ATE535538T1 - Verfahren zur herstellung von guggulsteronen und guggulsterol - Google Patents

Verfahren zur herstellung von guggulsteronen und guggulsterol

Info

Publication number: ATE535538T1
Authority: AT; Austria
Prior art keywords: formula; guggulsterol; guggulsterones; producing; guggulsterone
Prior art date: 2003-04-24

Application number

AT04729374T

Other languages

English (en)

Inventor

Jungyeob Ham

Heonjoong Kang

Jungwook Chin

Original Assignee

Seoul Nat Univ Ind Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-24

Filing date

2004-04-24

Publication date

2011-12-15

2003-04-24 Priority claimed from KR1020030025936A external-priority patent/KR100543542B1/ko

2003-04-24 Priority claimed from KR1020030025904A external-priority patent/KR100639655B1/ko

2003-04-24 Priority claimed from KR1020030025962A external-priority patent/KR100543544B1/ko

2003-04-24 Priority claimed from KR1020030025989A external-priority patent/KR100543547B1/ko

2003-04-24 Priority claimed from KR1020030025919A external-priority patent/KR100543533B1/ko

2004-04-24 Application filed by Seoul Nat Univ Ind Foundation filed Critical Seoul Nat Univ Ind Foundation

2011-12-15 Application granted granted Critical

2011-12-15 Publication of ATE535538T1 publication Critical patent/ATE535538T1/de

Links

WDXRGPWQVHZTQJ-AUKWTSKRSA-N Guggulsterone Natural products C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC(=O)/C(=C/C)[C@@]1(C)CC2 WDXRGPWQVHZTQJ-AUKWTSKRSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
WDXRGPWQVHZTQJ-UHFFFAOYSA-N trans-guggulsterone Natural products C1CC2=CC(=O)CCC2(C)C2C1C1CC(=O)C(=CC)C1(C)CC2 WDXRGPWQVHZTQJ-UHFFFAOYSA-N 0.000 abstract 3
WDXRGPWQVHZTQJ-OSJVMJFVSA-N (8r,9s,10r,13s,14s,17z)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC(=O)\C(=C/C)[C@@]1(C)CC2 WDXRGPWQVHZTQJ-OSJVMJFVSA-N 0.000 abstract 2
102000015779 HDL Lipoproteins Human genes 0.000 abstract 2
108010010234 HDL Lipoproteins Proteins 0.000 abstract 2
102000007330 LDL Lipoproteins Human genes 0.000 abstract 2
108010007622 LDL Lipoproteins Proteins 0.000 abstract 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
WDXRGPWQVHZTQJ-NRJJLHBYSA-N Guggulsterone E Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC(=O)C(=CC)[C@@]1(C)CC2 WDXRGPWQVHZTQJ-NRJJLHBYSA-N 0.000 abstract 1
235000012000 cholesterol Nutrition 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000003028 elevating effect Effects 0.000 abstract 1
150000003431 steroids Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
- C07J33/007—Cyclic thioketals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT04729374T 2003-04-24 2004-04-24 Verfahren zur herstellung von guggulsteronen und guggulsterol ATE535538T1 (de)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
KR1020030025936A KR100543542B1 (ko)	2003-04-24	2003-04-24	4-안드로스텐-3,17-디온으로부터 구굴스테론의 제조방법및 이를 제조하기 위한 중간체
KR1020030025904A KR100639655B1 (ko)	2003-04-24	2003-04-24	16α,17α-에폭시프레그네놀론으로부터4,17(20)-프로스타디엔-3,16-디온의 제조방법 및 이를제조하기 위한 중간체
KR1020030025962A KR100543544B1 (ko)	2003-04-24	2003-04-24	테스토스테론으로부터 구굴스테론의 제조방법 및 이를제조하기 위한 중간체
KR1020030025989A KR100543547B1 (ko)	2003-04-24	2003-04-24	프로제스테론으로부터 구굴스테론의 제조방법 및 이를제조하기 위한 중간체
KR1020030025919A KR100543533B1 (ko)	2003-04-24	2003-04-24	5-안드로스텐-3β-올-17-온으로부터4,17(20)-프로스타디엔-3,16-디온의 제조방법 및 이를제조하기 위한 중간체
PCT/KR2004/000950 WO2004094450A1 (en)	2003-04-24	2004-04-24	Process for preparing guggulsterones and guggulsterol

Publications (1)

Publication Number	Publication Date
ATE535538T1 true ATE535538T1 (de)	2011-12-15

Family

ID=36479563

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04729374T ATE535538T1 (de)	2003-04-24	2004-04-24	Verfahren zur herstellung von guggulsteronen und guggulsterol

Country Status (9)

Country	Link
US (1)	US20070055072A1 (de)
EP (4)	EP2251346A3 (de)
JP (2)	JP4895804B2 (de)
AT (1)	ATE535538T1 (de)
AU (1)	AU2004232615B2 (de)
BR (1)	BRPI0409767A (de)
CA (1)	CA2523369C (de)
ES (1)	ES2376549T3 (de)
WO (1)	WO2004094450A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2004232615B2 (en) *	2003-04-24	2007-05-24	Seoul National University Industry Foundation	Process for preparing guggulsterones and guggulsterol
EP1886685A1 (de)	2006-08-11	2008-02-13	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methoden, Verwendungen und Zusammensetzungen zur Modulation der Replikation von HCV durch Aktivierung oder Hemmung des Farnesoid X Rezeptors
US9637515B2 (en)	2006-11-06	2017-05-02	Jina Pharmaceuticals, Inc.	Guggulphospholipid methods and compositions
CN101195648A (zh) *	2007-12-03	2008-06-11	邵阳市科瑞化学品有限公司	制备二烯甾酮的方法
CN113082960B (zh) *	2021-04-09	2022-05-20	辽宁科技大学	一种宽温度窗口烟气脱硫用低共熔溶剂及生产、再生方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3141028A (en) *	1962-10-02	1964-07-14	Searle & Co	16-oxygenated pregna-4, 17(20)-[trans] dien-3-ones and intermediates thereto
EP0447706A1 (de)	1990-03-22	1991-09-25	Cipla Limited	Verfahren zur Herstellung einer pharmazeutischen aktiven Mischung der Guggulsteronen Z und E
DE4313089A1 (de) *	1993-04-22	1994-10-27	Basf Ag	Verfahren zur Herstellung von 13-(Z)-Retinsäure
KR100446068B1 (ko) *	2001-10-23	2004-08-30	동방에프티엘 주식회사	구굴스테론의 제조방법
WO2004021975A2 (en) *	2002-09-03	2004-03-18	Ganga Raju Gokaraju	An improved process for the synthesis of pharmacologically active (z/e)-guggulsterones
AU2004232615B2 (en) *	2003-04-24	2007-05-24	Seoul National University Industry Foundation	Process for preparing guggulsterones and guggulsterol

2004
- 2004-04-24 AU AU2004232615A patent/AU2004232615B2/en not_active Ceased
- 2004-04-24 JP JP2006507820A patent/JP4895804B2/ja not_active Expired - Fee Related
- 2004-04-24 WO PCT/KR2004/000950 patent/WO2004094450A1/en not_active Ceased
- 2004-04-24 BR BRPI0409767-0A patent/BRPI0409767A/pt not_active IP Right Cessation
- 2004-04-24 AT AT04729374T patent/ATE535538T1/de active
- 2004-04-24 US US10/554,439 patent/US20070055072A1/en not_active Abandoned
- 2004-04-24 EP EP10168887A patent/EP2251346A3/de not_active Withdrawn
- 2004-04-24 EP EP13153819.1A patent/EP2594577A1/de not_active Withdrawn
- 2004-04-24 CA CA002523369A patent/CA2523369C/en not_active Expired - Fee Related
- 2004-04-24 ES ES04729374T patent/ES2376549T3/es not_active Expired - Lifetime
- 2004-04-24 EP EP04729374A patent/EP1620455B1/de not_active Expired - Lifetime
- 2004-04-24 EP EP10168885A patent/EP2284176A1/de not_active Withdrawn
2011
- 2011-04-05 JP JP2011083955A patent/JP5430603B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US20070055072A1 (en)	2007-03-08
BRPI0409767A (pt)	2006-05-30
EP2594577A1 (de)	2013-05-22
EP1620455A1 (de)	2006-02-01
EP1620455A4 (de)	2009-08-05
CA2523369A1 (en)	2004-11-04
EP1620455B1 (de)	2011-11-30
AU2004232615A1 (en)	2004-11-04
JP5430603B2 (ja)	2014-03-05
ES2376549T3 (es)	2012-03-14
EP2284176A1 (de)	2011-02-16
EP2251346A3 (de)	2011-02-16
CA2523369C (en)	2009-08-04
JP2006524237A (ja)	2006-10-26
AU2004232615B2 (en)	2007-05-24
WO2004094450A1 (en)	2004-11-04
EP2251346A2 (de)	2010-11-17
JP4895804B2 (ja)	2012-03-14
JP2011157382A (ja)	2011-08-18

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