BRPI0410851A - solução aquosa de olanexidina, método de preparação da solução aquosa e desinfetante - Google Patents

solução aquosa de olanexidina, método de preparação da solução aquosa e desinfetante

Info

Publication number
BRPI0410851A
BRPI0410851A BRPI0410851-5A BRPI0410851A BRPI0410851A BR PI0410851 A BRPI0410851 A BR PI0410851A BR PI0410851 A BRPI0410851 A BR PI0410851A BR PI0410851 A BRPI0410851 A BR PI0410851A
Authority
BR
Brazil
Prior art keywords
aqueous solution
olanexidine
disinfectant
preparation
acid
Prior art date
Application number
BRPI0410851-5A
Other languages
English (en)
Inventor
Kazuyoshi Miyata
Yasuhide Inoue
Akifumi Hagi
Motoya Kikuchi
Hitoshi Ohno
Kinji Hashimoto
Kinue Ohguro
Tetsuya Sato
Hidetsugu Tsubouchi
Hiroshi Ishikawa
Takashi Okamura
Koushi Iwata
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of BRPI0410851A publication Critical patent/BRPI0410851A/pt
Publication of BRPI0410851B1 publication Critical patent/BRPI0410851B1/pt
Publication of BRPI0410851B8 publication Critical patent/BRPI0410851B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Oncology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

"SOLUçãO AQUOSA DE OLANEXIDINA, MéTODO DE PREPARAçãO DA SOLUçãO AQUOSA E DESINFETANTE". A presente invenção proporciona um desinfetante que contém olanexidina em uma concentração suficiente para exibir um eficaz efeito bactericida eficaz e que dificilmente apresenta quaisquer efeitos colaterais, como, por exemplo, irritação da pele. Especificamente, a presente invenção refere-se a um desinfetante contendo uma solução aquosa que contém olanexidina e pelo menos uma quantidade eqüimolar de ácido glicónico e substancialmente não contém nenhum ácido diferente de ácido glicónico nem um sal de ácido diferente de ácido glicónico.
BRPI0410851A 2003-05-28 2004-05-25 Solução aquosa de olanexidina, método de preparação da solução aquosa, desinfetante, seu uso e método de desinfecção ou esterilização de um objeto BRPI0410851B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003150846 2003-05-28
PCT/JP2004/007434 WO2004105745A1 (ja) 2003-05-28 2004-05-25 オラネキシジン水溶液、その調製方法および消毒剤

Publications (3)

Publication Number Publication Date
BRPI0410851A true BRPI0410851A (pt) 2006-07-04
BRPI0410851B1 BRPI0410851B1 (pt) 2016-06-07
BRPI0410851B8 BRPI0410851B8 (pt) 2023-04-25

Family

ID=33487195

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410851A BRPI0410851B8 (pt) 2003-05-28 2004-05-25 Solução aquosa de olanexidina, método de preparação da solução aquosa, desinfetante, seu uso e método de desinfecção ou esterilização de um objeto

Country Status (21)

Country Link
US (3) US7829518B2 (pt)
EP (1) EP1634589B9 (pt)
KR (1) KR101017334B1 (pt)
CN (2) CN1794983B (pt)
AR (2) AR044563A1 (pt)
AT (1) ATE499095T1 (pt)
AU (1) AU2004243183B2 (pt)
BR (1) BRPI0410851B8 (pt)
CA (1) CA2526570C (pt)
CY (1) CY1111503T1 (pt)
DE (1) DE602004031523D1 (pt)
DK (1) DK1634589T3 (pt)
ES (1) ES2358740T3 (pt)
MX (1) MXPA05012761A (pt)
MY (2) MY144306A (pt)
PL (1) PL1634589T3 (pt)
PT (1) PT1634589E (pt)
RU (1) RU2334508C2 (pt)
SI (1) SI1634589T1 (pt)
TW (2) TWI355930B (pt)
WO (1) WO2004105745A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5078993B2 (ja) 2006-08-30 2012-11-21 大塚製薬株式会社 １−（３，４−ジクロロベンジル）−５−オクチルビグアナイドまたはその塩の製造方法
US9044733B2 (en) * 2008-05-19 2015-06-02 Otsuka America Pharmaceutical, Inc. Method and apparatus for preparing a solution of a shear sensitive material
JP5383281B2 (ja) 2009-03-30 2014-01-08 花王株式会社 農薬含有組成物
JP6602639B2 (ja) * 2015-10-21 2019-11-06 株式会社大塚製薬工場 がんの治療による口腔粘膜炎の改善・予防用組成物
CN108289868B (zh) * 2015-12-07 2021-03-02 株式会社大塚制药工场 皮肤消毒用组合物
JP6802365B2 (ja) * 2017-04-19 2020-12-16 株式会社大塚製薬工場 抗炎症剤
CN107668062B (zh) * 2017-10-27 2021-03-09 金英花 基于透明质酸的奥兰西丁水溶液及其制备方法和应用
CN107646862B (zh) * 2017-10-27 2021-05-07 江苏食品药品职业技术学院 基于抗坏血酸的奥兰西丁水溶液及其制备方法和应用
SG11202012238WA (en) * 2018-07-18 2021-01-28 Otsuka Pharma Factory Inc Disinfectant composition

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
GB815925A (en) * 1956-06-06 1959-07-01 Ici Ltd New biguanide salts
JPS5974668A (ja) * 1982-09-20 1984-04-27 インタ−ナショナル　ビジネス　マシ−ンズ　コ−ポレ−ション 集積回路接点構造体
US4734222A (en) * 1986-04-03 1988-03-29 Ciba-Geigy Corporation Composition and method for cleaning soft and hard contact lenses
DE3816734A1 (de) * 1988-05-17 1989-11-30 Henkel Kgaa Verfahren zur reinigung und desinfektion von hitze- und korrosionsempfindlichen medizinischen geraeten, insbesondere von endoskopen und mittel zur durchfuehrung des verfahrens
JP3308980B2 (ja) 1991-03-15 2002-07-29 東燃ゼネラル石油株式会社 末端修飾ポリプロピレン及びその製法
CA2064664C (en) 1991-04-05 2000-01-11 Hiroshi Ishikawa Biguanide derivatives, manufacturing method thereof, and disinfectants containing the derivatives
JP2662343B2 (ja) * 1991-06-19 1997-10-08 大塚製薬株式会社 モノビグアナイド誘導体とこの誘導体を含有した消毒薬
GB2262283B (en) * 1991-12-12 1996-01-17 Mitsubishi Materials Corp Biguanide disinfectants
JP3118051B2 (ja) * 1991-12-12 2000-12-18 三菱マテリアル株式会社 殺菌剤
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Also Published As

Publication number Publication date
WO2004105745A1 (ja) 2004-12-09
TW201141384A (en) 2011-12-01
KR20060021868A (ko) 2006-03-08
MY144306A (en) 2011-08-29
EP1634589B1 (en) 2011-02-23
US7825080B2 (en) 2010-11-02
AR044563A1 (es) 2005-09-21
TWI355930B (en) 2012-01-11
SI1634589T1 (sl) 2011-05-31
ES2358740T3 (es) 2011-05-13
MY144204A (en) 2011-08-15
CN102715184B (zh) 2016-04-27
CN102715184A (zh) 2012-10-10
CA2526570C (en) 2012-09-11
CN1794983A (zh) 2006-06-28
HK1176817A1 (zh) 2013-08-09
EP1634589B9 (en) 2011-08-31
TW200427661A (en) 2004-12-16
AR095681A2 (es) 2015-11-04
US20060189500A1 (en) 2006-08-24
CA2526570A1 (en) 2004-12-09
US20100331423A1 (en) 2010-12-30
HK1086200A1 (en) 2006-09-15
AU2004243183A1 (en) 2004-12-09
BRPI0410851B1 (pt) 2016-06-07
BRPI0410851B8 (pt) 2023-04-25
US7829518B2 (en) 2010-11-09
RU2334508C2 (ru) 2008-09-27
US20070041866A1 (en) 2007-02-22
CY1111503T1 (el) 2015-10-07
PT1634589E (pt) 2011-03-24
DK1634589T3 (da) 2011-04-18
RU2005141134A (ru) 2006-06-10
AU2004243183B2 (en) 2009-08-06
ATE499095T1 (de) 2011-03-15
DE602004031523D1 (de) 2011-04-07
TWI400038B (zh) 2013-07-01
US8334248B2 (en) 2012-12-18
EP1634589A4 (en) 2007-11-07
EP1634589A1 (en) 2006-03-15
PL1634589T3 (pl) 2011-07-29
MXPA05012761A (es) 2006-05-17
KR101017334B1 (ko) 2011-02-28
CN1794983B (zh) 2012-07-18

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