BRPI0408403A - pó cristalino de triidrato de amoxicilina - Google Patents

pó cristalino de triidrato de amoxicilina

Info

Publication number
BRPI0408403A
BRPI0408403A BRPI0408403-9A BRPI0408403A BRPI0408403A BR PI0408403 A BRPI0408403 A BR PI0408403A BR PI0408403 A BRPI0408403 A BR PI0408403A BR PI0408403 A BRPI0408403 A BR PI0408403A
Authority
BR
Brazil
Prior art keywords
amoxicillin trihydrate
powder
amoxicillin
crystalline
crystalline powder
Prior art date
Application number
BRPI0408403-9A
Other languages
English (en)
Inventor
Jan Willem Groenendaal
Everardus Johannus A Leenderts
Thomas Van Der Does
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45007138&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0408403(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of BRPI0408403A publication Critical patent/BRPI0408403A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

"Pó CRISTALINO DE TRIIDRATO DE AMOXICILINA". A invenção está relacionada a pó cristalino de triidrato de amoxicilina possuindo uma densidade em massa maior que 0,45 g/mL. A invenção também está relacionada a um processo para a preparação de pó cristalino de triidrato de amoxicilina, o referido processo compreendendo: cristalizar o triidrato de amoxicilina a partir de uma solução contendo amoxicilina dissolvida; separar os cristais a partir da referida solução; e secar os cristais separados, resultando em pó cristalino possuindo uma densidade em massa maior que 0,45 g/mL.
BRPI0408403-9A 2003-03-21 2004-03-19 pó cristalino de triidrato de amoxicilina BRPI0408403A (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US45618803P 2003-03-21 2003-03-21
US45618703P 2003-03-21 2003-03-21
EP03100731 2003-03-21
EP03100732 2003-03-21
PCT/EP2004/002989 WO2004082661A1 (en) 2003-03-21 2004-03-19 Crystalline amoxicillin trihydrate powder

Publications (1)

Publication Number Publication Date
BRPI0408403A true BRPI0408403A (pt) 2006-03-21

Family

ID=45007138

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0408403-9A BRPI0408403A (pt) 2003-03-21 2004-03-19 pó cristalino de triidrato de amoxicilina
BRPI0408568-0A BRPI0408568A (pt) 2003-03-21 2004-03-19 triidrato de amoxicilina

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0408568-0A BRPI0408568A (pt) 2003-03-21 2004-03-19 triidrato de amoxicilina

Country Status (14)

Country Link
US (1) US20060172987A1 (pt)
EP (2) EP1610766B1 (pt)
JP (2) JP4949826B2 (pt)
CN (2) CN102260278B (pt)
AT (1) ATE362359T1 (pt)
BR (2) BRPI0408403A (pt)
CY (1) CY1106809T1 (pt)
DE (1) DE602004006507T2 (pt)
ES (1) ES2286627T3 (pt)
MX (2) MXPA05010102A (pt)
PL (1) PL1610766T3 (pt)
PT (1) PT1610766E (pt)
SI (1) SI1610766T1 (pt)
WO (3) WO2004082662A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102260278B (zh) * 2003-03-21 2015-05-06 中化帝斯曼制药有限公司荷兰公司 三水羟氨苄青霉素结晶粉末
US7534781B2 (en) * 2003-03-21 2009-05-19 Dsm Ip Assets B.V. Crystalline amoxicillin trihydrate powder
AU2008254037B2 (en) * 2007-05-21 2013-10-17 Toray Industries, Inc. Crystalline micropowder particles
US7985791B1 (en) 2008-02-22 2011-07-26 Lords Additives LLC Incorporation of SBP and ulexite into composites
EP2778171A1 (en) * 2013-03-15 2014-09-17 Synbias Pharma Ltd. Crystalline monohydrate of epirubicin hydrochloride
CN103145733B (zh) * 2013-03-20 2014-02-26 四川省惠达药业有限公司 一种阿莫西林化合物及该化合物和克拉维酸钾的药物组合物
CN111202713A (zh) * 2013-09-03 2020-05-29 灿盛制药有限公司荷兰公司 微粒化的阿莫西林
CN104059086B (zh) * 2014-06-19 2016-04-13 河南牧翔动物药业有限公司 一种阿莫西林晶体及其制备方法
CN104099396B (zh) * 2014-07-22 2016-03-23 石药集团中诺药业（石家庄）有限公司 一种直通法制备阿莫西林的工艺
WO2017186864A1 (en) 2016-04-27 2017-11-02 Sandoz Ag Enzymatic process for the production of beta-lactam antibiotics in the presence of particulate inoculum
CN109867687B (zh) * 2017-12-05 2021-08-17 上海朝瑞化工有限公司 一种高水溶性阿莫西林及其制备方法
CN111518119B (zh) * 2020-05-26 2021-12-21 联邦制药(内蒙古)有限公司 一种阿莫西林连续结晶工艺

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5583789A (en) * 1978-12-18 1980-06-24 Bristol Myers Co Preparation of penicillin
JPS6052751B2 (ja) * 1981-04-21 1985-11-21 富山化学工業株式会社 新規な結晶形を有するセフアレキシン１水和物
WO1994017800A1 (en) * 1993-02-15 1994-08-18 Gist-Brocades B.V. AN IMPROVED β-LACTAM ANTIBIOTIC COMPOSITION
GB9423459D0 (en) * 1994-11-21 1995-01-11 Biochemie Gmbh Silylation process
TWI225402B (en) * 1996-03-13 2004-12-21 Biochemie Gmbh Auxiliary-free agglomerates
AU9540898A (en) * 1997-08-29 1999-03-22 Dsm N.V. Granules free of excipients
US20020137926A1 (en) * 1998-06-01 2002-09-26 Smithkline Beecham Corporation Process for preparing crystalline salts of amoxycillin
US6979735B1 (en) * 1999-04-01 2005-12-27 Dsm N.V. Agglomerates by crystallization
AT412213B (de) * 2000-05-30 2004-11-25 Sandoz Ag Verfahren zur trocknung von amoxicillin oder amoxicillin-hältigen, oralen, festen pharmazeutischen zusammensetzungen unter verwendung eines gases mit einer definierten gasfeuchte
CN102260278B (zh) * 2003-03-21 2015-05-06 中化帝斯曼制药有限公司荷兰公司 三水羟氨苄青霉素结晶粉末

Also Published As

Publication number Publication date
EP1808166A1 (en) 2007-07-18
DE602004006507T2 (de) 2008-01-31
SI1610766T1 (sl) 2007-10-31
JP2006520765A (ja) 2006-09-14
JP4949827B2 (ja) 2012-06-13
PL1610766T3 (pl) 2007-08-31
CN1761457A (zh) 2006-04-19
PT1610766E (pt) 2007-08-01
ATE362359T1 (de) 2007-06-15
MXPA05010104A (es) 2005-11-23
ES2286627T3 (es) 2007-12-01
JP4949826B2 (ja) 2012-06-13
DE602004006507D1 (en) 2007-06-28
CN1761457B (zh) 2010-05-12
US20060172987A1 (en) 2006-08-03
CN102260278A (zh) 2011-11-30
EP1610766A1 (en) 2006-01-04
BRPI0408568A (pt) 2006-03-21
WO2004082662A1 (en) 2004-09-30
CN102260278B (zh) 2015-05-06
WO2004082663A1 (en) 2004-09-30
MXPA05010102A (es) 2005-11-23
CY1106809T1 (el) 2012-05-23
JP2006523188A (ja) 2006-10-12
WO2004082661A1 (en) 2004-09-30
EP1610766B1 (en) 2007-05-16

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: "PARA: INT. CL. A61K 9/20

Ipc: A61K 9/20 (2011.01), C07D 499/00 (2011.01), A61P 3

Free format text: PARA: INT. CL. A61K 9/20; C07D 499/00; A61P 31/00

Ipc: A61K 9/20 (2011.01), C07D 499/00 (2011.01), A61P 3

B15V Prolongation of time limit allowed

Free format text: RECONHECIDO O OBSTACULO ADMINISTRATIVO E CONCEDIDO A DEVOLUCAO DE PRAZO DE 17 DIAS , NOS TERMOS DO ARTIGO 221 2O DA LPI E DA RESOLUCAO 116/04.

B25A Requested transfer of rights approved

Owner name: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]