BRPI0409930A - cristais de solvato derivado do ácido quinolinacarboxìlico - Google Patents
cristais de solvato derivado do ácido quinolinacarboxìlicoInfo
- Publication number
- BRPI0409930A BRPI0409930A BRPI0409930-3A BRPI0409930A BRPI0409930A BR PI0409930 A BRPI0409930 A BR PI0409930A BR PI0409930 A BRPI0409930 A BR PI0409930A BR PI0409930 A BRPI0409930 A BR PI0409930A
- Authority
- BR
- Brazil
- Prior art keywords
- methyl
- crystal
- oxo
- compound
- acid
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 7
- LOAUVZALPPNFOQ-UHFFFAOYSA-N quinaldic acid Chemical class C1=CC=CC2=NC(C(=O)O)=CC=C21 LOAUVZALPPNFOQ-UHFFFAOYSA-N 0.000 title 1
- 239000012453 solvate Substances 0.000 title 1
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 6
- 239000002253 acid Substances 0.000 abstract 3
- -1 4- (5-methyl-2-oxo-1,3-dioxolen-4-yl) -methyl-1piperazinyl Chemical group 0.000 abstract 2
- JBMKAUGHUNFTOL-UHFFFAOYSA-N Aldoclor Chemical class C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NC=NS2(=O)=O JBMKAUGHUNFTOL-UHFFFAOYSA-N 0.000 abstract 2
- 229940126062 Compound A Drugs 0.000 abstract 2
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- DJXNJVFEFSWHLY-UHFFFAOYSA-N quinoline-3-carboxylic acid Chemical compound C1=CC=CC2=CC(C(=O)O)=CN=C21 DJXNJVFEFSWHLY-UHFFFAOYSA-N 0.000 abstract 2
- 239000003451 thiazide diuretic agent Substances 0.000 abstract 2
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"CRISTAIS DE SOLVATO DERIVADO DO áCIDO QUINOLINACARBOXìLICO". Um principal objetivo é fornecer um cristal de solvato em acetonitrila do ácido 6-flúor-1-metil-7-¢4-(5-metil-2-oxo-1,3-dioxolen-4-il)-metil-1piperazinil!- 4-oxo-4H-¢1,3! tiazeto ¢3,2-a! quinolina-3-carboxílico (Composto B), que é um intermediário para produzir preferencialmente o cristal do tipo III do ácido 6-flúor-1-metil-7-¢4-(5-metil-2-oxo-1,3-dioxolen-4-il)-metil-1-piperazinil!- 4-oxo-4H-¢1,3! tiazeto ¢3,2-a! quinolina-3-carboxílico (Composto A). Um cristal de Composto B pode ser precipitado preferencialmente por controle da concentração de supersaturação em cristalização usando-se acetonitrila como um solvente. Subseqüentemente, o cristal do tipo III de Composto A pode ser produzido por realização de dissolvatação do cristal.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003124643 | 2003-04-30 | ||
| JP2004006057 | 2004-01-13 | ||
| PCT/JP2004/006216 WO2004096815A1 (ja) | 2003-04-30 | 2004-04-28 | キノリンカルボン酸誘導体溶媒和物の結晶 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0409930A true BRPI0409930A (pt) | 2006-04-25 |
Family
ID=33422075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0409930-3A BRPI0409930A (pt) | 2003-04-30 | 2004-04-28 | cristais de solvato derivado do ácido quinolinacarboxìlico |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7612205B2 (pt) |
| EP (2) | EP1626051B1 (pt) |
| JP (1) | JP4655930B2 (pt) |
| KR (1) | KR101088988B1 (pt) |
| AU (2) | AU2004234287A1 (pt) |
| BR (1) | BRPI0409930A (pt) |
| CA (1) | CA2523854C (pt) |
| ES (1) | ES2388921T3 (pt) |
| MX (1) | MXPA05011525A (pt) |
| PL (1) | PL1626051T3 (pt) |
| PT (1) | PT1626051E (pt) |
| RU (1) | RU2335503C2 (pt) |
| WO (1) | WO2004096815A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2012MN02925A (pt) * | 2010-06-30 | 2015-05-22 | Cipla Ltd | |
| RU2484768C1 (ru) * | 2012-02-07 | 2013-06-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежская государственная медицинская академия им. Н.Н. Бурденко" Министерства здравоохранения и социального развития Российской Федерации | Способ прогнозирования течения глаукомной оптической нейропатии |
| JP2021519334A (ja) | 2018-03-26 | 2021-08-10 | クリア クリーク バイオ， インコーポレイテッド | ジヒドロオロト酸デヒドロゲナーゼを阻害するための組成物および方法 |
| US20210300873A1 (en) | 2020-03-20 | 2021-09-30 | Clear Creek Bio, Inc. | Stable polymorphic compositions of brequinar sodium and methods of use and manufacture thereof |
| AU2021236757A1 (en) * | 2020-03-20 | 2022-10-13 | Clear Creek Bio, Inc. | Stable polymorphic compositions of brequinar sodium and methods of use and manufacture thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0751579B2 (ja) | 1987-11-07 | 1995-06-05 | 日本新薬株式会社 | キノリンカルボン酸誘導体 |
| SU1558915A1 (ru) * | 1988-07-29 | 1990-04-23 | Пермский фармацевтический институт | 2-(5 @ -Нитрофурил)-2,3-дигидро-5Н-1,3,4-тиадиазоло[2,3-в]-хиназолинон-5, про вл ющий противомикробную активность |
-
2004
- 2004-04-28 EP EP04730102A patent/EP1626051B1/en not_active Expired - Lifetime
- 2004-04-28 RU RU2005137156/04A patent/RU2335503C2/ru active
- 2004-04-28 ES ES04730102T patent/ES2388921T3/es not_active Expired - Lifetime
- 2004-04-28 EP EP11161811A patent/EP2354144A1/en not_active Withdrawn
- 2004-04-28 BR BRPI0409930-3A patent/BRPI0409930A/pt not_active Application Discontinuation
- 2004-04-28 WO PCT/JP2004/006216 patent/WO2004096815A1/ja not_active Ceased
- 2004-04-28 JP JP2005505937A patent/JP4655930B2/ja not_active Expired - Lifetime
- 2004-04-28 CA CA2523854A patent/CA2523854C/en not_active Expired - Lifetime
- 2004-04-28 AU AU2004234287A patent/AU2004234287A1/en not_active Abandoned
- 2004-04-28 KR KR1020057020448A patent/KR101088988B1/ko not_active Expired - Lifetime
- 2004-04-28 PL PL04730102T patent/PL1626051T3/pl unknown
- 2004-04-28 MX MXPA05011525A patent/MXPA05011525A/es active IP Right Grant
- 2004-04-28 US US10/555,039 patent/US7612205B2/en not_active Expired - Lifetime
- 2004-04-28 PT PT04730102T patent/PT1626051E/pt unknown
-
2010
- 2010-04-01 AU AU2010201309A patent/AU2010201309B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004234287A1 (en) | 2004-11-11 |
| EP1626051A1 (en) | 2006-02-15 |
| CA2523854C (en) | 2012-10-16 |
| EP1626051A4 (en) | 2008-06-25 |
| EP1626051B1 (en) | 2012-06-13 |
| KR20060008930A (ko) | 2006-01-27 |
| JPWO2004096815A1 (ja) | 2006-07-13 |
| PL1626051T3 (pl) | 2012-10-31 |
| CA2523854A1 (en) | 2004-11-11 |
| RU2335503C2 (ru) | 2008-10-10 |
| WO2004096815A1 (ja) | 2004-11-11 |
| US7612205B2 (en) | 2009-11-03 |
| AU2010201309B2 (en) | 2011-10-13 |
| MXPA05011525A (es) | 2005-12-12 |
| KR101088988B1 (ko) | 2011-12-01 |
| US20070149540A1 (en) | 2007-06-28 |
| EP2354144A1 (en) | 2011-08-10 |
| ES2388921T3 (es) | 2012-10-19 |
| JP4655930B2 (ja) | 2011-03-23 |
| PT1626051E (pt) | 2012-08-01 |
| AU2010201309A1 (en) | 2010-04-22 |
| RU2005137156A (ru) | 2006-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |