BRPI0409767A - processo para a obtenção de guggulsterona e guggulsterol - Google Patents

processo para a obtenção de guggulsterona e guggulsterol

Info

Publication number
BRPI0409767A
BRPI0409767A BRPI0409767-0A BRPI0409767A BRPI0409767A BR PI0409767 A BRPI0409767 A BR PI0409767A BR PI0409767 A BRPI0409767 A BR PI0409767A BR PI0409767 A BRPI0409767 A BR PI0409767A
Authority
BR
Brazil
Prior art keywords
guggulsterone
formula
guggulsterol
obtaining
pregnadiene
Prior art date
Application number
BRPI0409767-0A
Other languages
English (en)
Inventor
Heonjoong Kang
Original Assignee
Heonjoong Kang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020030025936A external-priority patent/KR100543542B1/ko
Priority claimed from KR1020030025904A external-priority patent/KR100639655B1/ko
Priority claimed from KR1020030025962A external-priority patent/KR100543544B1/ko
Priority claimed from KR1020030025989A external-priority patent/KR100543547B1/ko
Priority claimed from KR1020030025919A external-priority patent/KR100543533B1/ko
Application filed by Heonjoong Kang filed Critical Heonjoong Kang
Publication of BRPI0409767A publication Critical patent/BRPI0409767A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C07J33/007—Cyclic thioketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"PROCESSO PARA A OBTENçãO DE GUGGULSTERONA E GUGGULSTEROL". Refere-se a presente invenção a um método para a obtenção seletiva de 4,17 (20)-E-pregnadieno-3,16-diona (guggulsterona do tipo E) da fórmula (III) e 4,17 (20)-Z-pregnadieno-3,16-diona (guggulsterona do tipo Z) da fórmula (IV) que possuem o efeito de abaixar os níveis elevados da lipoproteína de baixa densidade (LDL) e os altos níveis de colesterol de maneira eficaz e elevar os níveis baixos da lipoproteína de alta densidade (HDL) a partir de um esteróide de fácil disponibilidade da fórmula (I). A presente invenção também proporciona um método para a obtenção do composto da fórmula (II).
BRPI0409767-0A 2003-04-24 2004-04-24 processo para a obtenção de guggulsterona e guggulsterol BRPI0409767A (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
KR1020030025936A KR100543542B1 (ko) 2003-04-24 2003-04-24 4-안드로스텐-3,17-디온으로부터 구굴스테론의 제조방법및 이를 제조하기 위한 중간체
KR1020030025904A KR100639655B1 (ko) 2003-04-24 2003-04-24 16α,17α-에폭시프레그네놀론으로부터4,17(20)-프로스타디엔-3,16-디온의 제조방법 및 이를제조하기 위한 중간체
KR1020030025962A KR100543544B1 (ko) 2003-04-24 2003-04-24 테스토스테론으로부터 구굴스테론의 제조방법 및 이를제조하기 위한 중간체
KR1020030025989A KR100543547B1 (ko) 2003-04-24 2003-04-24 프로제스테론으로부터 구굴스테론의 제조방법 및 이를제조하기 위한 중간체
KR1020030025919A KR100543533B1 (ko) 2003-04-24 2003-04-24 5-안드로스텐-3β-올-17-온으로부터4,17(20)-프로스타디엔-3,16-디온의 제조방법 및 이를제조하기 위한 중간체
PCT/KR2004/000950 WO2004094450A1 (en) 2003-04-24 2004-04-24 Process for preparing guggulsterones and guggulsterol

Publications (1)

Publication Number Publication Date
BRPI0409767A true BRPI0409767A (pt) 2006-05-30

Family

ID=36479563

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409767-0A BRPI0409767A (pt) 2003-04-24 2004-04-24 processo para a obtenção de guggulsterona e guggulsterol

Country Status (9)

Country Link
US (1) US20070055072A1 (pt)
EP (4) EP2251346A3 (pt)
JP (2) JP4895804B2 (pt)
AT (1) ATE535538T1 (pt)
AU (1) AU2004232615B2 (pt)
BR (1) BRPI0409767A (pt)
CA (1) CA2523369C (pt)
ES (1) ES2376549T3 (pt)
WO (1) WO2004094450A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004232615B2 (en) * 2003-04-24 2007-05-24 Seoul National University Industry Foundation Process for preparing guggulsterones and guggulsterol
EP1886685A1 (en) 2006-08-11 2008-02-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods, uses and compositions for modulating replication of hcv through the farnesoid x receptor (fxr) activation or inhibition
US9637515B2 (en) 2006-11-06 2017-05-02 Jina Pharmaceuticals, Inc. Guggulphospholipid methods and compositions
CN101195648A (zh) * 2007-12-03 2008-06-11 邵阳市科瑞化学品有限公司 制备二烯甾酮的方法
CN113082960B (zh) * 2021-04-09 2022-05-20 辽宁科技大学 一种宽温度窗口烟气脱硫用低共熔溶剂及生产、再生方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3141028A (en) * 1962-10-02 1964-07-14 Searle & Co 16-oxygenated pregna-4, 17(20)-[trans] dien-3-ones and intermediates thereto
EP0447706A1 (en) 1990-03-22 1991-09-25 Cipla Limited A process for the preparation of pharmacologically active synthetic z and e steroisomeric mixture of guggulsterones
DE4313089A1 (de) * 1993-04-22 1994-10-27 Basf Ag Verfahren zur Herstellung von 13-(Z)-Retinsäure
KR100446068B1 (ko) * 2001-10-23 2004-08-30 동방에프티엘 주식회사 구굴스테론의 제조방법
WO2004021975A2 (en) * 2002-09-03 2004-03-18 Ganga Raju Gokaraju An improved process for the synthesis of pharmacologically active (z/e)-guggulsterones
AU2004232615B2 (en) * 2003-04-24 2007-05-24 Seoul National University Industry Foundation Process for preparing guggulsterones and guggulsterol

Also Published As

Publication number Publication date
US20070055072A1 (en) 2007-03-08
EP2594577A1 (en) 2013-05-22
EP1620455A1 (en) 2006-02-01
EP1620455A4 (en) 2009-08-05
CA2523369A1 (en) 2004-11-04
EP1620455B1 (en) 2011-11-30
AU2004232615A1 (en) 2004-11-04
JP5430603B2 (ja) 2014-03-05
ES2376549T3 (es) 2012-03-14
EP2284176A1 (en) 2011-02-16
EP2251346A3 (en) 2011-02-16
CA2523369C (en) 2009-08-04
JP2006524237A (ja) 2006-10-26
ATE535538T1 (de) 2011-12-15
AU2004232615B2 (en) 2007-05-24
WO2004094450A1 (en) 2004-11-04
EP2251346A2 (en) 2010-11-17
JP4895804B2 (ja) 2012-03-14
JP2011157382A (ja) 2011-08-18

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 11A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.