BRPI0409114A - métodos para obter 68ga e para produzir um complexo de 68ga-radiomarcado, kit para a preparação de 68ga a partir de um gerador de 68ge/68ga, e, uso do mesmo - Google Patents

métodos para obter 68ga e para produzir um complexo de 68ga-radiomarcado, kit para a preparação de 68ga a partir de um gerador de 68ge/68ga, e, uso do mesmo

Info

Publication number
BRPI0409114A
BRPI0409114A BRPI0409114-0A BRPI0409114A BRPI0409114A BR PI0409114 A BRPI0409114 A BR PI0409114A BR PI0409114 A BRPI0409114 A BR PI0409114A BR PI0409114 A BRPI0409114 A BR PI0409114A
Authority
BR
Brazil
Prior art keywords
sup
kit
generator
obtaining
producing
Prior art date
Application number
BRPI0409114-0A
Other languages
English (en)
Inventor
Irina Velikyan
Bengt Langstrom
Gerd J Beyer
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Publication of BRPI0409114A publication Critical patent/BRPI0409114A/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D59/00—Separation of different isotopes of the same chemical element
    • B01D59/28—Separation by chemical exchange
    • B01D59/30—Separation by chemical exchange by ion exchange
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B3/00—Extraction of metal compounds from ores or concentrates by wet processes
    • C22B3/20—Treatment or purification of solutions, e.g. obtained by leaching
    • C22B3/42—Treatment or purification of solutions, e.g. obtained by leaching by ion-exchange extraction
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B58/00—Obtaining gallium or indium
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B59/00—Obtaining rare earth metals
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
    • G21H5/00—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for 
    • G21H5/02—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for  as tracers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/20—Recycling

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Materials Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Environmental & Geological Engineering (AREA)
  • Geology (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Manufacture And Refinement Of Metals (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Catalysts (AREA)
  • Led Devices (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Physical Deposition Of Substances That Are Components Of Semiconductor Devices (AREA)

Abstract

"MéTODOS PARA OBTER ¬ 68¬Ga E PARA PRODUZIR UM COMPLEXO DE ¬ 68¬Ga-RADIOMARCADO, KIT PARA A PREPARAçãO DE ¬ 68¬Ga A PARTIR DE UM GERADOR DE ¬ 68¬Ge/¬ 68¬Ga, E, USO DO MESMO". A presente invenção diz respeito a um método para obter ¬ 68¬Ga a partir de um gerador de ¬ 68¬Ge/¬ 68¬Ga e um método para produzir complexos de ¬ 68¬Ga-radiomarcados usando o ¬ 68¬Ga obtido. A invenção também diz respeito a um kit que pode ser usado para obter ¬ 68¬Ga e um kit que pode ser usado para a produção de complexos de ¬ 68¬Ga-radiomarcados.
BRPI0409114-0A 2003-04-11 2004-04-08 métodos para obter 68ga e para produzir um complexo de 68ga-radiomarcado, kit para a preparação de 68ga a partir de um gerador de 68ge/68ga, e, uso do mesmo BRPI0409114A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0308407.6A GB0308407D0 (en) 2003-04-11 2003-04-11 Method of obtaining 68 GA
PCT/GB2004/001548 WO2004089517A1 (en) 2003-04-11 2004-04-08 Method of obtaining galliun-68 and use thereof and device for carrying out saif method

Publications (1)

Publication Number Publication Date
BRPI0409114A true BRPI0409114A (pt) 2006-04-04

Family

ID=9956633

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409114-0A BRPI0409114A (pt) 2003-04-11 2004-04-08 métodos para obter 68ga e para produzir um complexo de 68ga-radiomarcado, kit para a preparação de 68ga a partir de um gerador de 68ge/68ga, e, uso do mesmo

Country Status (19)

Country Link
US (1) US20070031329A1 (pt)
EP (1) EP1610886B1 (pt)
JP (1) JP4671956B2 (pt)
KR (1) KR20050119205A (pt)
CN (1) CN100381196C (pt)
AT (1) ATE448863T1 (pt)
AU (1) AU2004228745B2 (pt)
BR (1) BRPI0409114A (pt)
CA (1) CA2520176C (pt)
DE (1) DE602004024181D1 (pt)
DK (1) DK1610886T3 (pt)
ES (1) ES2336447T3 (pt)
GB (1) GB0308407D0 (pt)
IL (2) IL170863A (pt)
MX (1) MXPA05010855A (pt)
NO (1) NO20054614L (pt)
RU (1) RU2343965C2 (pt)
WO (1) WO2004089517A1 (pt)
ZA (1) ZA200508726B (pt)

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US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
US8926945B2 (en) 2005-10-07 2015-01-06 Guerbet Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
US7586102B2 (en) 2006-08-14 2009-09-08 Board Of Regents The University Of Texas System Automated system for formulating radiopharmaceuticals
JP5005024B2 (ja) * 2007-03-02 2012-08-22 国立大学法人 長崎大学 Ｇｅ吸着剤
RU2010120765A (ru) 2007-12-03 2012-01-10 Джи-И Хелткер Лимитед (GB) ОЧИСТКА ЭЛЮАТА ГЕНЕРАТОРА 68Ge/68Ga ОТ Fe(III), ПРЕДНАЗНАЧЕННАЯ ДЛЯ УЛУЧШЕНИЯ ИЗБИРАТЕЛЬНОЙ РАДИОАКТИВНОСТИ РАДИОФАРМАЦЕВТИЧЕСКИХ СРЕДСТВ НА ОСНОВЕ 68Ga
KR101051084B1 (ko) 2009-09-14 2011-07-21 서울대학교산학협력단 [１８ｆ]폴리프라이드의 개선된 제조방법
GB0922492D0 (en) * 2009-12-23 2010-02-03 Hammersmith Imanet Ltd Method for obtaining 68GA
JP6078463B2 (ja) * 2010-04-09 2017-02-08 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ 放射性医薬品の濃度測定システムおよび方法
GB201007354D0 (en) * 2010-04-30 2010-06-16 Algeta Asa Method
TWI397421B (zh) * 2010-07-14 2013-06-01 Inst Nuclear Energy Res Atomic Energy Council 鎵－６８放射性同位素產生裝置及其方法
CN101890297B (zh) * 2010-07-16 2012-06-27 中国人民解放军第四军医大学 一种放射性核素镓-68的浓缩纯化方法
RU2464043C1 (ru) * 2011-09-26 2012-10-20 Федеральное государственное бюджетное учреждение "Федеральный медицинский биофизический центр имени А.И. Бурназяна" СПОСОБ ПОЛУЧЕНИЯ РАСТВОРОВ 68Ga ВЫСОКОЙ ЧИСТОТЫ
WO2013082699A1 (en) 2011-12-08 2013-06-13 Nordion (Canada) Inc. Method of pre-treating an adsorbent for a chromatographic separation
RU2522892C1 (ru) * 2013-01-09 2014-07-20 Российская Федерация, от имени которой выступает Государственная корпорация по атомной энергии "Росатом" Способ получения активной фармацевтической субстанции для синтеза препаратов галлия-68
US9266084B2 (en) * 2013-06-13 2016-02-23 Institute Of Nuclear Energy Research Automatic synthesizer apparatus for producing radiopharmaceutical tumor imaging agent Gallium-68-DOTATATE and method thereof
MX373709B (es) 2015-01-30 2020-05-08 Advanced Accelerator Applications Int S A Proceso para la purificacion de ga-68 a partir del eluato que se deriva de generadores de 68ge/ 68ga y columnas cromatograficas para usarse en dicho proceso.
CN106328237B (zh) * 2015-06-29 2019-04-23 中国辐射防护研究院 一种放射性废离子交换树脂微波碳化、灰化工艺及专用装置
WO2017144959A1 (pt) * 2016-02-23 2017-08-31 Serviço Nacional De Aprendizagem Industrial - Senai. Equipamento para marcação de moléculas com gálio-68
WO2018039662A1 (en) * 2016-08-26 2018-03-01 Mayo Foundation For Medical Education And Research Rapid isolation of cyclotron-produced gallium-68
JP6837371B2 (ja) * 2017-03-30 2021-03-03 オルガノ株式会社 塩基性が改良された弱塩基性アニオン交換樹脂の製造方法
WO2020028825A1 (en) * 2018-08-03 2020-02-06 Board Of Regents, The University Of Texas System Method for extraction and purification of 68ga
CN114761100A (zh) * 2019-10-12 2022-07-15 阿尔特姆斯产品公司 分离镓-68的系统和方法
RU2714497C1 (ru) * 2019-12-02 2020-02-18 Общество с ограниченной ответственностью "НТЦ Амплитуда" Применение ионообменных картриджей типа Chromafix HR-XC в Н+-форме и Chromafix 30-PS в НСО3-форме в устройстве для очистки и концентрирования элюата генератора 68Ge/68Ga
CN113144225A (zh) * 2021-03-30 2021-07-23 广东回旋医药科技股份有限公司 一种高放射性核纯度的68Ga-GaCl3溶液的制备方法及应用
KR102873341B1 (ko) 2023-09-26 2025-10-21 재단법인 아산사회복지재단 다중 제너레이터를 이용한 방사성의약품 제조방법
CN117960133B (zh) * 2024-01-30 2026-08-04 杭州威圣健康科技有限公司 一种特异性吸附生物活性成分的材料及其制备方法
CN118949478A (zh) * 2024-07-29 2024-11-15 内蒙古医科大学附属医院(内蒙古自治区心血管研究所) 一种68Ga的浓缩方法及其在DNA单链标记方面的应用
KR102853247B1 (ko) 2024-09-19 2025-09-01 한국원자력연구원 대용량 68Ge의 회수 방법 및 회수된 68Ge 혼합물

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Also Published As

Publication number Publication date
CN100381196C (zh) 2008-04-16
RU2343965C2 (ru) 2009-01-20
JP4671956B2 (ja) 2011-04-20
DE602004024181D1 (de) 2009-12-31
MXPA05010855A (es) 2005-12-14
IL198894A0 (en) 2010-02-17
DK1610886T3 (da) 2010-03-29
GB0308407D0 (en) 2003-05-21
ES2336447T3 (es) 2010-04-13
CN1780679A (zh) 2006-05-31
ZA200508726B (en) 2007-07-25
AU2004228745B2 (en) 2009-06-11
WO2004089517A1 (en) 2004-10-21
KR20050119205A (ko) 2005-12-20
EP1610886B1 (en) 2009-11-18
CA2520176A1 (en) 2004-10-21
US20070031329A1 (en) 2007-02-08
RU2005130865A (ru) 2006-06-10
NO20054614L (no) 2005-10-07
IL170863A (en) 2012-01-31
EP1610886A1 (en) 2006-01-04
ATE448863T1 (de) 2009-12-15
JP2006526764A (ja) 2006-11-24
CA2520176C (en) 2012-06-05
AU2004228745A1 (en) 2004-10-21

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT. CL.: B01D 59/30, A61K 51/12, C22B 59/00.

Ipc: A61K 51/00 (2006.01), A61K 51/04 (2006.01), B01D 5

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014.