BRPI0409097A - derivados de imidazol para tratamento de distúrbios alérgicos e hiperproliferativos - Google Patents

derivados de imidazol para tratamento de distúrbios alérgicos e hiperproliferativos

Info

Publication number
BRPI0409097A
BRPI0409097A BRPI0409097-7A BRPI0409097A BRPI0409097A BR PI0409097 A BRPI0409097 A BR PI0409097A BR PI0409097 A BRPI0409097 A BR PI0409097A BR PI0409097 A BRPI0409097 A BR PI0409097A
Authority
BR
Brazil
Prior art keywords
allergic
treatment
hyperproliferative disorders
imidazole derivatives
preferred embodiments
Prior art date
Application number
BRPI0409097-7A
Other languages
English (en)
Inventor
Jagadish C Sircar
Richard J Thomas
Mark L Richards
Haripada Khatuya
Original Assignee
Avanir Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avanir Pharmaceuticals filed Critical Avanir Pharmaceuticals
Publication of BRPI0409097A publication Critical patent/BRPI0409097A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE IMIDAZOL PARA TRATAMENTO DE DISTúRBIOS ALéRGICOS E HIPERPROLIFERATIVOS". As modalidades preferidas da invenção referem-se a moléculas pequenas inibidoras da resposta de IgE a alérgenos, que são úteis no tratamento de alergia e/ou asma ou quaisquer doenças nas quais IgE é patogênica. As modalidades preferidas referem-se também a moléculas de imidazol que são inibidoras da proliferação celular, e assim sendo, são úteis como agentes contra câncer. As modalidades preferidas referem-se ainda a moléculas pequenas que suprimem citocinas e leucócitos.
BRPI0409097-7A 2003-04-10 2004-04-09 derivados de imidazol para tratamento de distúrbios alérgicos e hiperproliferativos BRPI0409097A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46209003P 2003-04-10 2003-04-10
PCT/US2004/011010 WO2004091610A1 (en) 2003-04-10 2004-04-09 Imidazole derivatives for treatment of allergic and hyperproliferative disorders

Publications (1)

Publication Number Publication Date
BRPI0409097A true BRPI0409097A (pt) 2006-04-11

Family

ID=33299906

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409097-7A BRPI0409097A (pt) 2003-04-10 2004-04-09 derivados de imidazol para tratamento de distúrbios alérgicos e hiperproliferativos

Country Status (15)

Country Link
US (1) US20040229927A1 (pt)
EP (1) EP1613310A1 (pt)
JP (1) JP2006522820A (pt)
KR (1) KR20050120711A (pt)
CN (1) CN1826111A (pt)
AR (1) AR045886A1 (pt)
AU (1) AU2004229466A1 (pt)
BR (1) BRPI0409097A (pt)
CA (1) CA2521841A1 (pt)
MX (1) MXJL05000041A (pt)
PL (1) PL378919A1 (pt)
RU (1) RU2005134670A (pt)
TW (1) TW200503695A (pt)
WO (1) WO2004091610A1 (pt)
ZA (1) ZA200508108B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6919366B2 (en) * 1998-05-22 2005-07-19 Avanir Pharmaceuticals Benzimidazole derivatives as modulators of IgE
US6911462B2 (en) * 1998-05-22 2005-06-28 Avanir Pharmaceuticals Benzimidazole compounds for regulating IgE
CA2441177A1 (en) * 2001-03-12 2002-09-19 Avanir Pharmaceuticals Benzimidazole compounds for modulating ige and inhibiting cellular proliferation
TW200304820A (en) * 2002-03-25 2003-10-16 Avanir Pharmaceuticals Use of benzimidazole analogs in the treatment of cell proliferation
AU2003270426A1 (en) 2002-09-12 2004-04-30 Avanir Pharmaceuticals PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION
TWI276631B (en) * 2002-09-12 2007-03-21 Avanir Pharmaceuticals Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
EP1651198A2 (en) * 2003-08-08 2006-05-03 Avanir Pharmaceuticals Selective pharmacologic inhibition of protein trafficking and related methods of treating human diseases
EP1737297B1 (en) * 2004-03-25 2012-12-19 Janssen Pharmaceutica NV Imidazole compounds
UA91129C2 (ru) 2006-05-09 2010-06-25 Пфайзер Продактс Инк. Производные циклоалкиламинокислот и фармацевтическая композиция, которая их содержит
PE20080948A1 (es) 2006-07-25 2008-09-10 Irm Llc Derivados de imidazol como moduladores de la senda de hedgehog
US9187485B2 (en) 2007-02-02 2015-11-17 Baylor College Of Medicine Methods and compositions for the treatment of cancer and related hyperproliferative disorders
US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
PT3289876T (pt) 2008-06-16 2022-10-28 Univ Tennessee Res Found Compostos para o tratamento do câncer
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
RU2506260C2 (ru) * 2008-06-25 2014-02-10 Энвиво Фармасьютикалз, Инк. 1,2-дизамещенные гетероциклические соединения
AU2010347233B2 (en) 2010-03-01 2015-06-18 Oncternal Therapeutics, Inc. Compounds for treatment of cancer
RU2712092C2 (ru) * 2013-11-05 2020-01-24 Байер Кропсайенс Акциенгезельшафт Замещенные бензамиды для борьбы с членистоногими
US10328064B2 (en) 2014-12-23 2019-06-25 Fgh Biotech, Inc. Compositions of fatostatin based heterocyclic compounds and uses thereof
KR102498741B1 (ko) 2016-04-29 2023-02-10 에프지에이치 바이오테크 인코포레이티드 질환 치료용 이-치환된 피라졸 화합물
US11339142B2 (en) 2016-09-07 2022-05-24 Fgh Biotech, Inc. Di-substituted pyrazole compounds for the treatment of diseases
EP3573957B1 (en) 2017-01-24 2023-04-26 Rivara, Mirko Compositions and methods for blocking sodium channels
CN108191667B (zh) * 2018-01-04 2021-03-26 利尔化学股份有限公司 2-硝基-4-三氟甲基苯甲酸甲酯的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206257A (en) * 1987-03-05 1993-04-27 May & Baker Limited Pesticidal method using 2-phenylimidazole derivatives
JP2630432B2 (ja) * 1987-08-24 1997-07-16 コニカ株式会社 新規なシアンカプラーを含有するハロゲン化銀カラー写真感光材料
JPH01224759A (ja) * 1988-03-03 1989-09-07 Konica Corp 新規なシアンカプラーを含有するハロゲン化銀写真感光材料
JPH01225949A (ja) * 1988-03-04 1989-09-08 Konica Corp ハロゲン化銀写真感光材料
JPH01262546A (ja) * 1988-04-13 1989-10-19 Konica Corp 新規なシアンカプラーを含有するハロゲン化銀写真感光材料
JPH0361946A (ja) * 1989-07-29 1991-03-18 Konica Corp ハロゲン化銀カラー写真感光材料
JPH03245140A (ja) * 1990-02-23 1991-10-31 Konica Corp 新規なシアンカプラーを含有するハロゲン化銀写真感光材料
US5633377A (en) * 1990-12-28 1997-05-27 Neurogen Corporation 4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands
JPH09304897A (ja) * 1996-05-10 1997-11-28 Konica Corp 新規なシアンカプラーを含有するハロゲン化銀写真感光材料
TW467902B (en) * 1996-07-31 2001-12-11 Bristol Myers Squibb Co Diphenyl heterocycles as potassium channel modulators
CA2232467A1 (en) * 1997-03-20 1998-09-20 Richard A. Glennon Imidazoles with serotonin receptor binding activity
GB0007405D0 (en) * 2000-03-27 2000-05-17 Smithkline Beecham Corp Compounds

Also Published As

Publication number Publication date
KR20050120711A (ko) 2005-12-22
MXJL05000041A (es) 2005-12-22
EP1613310A1 (en) 2006-01-11
AU2004229466A1 (en) 2004-10-28
TW200503695A (en) 2005-02-01
WO2004091610A1 (en) 2004-10-28
ZA200508108B (en) 2007-03-28
RU2005134670A (ru) 2006-06-10
PL378919A1 (pl) 2006-06-12
JP2006522820A (ja) 2006-10-05
CA2521841A1 (en) 2004-10-28
AR045886A1 (es) 2005-11-16
US20040229927A1 (en) 2004-11-18
CN1826111A (zh) 2006-08-30

Similar Documents

Publication Publication Date Title
BRPI0409097A (pt) derivados de imidazol para tratamento de distúrbios alérgicos e hiperproliferativos
BR0314235A (pt) Compostos de fenil-aza-benzimidazol para modulação de ige e inibição da proliferação celular
BR0314223A (pt) Compostos fenil-indol para modular ige e inibir proliferação celular
NO20005889L (no) Benzimidazolderivater som ned-regulatorer av IgE
MXJL03000027A (es) Compuestos de benzimidazol para modular la ige e inhibir la proliferacion celular.
DE60223262D1 (de) Verwendung von fucanen in der behandlung von adhäsion, arthritis und psoriasis
MA31167B1 (fr) Inhibiteurs de l'activite de akt
CY1116754T1 (el) Παραγωγα νιτροκατεχολης ως αναστολεις της comt
CY1115188T1 (el) Πολυκυκλικες ετεροαρυλ-υποκατεστημενες τριαζολες χρησιμες ως αναστολεις του axl
EA200700934A1 (ru) Производные пиримидина и их применение в качестве модуляторов cb2
EA200800555A1 (ru) Производные ксантина в качестве селективных агонистов hm74a
EP1606286A4 (en) BENZODIAZEPINE SPIROHYDANTOINES AS CGRP RECEPTOR ANTAGONISTS
WO2004071448A3 (en) Substituted azole derivatives as inhibitors of protein tyrosine phosphatases
NO20073574L (no) Triazolsubstituerte aminobenzofenonforbindelser
ATE526991T1 (de) Zusammensetzungen und ihre verwendungen für die gentherapeutische behandlung von knochenerkrankungen
MXPA05008478A (es) Heterociclos sustituidos.
TW200740808A (en) Inhibiteurs de proteines kinases
WO2005011611A3 (en) Bicyclic compounds and compositions as pdf inhibitors
NO20072048L (no) Anvendelse av IL-17F for behandling og/eller forebygging av neurologiske sykdommer.
NO20060781L (no) Anvendelse av loselig CD164 ved inflammatoriske og/eller autoimmune lidelser
UY28264A1 (es) Derivados de imidazol para el tratamiento de trastornos alergicos e hiperproliferativos.
MEP25308A (en) Aminoindazole derivatives and use thereof as kinase inhibitors
DE60326348D1 (de) Makrozyclen zur behandlung von krebserkrankungen
SE9901273D0 (sv) Novel compounds
DE60143043D1 (de) Nukleinsäuremoleküle aus peritrophin von flöhen, proteine und ihre anwendungen

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.