BR0312459A - Aparelho de eletroporação, aparelho para injetar um fluido no tecido corpóreo, método de eletroporação, método para injetar um fluido no tecido corpóreo, dispositivo de eletroporação, método de tratamento eletroporético de um humano ou animal não-humano, dispositivo para uso em eletroporação, e, método para determinar quando uma agulha foi inserida a uma profundidade desejada no tecido corpóreo - Google Patents

Aparelho de eletroporação, aparelho para injetar um fluido no tecido corpóreo, método de eletroporação, método para injetar um fluido no tecido corpóreo, dispositivo de eletroporação, método de tratamento eletroporético de um humano ou animal não-humano, dispositivo para uso em eletroporação, e, método para determinar quando uma agulha foi inserida a uma profundidade desejada no tecido corpóreo

Info

Publication number
BR0312459A
BR0312459A BR0312459-2A BR0312459A BR0312459A BR 0312459 A BR0312459 A BR 0312459A BR 0312459 A BR0312459 A BR 0312459A BR 0312459 A BR0312459 A BR 0312459A
Authority
BR
Brazil
Prior art keywords
electroporation
body tissue
fluid
injecting
human
Prior art date
Application number
BR0312459-2A
Other languages
English (en)
Inventor
Iacob Mathiesen
Torunn Elisabeth Tjelle
Knut Arvid Sorensen Bekdahl
Bjorn David-Andersen
Original Assignee
Inovio As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0215529A external-priority patent/GB0215529D0/en
Priority claimed from GB0215523A external-priority patent/GB0215523D0/en
Application filed by Inovio As filed Critical Inovio As
Publication of BR0312459A publication Critical patent/BR0312459A/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08Clinical applications
    • A61B8/0833Clinical applications involving detecting or locating foreign bodies or organic structures
    • A61B8/0841Clinical applications involving detecting or locating foreign bodies or organic structures for locating instruments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Pathology (AREA)
  • Anesthesiology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Electrotherapy Devices (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Neurology (AREA)

Abstract

"APARELHO DE ELETROPORAçãO, APARELHO PARA INJETAR UM FLUIDO NO TECIDO CORPóREO, MéTODO DE ELETROPORAçãO, MéTODO PARA INJETAR UM FLUIDO NO TECIDO CORPóREO, DISPOSITIVO DE ELETROPORAçãO, MéTODO DE TRATAMENTO ELETROPORéTICO DE UM HUMANO OU ANIMAL NãO-HUMANO, DISPOSITIVO PARA USO EM ELETROPORAçãO, E, MéTODO PARA DETERMINAR QUANDO UMA AGULHA FOI INSERIDA A UMA PROFUNDIDADE DESEJADA NO TECIDO CORPóREO". Um aparelho é provido para injetar um fluido no tecido corporal, o aparelho compreendendo: uma agulha oca (6); e meios de liberação de fluido (12, 10), em que o aparelho é adaptado para acionar os meios de liberação de fluido (12, 10) em uso, de forma a automaticamente injetar fluido no tecido corpóreo durante a inserção da agulha no tecido corpóreo.
BR0312459-2A 2002-07-04 2003-07-04 Aparelho de eletroporação, aparelho para injetar um fluido no tecido corpóreo, método de eletroporação, método para injetar um fluido no tecido corpóreo, dispositivo de eletroporação, método de tratamento eletroporético de um humano ou animal não-humano, dispositivo para uso em eletroporação, e, método para determinar quando uma agulha foi inserida a uma profundidade desejada no tecido corpóreo BR0312459A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0215529A GB0215529D0 (en) 2002-07-04 2002-07-04 Electroporation needle holder
GB0215523A GB0215523D0 (en) 2002-07-04 2002-07-04 Electroporation device
PCT/GB2003/002887 WO2004004825A2 (en) 2002-07-04 2003-07-04 Electroporation device and injection apparatus

Publications (1)

Publication Number Publication Date
BR0312459A true BR0312459A (pt) 2005-08-02

Family

ID=30117093

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0312459-2A BR0312459A (pt) 2002-07-04 2003-07-04 Aparelho de eletroporação, aparelho para injetar um fluido no tecido corpóreo, método de eletroporação, método para injetar um fluido no tecido corpóreo, dispositivo de eletroporação, método de tratamento eletroporético de um humano ou animal não-humano, dispositivo para uso em eletroporação, e, método para determinar quando uma agulha foi inserida a uma profundidade desejada no tecido corpóreo

Country Status (13)

Country Link
US (5) US7328064B2 (pt)
EP (1) EP1519770B1 (pt)
JP (2) JP4461012B2 (pt)
CN (1) CN1678369B (pt)
AU (2) AU2003251316A1 (pt)
BR (1) BR0312459A (pt)
CA (2) CA2491000C (pt)
DK (1) DK1519770T3 (pt)
EA (1) EA009203B1 (pt)
ES (1) ES2429037T3 (pt)
MX (1) MXPA05000155A (pt)
NZ (2) NZ562306A (pt)
WO (1) WO2004004825A2 (pt)

Families Citing this family (196)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
JP4350525B2 (ja) 2002-03-18 2009-10-21 イーライ リリー アンド カンパニー 機械的利点を与えるギヤーセット付き薬剤分与装置
US6912417B1 (en) 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
HUE025052T2 (en) 2004-03-08 2016-01-28 Ichor Medical Systems Inc A sharpened device for electrically mediated delivery of medical substances
AU2005231731B2 (en) 2004-03-30 2010-12-23 Eli Lilly And Company Medication dispensing apparatus with spring-driven locking feature enabled by administration of final dose
ATE526052T1 (de) 2004-03-30 2011-10-15 Lilly Co Eli Medikationsabgabegerät mit getriebeset mit einer öffnung zur aufnahme eines antriebselements
FR2872056B1 (fr) 2004-06-24 2007-08-10 Yves Scherman Dispositif pour l'administration de principe actif aux cellules et tissus utilisant une ou deux forces physiques
FR2880808A1 (fr) 2005-01-20 2006-07-21 Yves Scherman Dispositif pour l'administration de principe actif aux cellules et tissus a l'aide d'electrodes de surface non invasives
FR2872055B1 (fr) 2004-06-24 2008-02-08 Yves Leon Scherman Dispositif pour le transfert de molecules aux cellules utilisant une force d'origine physique et combinaison permettant la mise en oeuvre du procede
EP1804865B1 (en) 2004-10-21 2009-09-30 Novo Nordisk A/S Dial-down mechanism for wind-up pen
CA2588181A1 (en) * 2004-11-23 2006-06-01 International Bio-Therapeutic Research Inc. Method of delivery of therapeutic metal ions, alloys and salts
US7991559B2 (en) * 2004-11-30 2011-08-02 Maxcyte Inc. Computerized electroporation
WO2006123248A2 (en) * 2005-04-18 2006-11-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Improved methods and devices for delivering a therapeutic product to the ocular sphere of a subject
US20090043264A1 (en) 2005-04-24 2009-02-12 Novo Nordisk A/S Injection Device
US20150119794A1 (en) * 2005-08-05 2015-04-30 Gholam A. Peyman Methods to regulate polarization and enhance function of cells
US7931594B2 (en) * 2005-12-02 2011-04-26 The Cooper Health System Regional anesthetic method and apparatus
US7645238B2 (en) * 2005-12-02 2010-01-12 The Cooper Health System Regional anesthetic method and apparatus
US20080287857A1 (en) * 2006-02-11 2008-11-20 Rune Kjeken Device and method for single-needle in vivo electroporation
JP5059786B2 (ja) 2006-02-11 2012-10-31 ジェネトロニクス,インコーポレイティド 単針生体内エレクトロポレーションのための装置および方法
US20080045880A1 (en) * 2006-02-11 2008-02-21 Rune Kjeken Device and method for single-needle in vivo electroporation
US20070288078A1 (en) * 2006-03-17 2007-12-13 Steve Livneh Apparatus and method for skin tightening and corrective forming
ATE458517T1 (de) 2006-05-16 2010-03-15 Novo Nordisk As Getriebemechanismus für ein injektionsgerät
BRPI0712028A2 (pt) 2006-05-18 2011-12-20 Novo Nordisk As dispositivo de injenção com um meio de travamento de modo
CA2666501C (en) * 2006-10-17 2017-03-21 Vgx Pharmaceuticals, Inc. Electroporation devices and methods of using same for electroporation of cells in mammals
DK2548438T3 (en) 2006-11-08 2015-10-19 Veritas Bio LLC IN VIVO SUBMITTING DOUBLE-STRENGTH RNA TO A CELL
KR101642523B1 (ko) * 2008-01-17 2016-07-25 제네트로닉스, 인코포레이티드 가변성 전류 밀도 단일 바늘 전기 천공 시스템
US8518884B2 (en) 2008-04-25 2013-08-27 Northwestern University Methods for treating atrial or ventricular arrhythmias by administering a G-protein alpha inhibitor
US8193151B2 (en) * 2008-04-25 2012-06-05 Northwestern University Methods for treating atrial or ventricular arrhythmias
US9974904B2 (en) 2008-05-20 2018-05-22 Avant Medical Corp. Autoinjector system
US8052645B2 (en) 2008-07-23 2011-11-08 Avant Medical Corp. System and method for an injection using a syringe needle
WO2010133578A2 (en) * 2009-05-20 2010-11-25 Sonion A/S Electroporation device with improved tip and electrode support
US8932055B2 (en) * 2009-06-11 2015-01-13 Roberto Armanino Method employing electric fields to selectively kill microbes in a root canal preparation
KR102138780B1 (ko) 2009-11-02 2020-07-29 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 구제역 바이러스(fmdv) 공통 단백질, 이를 위한 코딩 서열 및 이로부터 만들어진 백신
RU2539991C2 (ru) * 2009-12-16 2015-01-27 Кронтек Фарма Аб Впрыскивающие игла и устройство
US8298820B2 (en) 2010-01-26 2012-10-30 The Trustees Of The University Of Pennsylvania Influenza nucleic acid molecules and vaccines made therefrom
EP2539354B1 (en) 2010-02-08 2017-04-05 The Trustees Of The University Of Pennsylvania Nucleic acid molecules encoding rantes, and compositions comprising and methods of using the same
CN101804224B (zh) * 2010-04-06 2011-11-30 上海塔瑞莎健康科技有限公司 药械结合的电脉冲导入装置
CN101822857B (zh) * 2010-04-06 2014-03-19 上海塔瑞莎生物技术有限公司 药械结合的电脉冲生成及导入装置
EP2621522A2 (en) 2010-09-27 2013-08-07 China Agricultural University Combined antigen and dna vaccine for preventing and treating autoimmune diseases
MX355501B (es) 2010-09-27 2018-04-20 Inovio Pharmaceuticals Inc Star Estructuras de consenso de antigenos y vacunas elaboradas a partir de estas y metodos para utilizarlas en el tratamiento de la malaria.
KR101180113B1 (ko) * 2010-10-18 2012-09-06 (주)엠큐어 피부 내에 가스와 약물 순차적 주입가능한 시술장치
JP6077450B2 (ja) 2010-11-12 2017-02-08 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア コンセンサス前立腺抗原、それをコードする核酸分子、ならびにそれを含むワクチンおよび用途
EA033467B1 (ru) 2011-01-31 2019-10-31 Univ Pennsylvania Молекула нуклеиновой кислоты для индукции иммунного ответа против герпесвируса и ее применение
US9238679B2 (en) 2011-02-11 2016-01-19 The Trustees Of The University Of Pennslyvania Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same
EA032364B1 (ru) 2011-02-11 2019-05-31 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Молекула нуклеиновой кислоты, кодирующая коровый белок вируса гепатита в, и вакцина, содержащая указанную молекулу
HUE042822T2 (hu) * 2011-04-20 2019-07-29 Amgen Inc Automata befecskendezõ szerkezet
CN103717249B (zh) * 2011-06-15 2017-03-22 克洛恩泰克制药股份公司 注射针和装置
KR102314421B1 (ko) 2011-07-11 2021-10-19 이노비오 파마수티컬즈, 인크. 교차-보호성 아레나바이러스 백신 및 이의 사용 방법
US9446112B2 (en) 2011-07-12 2016-09-20 Philadelphia Health & Education Corporation Clostridium difficile DNA vaccine
CN103946952A (zh) 2011-09-16 2014-07-23 宾夕法尼亚大学董事会 用于治疗癌症的rna改造的t细胞
WO2013044225A1 (en) 2011-09-22 2013-03-28 The Trustees Of The University Of Pennsylvania A universal immune receptor expressed by t cells for the targeting of diverse and multiple antigens
US9272002B2 (en) 2011-10-28 2016-03-01 The Trustees Of The University Of Pennsylvania Fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting
WO2013067652A1 (en) 2011-11-10 2013-05-16 Beijing Advaccine Biotechnology Co., Ltd. Facilitator-dna combination vaccine
JP6333730B2 (ja) 2011-12-12 2018-05-30 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 改善されたil−12遺伝子構築物を含む組成物、及びそれを用いたワクチン、免疫治療剤及び方法
JP6407028B2 (ja) 2011-12-12 2018-10-17 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア MRSAのPBP2a及びその断片を含むタンパク質、それをコードする核酸、並びにMRSA感染を予防する及び治療するための組成物及びそれらの使用
CA2861706A1 (en) 2011-12-29 2013-07-04 Novo Nordisk A/S Dial-up/dial-down mechanism for wind-up pen
CN103239734B (zh) 2012-02-10 2016-02-24 北京艾棣维欣生物技术有限公司 用于预防和/或治疗呼吸道合胞病毒感染的疫苗
WO2013126729A1 (en) 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Use of the cd2 signaling domain in second-generation chimeric antigen receptors
EP2817330B1 (en) 2012-02-22 2020-07-08 The Trustees of the University of Pennsylvania Use of icos-based cars to enhance antitumor activity and car persistence
HK1210479A1 (en) 2012-04-10 2016-04-22 The Trustees Of The University Of Pennsylvania Human respiratory syncytial virus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same
CA3194125A1 (en) 2012-04-12 2013-10-17 The Trustees Of The University Of Pennsylvania Filovirus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same
USD898908S1 (en) 2012-04-20 2020-10-13 Amgen Inc. Pharmaceutical product cassette for an injection device
JP2015524255A (ja) 2012-07-13 2015-08-24 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 二重特異性抗体を共導入することによってcart細胞の活性を強化する方法
JP6068057B2 (ja) * 2012-08-24 2017-01-25 南部化成株式会社 経皮投薬装置及びその装置に使用される薬液注入針
WO2014055442A2 (en) 2012-10-01 2014-04-10 The Trustees Of The University Of Pennsylvania Compositions and methods for targeting stromal cells for the treatment of cancer
WO2014055657A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
WO2014055771A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Human alpha-folate receptor chimeric antigen receptor
CN104812401B (zh) 2012-12-13 2017-10-13 宾夕法尼亚大学理事会 Wt1疫苗
WO2015089492A2 (en) 2013-12-13 2015-06-18 The Trustees Of The University Of Pennsylvania Dna antibody constructs and method of using same
CN105338998B (zh) 2013-03-15 2021-12-14 宾夕法尼亚大学理事会 口蹄疫病毒(fmdv)共有蛋白、其编码序列以及由其制造的疫苗
TWI614041B (zh) 2013-03-15 2018-02-11 安美基公司 用於注射器之匣盒
KR20150130284A (ko) 2013-03-15 2015-11-23 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 암 백신 및 이를 이용한 치료 방법
DK3054972T3 (da) 2013-10-07 2019-06-11 Univ Pennsylvania Vacciner med interleukin-33 som et adjuvans
US20160256539A1 (en) 2013-11-14 2016-09-08 The Trustees Of The University Of Pennsylvania HIV-1 ENV DNA Vaccine Plus Protein Boost Delivered by EP Expands B- and T-Cell Response and Neutralizing
WO2015073922A2 (en) 2013-11-15 2015-05-21 Northwestern University Inhibition of oxidative stress in atrial fibrillation
WO2015081155A1 (en) 2013-11-29 2015-06-04 The Trustees Of The University Of Pennsylvania Mers-cov vaccine
US10835595B2 (en) 2014-01-06 2020-11-17 The Trustees Of The University Of Pennsylvania PD1 and PDL1 antibodies and vaccine combinations and use of same for immunotherapy
WO2015112626A1 (en) 2014-01-21 2015-07-30 June Carl H Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules
CN103861202B (zh) 2014-03-18 2016-06-01 苏州壹达生物科技有限公司 一种利用空心电极针电穿孔给药的装置
KR101636775B1 (ko) * 2014-08-19 2016-07-08 아주대학교산학협력단 부위마취 장치 및 방법
KR20230145241A (ko) 2014-10-01 2023-10-17 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 항원 및 어쥬번트로서 인터류킨-21을 갖는 백신
ES2910227T3 (es) 2014-10-31 2022-05-12 Univ Pennsylvania Composición y métodos para la estimulación y expansión de células T
CA2964958A1 (en) 2014-10-31 2016-05-06 The Trustees Of The University Of Pennsylvania Methods and compositions for modified t cells
US20170335331A1 (en) 2014-10-31 2017-11-23 The Trustees Of The University Of Pennsylvania Altering Gene Expression in CART Cells and Uses Thereof
MX2017007187A (es) 2014-12-01 2018-01-30 Univ Pennsylvania Construcciones de anticuerpos de adn y metodo para utilizarlas.
EP3236882B1 (en) 2014-12-23 2020-02-05 Automed Pty Ltd Delivery apparatus, system and associated methods
WO2016123285A1 (en) 2015-01-29 2016-08-04 The Trustees Of The University Of Pennsylvania Checkpoint inhibitor and vaccine combinations and use of same for immunotherapy
US10828353B2 (en) 2015-01-31 2020-11-10 The Trustees Of The University Of Pennsylvania Compositions and methods for T cell delivery of therapeutic molecules
US20180049856A1 (en) * 2015-02-09 2018-02-22 Dan Andrei Ionescu Method and system for delivery of particles in a root canal system
CN107735142A (zh) * 2015-04-07 2018-02-23 伊哈卜·萨阿卜 植入式流体输送系统
BR112017023692A2 (pt) 2015-05-01 2018-07-17 The Regents Of The University Of California moléculas imunoterapêuticas glican-dependentes
CN108348551A (zh) 2015-08-28 2018-07-31 宾夕法尼亚大学董事会 表达嵌合细胞内信号传导分子的细胞的方法和组合物
US11793543B2 (en) 2015-09-18 2023-10-24 Obvius Robotics, Inc. Device and method for automated insertion of penetrating member
JP7088843B2 (ja) * 2015-12-28 2022-06-21 イノビオ ファーマシューティカルズ,インコーポレイティド 皮内ジェット注射式電気穿孔装置
WO2017136758A1 (en) 2016-02-05 2017-08-10 Inovio Pharmaceuticals, Inc. Cancer vaccines and methods of treatment using the same
WO2017145689A1 (ja) * 2016-02-22 2017-08-31 公益財団法人東京都医学総合研究所 エレクトロポレーション用電極
EP3432924A1 (en) 2016-03-23 2019-01-30 Novartis AG Cell secreted minibodies and uses thereof
AU2017241925B2 (en) 2016-03-28 2022-01-13 Ichor Medical Systems, Inc. Method and apparatus for delivery of therapeutic agents
JP7250520B2 (ja) 2016-04-13 2023-04-03 ヤンセン ファーマシューティカルズ,インコーポレーテッド 組換えアルテリウイルスレプリコン系およびその使用
KR102624967B1 (ko) 2016-04-29 2024-01-16 이노비오 파마수티컬즈, 인크. 제제의 전달을 향상시키기 위한 콘드로이티나제 및/또는 히알루로니다제의 생체내 용도
US10646374B2 (en) * 2016-06-17 2020-05-12 Orbit Biomedical Limited Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent
JP2018035137A (ja) 2016-07-13 2018-03-08 マブイミューン ダイアグノスティックス エイジーMabimmune Diagnostics Ag 新規な抗線維芽細胞活性化タンパク質(fap)結合薬剤およびその使用
KR102718353B1 (ko) 2016-10-17 2024-10-15 얀센 파마슈티칼즈, 인코포레이티드 재조합 바이러스 레플리콘 시스템 및 그의 용도
CA3045650A1 (en) 2016-12-05 2018-06-14 Janssen Pharmaceuticals, Inc. Compositions and methods for enhancing gene expression
US11827705B2 (en) 2017-03-28 2023-11-28 The Trustees Of The University Of Pennsylvania Methods to protect transplanted tissue from rejection
WO2018210345A1 (en) * 2017-05-18 2018-11-22 Chen Wen Shiang Apparatus for delivery of agent
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
CA3083532C (en) 2017-12-13 2023-09-05 Inovio Pharmaceuticals, Inc. Cancer vaccines targeting prame and uses thereof
KR102668476B1 (ko) 2017-12-13 2024-05-23 이노비오 파마수티컬즈, 인크. Boris를 표적으로 하는 암 백신 및 이의 용도
WO2019118760A1 (en) 2017-12-13 2019-06-20 Inovio Pharmaceuticals, Inc. Cancer vaccines targeting mesothelin and uses thereof
WO2019118764A1 (en) 2017-12-13 2019-06-20 Inovio Pharmaceuticals, Inc. Cancer vaccines targeting muc16 and uses thereof
EA202091516A1 (ru) 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и композиции для индукции иммунного ответа против вируса гепатита b (hbv)
US11021692B2 (en) 2017-12-19 2021-06-01 Janssen Sciences Ireland Unlimited Company Hepatitis B virus (HBV) vaccines and uses thereof
EA202091517A1 (ru) 2017-12-19 2020-11-03 Янссен Сайенсиз Айрлэнд Анлимитед Компани Способы и устройство для доставки вакцин против вируса гепатита b (hbv)
KR20200100745A (ko) 2017-12-19 2020-08-26 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 B형 간염 바이러스(hbv)에 대한 면역 반응 유도를 위한 방법 및 조성물
CN111836641A (zh) 2017-12-19 2020-10-27 杨森科学爱尔兰无限公司 乙型肝炎病毒(hbv)疫苗及其用途
EP3684399A1 (en) 2017-12-29 2020-07-29 Cellectis Method for improving production of car t cells
JP7494117B2 (ja) 2018-01-19 2024-06-03 ヤンセン ファーマシューティカルズ,インコーポレーテッド 組換えレプリコン系を使用する免疫応答の誘導および増強
US11447769B2 (en) 2018-03-27 2022-09-20 The Trustees Of The University Of Pennsylvania Modified immune cells having enhanced function and methods for screening for same
CN112839671A (zh) 2018-05-17 2021-05-25 明尼苏达大学董事会 抗药性免疫细胞及其使用方法
CN108653876A (zh) * 2018-06-06 2018-10-16 北京润美玉之光医疗美容门诊部 脂肪输送装置
US12497611B2 (en) 2018-08-17 2025-12-16 Yale University Compositions and methods for high-throughput activation screening to boost T cell effector function
WO2020076775A1 (en) 2018-10-08 2020-04-16 Janssen Pharmaceuticals, Inc. Alphavirus-based replicons for administration of biotherapeutics
US20220170097A1 (en) 2018-10-29 2022-06-02 The Broad Institute, Inc. Car t cell transcriptional atlas
CN111317891A (zh) * 2018-12-17 2020-06-23 中国医学科学院血液病医院(血液学研究所) 一种注射器用固定器
US12534714B2 (en) 2019-03-18 2026-01-27 The Broad Institute, Inc. Type VII CRISPR proteins and systems
JP7654557B2 (ja) 2019-03-27 2025-04-01 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Tn-MUC1キメラ抗原受容体(CAR)T細胞療法
CA3140588A1 (en) 2019-06-18 2020-12-24 Helen Horton Combination of hepatitis b virus (hbv) vaccines and small molecule pdl1 or pd1 inhibitor
WO2020255019A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and a quinazoline derivative
CA3140708A1 (en) 2019-06-18 2020-12-24 Helen Horton Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives
CA3140702A1 (en) 2019-06-18 2020-12-24 Helen Horton Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
US20220249647A1 (en) 2019-06-18 2022-08-11 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
US20250041386A1 (en) 2019-06-18 2025-02-06 Janssen Sciences Ireland Unlimited Company Recombinant Interleukin 12 Construct and Uses Thereof
WO2020255013A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators being amide derivatives
KR20220042116A (ko) 2019-06-18 2022-04-04 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 B형 간염 바이러스(HBV) 백신 및 HBV-타케팅 RNAi의 조합
KR20220041080A (ko) 2019-06-18 2022-03-31 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 B형 간염 바이러스(hbv) 백신 및 항-pd-1 또는 항-pc-l1 항체의 조합
WO2020255010A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of recombinant interleukin 12 construct and hepatitis b virus (hbv) vaccines
WO2020255016A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
CA3140707A1 (en) 2019-06-18 2020-12-24 Helen Horton Combination of hepatitis b virus (hbv) vaccines and quinazoline derivatives
WO2020255012A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and capsid assembly modulators being sulfonamide derivatives
KR102470989B1 (ko) * 2019-06-18 2022-11-28 (주)플럼라인생명과학 전기천공용 주사기 및 이를 이용한 전기천공용 주사 시스템
WO2020255022A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and aminopyridine derivatives as hpk1 inhibitors
EP3986460A2 (en) 2019-06-18 2022-04-27 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and anti-pd-1 antibody
WO2020254876A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Virus-like particle delivery of hepatitis b virus (hbv) vaccines
WO2020255042A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and a pyrimidine derivative
CA3141003A1 (en) 2019-06-18 2020-12-24 Helen Horton Combination of hepatitis b virus (hbv) vaccines and pd-l1 inhibitors
CA3143679A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and hbv-targeting rnai
WO2020255018A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Hepatitis b virus (hbv) vaccines and uses thereof
WO2020256375A2 (ko) * 2019-06-18 2020-12-24 (주)플럼라인생명과학 전기천공용 주사기 및 이를 이용한 전기천공용 주사 시스템
WO2020255035A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and pyrimidine derivatives
EP3986457A1 (en) 2019-06-20 2022-04-27 Janssen Sciences Ireland Unlimited Company Carbohydrate nanocarrier delivery of hepatitis b virus (hbv) vaccines
WO2020255062A1 (en) 2019-06-20 2020-12-24 Janssen Sciences Ireland Unlimited Company Lipid nanoparticle or liposome delivery of hepatitis b virus (hbv) vaccines
WO2021074695A1 (en) 2019-10-16 2021-04-22 Avacta Life Sciences Limited PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
WO2021108050A2 (en) 2019-10-23 2021-06-03 Yale University Compositions and methods comprising viral vector systems for multiplexed activation of endogenous genes as immunotherapy and viral-based immune-gene therapy
CN110801302B (zh) * 2019-10-23 2021-06-22 徐州生物工程职业技术学院 一种牲畜自动注射器
CN110974477B (zh) * 2019-11-22 2022-10-28 张珂孟 一种畜牧业使用的注射装置
CN110974476A (zh) * 2019-11-22 2020-04-10 张珂孟 一种动物用的注射设备
JP2023511780A (ja) 2020-02-25 2023-03-22 イノビオ ファーマシューティカルズ,インコーポレイティド コロナウイルスに対するワクチンおよび使用方法
JP2023516080A (ja) 2020-03-06 2023-04-17 ジーオー セラピューティクス,インコーポレイテッド 抗グリコcd44抗体およびその使用
CN115916963A (zh) 2020-03-27 2023-04-04 门德斯有限公司 白血病来源的经修饰细胞用于增强过继性细胞治疗的效力的离体用途
US20210322471A1 (en) 2020-03-27 2021-10-21 Dcprime B.V. In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
US11957542B2 (en) 2020-04-30 2024-04-16 Automed Patent Holdco, Llc Sensing complete injection for animal injection device
BR112022022719A2 (pt) 2020-05-14 2023-02-14 Inovio Pharmaceuticals Inc Vacinas para papilomatose respiratória recorrente e métodos de usar a mesma
GB202101299D0 (en) 2020-06-09 2021-03-17 Avacta Life Sciences Ltd Diagnostic polypetides and methods
CA3181680A1 (en) 2020-06-12 2021-12-16 University Of Rochester Encoding and expression of ace-trnas
EP4171617A1 (en) 2020-06-30 2023-05-03 Mendus B.V. Use of leukemia-derived cells in ovarian cancer vaccines
IL299571A (en) 2020-07-08 2023-02-01 Janssen Sciences Ireland Unlimited Co Rna replicon vaccines against hbv
EP4210832A1 (en) 2020-09-14 2023-07-19 Vor Biopharma, Inc. Chimeric antigen receptors for treatment of cancer
DE102020126224A1 (de) * 2020-10-07 2022-04-07 Fresenius Medical Care Deutschland Gmbh Zugangssystem für ein medizintechnisches Gerät zur Entnahme einer medizinischen Flüssigkeit und Überwachungssystem mit einem derartigen Zugangssystem und ein medizinisches Behandlungsgerät mit einem derartigen Überwachungssystem
CA3196677A1 (en) 2020-11-05 2022-05-12 Erik Hans MANTING Use of tumor-independent antigens in immunotherapies
TW202245809A (zh) 2020-12-18 2022-12-01 美商詹森藥物公司 用於治療b型肝炎病毒感染之組合療法
WO2022146654A1 (en) 2020-12-28 2022-07-07 Janssen Pharmaceuticals, Inc. Transcription activator-like effector nucleases (talens) targeting hbv
JP2024506249A (ja) 2021-01-22 2024-02-13 メンドゥス・ベスローテン・フェンノートシャップ 腫瘍ワクチン接種の方法
EP4301782A1 (en) 2021-03-05 2024-01-10 Go Therapeutics, Inc. Anti-glyco-cd44 antibodies and their uses
CA3212351A1 (en) 2021-03-12 2022-09-15 Mendus B.V. Methods of vaccination and use of cd47 blockade
KR102413427B1 (ko) * 2021-04-14 2022-06-28 주식회사 고산테크 멀티 니들 헤드와 멀티 니들 헤드의 단부 정렬 방법 및 그에 사용되는 정렬장치
CN113274116B (zh) * 2021-05-12 2024-05-14 普亚生物科技有限公司 全自动电脉冲穿孔术注射器
WO2023010118A1 (en) 2021-07-29 2023-02-02 Vor Biopharma Inc. Nfat-responsive reporter systems for assessing chimeric antigen receptor activation and methods of making and using the same
EP4376877A2 (en) 2021-07-29 2024-06-05 Vor Biopharma Inc. Chimeric antigen receptors for treatment of cancer
US20250101126A1 (en) 2021-08-05 2025-03-27 Go Therapeutics, Inc. Anti-glyco-muc4 antibodies and their uses
IL310808A (en) 2021-08-13 2024-04-01 Inovio Pharmaceuticals Inc Combination therapy to treat brain cancer
EP4396232A1 (en) 2021-09-03 2024-07-10 Go Therapeutics, Inc. Anti-glyco-lamp1 antibodies and their uses
CN118354789A (zh) 2021-09-03 2024-07-16 Go医疗股份有限公司 抗糖-cMET抗体及其用途
KR102576111B1 (ko) * 2021-10-18 2023-09-08 주식회사 밀알 미들커넥터를 포함하는 가역적 전기천공시스템
WO2023129636A1 (en) 2021-12-29 2023-07-06 Creare Llc Penetrative medical access devices, and related methods and systems
AU2023215397A1 (en) 2022-02-07 2024-08-22 University Of Rochester Optimized sequences for enhanced trna expression or/and nonsense mutation suppression.
US20240002800A1 (en) 2022-05-16 2024-01-04 Mendus B.V. Use of leukemia-derived cells for enhancing natural killer (nk) cell therapy
KR102691282B1 (ko) * 2022-05-19 2024-08-05 주식회사 밀알 일회용 카트리지를 포함하는 전기천공용 분배기
WO2023233290A1 (en) 2022-05-31 2023-12-07 Janssen Sciences Ireland Unlimited Company Rnai agents targeting pd-l1
EP4634373A1 (en) 2022-12-16 2025-10-22 University of Rochester Repairment of barrier dysfunction in esophagus
WO2024236547A1 (en) 2023-05-18 2024-11-21 Inceptor Bio, Llc Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof
US12426965B2 (en) 2023-06-15 2025-09-30 Obvius Robotics, Inc. Image-guided robotic arm for inserting a penetrating member into a body lumen
WO2025046513A1 (en) 2023-08-29 2025-03-06 Inceptor Bio, Llc Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof
WO2025101685A1 (en) 2023-11-09 2025-05-15 University Of Rochester Suppression of nonsense mutations using anticodon engineered (ace)-trnas
WO2026030209A1 (en) 2024-07-29 2026-02-05 University Of Rochester Use of decoding trnas to boost protein expression or function
WO2026047626A1 (en) 2024-08-30 2026-03-05 Inceptor Bio, Llc Compositions and methods involving immune cells engineered for binding bispecific antibodies for use in cell therapy

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1882127A (en) * 1930-12-31 1932-10-11 Nelson Emmons Jr Culinary apparatus
US3645692A (en) * 1968-07-15 1972-02-29 Boehringer Mannheim Gmbh Process for the preparation, preservation and transportation of blood and serum samples for use in clinical analyses
US4220669A (en) * 1978-10-02 1980-09-02 Townsend Engineering Company Method and means for injecting fluids into meat products
US4341735A (en) * 1980-03-28 1982-07-27 American Cyanamid Company Sample carrier material handling apparatus
CH655392B (pt) 1982-06-05 1986-04-15
US4849077A (en) 1984-08-06 1989-07-18 Akademie Der Wissenschaften Der Ddr Process for solid phase-sequencing of nucleic acid fragments
US4908017A (en) * 1985-05-14 1990-03-13 Ivion Corporation Failsafe apparatus and method for effecting syringe drive
ES8706023A1 (es) * 1986-02-20 1987-05-16 Yuste Pascual Jose A Aparato para la localizacion del espacio extradural.
US4877134A (en) 1988-03-29 1989-10-31 Klein David C Test tube cassette system and cassettes for use therein
FI902856A7 (fi) 1990-06-07 1991-12-08 Labsystems Oy Foerfarande foer bestaemning av en analyt.
US6231591B1 (en) * 1991-10-18 2001-05-15 2000 Injectx, Inc. Method of localized fluid therapy
US5250026A (en) * 1992-05-27 1993-10-05 Destron/Idi, Inc. Adjustable precision transponder injector
FI923220L (fi) 1992-07-14 1994-01-15 Wallac Oy Foerfarande och apparatur foer hantering av prov samt provuppsamlingssystem
US5271413A (en) * 1992-07-22 1993-12-21 Dalamagas Photios P Method to sense the tissue for injection from a hypodermic needle
US5273525A (en) * 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
IL107038A (en) 1992-10-05 1997-04-15 Senetek Plc Medicament injectors and methods for injection using same
DE69319753T2 (de) * 1992-11-19 1999-04-15 Tebro S.A., Luxembourg Automatische injektionsvorrichtung für vorgefüllte spritzen
FR2703253B1 (fr) 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5439440A (en) * 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5702359A (en) 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5620421A (en) * 1993-12-09 1997-04-15 Schmitz; William L. Syringe injector system
US5571083A (en) 1994-02-18 1996-11-05 Lemelson; Jerome H. Method and system for cell transplantation
DE4419844B4 (de) * 1994-06-07 2009-11-19 Robert Bosch Gmbh Beschleunigungssensor
US5672317A (en) 1995-04-19 1997-09-30 Roche Diagnostics Systems, Inc. Analyzer with fixed position bar code reader
US6159161A (en) * 1995-10-20 2000-12-12 Hodosh; Milton Microprocessor-controlled fluid dispensing apparatus
US20030073908A1 (en) * 1996-04-26 2003-04-17 2000 Injectx, Inc. Method and apparatus for delivery of genes, enzymes and biological agents to tissue cells
CA2285056C (en) 1997-04-03 2004-12-14 Iacob Mathiesen Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle
US6055453A (en) * 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6208893B1 (en) * 1998-01-27 2001-03-27 Genetronics, Inc. Electroporation apparatus with connective electrode template
US6391005B1 (en) * 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
DE19819409A1 (de) * 1998-04-30 1999-11-11 Schering Ag Injektionsvorrichtung
US6697669B2 (en) 1998-07-13 2004-02-24 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
JP2001000543A (ja) * 1999-06-18 2001-01-09 Shirota Denki Rozai Kk 電動注射器における注射液の注射速度の確認装置
JP2001170175A (ja) * 1999-12-15 2001-06-26 Opt:Kk 静注装置
CN2427215Y (zh) 2000-07-07 2001-04-25 卢小兵 肌肉自动注射器针筒
CN1345607A (zh) 2000-09-30 2002-04-24 杭州泰士生物科技有限公司 带电极的肌内基因注射针装置
EP1404214A2 (en) * 2000-11-24 2004-04-07 CKM Diagnostics, Inc. Nerve stimulator output control needle with depth determination capability and method of use
US6835193B2 (en) * 2001-07-10 2004-12-28 Myocardial Therapeutics, Inc. Methods for controlled depth injections into interior body cavities
US7033345B2 (en) * 2002-05-21 2006-04-25 Advanced Cardiovascular Systems, Inc. Deflectable microimplant delivery system
EP1462141B1 (en) * 2003-03-26 2006-09-20 Terumo Kabushiki Kaisha Catheter with puncture sensor

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