NO20063821L - Kinolinderivater for anvendelse som mykobakterielle inhibitorer - Google Patents

Kinolinderivater for anvendelse som mykobakterielle inhibitorer

Info

Publication number
NO20063821L
NO20063821L NO20063821A NO20063821A NO20063821L NO 20063821 L NO20063821 L NO 20063821L NO 20063821 A NO20063821 A NO 20063821A NO 20063821 A NO20063821 A NO 20063821A NO 20063821 L NO20063821 L NO 20063821L
Authority
NO
Norway
Prior art keywords
quinoline derivatives
mycobacterial
mycobacterial inhibitors
inhibitors
derivatives
Prior art date
Application number
NO20063821A
Other languages
English (en)
Other versions
NO337253B1 (no
Inventor
Elisabeth Therese Jea Pasquier
Jerome Emile George Guillemont
David Francis Alain Lancois
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20063821L publication Critical patent/NO20063821L/no
Publication of NO337253B1 publication Critical patent/NO337253B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Den foreliggende oppfinnelse vedrører nye substituerte kinolinderivater ifølge den generelle formel (I) nyttige i behandlingen av mykobakterielle sykdommer slik som TB.
NO20063821A 2004-01-29 2006-08-28 Kinolinderivater for anvendelse som mykobakterielle inhibitorer NO337253B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04075286 2004-01-29
PCT/EP2005/050375 WO2005075428A1 (en) 2004-01-29 2005-01-28 Quinoline derivatives for use as mycobacterial inhibitors

Publications (2)

Publication Number Publication Date
NO20063821L true NO20063821L (no) 2006-08-28
NO337253B1 NO337253B1 (no) 2016-02-22

Family

ID=34833674

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063821A NO337253B1 (no) 2004-01-29 2006-08-28 Kinolinderivater for anvendelse som mykobakterielle inhibitorer

Country Status (20)

Country Link
US (1) US7790894B2 (no)
EP (1) EP1713776B1 (no)
JP (1) JP4919810B2 (no)
KR (1) KR101160183B1 (no)
CN (1) CN1910154B (no)
AP (1) AP2321A (no)
AT (1) ATE395336T1 (no)
AU (1) AU2005210036B2 (no)
BR (1) BRPI0507312A (no)
CA (1) CA2554049C (no)
DE (1) DE602005006744D1 (no)
EA (1) EA011572B9 (no)
ES (1) ES2306098T3 (no)
IL (1) IL177101A (no)
MX (1) MXPA06008596A (no)
NO (1) NO337253B1 (no)
NZ (1) NZ547614A (no)
UA (1) UA83875C2 (no)
WO (1) WO2005075428A1 (no)
ZA (1) ZA200606291B (no)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO341242B1 (no) * 2005-08-03 2017-09-25 Janssen Pharmaceutica Nv Kinolinderivater som antibakterielle midler

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2683B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO2684B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
JO2685B1 (en) 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
JO2970B1 (en) 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO3271B1 (ar) 2006-12-06 2018-09-16 Janssen Pharmaceutica Nv مشتقات الكوينولين المضادة للجراثيم
US8741917B2 (en) 2009-01-15 2014-06-03 Rutgers, The State University Of New Jersey Benzo [C] phenanthridines as antimicrobial agents
US20120059026A1 (en) 2009-04-30 2012-03-08 University Of Medicine And Dentistry Of New Jersey Antimicrobial agents
WO2011156626A1 (en) 2010-06-09 2011-12-15 Rutgers, The State University Of New Jersey Antimicrobial agents
CA2803890A1 (en) 2010-06-25 2011-12-29 Rutgers, The State University Of New Jersey Antimicrobial agents
RU2486175C2 (ru) * 2011-09-12 2013-06-27 Закрытое Акционерное Общество "Фарм-Синтез" Производные хинолина, в частности 5,6,7-замещенные 1-(2-хлорхинолин-3-ил)-4-диметиламино-2-(нафталин-1-ил)-1-фенилбутан-2-олы, способ получения и применение соединений
WO2013106756A2 (en) 2012-01-13 2013-07-18 Rutgers, The State University Of New Jersey Antimicrobial agents
AU2013235038A1 (en) 2012-03-21 2014-10-09 Malvika Kaul Antimicrobial agents
US9133167B2 (en) 2012-04-27 2015-09-15 Janssen Pharmaceutica Nv Antibacterial quinoline derivatives
KR102110366B1 (ko) 2012-04-27 2020-05-14 얀센 파마슈티카 엔.브이. 항균성 퀴놀린 유도체
JP6466335B2 (ja) 2012-10-16 2019-02-06 ヤンセン ファーマシューティカ エヌ．ベー． ＲＯＲ−γ−Ｔのメチレン連結キノリニルモジュレーター
CN104884448A (zh) 2012-10-16 2015-09-02 詹森药业有限公司 Rorγt的杂芳基连接的喹啉基调节剂
US9309222B2 (en) 2012-10-16 2016-04-12 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
CN105873439A (zh) 2013-10-15 2016-08-17 詹森药业有限公司 RORγt的烷基连接的喹啉基调节剂
KR20160068956A (ko) 2013-10-15 2016-06-15 얀센 파마슈티카 엔.브이. RORyT의 퀴놀리닐 조절제
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US9458150B2 (en) 2013-11-08 2016-10-04 Rutgers, The State University Of New Jersey Antimicrobial agents
CN109195957A (zh) 2016-02-25 2019-01-11 塔克西斯医药股份有限公司 合成方法和中间体
CA3058183A1 (en) 2017-03-30 2018-10-04 Taxis Pharmaceuticals, Inc. Synthetic processes and synthetic intermediates towardthe production of txa709

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965572A (en) * 1996-10-28 1999-10-12 The United States Of America As Respresented By The Secretary Of The Army Methods for treating antibiotic-resistant infections
WO1998057931A2 (en) * 1997-06-19 1998-12-23 Sepracor Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6103905A (en) 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
DE69908555T2 (de) * 1998-01-26 2004-05-06 Smithkline Beecham P.L.C., Brentford Chinolinderivate als antibakterielles arzneimittel
PT1527050E (pt) * 2002-07-25 2010-06-22 Janssen Pharmaceutica Nv Derivados de quinolina e sua utilização como inibidores de micobactérias
KR101150172B1 (ko) * 2004-01-23 2012-05-25 얀센 파마슈티카 엔.브이. 치환된 퀴놀린 및 마이코박테리아 저해제로서의 용도

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO341242B1 (no) * 2005-08-03 2017-09-25 Janssen Pharmaceutica Nv Kinolinderivater som antibakterielle midler

Also Published As

Publication number Publication date
NO337253B1 (no) 2016-02-22
WO2005075428A1 (en) 2005-08-18
IL177101A0 (en) 2006-12-10
CA2554049C (en) 2012-12-18
JP2007519687A (ja) 2007-07-19
CN1910154B (zh) 2011-08-17
US20070299106A1 (en) 2007-12-27
US7790894B2 (en) 2010-09-07
KR20070004597A (ko) 2007-01-09
EA011572B9 (ru) 2018-01-31
ZA200606291B (en) 2008-02-27
MXPA06008596A (es) 2006-08-28
CN1910154A (zh) 2007-02-07
HK1099297A1 (en) 2007-08-10
IL177101A (en) 2012-01-31
AP2006003705A0 (en) 2006-08-31
ES2306098T3 (es) 2008-11-01
AU2005210036A1 (en) 2005-08-18
ATE395336T1 (de) 2008-05-15
CA2554049A1 (en) 2005-08-18
DE602005006744D1 (de) 2008-06-26
BRPI0507312A (pt) 2007-06-26
UA83875C2 (ru) 2008-08-26
EP1713776B1 (en) 2008-05-14
EA011572B1 (ru) 2009-04-28
NZ547614A (en) 2009-04-30
EA200601391A1 (ru) 2006-12-29
JP4919810B2 (ja) 2012-04-18
AU2005210036B2 (en) 2010-12-23
KR101160183B1 (ko) 2012-06-26
EP1713776A1 (en) 2006-10-25
AP2321A (en) 2011-11-16

Similar Documents

Publication Publication Date Title
EA200601391A1 (ru) Производные хинолина для применения в качестве микобактериальных ингибиторов
NO20063748L (no) Kinolinderivater og anvendelse derav som mykobakterielle inhibitorer
NO20083427L (no) Cystoksiske midler omfattende nye tomaymycinderivater og deres terapeutiske anvendelse
NO20044731L (no) Kinolin- og isokinolinderivater fremgangsmate for fremstilling derav og anvendelse derav som betennelseshemmere
EA200970156A1 (ru) Пиридизиноновые производные
NO20070224L (no) 2-karbamid-4-fenyltiazolderivater, fremstilling og terapeutisk anvendelse derav
NO20073791L (no) Pyrazolylaminopyridinderivater anvendbare som kinaseinhibitorer
EA200801996A1 (ru) 2-замещенные производные 4-бензилфталазинонов в качестве гистаминовых h1- и h3-антагонистов
ATE442847T1 (de) Benzimidazol-derivate als mek-hemmer
EA201170508A1 (ru) Производные 1-амино-2-циклобутилэтилбороновой кислоты
NO20071593L (no) Pyrimidinderivater
EA201001683A1 (ru) Производные фенил- или пиридинилзамещенных индазолов
NO20066055L (no) Pyridinderivater
NO20092723L (no) Indazolylester og amidderivater for behandling av gluccocorticoid reseptormedierte sykdommer
NO20076635L (no) Krystallinske og andre former for 4-amino-5-fluor-3-[6-(4-metylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-kinolin-2-on-melkesyresalter
EA201000149A1 (ru) Производные 1-фенил-2-пиридинилалкиловых спиртов в качестве ингибиторов фосфодиэстераз
CY1108230T1 (el) Παραγωγα 2-(1η-ινδολυλοσουλφανυλ)-βενζυλαμινης ως ssri
ATE307810T1 (de) Imidazol-2-carbonsäureamid derivate als raf- kinase-inhibitoren
NO20056192L (no) Kapaseinhibitorer og anvendelse derav
MA32544B1 (fr) Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
NO20083708L (no) 4-Fenyl-tiazol-5-karboksylsyre og 4-fenyl-tiazol-5-karboksylmider som PLK1-inhibitorer
EA200801608A1 (ru) Производные бензимидазолонкарбоновой кислоты
EA200700982A1 (ru) Производные хинолина и изохинолина, замещённые в 5-ом положении, способ их получения и их применение в качестве противовоспалительных средств
ATE517873T1 (de) 6-oxo-1,6-dihydropyrimidin-2-yle bei der behandlung proliferativer krankheiten
NO20085317L (no) Imidazoazepinonforbindelser