BRPI0411112A - proteìna de fusão heteróloga, polinucleotìdeo, vetor, célula hospedeira, processo para produzir uma proteìna de fusão heteróloga, método para tratar um paciente, e, uso de proteìna de fusão heteróloga - Google Patents

proteìna de fusão heteróloga, polinucleotìdeo, vetor, célula hospedeira, processo para produzir uma proteìna de fusão heteróloga, método para tratar um paciente, e, uso de proteìna de fusão heteróloga

Info

Publication number
BRPI0411112A
BRPI0411112A BRPI0411112-5A BRPI0411112A BRPI0411112A BR PI0411112 A BRPI0411112 A BR PI0411112A BR PI0411112 A BRPI0411112 A BR PI0411112A BR PI0411112 A BRPI0411112 A BR PI0411112A
Authority
BR
Brazil
Prior art keywords
fusion protein
heterologous fusion
treating
polynucleotide
vector
Prior art date
Application number
BRPI0411112-5A
Other languages
English (en)
Inventor
Wolfgang Glaesner
Yu Tian
Sheng-Hung Rainbow Tschang
Andrew Mark Vick
Rohn Lee Junior Millican
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BRPI0411112A publication Critical patent/BRPI0411112A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"PROTEìNA DE FUSãO HETERóLOGA, POLINUCLEOTìDEO, VETOR, CéLULA HOSPEDEIRA, PROCESSO PARA PRODUZIR UMA PROTEìNA DE FUSãO HETERóLOGA, MéTODO PAPA TRATAR UM PACIENTE, E, USO DE PROTEìNA DE FUSãO HETERóLOGA". A invenção proporciona peptídeos terapêuticos ativos fundidos em derivados de IgG4-Fc específicos. Estas proteínas de fusão possuem uma meia-vida aumentada, uma formação de meio anticorpo reduzida, e uma atividade efetuadora reduzida, ao mesmo tempo não sendo imunogênicas. As proteínas de fusão são úteis no tratamento de doenças bem como de uma variedade de outras condições e de outros distúrbios.
BRPI0411112-5A 2003-06-12 2004-06-10 proteìna de fusão heteróloga, polinucleotìdeo, vetor, célula hospedeira, processo para produzir uma proteìna de fusão heteróloga, método para tratar um paciente, e, uso de proteìna de fusão heteróloga BRPI0411112A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47788003P 2003-06-12 2003-06-12
US57090804P 2004-05-13 2004-05-13
PCT/US2004/016611 WO2004110472A2 (en) 2003-06-12 2004-06-10 Fusion proteins

Publications (1)

Publication Number Publication Date
BRPI0411112A true BRPI0411112A (pt) 2006-07-18

Family

ID=33555478

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0411112-5A BRPI0411112A (pt) 2003-06-12 2004-06-10 proteìna de fusão heteróloga, polinucleotìdeo, vetor, célula hospedeira, processo para produzir uma proteìna de fusão heteróloga, método para tratar um paciente, e, uso de proteìna de fusão heteróloga

Country Status (17)

Country Link
US (1) US20070253966A1 (pt)
EP (1) EP1641483B1 (pt)
JP (1) JP2007505643A (pt)
CN (1) CN1802167A (pt)
AT (1) ATE385806T1 (pt)
AU (1) AU2004247042A1 (pt)
BR (1) BRPI0411112A (pt)
CA (1) CA2526169A1 (pt)
CY (1) CY1107248T1 (pt)
DE (1) DE602004011770T2 (pt)
DK (1) DK1641483T3 (pt)
ES (1) ES2298785T3 (pt)
MX (1) MXPA05013564A (pt)
PL (1) PL1641483T3 (pt)
PT (1) PT1641483E (pt)
SI (1) SI1641483T1 (pt)
WO (1) WO2004110472A2 (pt)

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Publication number Publication date
AU2004247042A1 (en) 2004-12-23
DE602004011770T2 (de) 2009-02-05
US20070253966A1 (en) 2007-11-01
EP1641483B1 (en) 2008-02-13
CA2526169A1 (en) 2004-12-23
PL1641483T3 (pl) 2008-07-31
EP1641483A2 (en) 2006-04-05
ES2298785T3 (es) 2008-05-16
DE602004011770D1 (de) 2008-03-27
MXPA05013564A (es) 2006-03-09
ATE385806T1 (de) 2008-03-15
SI1641483T1 (sl) 2008-08-31
JP2007505643A (ja) 2007-03-15
WO2004110472A3 (en) 2005-02-03
WO2004110472A2 (en) 2004-12-23
CN1802167A (zh) 2006-07-12
PT1641483E (pt) 2008-04-29
CY1107248T1 (el) 2012-11-21
DK1641483T3 (da) 2008-06-02

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