ATE348101T1 - Carbolin derivate als hemmstoffe von phospphodiesterase 5 (pde5) zur behandlung kardiovaskulärer erkrankungen und der erektilen dysfunktion - Google Patents

Carbolin derivate als hemmstoffe von phospphodiesterase 5 (pde5) zur behandlung kardiovaskulärer erkrankungen und der erektilen dysfunktion

Info

Publication number: ATE348101T1
Authority: AT; Austria
Prior art keywords: inhibitors; phospphodiesterase; pde5; treatment; cardiovascular diseases
Prior art date: 2001-04-25

Application number

AT02766739T

Other languages

English (en)

Inventor

Jason Scott Sawyer

Mark W Orme

James D Copp

Original Assignee

Lilly Icos Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-25

Filing date

2002-04-02

Publication date

2007-01-15

2002-04-02 Application filed by Lilly Icos Llc filed Critical Lilly Icos Llc

2007-01-15 Application granted granted Critical

2007-01-15 Publication of ATE348101T1 publication Critical patent/ATE348101T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Immunology (AREA)
Hospice & Palliative Care (AREA)
Gynecology & Obstetrics (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT02766739T 2001-04-25 2002-04-02 Carbolin derivate als hemmstoffe von phospphodiesterase 5 (pde5) zur behandlung kardiovaskulärer erkrankungen und der erektilen dysfunktion ATE348101T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US28673001P	2001-04-25	2001-04-25

Publications (1)

Publication Number	Publication Date
ATE348101T1 true ATE348101T1 (de)	2007-01-15

Family

ID=23099912

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02766739T ATE348101T1 (de)	2001-04-25	2002-04-02	Carbolin derivate als hemmstoffe von phospphodiesterase 5 (pde5) zur behandlung kardiovaskulärer erkrankungen und der erektilen dysfunktion

Country Status (9)

Country	Link
US (1)	US7115621B2 (de)
EP (1)	EP1383765B1 (de)
JP (1)	JP4216606B2 (de)
AT (1)	ATE348101T1 (de)
CA (1)	CA2441792C (de)
DE (1)	DE60216745T2 (de)
ES (1)	ES2278956T3 (de)
MX (1)	MXPA03009750A (de)
WO (1)	WO2002088123A1 (de)

Families Citing this family (24)

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Publication number	Priority date	Publication date	Assignee	Title
TWI329111B (en)	2002-05-24	2010-08-21	X Ceptor Therapeutics Inc	Azepinoindole and pyridoindole derivatives as pharmaceutical agents
US7872133B2 (en)	2003-06-23	2011-01-18	Ono Pharmaceutical Co., Ltd.	Tricyclic heterocycle compound
US8076353B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Inhibition of VEGF translation
US7767689B2 (en)	2004-03-15	2010-08-03	Ptc Therapeutics, Inc.	Carboline derivatives useful in the treatment of cancer
US8076352B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Administration of carboline derivatives useful in the treatment of cancer and other diseases
UA92317C2 (ru)	2004-03-15	2010-10-25	Пи-Ти-Си ТЕРАПЬЮТИКС, ИНК.	Производные карболина, пригодные для ингибирования развития кровеносных сосудов
EP2216329A1 (de) *	2004-10-28	2010-08-11	Dr. Reddy's Laboratories Ltd.	Verfahren zur Herstellung von Tadalafil
AR051780A1 (es) *	2004-11-29	2007-02-07	Japan Tobacco Inc	Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
EP1829874B1 (de) *	2004-12-22	2014-02-12	Ono Pharmaceutical Co., Ltd.	Tricyclische verbindung und deren verwendung
EP1747779A1 (de)	2005-07-28	2007-01-31	Laboratorios Del Dr. Esteve, S.A.	Tetrahydro-b-carbolinsulfonamid-Derivate als 5-HT6 Liganden
AU2006275702A1 (en) *	2005-07-29	2007-02-08	Concert Pharmaceuticals Inc.	Novel pharmaceutical compounds
WO2007020521A1 (en) *	2005-08-16	2007-02-22	Pharmacia & Upjohn Company Llc	Pyridoyrazinones as pde-5 inhibitors
EP2004644A1 (de) *	2006-03-24	2008-12-24	Glenmark Pharmaceuticals Limited	Verfahren zur herstellung von tadalafil
AU2008302751A1 (en) *	2007-09-20	2009-03-26	D2E, Llc	Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use
KR101614723B1 (ko)	2008-01-11	2016-04-22	알바니 몰레큘라 리써치, 인크.	Ｍｃｈ 길항물질로서 (1-아지논)-치환된 피리도인돌
WO2011003007A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
US8618299B2 (en)	2009-07-01	2013-12-31	Albany Molecular Research, Inc.	Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
JP2012532144A (ja)	2009-07-01	2012-12-13	アルバニーモレキュラーリサーチ，インコーポレイテッド	アジノン置換アゼピノ［ｂ］インドールおよびピリド−ピロロ−アゼピンｍｃｈ−１拮抗薬、ならびにその作製方法および使用
US9073925B2 (en) *	2009-07-01	2015-07-07	Albany Molecular Research, Inc.	Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US8697700B2 (en)	2010-12-21	2014-04-15	Albany Molecular Research, Inc.	Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof
US8993765B2 (en)	2010-12-21	2015-03-31	Albany Molecular Research, Inc.	Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
WO2012127885A1 (ja)	2011-03-18	2012-09-27	小野薬品工業株式会社	テトラヒドロカルボリン誘導体
CN102391323B (zh) *	2011-10-18	2013-09-25	首都医科大学	四氢-β-咔啉衍生物、其制备方法及其用途
TW201710258A (zh)	2015-06-23	2017-03-16	碩騰服務公司	咔啉抗寄生蟲藥

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ES273769A1 (es) *	1961-01-18	1962-06-01	Geigy Ag J R	Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico
JPS5543475B2 (de) *	1972-09-14	1980-11-06
US4336260A (en) *	1977-12-08	1982-06-22	The Dow Chemical Company	Method and compositions using 1-aryl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid for treating depression
JPS5936676A (ja) *	1982-08-20	1984-02-28	Tanabe Seiyaku Co Ltd	β−カルボリン誘導体の新規製法
FR2663935A1 (fr) *	1990-06-27	1992-01-03	Adir	Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
GB9401090D0 (en) *	1994-01-21	1994-03-16	Glaxo Lab Sa	Chemical compounds
GB9514473D0 (en) *	1995-07-14	1995-09-13	Glaxo Lab Sa	Chemical compounds
JP2000508302A (ja) *	1996-04-04	2000-07-04	エフ．ホフマン―ラロッシュエイジー	抗転移剤としてのテトラヒドロ―β―カルボリン誘導体の使用
BR9709230A (pt) *	1996-05-10	1999-08-10	Icos Corp	Composto
EP0914318A1 (de)	1996-05-11	1999-05-12	Kings College London	Pyrazine
US6043252A (en) *	1997-05-05	2000-03-28	Icos Corporation	Carboline derivatives
AU1025899A (en) *	1998-09-16	2000-04-03	Icos Corporation	Carboline derivatives as cgmp phosphodiesterase inhibitors
PT1200090E (pt) *	1999-08-03	2013-11-25	Icos Corp	Formulação farmacêutica à base de um beta-carbolina e seu uso para tratar a disfunção sexual.
UA74826C2 (en) *	2000-05-17	2006-02-15	Ortho Mcneil Pharm Inc	?-carboline derivatives as phosphodiesterase inhibitors
JP2004501124A (ja) *	2000-06-07	2004-01-15	リリー　アイコス　リミテッド　ライアビリティ　カンパニー	化合物
US20030153575A1 (en)	2000-06-08	2003-08-14	Orme Mark W.	Tetracyclic diketopiperazine compounds as pdev inhibitors
DE60121461T2 (de)	2000-10-03	2007-02-08	Lilly Icos Llc, Wilmington	Kondensierte pyridoindolderivate
ATE337320T1 (de)	2000-11-06	2006-09-15	Lilly Icos Llc	Indolderivate als pde5-inhibitoren

2002
- 2002-04-02 EP EP02766739A patent/EP1383765B1/de not_active Expired - Lifetime
- 2002-04-02 JP JP2002585422A patent/JP4216606B2/ja not_active Expired - Fee Related
- 2002-04-02 US US10/471,476 patent/US7115621B2/en not_active Expired - Fee Related
- 2002-04-02 WO PCT/US2002/010367 patent/WO2002088123A1/en not_active Ceased
- 2002-04-02 MX MXPA03009750A patent/MXPA03009750A/es active IP Right Grant
- 2002-04-02 CA CA2441792A patent/CA2441792C/en not_active Expired - Fee Related
- 2002-04-02 ES ES02766739T patent/ES2278956T3/es not_active Expired - Lifetime
- 2002-04-02 DE DE60216745T patent/DE60216745T2/de not_active Expired - Lifetime
- 2002-04-02 AT AT02766739T patent/ATE348101T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2441792C (en)	2010-08-03
MXPA03009750A (es)	2004-06-30
US7115621B2 (en)	2006-10-03
CA2441792A1 (en)	2002-11-07
US20040147542A1 (en)	2004-07-29
EP1383765B1 (de)	2006-12-13
JP2004532852A (ja)	2004-10-28
DE60216745D1 (de)	2007-01-25
JP4216606B2 (ja)	2009-01-28
WO2002088123A1 (en)	2002-11-07
DE60216745T2 (de)	2007-05-16
ES2278956T3 (es)	2007-08-16
EP1383765A1 (de)	2004-01-28

Legal Events

Date	Code	Title	Description
2007-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60216745D1 (de)	2007-01-25	Carbolin Derivate als Hemmstoffe von Phospphodiesterase 5 (PDE5) zur Behandlung kardiovaskulärer Erkrankungen und der erektilen Dysfunktion
ATE302775T1 (de)	2005-09-15	Carbolinderivate
EA200200208A1 (ru)	2002-08-29	Синергитическая композиция
ATE371656T1 (de)	2007-09-15	Heteroaryl-pyrimidinderivate als jak-inhibitoren
ES2170252T3 (es)	2002-08-01	Tetrahidroimidazopiridoindoldionas como inhibidores de cgmp especifico pde.
EA200700099A1 (ru)	2007-08-31	Производные пиридина
AU5584901A (en)	2001-10-30	Use of cyclic gmp-specific phosphodiesterase inhibitors for treatment of parkinson's disease
TNSN03144A1 (en)	2005-12-23	Pyrrolopyrimidines as protein kinase inhibitors
CY1107747T1 (el)	2013-04-18	Υποκατεστημενα τετρακυκλικα παραγωγα πυρρολοκινολονης χρησιμα ως αναστολεις της φωσφοδιεστερασης
ATE307810T1 (de)	2005-11-15	Imidazol-2-carbonsäureamid derivate als raf- kinase-inhibitoren
ATE346067T1 (de)	2006-12-15	Carbolinderivate
ATE332903T1 (de)	2006-08-15	Kondensierte pyridoindolderivate
MXPA04005886A (es)	2004-09-13	Derivados de azaindolilalquilamina como ligandos de 5-hidroxitirptamina-6.
MXPA05012247A (es)	2006-02-10	Derivados de bencimidazol nuevos.
DE60112306D1 (de)	2005-09-01	Kondensierte pyrazindionderivate als pde5 inhibitore
DE60312736D1 (de)	2007-05-03	1,2,4-triaminobenzolderivate zur behandlung von erkrankungen des zentralnervensystems
AP2003002929A0 (en)	2003-12-31	Pyrrolopyrimidines as protein kinase inhibitors
ECSP055809A (es)	2005-08-11	Inhibidores 4-oxo-1-(3-fenil sustituido)-1,4-dihidro-1,8-naftiridina-3-carboxamida de la fosfodiesterasa-4
ATE333457T1 (de)	2006-08-15	Zyklische gmp-spezifische phosphodiesteraseinhibitoren
ATE302776T1 (de)	2005-09-15	Kondensierte pyridoindolderivate
DE60226970D1 (de)	2008-07-17	Pyrazinoä1',2':1,6ü-pyridoä3,4-bü indole-1,4-dionderivate
ATE337320T1 (de)	2006-09-15	Indolderivate als pde5-inhibitoren
MXPA03004023A (es)	2004-02-12	Compuestos quimicos.
ATE297926T1 (de)	2005-07-15	Hexahydropyrazino(1'2':1,6)-pyrido(3,4-b)indole 1,4-dion-derivate zur behandlung von cardiovaskulären erkrankungen und erektionsstörungen
ATE335742T1 (de)	2006-09-15	Carbolinderivate als pdev inhibitoren