxidation of the brain in mice
Stańdo et al. Omega‐3 polyunsaturated fatty acids as an adjunct to non‐surgical treatment of periodontitis
WO2002092779A3 (en) Method for enriching tissues in long chain polyunsaturated fatty acids
DE60101859D1 (de) Pinolensäure gegen Diabetes
WO2008052709A3 (en) Monoesters of estrogens with conjugated linoleic acid and uses thereof
UA94693C2 (ru) Незаменимые жирные кислоты, предназначенные для предупреждения и/или лечения депрессии у пациентов, которые страдают сердечно-сосудистым заболеванием

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired