ECSP056032A - Expresión optimizada de hpv 31 l1 en levadura - Google Patents

Expresión optimizada de hpv 31 l1 en levadura

Info

Publication number
ECSP056032A
ECSP056032A EC2005006032A ECSP056032A ECSP056032A EC SP056032 A ECSP056032 A EC SP056032A EC 2005006032 A EC2005006032 A EC 2005006032A EC SP056032 A ECSP056032 A EC SP056032A EC SP056032 A ECSP056032 A EC SP056032A
Authority
EC
Ecuador
Prior art keywords
hpv31
yeast
polynucleotides
synthetic
protein
Prior art date
Application number
EC2005006032A
Other languages
English (en)
Inventor
Kathrin U Jansen
Loren D Schultz
Michael P Neeper
Henry Z Markus
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ECSP056032A publication Critical patent/ECSP056032A/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Se proveen moléculas de ADN sintéticas que codifican la proteína de HPV31 L1. Específicamente, la presente invención provee polinucleótidos que codifican la proteína de HPV31 L1, en donde dichos polinucleótidos están libres de señales de terminación de la transcripción internas que son reconocidas por levadura. También se proveen polinucleótidos sintéticos que codifican HPV31 L1 en donde los polinucleótidos han sido optimizados por codones para obtener altos niveles de expresión en una célula de levadura. Las moléculas sintéticas pueden ser utilizadas para producir partículas del tipo virus HPV31 (VLPs), y para producir vacunas y composiciones farmacéuticas que comprenden las VLPs de HPV31. Las vacunas de la presente invención proveen inmunoprofilaxis efectiva contra la infección por papilomavirus a través de anticuerpo neutralizante e inmunidad mediada por células.
EC2005006032A 2003-03-24 2005-09-20 Expresión optimizada de hpv 31 l1 en levadura ECSP056032A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45717203P 2003-03-24 2003-03-24

Publications (1)

Publication Number Publication Date
ECSP056032A true ECSP056032A (es) 2006-01-27

Family

ID=33098208

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005006032A ECSP056032A (es) 2003-03-24 2005-09-20 Expresión optimizada de hpv 31 l1 en levadura

Country Status (21)

Country Link
US (2) US7276243B2 (es)
EP (1) EP1608767B1 (es)
JP (1) JP4505452B2 (es)
KR (1) KR101080628B1 (es)
CN (1) CN100506999C (es)
AT (1) ATE546529T1 (es)
AU (1) AU2004224335B2 (es)
BR (1) BRPI0408639B8 (es)
CA (1) CA2519112C (es)
EC (1) ECSP056032A (es)
ES (1) ES2381964T3 (es)
FR (1) FR15C0079I2 (es)
IL (1) IL171067A (es)
IS (1) IS2859B (es)
MX (1) MXPA05010285A (es)
NL (1) NL300772I2 (es)
NO (3) NO341527B1 (es)
NZ (1) NZ542246A (es)
RU (1) RU2356943C2 (es)
WO (1) WO2004084831A2 (es)
ZA (1) ZA200507178B (es)

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CN103361377B (zh) * 2012-03-28 2017-12-05 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv6 l1蛋白的方法
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RU2546243C1 (ru) * 2014-02-13 2015-04-10 Закрытое акционерное общество научно-производственная компания "Комбиотех" Рекомбинантная вакцина для профилактики папилломавирусной инфекции человека и способ ее получения
WO2016057954A2 (en) * 2014-10-10 2016-04-14 Board Of Regents Of The University Of Texas System Exogenous terminators for controlling fungal gene expression
KR101825996B1 (ko) * 2014-12-26 2018-02-09 아이진 주식회사 인유두종 바이러스의 바이러스 유사 입자 제조방법
CN117187263A (zh) * 2015-03-30 2023-12-08 上海泽润生物科技有限公司 重组人乳头瘤病毒33亚型蛋白表达
CN106701797B (zh) * 2015-08-12 2021-06-15 北京康乐卫士生物技术股份有限公司 31型重组人乳头瘤病毒病毒样颗粒及其制备方法
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WO2021013062A1 (zh) * 2019-07-19 2021-01-28 神州细胞工程有限公司 嵌合的人乳头瘤病毒31型l1蛋白
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Publication number Publication date
US20080166371A1 (en) 2008-07-10
IS8019A (is) 2005-09-12
BRPI0408639B8 (pt) 2021-05-25
FR15C0079I1 (es) 2016-08-01
US7276243B2 (en) 2007-10-02
CN1761759A (zh) 2006-04-19
ZA200507178B (en) 2006-08-30
AU2004224335A1 (en) 2004-10-07
NL300772I1 (es) 2015-12-29
RU2356943C2 (ru) 2009-05-27
HK1090953A1 (zh) 2007-01-05
BRPI0408639A (pt) 2006-03-28
KR20050119141A (ko) 2005-12-20
IS2859B (is) 2013-12-15
MXPA05010285A (es) 2005-11-17
AU2004224335B2 (en) 2010-01-28
NO2022053I1 (no) 2022-11-30
CN100506999C (zh) 2009-07-01
NO20054889L (no) 2005-12-19
JP2006523099A (ja) 2006-10-12
CA2519112A1 (en) 2004-10-07
ES2381964T3 (es) 2012-06-04
EP1608767A4 (en) 2006-08-30
NZ542246A (en) 2007-12-21
NO20054889D0 (no) 2005-10-21
CA2519112C (en) 2012-09-11
NO341527B1 (no) 2017-12-04
US20060177817A1 (en) 2006-08-10
EP1608767A2 (en) 2005-12-28
ATE546529T1 (de) 2012-03-15
KR101080628B1 (ko) 2011-11-08
JP4505452B2 (ja) 2010-07-21
BRPI0408639B1 (pt) 2020-08-18
RU2005132603A (ru) 2006-04-27
FR15C0079I2 (fr) 2016-11-25
US7482428B2 (en) 2009-01-27
NL300772I2 (es) 2015-12-29
IL171067A (en) 2011-11-30
EP1608767B1 (en) 2012-02-22
NO2018010I1 (no) 2018-03-27
WO2004084831A2 (en) 2004-10-07
WO2004084831A3 (en) 2004-11-11

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