BRPI0412837A - 3-nitro-pirazol[1,5-a]pirimidinas 7-substituìdas - Google Patents

3-nitro-pirazol[1,5-a]pirimidinas 7-substituìdas

Info

Publication number
BRPI0412837A
BRPI0412837A BRPI0412837-0A BRPI0412837A BRPI0412837A BR PI0412837 A BRPI0412837 A BR PI0412837A BR PI0412837 A BRPI0412837 A BR PI0412837A BR PI0412837 A BRPI0412837 A BR PI0412837A
Authority
BR
Brazil
Prior art keywords
nitro
pyrazolo
pyrimidines
substituted
gaba
Prior art date
Application number
BRPI0412837-0A
Other languages
English (en)
Inventor
Luis Anglada
Albert Palomer
Marta Princep
Antonio Guglietta
Original Assignee
Ferrer Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES200301747A external-priority patent/ES2222814B1/es
Application filed by Ferrer Int filed Critical Ferrer Int
Publication of BRPI0412837A publication Critical patent/BRPI0412837A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"3-NITRO-PIRAZOL¢1,5-A!PIRIMIDINAS 7-SUBSTITUìDAS". A presente invenção refere-se a compostos da Fórmula (I): onde R~ 1~ é conforme definido nas reivindicações. Os compostos têm afinidade específica para o receptor de GABA~ A~ e são então úteis no tratamento e prevenção de doenças moduladas pelos receptores de GABA~ A~ <244>1 e <244>2.
BRPI0412837-0A 2003-07-24 2004-07-22 3-nitro-pirazol[1,5-a]pirimidinas 7-substituìdas BRPI0412837A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200301747A ES2222814B1 (es) 2003-07-24 2003-07-24 3-nitro-pirazolo(1,5-a)pirimidinas 7-sustituidas y composiciones y metodos relacionados.
ES200401696A ES2245893B1 (es) 2003-07-24 2004-07-12 Mejoras en el objeto de la patente de invencion n.p200301747 que se refiere a "3-nitro-pirazolo(1,5-a)pirimidinas 7-sustituidas y composiciones y metodos relacionados".
PCT/EP2004/008207 WO2005014596A1 (en) 2003-07-24 2004-07-22 7-substituted 3-nitro-pyrazolo `1,5-a! pyrimidines

Publications (1)

Publication Number Publication Date
BRPI0412837A true BRPI0412837A (pt) 2006-09-26

Family

ID=34137683

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412837-0A BRPI0412837A (pt) 2003-07-24 2004-07-22 3-nitro-pirazol[1,5-a]pirimidinas 7-substituìdas

Country Status (15)

Country Link
US (1) US20070043064A1 (pt)
EP (1) EP1648896B1 (pt)
JP (1) JP2006528607A (pt)
KR (1) KR20060030907A (pt)
AT (1) ATE386040T1 (pt)
AU (1) AU2004263277A1 (pt)
BR (1) BRPI0412837A (pt)
CA (1) CA2532431A1 (pt)
DE (1) DE602004011780D1 (pt)
HR (1) HRP20060008A2 (pt)
MX (1) MXPA06000774A (pt)
NO (1) NO20060586L (pt)
TW (1) TWI252851B (pt)
UY (1) UY28439A1 (pt)
WO (1) WO2005014596A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050245517A1 (en) * 2004-04-29 2005-11-03 Phil Skolnick 2-pyridinyl[7-(substituted-pyridin-4-yl) pyrazolo[1,5-a]pyrimidin-3-yl]methanones
EP1884516A1 (en) * 2006-08-04 2008-02-06 Ferrer Internacional, S.A. Pyrazolo[1,5-a]pyrimidines, processes, uses and compositions
GB201223308D0 (en) 2012-12-21 2013-02-06 Univ Sunderland Enzyme inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792533A (fr) * 1971-12-09 1973-06-08 Int Chem & Nuclear Corp Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
EP0264773A1 (en) * 1986-10-16 1988-04-27 American Cyanamid Company 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines
DE4333705C2 (de) * 1993-10-02 2003-10-30 Guenter Ege Arylmethylsubstituierte Pyrazolo-azine, insbesondere 3-Arylmethylpyrazolo[1,5-a]pyrimidine und Verfahren zur Herstellung von 8-Arylmethyl-pyrazolo[5,1-c][1,2,4]triazinen
US5538977A (en) * 1995-03-17 1996-07-23 American Cyanamid Company 3-Substituted-7-[3-(imidazol-1-yl)phenyl]-pyrazolo[1,5-a]pyrimidines
AU4203500A (en) * 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
US6399621B1 (en) * 1999-08-10 2002-06-04 American Cyanamid Company N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
DE10153344A1 (de) * 2001-10-29 2003-05-15 Gruenenthal Gmbh Verwendung von substituierten Pyrazolopyrimidinen als Liganden von Nucleosid-Transport-Proteinen und/oder von Purinorezeptoren

Also Published As

Publication number Publication date
WO2005014596A1 (en) 2005-02-17
MXPA06000774A (es) 2006-04-18
US20070043064A1 (en) 2007-02-22
HRP20060008A2 (en) 2006-07-31
KR20060030907A (ko) 2006-04-11
DE602004011780D1 (de) 2008-03-27
NO20060586L (no) 2006-02-06
JP2006528607A (ja) 2006-12-21
CA2532431A1 (en) 2005-02-17
ATE386040T1 (de) 2008-03-15
EP1648896B1 (en) 2008-02-13
UY28439A1 (es) 2004-11-08
AU2004263277A1 (en) 2005-02-17
TWI252851B (en) 2006-04-11
TW200504074A (en) 2005-02-01
EP1648896A1 (en) 2006-04-26

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A, 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.