BRPI0408332A - derivados heterocìclicos contendo nitrogênio e medicamentos contendo os mesmos como ingrediente ativo - Google Patents

derivados heterocìclicos contendo nitrogênio e medicamentos contendo os mesmos como ingrediente ativo

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Publication number
BRPI0408332A
BRPI0408332A BRPI0408332-6A BRPI0408332A BRPI0408332A BR PI0408332 A BRPI0408332 A BR PI0408332A BR PI0408332 A BRPI0408332 A BR PI0408332A BR PI0408332 A BRPI0408332 A BR PI0408332A
Authority
BR
Brazil
Prior art keywords
diseases
allergic
medicinal products
heterocyclic derivatives
general formula
Prior art date
Application number
BRPI0408332-6A
Other languages
English (en)
Inventor
Rena Nishizawa
Yoshikazu Takaoka
Shiro Shibayama
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of BRPI0408332A publication Critical patent/BRPI0408332A/pt

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    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
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    • C07D211/40—Oxygen atoms
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Abstract

"DERIVADOS HETEROCìCLICOS CONTENDO NITROGêNIO E MEDICAMENTOS CONTENDO OS MESMOS COMO INGREDIENTE ATIVO". Um composto representado pela fórmula geral abaixo (I), seu sal, seus solvatos ou seus promedicamentos; (I) (em que cada símbolo é conforme definido na descrição) . os compostos representados pela fórmula geral (I) são úteis para a prevenção e/ou tratamento de diversas doenças in inflamatórias (asma, nefrite, nefropatia, hepatite, artrite, artrite reumatóide, rinite, conjuntivite, colite ulcerativa etc.) , doenças imunológicas (doenças autoimunes, rejeição em transplante de órgãos, imunossupressão, psoríase, esclerose múltipla etc.), infecção por vírus de imunodeficiência humana (síndrome de imunodeficiência adquirida etc), doenças alérgicas (dermatite atópica, urticária, aspergilose broncopulmonar alérgica, gastrenterite eosinófila alérgica etc.), lesão por reperfusão isquêmica, sindrome de aflição respiratória aguda, choque que acompanha infecção bacteriana, diabete, metástase cancerosa e assim por diante
BRPI0408332-6A 2003-03-14 2004-03-12 derivados heterocìclicos contendo nitrogênio e medicamentos contendo os mesmos como ingrediente ativo BRPI0408332A (pt)

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PCT/JP2004/003333 WO2004080966A1 (ja) 2003-03-14 2004-03-12 含窒素複素環誘導体およびそれらを有効成分とする薬剤

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