BRPI0408988A - composto de piperidinilamino-tieno[2,3-d]pirimidina - Google Patents

composto de piperidinilamino-tieno[2,3-d]pirimidina

Info

Publication number
BRPI0408988A
BRPI0408988A BRPI0408988-0A BRPI0408988A BRPI0408988A BR PI0408988 A BRPI0408988 A BR PI0408988A BR PI0408988 A BRPI0408988 A BR PI0408988A BR PI0408988 A BRPI0408988 A BR PI0408988A
Authority
BR
Brazil
Prior art keywords
piperidinylaminothieno
pyrimidine compound
novel
piperidinylamino
thieno
Prior art date
Application number
BRPI0408988-0A
Other languages
English (en)
Inventor
Dale S Dhanoa
Oren Becker
Silvia Noiman
Srinivasa Rao Cheruku
Sharon Shachem
Alexander Heifetz
Boaz Inbal
Yael Marantz
Venkitasamy Kesavan
Shay Bar-Haim
Sekar A Reddy
Rosa E Melendez
Anurag Sharadendu
Dongli Chen
Original Assignee
Predix Pharmaceuticals Holding
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Predix Pharmaceuticals Holding filed Critical Predix Pharmaceuticals Holding
Publication of BRPI0408988A publication Critical patent/BRPI0408988A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

"COMPOSTOS DE PIPERIDINILAMINO-TIENO ¢2,3-D!PIRIMIDINA". A presente invenção refere-se a antagonista de receptor de 5-HT. Novos compostos de piperidinilamino-tieno¢2,3-d!pirimidina representado pela Formula 1, e síntese e empregos destes para tratar de doenças mediadas diretamente o indiretamente por receptores 5-HT, são descritos. Tais condições incluem distúrbio do sistema nervoso central tais como, ansiedade, depressão, esquizofrenia, lesão neural, acidente vascular cerebral, hemicrânia. Métodos de preparação e novos intermediários; e sais farmacêuticos destes são também incluídos.
BRPI0408988-0A 2003-03-31 2004-03-31 composto de piperidinilamino-tieno[2,3-d]pirimidina BRPI0408988A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45883103P 2003-03-31 2003-03-31
PCT/US2004/009944 WO2004089312A2 (en) 2003-03-31 2004-03-31 New piperidinylamino-thieno[2,3-d] pyrimidine compounds

Publications (1)

Publication Number Publication Date
BRPI0408988A true BRPI0408988A (pt) 2006-03-28

Family

ID=33159606

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408988-0A BRPI0408988A (pt) 2003-03-31 2004-03-31 composto de piperidinilamino-tieno[2,3-d]pirimidina

Country Status (13)

Country Link
US (1) US7030240B2 (pt)
EP (1) EP1622914B1 (pt)
JP (1) JP4677518B2 (pt)
KR (1) KR20060013370A (pt)
CN (1) CN1777612A (pt)
AT (1) ATE511511T1 (pt)
AU (1) AU2004227913B2 (pt)
BR (1) BRPI0408988A (pt)
CA (1) CA2517833A1 (pt)
MX (1) MXPA05009818A (pt)
NO (1) NO20055029L (pt)
NZ (1) NZ542236A (pt)
WO (1) WO2004089312A2 (pt)

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US20050222175A1 (en) * 2004-03-31 2005-10-06 Dhanoa Dale S New piperidinylamino-thieno[2,3-D] pyrimidine compounds
US7488736B2 (en) 2004-05-17 2009-02-10 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
US7576211B2 (en) 2004-09-30 2009-08-18 Epix Delaware, Inc. Synthesis of thienopyridinone compounds and related intermediates
US7598265B2 (en) * 2004-09-30 2009-10-06 Epix Delaware, Inc. Compositions and methods for treating CNS disorders
US7407966B2 (en) 2004-10-07 2008-08-05 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
EP1802634A2 (en) * 2004-10-20 2007-07-04 Compass Pharmaceuticals LLC Thiophens and their use as anti-tumor agents
JP5186219B2 (ja) * 2005-01-25 2013-04-17 エピックス デラウェア， インコーポレイテッド 置換アリールアミン化合物および５−ｈｔ６調節因子としてのその使用
WO2007110868A2 (en) 2006-03-28 2007-10-04 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
EP2896624B1 (en) * 2007-03-28 2016-07-13 Atir Holding S.A. Heterotricyclic compounds as serotonergic and/or dopaminergic agents and uses thereof
EA201070334A1 (ru) * 2007-09-04 2010-10-29 ПиДжиэксХЭЛТ ЭлЭлСи Пиперидиниламинотиено[2,3-d]пиримидиновые соединения для лечения фиброза
WO2010065743A2 (en) 2008-12-03 2010-06-10 Nanotherapeutics, Inc. Bicyclic compounds and methods of making and using same
CN103119047B (zh) 2010-07-23 2016-06-15 哈佛大学校长及研究员协会 三环类蛋白酶体活性增强化合物
EP3239154A1 (en) * 2011-01-10 2017-11-01 Nimbus Iris, Inc. Irak inhibitors and uses thereof
WO2012140642A1 (en) 2011-04-10 2012-10-18 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
EP2872144A4 (en) 2012-07-11 2015-12-02 Nimbus Iris Inc IRAQ INHIBITOR AND USES THEREOF
WO2014110114A1 (en) 2013-01-10 2014-07-17 Nimbus Iris, Inc. Irak inhibitors and uses thereof
EP3049086A4 (en) 2013-09-27 2017-02-22 Nimbus Iris, Inc. Irak inhibitors and uses thereof
TWI648281B (zh) 2013-10-17 2019-01-21 日商安斯泰來製藥股份有限公司 含硫二環式化合物
WO2015090226A1 (zh) * 2013-12-20 2015-06-25 中国人民解放军军事医学科学院毒物药物研究所 N，n'取代哌啶胺类化合物、其制备方法及用途
USRE49687E1 (en) 2014-09-09 2023-10-10 The Regents Of The University Of Michigan Thienopyrimidine and thienopyridine compounds and methods of use thereof
CN104592248A (zh) * 2014-12-31 2015-05-06 芜湖杨燕制药有限公司 一种4-氯-6-取代噻吩并[2,3-d]嘧啶化合物的制备方法
WO2016197027A1 (en) 2015-06-04 2016-12-08 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with mll proteins
TWI703150B (zh) 2015-06-04 2020-09-01 美商庫拉腫瘤技術股份有限公司 用於抑制ｍｅｎｉｎ及ｍｌｌ蛋白之交互作用的方法及組合物
WO2017161028A1 (en) 2016-03-16 2017-09-21 Kura Oncology, Inc. Substituted inhibitors of menin-mll and methods of use
US10752639B2 (en) 2016-03-16 2020-08-25 Kura Oncology, Inc. Bridged bicyclic inhibitors of menin-MLL and methods of use
CN110691779B (zh) 2017-03-24 2023-10-10 库拉肿瘤学公司 治疗血液系统恶性肿瘤和尤因肉瘤的方法
US11542248B2 (en) 2017-06-08 2023-01-03 Kura Oncology, Inc. Methods and compositions for inhibiting the interaction of menin with MLL proteins
TW201920170A (zh) 2017-09-20 2019-06-01 美商庫拉腫瘤技術股份有限公司 經取代之menin-mll 抑制劑及使用方法

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WO2004017950A2 (en) 2002-08-22 2004-03-04 Piramed Limited Phosphadidylinositol 3,5-biphosphate inhibitors as anti-viral agents

Also Published As

Publication number Publication date
WO2004089312A2 (en) 2004-10-21
KR20060013370A (ko) 2006-02-09
US7030240B2 (en) 2006-04-18
AU2004227913B2 (en) 2010-12-02
US20040248904A1 (en) 2004-12-09
JP2006522141A (ja) 2006-09-28
CN1777612A (zh) 2006-05-24
NO20055029L (no) 2005-12-08
EP1622914A2 (en) 2006-02-08
EP1622914A4 (en) 2008-03-12
NO20055029D0 (no) 2005-10-28
WO2004089312A3 (en) 2005-05-12
AU2004227913A1 (en) 2004-10-21
EP1622914B1 (en) 2011-06-01
NZ542236A (en) 2008-05-30
JP4677518B2 (ja) 2011-04-27
MXPA05009818A (es) 2006-03-13
CA2517833A1 (en) 2004-10-21
ATE511511T1 (de) 2011-06-15

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B08L Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 9A E 10A ANUIDADES.

B08I Publication cancelled [chapter 8.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2258 DE 15/04/2014 POR TER SIDO INDEVIDA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 9A, 10A, 11A, 12A, 13A, 14A, 15A E 16A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.