BRPI0410283A - métodos de análise de uma região de ácido nucleico marcadora, de detecção ou monitoração de uma população clonal de células em um mamìfero, de diagnóstico e/ou de monitoração de uma condição de doença de mamìfero e de enriquecimento de uma população de moléculas de ácido nucleico em uma amostra biológica - Google Patents

métodos de análise de uma região de ácido nucleico marcadora, de detecção ou monitoração de uma população clonal de células em um mamìfero, de diagnóstico e/ou de monitoração de uma condição de doença de mamìfero e de enriquecimento de uma população de moléculas de ácido nucleico em uma amostra biológica

Info

Publication number
BRPI0410283A
BRPI0410283A BRPI0410283-5A BRPI0410283A BRPI0410283A BR PI0410283 A BRPI0410283 A BR PI0410283A BR PI0410283 A BRPI0410283 A BR PI0410283A BR PI0410283 A BRPI0410283 A BR PI0410283A
Authority
BR
Brazil
Prior art keywords
nucleic acid
monitoring
acid region
population
analyzing
Prior art date
Application number
BRPI0410283-5A
Other languages
English (en)
Inventor
Alexander Alan Morley
Michael Brisco
Pamela Sykes
Original Assignee
Monoquant Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monoquant Pty Ltd filed Critical Monoquant Pty Ltd
Publication of BRPI0410283A publication Critical patent/BRPI0410283A/pt
Publication of BRPI0410283B1 publication Critical patent/BRPI0410283B1/pt
Publication of BRPI0410283B8 publication Critical patent/BRPI0410283B8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

"MéTODOS DE ANáLISE DE UMA REGIãO DE áCIDO NUCLEICO MARCADORA, DE DETECçãO OU MONITORAçãO DE UMA POPULAçãO CLONAL DE CéLULAS EM UM MAMìFERO, DE DIAGNóSTICO E/OU DE MONITORAçãO DE UMA CONDIçãO DE DOENçA DE MAMìFERO E DE ENRIQUECIMENTO DE UMA POPULAçãO DE MOLéCULAS DE áCIDO NUCLEICO EM UMA AMOSTRA BIOLóGICA". A presente invenção refere-se a um método de caracterização de uma região de ácido nucleico e, mais particularmente, a um método de análise de uma região de ácido nucleico marcadora. O método da presente invenção baseia-se na identificação de uma ou de ambas as regiões de ácido nucleico flanqueando uma região de ácido nucleico marcadora e proporciona um meio de análise de uma região de ácido nucleico marcadora que é característica de uma população clonal de células. O método da presente invenção é útil no contexto de permitir uma variedade de aplicações incluindo, mas não limitadas a, monitoração da progressão de uma condição caracterizada pela presença de uma população clonal de células (tais como condições neoplásicas), monitoração dos níveis de uma ou mais populações clonais de células, predição da possibilidade de uma reincidência de um indivíduo de um estado remissivo para um estado doentio, para avaliar a efetividade de drogas terapêuticas existentes e/ou agentes terapêuticos novos e identificação da presença de uma região marcadora.
BRPI0410283A 2003-05-13 2004-05-13 método de caracterização de um gene de região variável de receptor de células t ou imunoglobulina rearranjado BRPI0410283B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2003902299A AU2003902299A0 (en) 2003-05-13 2003-05-13 A method of analysing a marker nucleic acid molecule
AU2003902299 2003-05-13
PCT/AU2004/000625 WO2004101815A1 (en) 2003-05-13 2004-05-13 Identification of clonal cells by repeats in (eg.) t-cell receptor v/d/j genes

Publications (3)

Publication Number Publication Date
BRPI0410283A true BRPI0410283A (pt) 2006-05-16
BRPI0410283B1 BRPI0410283B1 (pt) 2018-02-06
BRPI0410283B8 BRPI0410283B8 (pt) 2021-07-27

Family

ID=31501168

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410283A BRPI0410283B8 (pt) 2003-05-13 2004-05-13 método de caracterização de um gene de região variável de receptor de células t ou imunoglobulina rearranjado

Country Status (9)

Country Link
US (1) US7785783B2 (pt)
EP (1) EP1633884B1 (pt)
JP (3) JP2007515154A (pt)
KR (2) KR101215194B1 (pt)
CN (1) CN1806051B (pt)
AU (3) AU2003902299A0 (pt)
BR (1) BRPI0410283B8 (pt)
CA (1) CA2525122C (pt)
WO (1) WO2004101815A1 (pt)

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Also Published As

Publication number Publication date
US7785783B2 (en) 2010-08-31
CN1806051B (zh) 2012-05-30
EP1633884A1 (en) 2006-03-15
AU2009238365A1 (en) 2009-12-10
WO2004101815A1 (en) 2004-11-25
EP1633884A4 (en) 2008-03-05
KR101215194B1 (ko) 2012-12-24
EP1633884B1 (en) 2014-06-25
JP2016027825A (ja) 2016-02-25
CA2525122C (en) 2015-11-24
BRPI0410283B8 (pt) 2021-07-27
JP6189600B2 (ja) 2017-08-30
JP2013116116A (ja) 2013-06-13
US20050255482A1 (en) 2005-11-17
BRPI0410283B1 (pt) 2018-02-06
KR20120107521A (ko) 2012-10-02
AU2004238887A1 (en) 2004-11-25
CA2525122A1 (en) 2004-11-25
JP2007515154A (ja) 2007-06-14
AU2003902299A0 (en) 2003-05-29
CN1806051A (zh) 2006-07-19
KR20060015604A (ko) 2006-02-17

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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 13/05/2004, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO