BRPI0411250A - método de inibição de receptor tirosina cinase com um antagonista extracelular e um antagonista intracellular - Google Patents

método de inibição de receptor tirosina cinase com um antagonista extracelular e um antagonista intracellular

Info

Publication number
BRPI0411250A
BRPI0411250A BRPI0411250-4A BRPI0411250A BRPI0411250A BR PI0411250 A BRPI0411250 A BR PI0411250A BR PI0411250 A BRPI0411250 A BR PI0411250A BR PI0411250 A BRPI0411250 A BR PI0411250A
Authority
BR
Brazil
Prior art keywords
antagonist
tyrosine kinase
intracellular
extracellular
receptor
Prior art date
Application number
BRPI0411250-4A
Other languages
English (en)
Inventor
Samuel Waksal
Original Assignee
Samuel Waksal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samuel Waksal filed Critical Samuel Waksal
Publication of BRPI0411250A publication Critical patent/BRPI0411250A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"MéTODO DE INIBIçãO DE RECEPTOR TIROSINA CINASE COM UM ANTAGONISTA EXTRACELULAR E UM ANTAGONISTA INTRACELLULAR". Apresente invenção relata método de inibição receptor tirosina cinase pela utilização de ambos um antagonista extracelular e um intracelular RTK. O antagonista extracelular RTK é uma molécula biológica ou uma pequena molécula que inibe a ativação de receptor de tirosina cinase pela interação com a região de ligação extracelular do receptor. O antagonista intracelular é uma molécula biológica ou uma pequena molécula que inibe a atividade de tirosina cinase do receptor de tirosina cinase pela interação com as regiões intracelular dos receptores que ligam-se ao domínio cinase ou pela interação com uma proteína intracelular envolvida na cascata de sinalização do receptor tirosina cinase. A presente invenção também fornece métodos de tratamento de doenças tirosina cinase dependente e composições para uso em tais métodos pela administração de uma combinação de ambos antagonista intracelular e extracelular RTK.
BRPI0411250-4A 2003-06-09 2004-06-09 método de inibição de receptor tirosina cinase com um antagonista extracelular e um antagonista intracellular BRPI0411250A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47779603P 2003-06-09 2003-06-09
PCT/US2004/018451 WO2005001053A2 (en) 2003-06-09 2004-06-09 Method of inhibiting receptor tyrosine kinases with an extracellular antagonist and an intracellular antagonist

Publications (1)

Publication Number Publication Date
BRPI0411250A true BRPI0411250A (pt) 2006-08-29

Family

ID=33551763

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0411250-4A BRPI0411250A (pt) 2003-06-09 2004-06-09 método de inibição de receptor tirosina cinase com um antagonista extracelular e um antagonista intracellular

Country Status (10)

Country Link
US (3) US20070036795A1 (pt)
EP (2) EP2389953A1 (pt)
JP (2) JP2007500248A (pt)
CN (2) CN1972712A (pt)
BR (1) BRPI0411250A (pt)
CA (1) CA2528961A1 (pt)
IL (1) IL172473A0 (pt)
RU (2) RU2431500C2 (pt)
TN (1) TNSN05315A1 (pt)
WO (1) WO2005001053A2 (pt)

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PT2525824T (pt) * 2010-01-22 2017-07-13 Univ Leland Stanford Junior Inibição da sinalização de axl em terapêutica antimetastática
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Also Published As

Publication number Publication date
RU2006100030A (ru) 2007-07-20
WO2005001053A2 (en) 2005-01-06
IL172473A0 (en) 2006-04-10
EP1638600A4 (en) 2008-06-11
EP1638600A2 (en) 2006-03-29
CN101966338A (zh) 2011-02-09
JP2012211158A (ja) 2012-11-01
RU2431500C2 (ru) 2011-10-20
CN1972712A (zh) 2007-05-30
US20070036795A1 (en) 2007-02-15
RU2011122542A (ru) 2012-12-20
WO2005001053A3 (en) 2005-08-11
US20090232805A1 (en) 2009-09-17
TNSN05315A1 (en) 2007-07-10
EP2389953A1 (en) 2011-11-30
CA2528961A1 (en) 2005-01-06
US20120201817A1 (en) 2012-08-09
JP2007500248A (ja) 2007-01-11

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