BRPI0409730A - tratamento da incontinência - Google Patents
tratamento da incontinênciaInfo
- Publication number
- BRPI0409730A BRPI0409730A BRPI0409730-0A BRPI0409730A BRPI0409730A BR PI0409730 A BRPI0409730 A BR PI0409730A BR PI0409730 A BRPI0409730 A BR PI0409730A BR PI0409730 A BRPI0409730 A BR PI0409730A
- Authority
- BR
- Brazil
- Prior art keywords
- incontinence
- treatment
- relates
- treating
- incontinence treatment
- Prior art date
Links
- 206010021639 Incontinence Diseases 0.000 title abstract 4
- 102000006902 5-HT2C Serotonin Receptor Human genes 0.000 abstract 2
- 108010072553 5-HT2C Serotonin Receptor Proteins 0.000 abstract 2
- 206010046543 Urinary incontinence Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 206010053236 Mixed incontinence Diseases 0.000 abstract 1
- 206010066218 Stress Urinary Incontinence Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000014759 maintenance of location Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 210000002700 urine Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"TRATAMENTO DA INCONTINêNCIA". A invenção presente refere-se à utilização de agonistas de receptores 5-HT2C para o tratamento da incontinência urinária, de preferência a incontinência mista ou a incontinência urinária de estresse. A invenção também refere-se à utilização de antagonistas de receptores 5-HT2C para o tratamento da retenção de urina. A invenção presente Também refere-se a um método de tratamento da incontinência, a testes para despistar compostos úteis para o tratamento da incontinência, e a métodos para preparar composições para o tratamento da incontinência urinária.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0309533 | 2003-04-25 | ||
| PCT/IB2004/001437 WO2004096196A2 (en) | 2003-04-25 | 2004-04-21 | Treatment of incontinence with 5htc2 agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0409730A true BRPI0409730A (pt) | 2006-05-09 |
Family
ID=33397006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0409730-0A BRPI0409730A (pt) | 2003-04-25 | 2004-04-21 | tratamento da incontinência |
Country Status (13)
| Country | Link |
|---|---|
| EP (2) | EP1620081A2 (pt) |
| JP (2) | JP2006524679A (pt) |
| KR (3) | KR20060006063A (pt) |
| CN (1) | CN1780612B (pt) |
| AU (2) | AU2004233745B2 (pt) |
| BR (1) | BRPI0409730A (pt) |
| CA (2) | CA2670067A1 (pt) |
| CL (1) | CL2004000826A1 (pt) |
| MX (1) | MXPA05011410A (pt) |
| MY (1) | MY142857A (pt) |
| TW (1) | TW200426142A (pt) |
| WO (1) | WO2004096196A2 (pt) |
| ZA (1) | ZA200507158B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8685924B2 (en) * | 2004-08-25 | 2014-04-01 | Takeda Pharmaceutical Company Limited | Preventives/remedies for stress urinary incontinence and method of screening the same |
| JP2008538784A (ja) * | 2005-04-24 | 2008-11-06 | ワイス | 膀胱機能を調節するための方法 |
| WO2007015157A2 (en) * | 2005-08-01 | 2007-02-08 | Pfizer Limited | Mc4r-ag0nists for the treatment of urinary tract dysfunction |
| EP2727585A1 (en) | 2006-05-16 | 2014-05-07 | Takeda Pharmaceutical Company Limited | In-vivo screening method |
| JPWO2008007664A1 (ja) | 2006-07-11 | 2009-12-10 | 武田薬品工業株式会社 | 二環性複素環化合物およびその用途 |
| EP2123644B1 (en) | 2007-03-07 | 2014-12-17 | Takeda Pharmaceutical Company Limited | Benzoxazepine derivatives and use thereof |
| JP5361733B2 (ja) | 2007-11-15 | 2013-12-04 | 武田薬品工業株式会社 | ピリドオキサゼピン誘導体およびその用途 |
| WO2009063993A1 (ja) * | 2007-11-15 | 2009-05-22 | Takeda Pharmaceutical Company Limited | 縮合ピリジン誘導体およびその用途 |
| EP2789338A3 (en) | 2007-11-15 | 2015-01-14 | Takeda Pharmaceutical Company Limited | Condensed pyridine derivate and use thereof |
| PL2442870T3 (pl) | 2009-06-15 | 2014-12-31 | Takeda Pharmaceuticals Co | Pochodne pirazynooksazepiny |
| EP2510949A4 (en) | 2009-12-11 | 2013-11-13 | Astellas Pharma Inc | THERAPEUTICS FOR FIBROMYALGIA |
| WO2012002583A1 (en) * | 2010-07-02 | 2012-01-05 | Vanderbilt University | Method for treating schizophrenia and related diseases with a combination therapy |
| WO2013133325A1 (ja) | 2012-03-06 | 2013-09-12 | 武田薬品工業株式会社 | 三環性化合物 |
| JPWO2019131902A1 (ja) | 2017-12-27 | 2020-12-10 | 武田薬品工業株式会社 | 腹圧性尿失禁および便失禁の治療薬 |
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| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| CA2044854A1 (en) | 1990-07-19 | 1992-01-20 | Hong-I Chen | Method for preventing or treating urinary incontinence |
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| TW334423B (en) | 1993-10-22 | 1998-06-21 | Hoffmann La Roche | Tricyclic 1-aminoethylpyrrole-derivatives |
| TW270114B (pt) | 1993-10-22 | 1996-02-11 | Hoffmann La Roche | |
| IT1282705B1 (it) | 1996-02-28 | 1998-03-31 | Recordati Chem Pharm | Uso di antagonisti del recettore serotoninergico 5-ht|a per il trattamento dell'incontinenza urinaria |
| WO1998030548A1 (en) | 1997-01-13 | 1998-07-16 | Yamanouchi Pharmaceutical Co., Ltd. | 5-HT2c RECEPTOR AGONISTS AND AMINOALKYLINDAZOLE DERIVATIVES |
| WO1998033504A1 (en) * | 1997-02-03 | 1998-08-06 | Akzo Nobel N.V. | Treatment of urinary incontinence |
| EP0863136B1 (en) | 1997-02-25 | 2003-09-24 | Akzo Nobel N.V. | Derivatives of azetidine and pyrrolidine |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
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| JP4422331B2 (ja) * | 1998-02-26 | 2010-02-24 | ナームローゼ・フエンノートチヤツプ・オルガノン | アゼチジン誘導体およびピロリジン誘導体 |
| WO1999058490A2 (en) | 1998-05-08 | 1999-11-18 | Akzo Nobel N.V. | Novel aryl-hydro naphthalenal kanamines |
| GB9819033D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds VI |
| GB9819035D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Res Ltd | Chemical compounds VII |
| GB9819019D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds II |
| GB9819020D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds III |
| GB9819032D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds IV |
| GB9820767D0 (en) | 1998-09-23 | 1998-11-18 | Cerebrus Ltd | Chemical compounds VIII |
| WO2000028993A1 (en) | 1998-11-19 | 2000-05-25 | Nortran Pharmaceuticals, Inc. | Serotonin ligands as pro-erectile compounds |
| IL143323A0 (en) | 1998-12-17 | 2002-04-21 | American Home Prod | 2,3,4,4a-tetrahydro-1h-pyrazino (1,2-a) quinoxalin-5 (6h) one derivatives being 5ht2c agonists |
| CA2361516A1 (en) | 1999-01-27 | 2000-08-03 | Jeffrey Thomas Mullaney | Aminoalkylbenzofurans as serotonin (5-ht(2c)) agonists |
| WO2000069437A1 (en) | 1999-05-18 | 2000-11-23 | Synaptic Pharmaceutical Corporation | Use of agonists or antagonists of the 5-ht7 receptor to treat disorders of the bladder |
| SE9901884D0 (sv) * | 1999-05-21 | 1999-05-21 | Pharmacia & Upjohn Ab | Novel compounds their use and preparation |
| US6465467B1 (en) * | 1999-05-21 | 2002-10-15 | Biovitrum Ab | Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases |
| WO2000076984A2 (en) | 1999-05-21 | 2000-12-21 | Biovitrum Ab | Novel compounds, their use and preparation |
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| WO2001083487A1 (en) | 2000-04-28 | 2001-11-08 | Yamanouchi Pharmaceutical Co., Ltd. | Froindazole derivative |
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| ATE433962T1 (de) * | 2000-11-20 | 2009-07-15 | Biovitrum Ab Publ | Piperazinylpyrazinverbindungen als antagonisten des serotonin-5-ht2-rezeptors |
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| US6498184B2 (en) * | 2000-12-05 | 2002-12-24 | Akzo Nobel N.V. | Serotonergic compound for a method of treatment of hot flushes in post-menopausal women |
| GB0030710D0 (en) | 2000-12-15 | 2001-01-31 | Hoffmann La Roche | Piperazine derivatives |
| WO2002059124A2 (en) | 2000-12-20 | 2002-08-01 | Bristol-Myers Squibb Company | Substituted pyrroloquinolines and pyridoquinolines as serotonin agonists and antagonists |
| MXPA03005438A (es) | 2000-12-20 | 2004-05-05 | Bristol Myers Squibb Co | Pirioindoles substituidos como agonistas y antagonistas de serotonina. |
| EP1347979B1 (en) | 2000-12-27 | 2007-08-08 | F. Hoffmann-La Roche Ag | Indole derivatives and their use as 5-ht2b and 5-ht2c receptor ligands |
| GB0106177D0 (en) | 2001-03-13 | 2001-05-02 | Hoffmann La Roche | Piperazine derivatives |
| JPWO2002074746A1 (ja) | 2001-03-16 | 2004-07-08 | 山之内製薬株式会社 | ベンゾアゼピン誘導体 |
| US6825198B2 (en) * | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
| CA2451606A1 (en) | 2001-07-05 | 2003-01-16 | Pharmacia & Upjohn Company | (hetero) aryl substituted benzofurans as 5-ht ligands |
| US6720316B2 (en) | 2001-08-06 | 2004-04-13 | Pharmacia & Upjohn Company | Therapeutic 5-HT ligand compounds |
| EP1414819B1 (en) | 2001-08-08 | 2005-10-12 | Pharmacia & Upjohn Company LLC | THERAPEUTIC 1H-PYRIDO[4,3-b]INDOLES |
| AU2002336749A1 (en) | 2001-09-21 | 2003-04-01 | Pharmacia And Upjohn Company | Tricyclic indole derivatives as 5-ht ligands |
| CA2464412A1 (en) * | 2001-10-18 | 2003-04-24 | Pharmacia & Upjohn Company | Tetracyclic azaindoles and -indolines having serotonin 5-ht2cactivity |
| MXPA04006184A (es) | 2001-12-28 | 2004-12-06 | Bayer Pharmaceuticals Corp | Compuestos derivados de 1h-pirazolilo, para el uso en enfermedades asociadas con el receptor 5-ht2c. |
| AU2002367323A1 (en) | 2001-12-28 | 2003-07-24 | Bayer Pharmaceuticals Corporation | Benzothieno (3,2- |
| AU2002364035A1 (en) | 2001-12-28 | 2003-07-24 | Bayer Pharmaceuticals Corporation | 4-sulfide / sulfoxide / sulfonyl-1h-pyrazolyl derivative compounds, for use in diseases associated with the 5-ht2c receptor |
| AU2002360819A1 (en) | 2001-12-28 | 2003-07-24 | Bayer Corporation | Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor |
| WO2004000830A1 (en) | 2002-06-19 | 2003-12-31 | Biovitrum Ab | Novel compounds, their use and preparation |
-
2004
- 2004-04-16 CL CL200400826A patent/CL2004000826A1/es unknown
- 2004-04-21 CA CA002670067A patent/CA2670067A1/en not_active Abandoned
- 2004-04-21 EP EP04728610A patent/EP1620081A2/en not_active Withdrawn
- 2004-04-21 CA CA2523379A patent/CA2523379C/en not_active Expired - Fee Related
- 2004-04-21 KR KR1020057020223A patent/KR20060006063A/ko not_active Ceased
- 2004-04-21 WO PCT/IB2004/001437 patent/WO2004096196A2/en not_active Ceased
- 2004-04-21 EP EP10177541A patent/EP2277513A3/en not_active Withdrawn
- 2004-04-21 MX MXPA05011410A patent/MXPA05011410A/es unknown
- 2004-04-21 JP JP2006506590A patent/JP2006524679A/ja active Pending
- 2004-04-21 BR BRPI0409730-0A patent/BRPI0409730A/pt not_active IP Right Cessation
- 2004-04-21 AU AU2004233745A patent/AU2004233745B2/en not_active Ceased
- 2004-04-21 KR KR1020107019252A patent/KR20100103726A/ko not_active Ceased
- 2004-04-21 KR KR1020077022222A patent/KR20070108921A/ko not_active Ceased
- 2004-04-21 CN CN2004800111992A patent/CN1780612B/zh not_active Expired - Fee Related
- 2004-04-23 MY MYPI20041485A patent/MY142857A/en unknown
- 2004-04-23 TW TW093111427A patent/TW200426142A/zh unknown
-
2005
- 2005-09-06 ZA ZA200507158A patent/ZA200507158B/en unknown
-
2010
- 2010-07-20 AU AU2010203093A patent/AU2010203093A1/en not_active Abandoned
- 2010-11-08 JP JP2010249395A patent/JP2011064695A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN1780612B (zh) | 2010-12-01 |
| EP2277513A3 (en) | 2011-09-07 |
| AU2004233745A1 (en) | 2004-11-11 |
| EP1620081A2 (en) | 2006-02-01 |
| KR20100103726A (ko) | 2010-09-27 |
| MY142857A (en) | 2011-01-14 |
| AU2004233745B2 (en) | 2010-03-25 |
| KR20060006063A (ko) | 2006-01-18 |
| EP2277513A2 (en) | 2011-01-26 |
| WO2004096196A3 (en) | 2005-03-10 |
| CA2523379C (en) | 2010-06-22 |
| WO2004096196A2 (en) | 2004-11-11 |
| JP2006524679A (ja) | 2006-11-02 |
| MXPA05011410A (es) | 2005-12-12 |
| CN1780612A (zh) | 2006-05-31 |
| CA2523379A1 (en) | 2004-11-11 |
| CL2004000826A1 (es) | 2005-03-04 |
| CA2670067A1 (en) | 2004-11-11 |
| JP2011064695A (ja) | 2011-03-31 |
| AU2010203093A1 (en) | 2010-08-12 |
| TW200426142A (en) | 2004-12-01 |
| ZA200507158B (en) | 2006-11-29 |
| KR20070108921A (ko) | 2007-11-13 |
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