BRPI0413360A - método e dispositivo para aumentar o fluxo de agentes transdérmicos - Google Patents

método e dispositivo para aumentar o fluxo de agentes transdérmicos

Info

Publication number
BRPI0413360A
BRPI0413360A BRPI0413360-9A BRPI0413360A BRPI0413360A BR PI0413360 A BRPI0413360 A BR PI0413360A BR PI0413360 A BRPI0413360 A BR PI0413360A BR PI0413360 A BRPI0413360 A BR PI0413360A
Authority
BR
Brazil
Prior art keywords
microprojection member
increasing
flow
transdermal agents
interstitial fluid
Prior art date
Application number
BRPI0413360-9A
Other languages
English (en)
Inventor
Patrick S L Wong
Peter Daddona
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of BRPI0413360A publication Critical patent/BRPI0413360A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B10/0064—Devices for taking samples of body liquids for taking sweat or sebum samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B2010/0009—Testing for drug or alcohol abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Prostheses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"MéTODO E DISPOSITIVO PARA AUMENTAR O FLUXO DE AGENTES TRANSDéRMICOS". Um elemento de microprojeção poroso (20, 30, 40, 50), para inserção em tecido biológico, circundado por fluido intersticial, com uma parede que inclui uma superfície interna e uma superfície externa, sendo que a superfície externa substancialmente envolve a superfície interna; e um revestimento biocompatível disposto sobre a superfície interna, sendo que o elemento de microprojeção está adaptado para restringir, substancialmente, o contato do revestimento com o tecido durante a inserção do elemento de microprojeção no tecido, sendo que o elemento de microprojeção tem porosidade suficiente para permitir a migração do fluido intersticial através da parede do elemento de microprojeção.
BRPI0413360-9A 2003-08-04 2004-08-03 método e dispositivo para aumentar o fluxo de agentes transdérmicos BRPI0413360A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49261003P 2003-08-04 2003-08-04
PCT/US2004/025168 WO2005016440A1 (en) 2003-08-04 2004-08-03 Method and device for enhancing transdermal agent flux

Publications (1)

Publication Number Publication Date
BRPI0413360A true BRPI0413360A (pt) 2006-10-10

Family

ID=34193137

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0413360-9A BRPI0413360A (pt) 2003-08-04 2004-08-03 método e dispositivo para aumentar o fluxo de agentes transdérmicos
BRPI0413354-4A BRPI0413354A (pt) 2003-08-04 2004-08-03 método e dispositivo para intensificar fluxo de agente transdérmico

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0413354-4A BRPI0413354A (pt) 2003-08-04 2004-08-03 método e dispositivo para intensificar fluxo de agente transdérmico

Country Status (13)

Country Link
US (2) US20050049549A1 (pt)
EP (2) EP1656178A1 (pt)
JP (2) JP2007501070A (pt)
KR (2) KR20060115717A (pt)
CN (2) CN1863571A (pt)
AR (2) AR045205A1 (pt)
AU (2) AU2004264319A1 (pt)
BR (2) BRPI0413360A (pt)
CA (2) CA2534821A1 (pt)
MX (2) MXPA06001409A (pt)
SG (2) SG130190A1 (pt)
TW (2) TW200514593A (pt)
WO (2) WO2005016441A1 (pt)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
WO2004009172A1 (en) 2002-07-19 2004-01-29 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
US20050049549A1 (en) * 2003-08-04 2005-03-03 Wong Patrick S.L. Method and device for enhancing transdermal agent flux
CA2536249A1 (en) * 2003-08-25 2005-03-10 3M Innovative Properties Company Delivery of immune response modifier compounds
JP2007523771A (ja) * 2004-02-23 2007-08-23 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルアレイの成形方法
MXPA06013168A (es) * 2004-05-13 2007-05-15 Johnson & Johnson Aparato y metodo para el suministro transdermico de agentes de la hormona paratiroidea.
MX2007001667A (es) * 2004-08-11 2007-10-02 Johnson & Johnson Aparato y metodo para el suministro transdermico de peptidos natriureticos.
AU2005305157B2 (en) 2004-10-27 2011-09-01 Oklahoma Medical Research Foundation Adrenocorticotropic hormone analogs and related methods
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
WO2006055799A1 (en) * 2004-11-18 2006-05-26 3M Innovative Properties Company Masking method for coating a microneedle array
WO2006055844A2 (en) 2004-11-18 2006-05-26 3M Innovative Properties Company Method of contact coating a microneedle array
CN100591293C (zh) * 2005-03-28 2010-02-24 阿尔扎公司 具有毛细控制部件的微突物和方法
WO2007002523A2 (en) 2005-06-24 2007-01-04 3M Innovative Properties Company Collapsible patch with microneedle array
EP1917976B1 (en) 2005-08-01 2011-03-16 Hisamitsu Pharmaceutical Co. Inc. Adjuvant or pharmaceutical preparation for transdermal or transmucosal administration
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
WO2007061781A1 (en) * 2005-11-18 2007-05-31 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
JPWO2007091608A1 (ja) 2006-02-10 2009-07-02 久光製薬株式会社 マイクロニードル付き経皮薬物投与装置
EP2005990B1 (en) * 2006-04-07 2013-08-28 Hisamitsu Pharmaceutical Co., Inc. Microneedle device and transdermal administration device provided with microneedles
US7785301B2 (en) * 2006-11-28 2010-08-31 Vadim V Yuzhakov Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection
JP5275047B2 (ja) 2007-01-31 2013-08-28 久光製薬株式会社 経皮または経粘膜投与のためのアジュバントおよびこれを含む医薬製剤
US8911749B2 (en) * 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
AU2014200648B2 (en) * 2007-04-16 2015-09-24 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
WO2008130587A2 (en) 2007-04-16 2008-10-30 Corium International, Inc. Solvent-cast microneedle arrays containing active
WO2009021007A1 (en) * 2007-08-06 2009-02-12 Serenity Pharmaceuticals Corporation Methods and devices for desmopressin drug delivery
US20100010413A1 (en) * 2008-07-09 2010-01-14 Loiterman David A Needle for Subcutaneous Port
KR101634836B1 (ko) 2008-12-26 2016-06-29 히사미쓰 세이야꾸 가부시키가이샤 마이크로 니들 디바이스
JP5820805B2 (ja) * 2009-04-24 2015-11-24 コリウム インターナショナル， インコーポレイテッド マイクロプロジェクションのアレイの製造のためのプロセス
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
CA2784488A1 (en) * 2009-12-16 2011-06-23 Chrontech Pharma Ab Injection needle and device
JP6327852B2 (ja) 2010-05-04 2018-05-23 コリウム インターナショナル， インコーポレイテッド 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス
CN101961508A (zh) * 2010-09-30 2011-02-02 浙江大学 一种聚电解质复合涂层的制备方法
EP2665504A4 (en) * 2011-01-18 2017-01-25 Massachusetts Institute of Technology Deployable barbed microneedle array and uses thereof
WO2012115222A1 (ja) 2011-02-25 2012-08-30 久光製薬株式会社 経皮または経粘膜投与のためのアジュバントおよびこれを含む医薬製剤
KR20140068000A (ko) 2011-06-15 2014-06-05 크론테크 파마 아베 주사 바늘 및 장치
EP4112112A1 (en) * 2012-05-01 2023-01-04 University of Pittsburgh - Of the Commonwealth System of Higher Education Tip-loaded microneedle arrays for transdermal insertion
RU2698095C2 (ru) 2012-12-21 2019-08-22 Кориум Интернэшнл, Инк. Микроматрица для доставки терапевтического средства и способы использования
BR122020006959B1 (pt) 2013-03-12 2022-04-26 Corium, Inc Aplicador de microprojeções
WO2014144973A1 (en) 2013-03-15 2014-09-18 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US10384045B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
WO2014150285A2 (en) 2013-03-15 2014-09-25 Corium International, Inc. Multiple impact microprojection applicators and methods of use
AU2014233695A1 (en) 2013-03-15 2015-10-01 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
ES2871105T3 (es) * 2013-07-16 2021-10-28 Kindeva Drug Delivery Lp Artículo que comprende una microaguja
SG11201600331YA (en) * 2013-07-16 2016-02-26 3M Innovative Properties Co Hollow microneedle with bevel opening
US10232157B2 (en) * 2013-07-16 2019-03-19 3M Innovative Properties Company Hollow microneedle with beveled tip
JP6272333B2 (ja) * 2013-09-06 2018-01-31 久光製薬株式会社 マイクロニードル・シート
ES2744454T3 (es) 2013-10-31 2020-02-25 Hisamitsu Pharmaceutical Co Composición de adyuvante
EP2905047A1 (de) * 2014-02-10 2015-08-12 LTS LOHMANN Therapie-Systeme AG Mikronadelsystem und Verfahren seiner Herstellung
WO2015129545A1 (ja) * 2014-02-27 2015-09-03 久光製薬株式会社 マイクロニードル・シート
US9138191B1 (en) * 2014-07-09 2015-09-22 Qualcomm Incorporated Integrated circuit module with lead frame micro-needles
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
US10589077B2 (en) 2014-12-05 2020-03-17 Hisamitsu Pharmaceutical Co., Inc. Microneedle device system
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
JP2015192879A (ja) * 2015-06-19 2015-11-05 ニプロ株式会社 ワクチン接種針
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US11684763B2 (en) 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
US10022436B2 (en) * 2016-01-11 2018-07-17 Verndari, Inc. Microneedle compositions and methods of using same
EP3412331B1 (en) * 2016-02-04 2020-04-29 Toppan Printing Co., Ltd. Microneedle
US10939912B2 (en) * 2016-03-01 2021-03-09 Kitotech Medical, Inc. Microstructure-based systems, apparatus, and methods for wound closure
JP6717638B2 (ja) * 2016-03-31 2020-07-01 花王株式会社 開孔部を有する微細中空突起具の製造方法
KR20170115429A (ko) * 2016-04-07 2017-10-17 랩앤피플주식회사 생체분해성 금속을 이용한 마이크로 니들
WO2017176069A2 (ko) * 2016-04-07 2017-10-12 랩앤피플주식회사 생체흡수성 금속을 이용한 마이크로 니들
CN108403617A (zh) * 2018-02-24 2018-08-17 中山大学 曲安奈德可溶性微针及其制备方法
KR102291392B1 (ko) * 2018-03-30 2021-08-20 랩앤피플주식회사 멀티형 마이크로 니들
WO2020004234A1 (ja) * 2018-06-26 2020-01-02 久光製薬株式会社 マイクロニードルデバイス及びそれを製造する方法
EP4003486A4 (en) * 2019-07-22 2023-12-13 The Trustees of Indiana University Technologies for needles with microchannels
CN110664439B (zh) * 2019-09-05 2021-07-27 华中科技大学 一种可提取皮肤组织液的微针及其制备方法
US11986613B2 (en) 2020-02-19 2024-05-21 Kitotech Medical, Inc. Microstructure systems and methods for pain treatment
AU2021413245B2 (en) * 2020-12-30 2025-12-18 Children's Healthcare Of Atlanta, Inc. Methods and devices for inducement of sweat for medical diagnostics
WO2023159181A1 (en) 2022-02-18 2023-08-24 Kitotech Medical, Inc. Force modulating deep skin staples and instruments
FR3162613B1 (fr) * 2024-06-04 2026-06-12 Anatox Système de recueil de biomatériau et/ou de dépôt de particules sur une cible et procédé associé

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3123212A (en) * 1964-03-03 Multiple disposable intracutaneous injector package
USRE25637E (en) * 1964-09-08 Means for vaccinating
US2619962A (en) * 1948-02-19 1952-12-02 Res Foundation Vaccination appliance
US2893392A (en) * 1958-01-08 1959-07-07 American Cyanamid Co Article of manufacture for intracutaneous injections
US3072122A (en) * 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3034507A (en) * 1960-05-10 1962-05-15 American Cyanamid Co Intracutaneous injection device
US3221739A (en) * 1962-03-26 1965-12-07 Rosenthal Sol Roy Injection device
US3221740A (en) * 1962-08-31 1965-12-07 Rosenthal Sol Roy Injection device
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) * 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
US6559123B1 (en) * 1985-04-19 2003-05-06 Osi Pharmaceuticals, Inc. Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof
SE8501990D0 (sv) * 1985-04-24 1985-04-24 Pharmacia Ab Beleggningsforfarande
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5147296A (en) * 1988-10-03 1992-09-15 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5169382A (en) * 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5205023A (en) * 1990-04-18 1993-04-27 Hunter Robert M Child-resistant buckle and buckle guard combination
US6586006B2 (en) * 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US6033582A (en) * 1996-01-22 2000-03-07 Etex Corporation Surface modification of medical implants
ATE234129T1 (de) * 1996-06-18 2003-03-15 Alza Corp Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
US5916524A (en) * 1997-07-23 1999-06-29 Bio-Dot, Inc. Dispensing apparatus having improved dynamic range
US5743960A (en) * 1996-07-26 1998-04-28 Bio-Dot, Inc. Precision metered solenoid valve dispenser
US5741554A (en) * 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
CN1161164C (zh) * 1997-12-11 2004-08-11 阿尔扎有限公司 用于通过体表导入或提取质剂的装置
DK1037687T3 (da) * 1997-12-11 2009-01-26 Alza Corp Anordning til at forbedre et middels transdermale strömning
PT1037686E (pt) * 1997-12-11 2005-10-31 Alza Corp Aparelho para potenciar o fluxo de agente transdermico
US6091975A (en) * 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9817662D0 (en) * 1998-08-13 1998-10-07 Crocker Peter J Substance delivery
DE69921489T2 (de) * 1998-08-31 2005-10-27 Johnson & Johnson Consumer Companies, Inc. Elektrotransportvorrichtung mit klingen
WO2000074763A2 (en) * 1999-06-04 2000-12-14 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
AU2001296828B2 (en) * 2000-10-13 2005-11-24 Alza Corporation Apparatus and method for piercing skin with microprotrusions
ES2317940T3 (es) * 2000-10-13 2009-05-01 Alza Corporation Dispositivo de retencion para un elemento de microsalientes para aplicador de impactos.
EP1341442B1 (en) * 2000-10-13 2005-06-29 Alza Corporation Microblade array impact applicator
CA2427381A1 (en) * 2000-10-26 2002-11-28 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
US6855372B2 (en) * 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
NZ529029A (en) * 2001-04-20 2005-07-29 Alza Corp Microprojection array having a beneficial agent containing coating
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US20030199810A1 (en) * 2001-11-30 2003-10-23 Trautman Joseph Creagan Methods and apparatuses for forming microprojection arrays
US20030181936A1 (en) * 2001-12-20 2003-09-25 Trautman Joseph C. Skin-piercing microprojections having piercing depth control
US20030231984A1 (en) * 2002-05-07 2003-12-18 Bright Frank V. Method to rapidly prepare and screen formulations and compositions containing same
AR040302A1 (es) * 2002-06-28 2005-03-23 Alza Corp Dispositivos para la liberacion transdermica de farmacos, que presentan microprotrusiones recubiertas
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
CA2530531A1 (en) * 2003-06-30 2005-01-20 Alza Corporation Formulations for coated microprojections containing non-volatile counterions
US20050049549A1 (en) * 2003-08-04 2005-03-03 Wong Patrick S.L. Method and device for enhancing transdermal agent flux

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AR045206A1 (es) 2005-10-19
EP1654030A1 (en) 2006-05-10
KR20060115716A (ko) 2006-11-09
CA2534821A1 (en) 2005-02-24
TW200514596A (en) 2005-05-01
TW200514593A (en) 2005-05-01
SG130190A1 (en) 2007-03-20
BRPI0413354A (pt) 2006-10-10
US20050049549A1 (en) 2005-03-03
SG130191A1 (en) 2007-03-20
EP1656178A1 (en) 2006-05-17
AR045205A1 (es) 2005-10-19
US20050031676A1 (en) 2005-02-10
WO2005016440A1 (en) 2005-02-24
CA2534823A1 (en) 2005-02-24
MXPA06001409A (es) 2006-08-25
KR20060115717A (ko) 2006-11-09
JP2007501071A (ja) 2007-01-25
WO2005016441A1 (en) 2005-02-24
MXPA06001414A (es) 2006-08-25
CN1863572A (zh) 2006-11-15
AU2004264320A1 (en) 2005-02-24
JP2007501070A (ja) 2007-01-25
CN1863571A (zh) 2006-11-15
AU2004264319A1 (en) 2005-02-24

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