BRPI0411123A - porfirinas e metaloporfirinas para inibir a absorção de ferro de heme - Google Patents
porfirinas e metaloporfirinas para inibir a absorção de ferro de hemeInfo
- Publication number
- BRPI0411123A BRPI0411123A BRPI0411123-0A BRPI0411123A BRPI0411123A BR PI0411123 A BRPI0411123 A BR PI0411123A BR PI0411123 A BRPI0411123 A BR PI0411123A BR PI0411123 A BRPI0411123 A BR PI0411123A
- Authority
- BR
- Brazil
- Prior art keywords
- porphyrins
- heme iron
- iron absorption
- absorption
- iron
- Prior art date
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title abstract 14
- 150000004032 porphyrins Chemical class 0.000 title abstract 9
- 229910052742 iron Inorganic materials 0.000 title abstract 7
- 238000010521 absorption reaction Methods 0.000 title abstract 6
- 150000003278 haem Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 abstract 3
- 238000001727 in vivo Methods 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 208000031306 Rare hereditary hemochromatosis Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"PORFIRINAS E METALOPORFIRINAS PARA INIBIR A ABSORçãO DE FERRO DE HEME". A presente invenção fornece uma classe de porfirinas e porfirinas queladas com metal para uso como inibidores de absorção de ferro de heme. As moléculas de porfirina quelada com porfirina/metal da invenção são porfirinas tetrapositivamente carregadas com base em meso-tetra (4-piridil) porfinas. Vários tais agentes são mostrados aqui para causar a inibição de absorção de ferro in vivo e in vitro. A invenção também fornece composições terapêuticas incluindo as porfirinas e metaloporfirinas da invenção. Além disso, métodos de inibição de absorção de ferro de heme in vivo são ensinados, bem como métodos de tratamento de doenças caracterizadas por sobrecarga de ferro. Estes métodos incluem a administração de uma porfirina ou metaloporfirina em uma composição terapêutica da invenção para prevenir a absorção de ferro de heme, desse modo prevenindo o reabastecimento de depósitos de ferro de um paciente.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47717803P | 2003-06-10 | 2003-06-10 | |
| US10/859,810 US7008937B2 (en) | 2003-06-10 | 2004-06-03 | Porphyrins and metalloporphyrins for inhibiting heme iron uptake |
| PCT/US2004/017828 WO2004110377A2 (en) | 2003-06-10 | 2004-06-04 | Porphyrins and metalloporphyrins for inhibiting heme iron uptake |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0411123A true BRPI0411123A (pt) | 2006-07-18 |
Family
ID=33514107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0411123-0A BRPI0411123A (pt) | 2003-06-10 | 2004-06-04 | porfirinas e metaloporfirinas para inibir a absorção de ferro de heme |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7008937B2 (pt) |
| EP (1) | EP1641391A4 (pt) |
| AU (1) | AU2004247099A1 (pt) |
| BR (1) | BRPI0411123A (pt) |
| CA (1) | CA2528090A1 (pt) |
| WO (1) | WO2004110377A2 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2397067B (en) * | 2002-12-23 | 2005-05-11 | Destiny Pharma Ltd | Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation |
| GB2415372A (en) | 2004-06-23 | 2005-12-28 | Destiny Pharma Ltd | Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent |
| US7585527B2 (en) * | 2005-09-19 | 2009-09-08 | Bala Venkataraman | Composition and method for treating iron deficiency anemia |
| US8586530B2 (en) | 2006-04-27 | 2013-11-19 | University Of South Florida | Modulation of inhibition of ferrochelatase by N-methyl protoporphyrin |
| EP2785339A4 (en) * | 2011-12-02 | 2015-11-25 | Univ Colorado Regents | NEUROLOGICAL TREATMENTS WITH METALOPORPHYRINE |
| EP3200582B1 (en) | 2014-09-29 | 2023-11-15 | Fred Hutchinson Cancer Center | Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers |
| CN105622620B (zh) * | 2014-10-31 | 2017-11-03 | 北京大学 | 一种具有可视化光动力治疗特性的卟啉光敏剂的制备方法 |
| CN116271206B (zh) * | 2023-04-10 | 2025-02-25 | 温州市工业科学研究院 | 一种镓卟啉配合物/丝素蛋白抗菌敷料及其制作方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4657902A (en) * | 1985-03-25 | 1987-04-14 | The Rockefeller University | Therapeutic use of tin mesoporphyrin |
| US4699903A (en) * | 1986-06-20 | 1987-10-13 | The Rockefeller University | Therapeutic use of tin diiododeuteroporphyrin |
| US5223494A (en) * | 1989-09-25 | 1993-06-29 | The Rockefeller University | Orally administered porphyrins to control intestinal iron absorption |
| EP0988037A1 (en) * | 1997-02-05 | 2000-03-29 | Board Of Regents, The University Of Texas System | Porphyrin compounds as telomerase inhibitors |
| EP1107971B1 (en) * | 1998-08-28 | 2004-11-24 | Destiny Pharma Limited | Porphyrin derivatives, their use in photodynamic therapy and medical devices containing them |
-
2004
- 2004-06-03 US US10/859,810 patent/US7008937B2/en not_active Expired - Fee Related
- 2004-06-04 BR BRPI0411123-0A patent/BRPI0411123A/pt not_active IP Right Cessation
- 2004-06-04 EP EP04754439A patent/EP1641391A4/en not_active Withdrawn
- 2004-06-04 CA CA002528090A patent/CA2528090A1/en not_active Abandoned
- 2004-06-04 AU AU2004247099A patent/AU2004247099A1/en not_active Abandoned
- 2004-06-04 WO PCT/US2004/017828 patent/WO2004110377A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US20040254155A1 (en) | 2004-12-16 |
| AU2004247099A1 (en) | 2004-12-23 |
| WO2004110377A2 (en) | 2004-12-23 |
| EP1641391A2 (en) | 2006-04-05 |
| EP1641391A4 (en) | 2007-05-30 |
| WO2004110377A3 (en) | 2005-08-11 |
| CA2528090A1 (en) | 2004-12-23 |
| US7008937B2 (en) | 2006-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A, 6A, 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012. |