BRPI0412457A - composição farmacêutica para aumento da solubilidade de drogas hidrofóbicas - Google Patents

composição farmacêutica para aumento da solubilidade de drogas hidrofóbicas

Info

Publication number
BRPI0412457A
BRPI0412457A BRPI0412457-0A BRPI0412457A BRPI0412457A BR PI0412457 A BRPI0412457 A BR PI0412457A BR PI0412457 A BRPI0412457 A BR PI0412457A BR PI0412457 A BRPI0412457 A BR PI0412457A
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
solubility
increasing
polyethylene glycol
hydrophobic drugs
Prior art date
Application number
BRPI0412457-0A
Other languages
English (en)
Inventor
Anup Kumar Ray
Indranil Nandi
Suresh Palaniswamy
Pablo Dasvila
Aakanksha Harshad
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of BRPI0412457A publication Critical patent/BRPI0412457A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPOSIçãO FARMACêUTICA PARA AUMENTO DA SOLUBILIDADE DE DROGAS HIDROFóBICAS". A presente invenção fornece uma composição farmacêutica contendo uma droga e polietileno glicol, na qual a razão em peso de polietileno glicol para a droga é de cerca de 0,2:1 a cerca de 10:1 e o polietileno glicol tem um ponto de fusão de pelo menos 37<198>C. As composições farmacêuticas da invenção exibem rápida dissolução em contato com solventes fisiológicos, tais como água, saliva ou fluidos gastrointestinais.
BRPI0412457-0A 2003-07-11 2004-07-09 composição farmacêutica para aumento da solubilidade de drogas hidrofóbicas BRPI0412457A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/618,545 US20050008704A1 (en) 2003-07-11 2003-07-11 Pharmaceutical composition for solubility enhancement of hydrophobic drugs
PCT/EP2004/007585 WO2005004917A2 (en) 2003-07-11 2004-07-09 Pharmaceutical composition for solubility enhancement of hydrophobic drugs

Publications (1)

Publication Number Publication Date
BRPI0412457A true BRPI0412457A (pt) 2006-10-17

Family

ID=33565153

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412457-0A BRPI0412457A (pt) 2003-07-11 2004-07-09 composição farmacêutica para aumento da solubilidade de drogas hidrofóbicas

Country Status (10)

Country Link
US (1) US20050008704A1 (pt)
EP (1) EP1646403A2 (pt)
CN (1) CN1856297A (pt)
AR (1) AR045906A1 (pt)
AU (1) AU2004255459A1 (pt)
BR (1) BRPI0412457A (pt)
CA (1) CA2529606A1 (pt)
MX (1) MXPA06000445A (pt)
RU (1) RU2006104025A (pt)
WO (1) WO2005004917A2 (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080051411A1 (en) * 2002-12-17 2008-02-28 Cink Russell D Salts of Fenofibric Acid and Pharmaceutical Formulations Thereof
US7259186B2 (en) * 2002-12-17 2007-08-21 Abbott Laboratories Salts of fenofibric acid and pharmaceutical formulations thereof
CN101480384A (zh) * 2002-12-17 2009-07-15 阿伯特有限及两合公司 包含非诺贝酸、其生理可接受的盐或衍生物的制剂
US20040253308A1 (en) * 2003-04-29 2004-12-16 Barr Laboratories, Inc. Surface-treated modafinil particles
CA2540984C (en) 2003-10-10 2011-02-08 Lifecycle Pharma A/S A solid dosage form comprising a fibrate
US20080152714A1 (en) * 2005-04-08 2008-06-26 Yi Gao Pharmaceutical Formulations
AU2006249349B2 (en) 2005-05-26 2012-01-12 Teva Women's Health, Inc. Oral dosage forms comprising progesterone and methods of making and using the same
AU2007272501A1 (en) * 2006-07-12 2008-01-17 Elan Pharma International Limited Nanoparticulate formulations of modafinil
EP2051696A2 (en) * 2006-08-18 2009-04-29 Morton Grove Pharmaceuticals, Inc. Stable liquid levetiracetam compositions and methods
US7607596B1 (en) 2007-03-07 2009-10-27 Exxpharma, LLC Process for enhancing the solubility of poorly soluble drugs
US8173169B2 (en) 2007-07-11 2012-05-08 Hikma Pharmaceuticals Formulation and process for the preparation of modafinil
ITMI20071616A1 (it) 2007-08-03 2009-02-04 Cosmo Spa Processo enzimatico per l'ottenimento di 17-alfa monoesteri del cortexolone e/o suoi 9,11-deidroderivati.
EP2200613B1 (en) 2007-09-21 2018-09-05 The Johns Hopkins University Phenazine derivatives and uses thereof
US20090155325A1 (en) * 2007-12-14 2009-06-18 Kimberly-Clark Worldwide, Inc. Formulation and products for promoting skin cleanliness and health
AT10562U3 (de) * 2008-12-05 2010-01-15 Aop Orphan Pharmaceuticals Ag Neuartige zusammensetzung zur behandlung einer essenziellen thrombozytämie
DE102011010437A1 (de) * 2011-02-04 2012-08-09 J. Rettenmaier & Söhne Gmbh + Co. Kg Tablettierhilfsmittel
CN102321048A (zh) * 2011-06-13 2012-01-18 中国药科大学 糖精瑞格列奈无定形物
FR2987265B1 (fr) 2012-02-28 2014-02-28 Debregeas Et Associes Pharma Composition pharmaceutique sous forme de sirop a base de modafinil, son procede de fabrication et son application
EP2897590A4 (en) * 2012-09-20 2016-05-04 Ipca Lab Ltd PHARMACEUTICAL COMPOSITION
CN103006570B (zh) * 2012-10-08 2013-12-25 孙维会 一种阿佐昔芬速释微丸及其制备方法
EP2915526B1 (en) * 2014-03-07 2021-06-02 Galenicum Health S.L.U. Pharmaceutical compositions comprising anagrelide
CN103830197A (zh) * 2014-03-14 2014-06-04 崔书豪 一种盐酸雷洛昔芬分散片及其制备方法
WO2016198166A1 (en) * 2015-06-10 2016-12-15 Disphar International B.V. Improved pharmaceutical formulation
EP3108879A1 (en) 2015-06-25 2016-12-28 Cassiopea S.p.A. High concentration formulation
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
EP3915540A1 (en) * 2017-02-01 2021-12-01 Johnson & Johnson Consumer Inc. A lozenge
TWI661841B (zh) * 2017-04-19 2019-06-11 三凡生技研發股份有限公司 用於分散疏水性植物萃取物之載劑
EP3586827A1 (en) 2018-06-29 2020-01-01 Consejo Superior de Investigaciones Cientificas (CSIC) Pharmaceutical formulation with improved solubility and bioavailability
WO2022008515A1 (en) * 2020-07-07 2022-01-13 Atxa Therapeutics Limited Thromboxane receptor antagonist formulations
CN114306253B (zh) * 2021-11-16 2023-08-22 扬子江药业集团广州海瑞药业有限公司 格列美脲片剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811120A (en) * 1994-03-02 1998-09-22 Eli Lilly And Company Solid orally administerable raloxifene hydrochloride pharmaceutical formulation
CA2143263C (en) * 1994-03-02 2002-01-08 Kerry John Hartauer Orally administrable raloxifene formulations
BR9713176A (pt) * 1996-08-28 2000-02-08 Lilly Co Eli Benzotiofenos amorfos,métodos de preparação e métodos de uso
US6395300B1 (en) * 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6919378B2 (en) * 2000-10-11 2005-07-19 Cephalon, Inc. Pharmaceutical solutions of modafinil compounds

Also Published As

Publication number Publication date
AU2004255459A1 (en) 2005-01-20
WO2005004917A3 (en) 2006-03-16
US20050008704A1 (en) 2005-01-13
CN1856297A (zh) 2006-11-01
RU2006104025A (ru) 2007-08-27
CA2529606A1 (en) 2005-01-20
MXPA06000445A (es) 2006-04-05
AR045906A1 (es) 2005-11-16
WO2005004917A2 (en) 2005-01-20
EP1646403A2 (en) 2006-04-19

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired