BRPI0408639A - molécula de ácido nucleico, vetor, célula hospedeira, partìculas semelhantes a vìrus, método para produzir partìculas semelhantes a vìrus, vacina, composições farmacêuticas, e, métodos para prevenir a infecção por hpv e para induzir uma resposta imune em um animal - Google Patents

molécula de ácido nucleico, vetor, célula hospedeira, partìculas semelhantes a vìrus, método para produzir partìculas semelhantes a vìrus, vacina, composições farmacêuticas, e, métodos para prevenir a infecção por hpv e para induzir uma resposta imune em um animal

Info

Publication number
BRPI0408639A
BRPI0408639A BRPI0408639-2A BRPI0408639A BRPI0408639A BR PI0408639 A BRPI0408639 A BR PI0408639A BR PI0408639 A BRPI0408639 A BR PI0408639A BR PI0408639 A BRPI0408639 A BR PI0408639A
Authority
BR
Brazil
Prior art keywords
particles
virus
hpv31
vaccine
vector
Prior art date
Application number
BRPI0408639-2A
Other languages
English (en)
Inventor
Kathrin U Jansen
Loren D Schultz
Michael P Neeper
Henry Z Markus
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of BRPI0408639A publication Critical patent/BRPI0408639A/pt
Publication of BRPI0408639B1 publication Critical patent/BRPI0408639B1/pt
Publication of BRPI0408639B8 publication Critical patent/BRPI0408639B8/pt

Links

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medical Informatics (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"MOLéCULA DE áCIDO NUCLEICO, VETOR, CéLULA HOSPEDEIRA, PARTìCULAS SEMELHANTES A VìRUS, MéTODO PARA PRODUZIR PARTìCULAS SEMELHANTES A VìRUS, VACINA, COMPOSIçõES FARMACêUTICAS, E, MéTODOS PARA PREVENIR A INFECçãO POR HPV E PARA INDUZIR UMA RESPOSTA IMUNE EM UM ANIMAL". As moléculas de DNA sintéticas que codificam a proteína HPV31 L1 são fornecidas. Especificamente, a presente invenção fornece polinucleotídeos que codificam a proteína HPV31 L1, em que os ditos polinucleotídeos são isentos de sinais de terminação de transcrição internos que são reconhecidos pela levedura. Também são fornecidos polinucleotídeos sintéticos que codifica HPV31 L1 em que os polinucleotídeos foram otimizados por códon para a expressão de alto nível em uma célula de levedura. As moléculas sintéticas podem ser usadas para produzir partículas semelhantes ao vírus HPV31 (VLPs) e para produzir vacinas e composições farmacêuticas que compreendem os HPV31 VLPs. As vacinas da presente invenção fornecem imunoprofilaxia eficaz contra infecção por papilomavírus através do anticorpo neutralizador e imunidade mediada por célula.
BRPI0408639A 2003-03-24 2004-03-19 molécula de ácido nucleico, vetor, célula hospedeira de levedura e método para produzir partículas semelhantes a vírus de hpv31 BRPI0408639B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45717203P 2003-03-24 2003-03-24
US60/457,172 2003-03-24
PCT/US2004/008677 WO2004084831A2 (en) 2003-03-24 2004-03-19 Optimized expression of hpv 31 l1 in yeast

Publications (3)

Publication Number Publication Date
BRPI0408639A true BRPI0408639A (pt) 2006-03-28
BRPI0408639B1 BRPI0408639B1 (pt) 2020-08-18
BRPI0408639B8 BRPI0408639B8 (pt) 2021-05-25

Family

ID=33098208

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408639A BRPI0408639B8 (pt) 2003-03-24 2004-03-19 molécula de ácido nucleico, vetor, célula hospedeira de levedura e método para produzir partículas semelhantes a vírus de hpv31

Country Status (21)

Country Link
US (2) US7276243B2 (pt)
EP (1) EP1608767B1 (pt)
JP (1) JP4505452B2 (pt)
KR (1) KR101080628B1 (pt)
CN (1) CN100506999C (pt)
AT (1) ATE546529T1 (pt)
AU (1) AU2004224335B2 (pt)
BR (1) BRPI0408639B8 (pt)
CA (1) CA2519112C (pt)
EC (1) ECSP056032A (pt)
ES (1) ES2381964T3 (pt)
FR (1) FR15C0079I2 (pt)
IL (1) IL171067A (pt)
IS (1) IS2859B (pt)
MX (1) MXPA05010285A (pt)
NL (1) NL300772I1 (pt)
NO (3) NO341527B1 (pt)
NZ (1) NZ542246A (pt)
RU (1) RU2356943C2 (pt)
WO (1) WO2004084831A2 (pt)
ZA (1) ZA200507178B (pt)

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Also Published As

Publication number Publication date
NO20054889D0 (no) 2005-10-21
RU2356943C2 (ru) 2009-05-27
NO20054889L (no) 2005-12-19
US20080166371A1 (en) 2008-07-10
JP4505452B2 (ja) 2010-07-21
CA2519112C (en) 2012-09-11
NL300772I2 (pt) 2015-12-29
US7276243B2 (en) 2007-10-02
KR101080628B1 (ko) 2011-11-08
NL300772I1 (pt) 2015-12-29
FR15C0079I2 (fr) 2016-11-25
NO341527B1 (no) 2017-12-04
NO2018010I1 (no) 2018-03-27
NO2022053I1 (no) 2022-11-30
KR20050119141A (ko) 2005-12-20
IS2859B (is) 2013-12-15
EP1608767B1 (en) 2012-02-22
HK1090953A1 (zh) 2007-01-05
ECSP056032A (es) 2006-01-27
ZA200507178B (en) 2006-08-30
BRPI0408639B8 (pt) 2021-05-25
US20060177817A1 (en) 2006-08-10
IS8019A (is) 2005-09-12
FR15C0079I1 (pt) 2016-08-01
WO2004084831A3 (en) 2004-11-11
EP1608767A4 (en) 2006-08-30
RU2005132603A (ru) 2006-04-27
IL171067A (en) 2011-11-30
ES2381964T3 (es) 2012-06-04
CN1761759A (zh) 2006-04-19
BRPI0408639B1 (pt) 2020-08-18
NZ542246A (en) 2007-12-21
MXPA05010285A (es) 2005-11-17
AU2004224335A1 (en) 2004-10-07
EP1608767A2 (en) 2005-12-28
ATE546529T1 (de) 2012-03-15
WO2004084831A2 (en) 2004-10-07
AU2004224335B2 (en) 2010-01-28
JP2006523099A (ja) 2006-10-12
CN100506999C (zh) 2009-07-01
CA2519112A1 (en) 2004-10-07
US7482428B2 (en) 2009-01-27

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