BRPI0416674A - tiazolidinona amidas, amidas de ácido tiazolidino carboxìlico, processos de fabricação, e uso das mesmas - Google Patents

tiazolidinona amidas, amidas de ácido tiazolidino carboxìlico, processos de fabricação, e uso das mesmas

Info

Publication number
BRPI0416674A
BRPI0416674A BRPI0416674-4A BRPI0416674A BRPI0416674A BR PI0416674 A BRPI0416674 A BR PI0416674A BR PI0416674 A BRPI0416674 A BR PI0416674A BR PI0416674 A BRPI0416674 A BR PI0416674A
Authority
BR
Brazil
Prior art keywords
carboxylic acid
amides
manufacturing processes
acid amides
thiazolidine carboxylic
Prior art date
Application number
BRPI0416674-4A
Other languages
English (en)
Inventor
Duane D Miller
Veeresa Gududuru
James T Dalton
Eunju Hurh
Original Assignee
Univ Tennessee Res Foundation
Univ Ohio State Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tennessee Res Foundation, Univ Ohio State Res Found filed Critical Univ Tennessee Res Foundation
Publication of BRPI0416674A publication Critical patent/BRPI0416674A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"TIAZOLIDINONA AMIDAS, AMIDAS DE áCIDO TIAZOLIDINO CARBOXìLICO, PROCESSOS DE FABRICAçãO, E USO DAS MESMAS". Amidas de ácido tiazolidinono carboxílico substituídas e amidas de ácido tiazolidino carboxílico substituídas de acordo com as fórmulas (I) e (II) são mostradas onde os vários grupos substituintes são como definidos no relatório descritivo. Processos de fabricação destes compostos, composições farmacêuticas contendo os compostos, e seu uso, particularmente para tratamento ou prevenção de câncer, também são mostrados.
BRPI0416674-4A 2003-11-18 2004-11-18 tiazolidinona amidas, amidas de ácido tiazolidino carboxìlico, processos de fabricação, e uso das mesmas BRPI0416674A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52307903P 2003-11-18 2003-11-18
PCT/US2004/038662 WO2005049591A1 (en) 2003-11-18 2004-11-18 Thiazolidinone amides, thiazolidine carboxylic acid amides, methods of making, and uses thereof

Publications (1)

Publication Number Publication Date
BRPI0416674A true BRPI0416674A (pt) 2007-02-13

Family

ID=34619564

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416674-4A BRPI0416674A (pt) 2003-11-18 2004-11-18 tiazolidinona amidas, amidas de ácido tiazolidino carboxìlico, processos de fabricação, e uso das mesmas

Country Status (11)

Country Link
US (3) US7307093B2 (pt)
EP (1) EP1692121A1 (pt)
JP (1) JP2007513090A (pt)
CN (1) CN1902184A (pt)
AU (1) AU2004291539A1 (pt)
BR (1) BRPI0416674A (pt)
CA (1) CA2546324A1 (pt)
EA (1) EA200600992A1 (pt)
IL (1) IL175633A0 (pt)
MX (1) MXPA06005528A (pt)
WO (1) WO2005049591A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200600992A1 (ru) * 2003-11-18 2006-10-27 Юниверсити Оф Теннесси Рисерч Фаундейшн Амиды тиазолидинона, амиды тиазолидинкарбоновой кислоты, способы их получения и их применение
EP1698696A4 (en) * 2003-12-01 2007-01-10 Reverse Proteomics Res Inst Co TARGET PROTEIN OF AN ANTI-DIABETICS AND RELATED NEW ANTIDIABETIC INSUFUL
EP1926487A2 (en) * 2005-07-19 2008-06-04 University of Tennessee Research Foundation Thiazolidinone amides, thiazolidine carboxylic acid amides, and serine amides, including polyamine conjugates thereof, as selective anti-cancer agents
CA2646541A1 (en) * 2006-03-21 2007-09-27 The European Molecular Biology Laboratory Agents that disrupt cellular replication and their use in inhibiting pathological conditions
WO2008090356A1 (en) * 2007-01-25 2008-07-31 Betagenon Ab Thiazolidinone derivatives useful in the treatment of cancer and disorders caused by excess adiposity
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
UA105005C2 (uk) * 2008-06-16 2014-04-10 Юніверсіті Оф Теннессі Рісерч Фаундейшн Сполуки для лікування раку
US8822513B2 (en) 2010-03-01 2014-09-02 Gtx, Inc. Compounds for treatment of cancer
CA2791738C (en) 2010-03-01 2020-06-09 Gtx, Inc. Aryl imidazolyl compounds for the treatment of cancer
CN105163584B (zh) 2013-03-05 2019-06-04 田纳西大学研究基金会 用于治疗癌症的化合物
PL2968346T3 (pl) 2013-03-15 2024-11-04 Cancer Research Technologies Llc Sposoby i kompozycje do modulacji cyklu gamma-glutamylowego
CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1030415A (zh) 1987-02-20 1989-01-18 山之内制药株式会社 饱和的杂环碳酰胺衍生物和它的制备方法
DK0798298T3 (da) 1994-12-15 2001-10-22 Sankyo Co Thiazolidinon- eller oxazolidonderivater til behandling af angina pectoris eller sammensætninger indeholdende samme som aktiv bestanddel
EP0812835B1 (en) 1995-03-02 2001-05-23 Sankyo Company Limited Optically active thiazolidinone derivatives
US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
AU2003214534B2 (en) * 2002-04-08 2006-08-31 Torrent Pharmaceuticals Ltd. Thiazolidine-4-carbonitriles and analogues and their use as dipeptidyl-peptidas inhibitors
US20060014740A1 (en) * 2003-11-18 2006-01-19 Miller Duane D Analogs exhibiting inhibition of cell proliferation, methods of making, and uses thereof
EA200600992A1 (ru) * 2003-11-18 2006-10-27 Юниверсити Оф Теннесси Рисерч Фаундейшн Амиды тиазолидинона, амиды тиазолидинкарбоновой кислоты, способы их получения и их применение

Also Published As

Publication number Publication date
US20090143446A1 (en) 2009-06-04
JP2007513090A (ja) 2007-05-24
CA2546324A1 (en) 2005-06-02
IL175633A0 (en) 2006-09-05
US20060040998A1 (en) 2006-02-23
US20070155807A1 (en) 2007-07-05
US7307093B2 (en) 2007-12-11
MXPA06005528A (es) 2007-01-30
AU2004291539A1 (en) 2005-06-02
EP1692121A1 (en) 2006-08-23
US7662842B2 (en) 2010-02-16
EA200600992A1 (ru) 2006-10-27
WO2005049591A1 (en) 2005-06-02
CN1902184A (zh) 2007-01-24

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 5A., 6A. E 7A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 5A, 6A E 7A ANUIDADES.