BRPI0413437A - preparação de peptìdeos de somatostatina - Google Patents

preparação de peptìdeos de somatostatina

Info

Publication number
BRPI0413437A
BRPI0413437A BRPI0413437-0A BRPI0413437A BRPI0413437A BR PI0413437 A BRPI0413437 A BR PI0413437A BR PI0413437 A BRPI0413437 A BR PI0413437A BR PI0413437 A BRPI0413437 A BR PI0413437A
Authority
BR
Brazil
Prior art keywords
preparation
somatostatin peptides
somatostatin
peptides
relates
Prior art date
Application number
BRPI0413437-0A
Other languages
English (en)
Inventor
Heribert Hellstern
Werner Pachinger
Walter Prikoszovich
Bernhard Wietfeld
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0413437A publication Critical patent/BRPI0413437A/pt
Publication of BRPI0413437B1 publication Critical patent/BRPI0413437B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"PREPARAçãO DE PEPTìDEOS DE SOMATOSTATINA". A presente invenção refere-se a um processo para preparação de análogos cíclicos de somatostatina e intermediários lineares usados no processo.
BRPI0413437-0A 2003-08-08 2004-08-06 Process for preparing somatostatin peptide BRPI0413437B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0318682.2 2003-08-08
GBGB0318682.2A GB0318682D0 (en) 2003-08-08 2003-08-08 Organic compounds
PCT/EP2004/008850 WO2005014624A2 (en) 2003-08-08 2004-08-06 Preparation of somatostatin peptides

Publications (2)

Publication Number Publication Date
BRPI0413437A true BRPI0413437A (pt) 2006-10-10
BRPI0413437B1 BRPI0413437B1 (pt) 2017-12-12

Family

ID=27839906

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413437-0A BRPI0413437B1 (pt) 2003-08-08 2004-08-06 Process for preparing somatostatin peptide

Country Status (34)

Country Link
US (1) US7615609B2 (pt)
EP (1) EP1654280B8 (pt)
JP (1) JP4580928B2 (pt)
KR (1) KR101136633B1 (pt)
CN (2) CN1832962A (pt)
AR (1) AR045327A1 (pt)
AT (1) ATE394424T1 (pt)
AU (1) AU2004262570B2 (pt)
BR (1) BRPI0413437B1 (pt)
CA (1) CA2534224C (pt)
CO (1) CO5660271A2 (pt)
CY (1) CY1108775T1 (pt)
DE (1) DE602004013599D1 (pt)
DK (1) DK1654280T3 (pt)
EC (1) ECSP066352A (pt)
ES (1) ES2307039T3 (pt)
GB (1) GB0318682D0 (pt)
HR (1) HRP20080350T3 (pt)
IL (1) IL173272A (pt)
IS (1) IS2894B (pt)
MA (1) MA27982A1 (pt)
MX (1) MXPA06001525A (pt)
MY (1) MY141731A (pt)
NO (1) NO338367B1 (pt)
NZ (1) NZ544961A (pt)
PE (2) PE20050356A1 (pt)
PL (1) PL1654280T3 (pt)
PT (1) PT1654280E (pt)
RU (1) RU2360921C2 (pt)
SI (1) SI1654280T1 (pt)
TN (1) TNSN06045A1 (pt)
TW (1) TWI345570B (pt)
WO (1) WO2005014624A2 (pt)
ZA (1) ZA200600584B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2067786A1 (en) 2007-12-07 2009-06-10 ITALFARMACO S.p.A. Novel non selective analogs of somatostatin
US8937152B2 (en) * 2007-12-03 2015-01-20 Italfarmaco Spa Non-selective somatostatin analogues
DK2343051T3 (da) 2010-01-05 2014-10-27 Nat Univ Dong Hwa Anti-cancer formulering
CN103467575B (zh) * 2013-08-22 2016-03-02 深圳翰宇药业股份有限公司 一种帕西瑞肽的制备方法
CN103641894B (zh) * 2013-12-06 2015-10-28 深圳翰宇药业股份有限公司 一种治疗库欣病的多肽药物的制备方法
WO2016097962A1 (en) * 2014-12-19 2016-06-23 Auro Peptides Ltd A process for the preparation of pasireotide
CN106188231B (zh) * 2015-05-25 2021-10-22 中国医学科学院药物研究所 帕西瑞肽五肽中间体的合成与应用
CN114621326B (zh) * 2020-12-10 2023-12-26 武汉武药科技有限公司 门冬氨酸帕瑞肽及其中间体和其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3303345A1 (de) 1983-02-02 1984-08-02 Hoechst Ag, 6230 Frankfurt Cyclische peptide mit somatostatin-wirkung
EP0255224A3 (en) 1986-06-30 1990-04-18 Merck & Co. Inc. Cyclic and bridged cyclic somatostatin analogs useful as analgesic agents
US5811512A (en) 1991-08-22 1998-09-22 The Trustees Of The University Of Pennsylvania Non-peptide peptidomimetics and related cyclic hexapeptides
DK0720621T3 (da) 1992-01-14 2001-08-06 Diatide Inc Radiomærkede somatostation-afledte peptider til billeddannende og terapeutiske anvendelser
US5770687A (en) 1995-06-07 1998-06-23 Peptor Limited Comformationally constrained backbone cyclized somatostatin analogs
GB9513224D0 (en) * 1995-06-29 1995-09-06 Sandoz Ltd Organic compounds
US6355613B1 (en) 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
GB0018891D0 (en) * 2000-08-01 2000-09-20 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
IS8338A (is) 2006-03-02
PE20050356A1 (es) 2005-06-17
NO20061125L (no) 2006-05-08
MXPA06001525A (es) 2006-05-15
CN1832962A (zh) 2006-09-13
US7615609B2 (en) 2009-11-10
CN102127155A (zh) 2011-07-20
NZ544961A (en) 2008-08-29
EP1654280B1 (en) 2008-05-07
KR101136633B1 (ko) 2012-04-18
HK1090065A1 (en) 2006-12-15
TW200524955A (en) 2005-08-01
CN102127155B (zh) 2013-11-27
TNSN06045A1 (en) 2007-10-03
PE20091210A1 (es) 2009-09-07
BRPI0413437B1 (pt) 2017-12-12
IL173272A (en) 2012-03-29
CA2534224A1 (en) 2005-02-17
EP1654280B8 (en) 2008-08-13
DK1654280T3 (da) 2008-09-29
AU2004262570A1 (en) 2005-02-17
ES2307039T3 (es) 2008-11-16
RU2360921C2 (ru) 2009-07-10
MA27982A1 (fr) 2006-07-03
RU2006106721A (ru) 2007-09-20
NO338367B1 (no) 2016-08-15
IL173272A0 (en) 2006-06-11
CO5660271A2 (es) 2006-07-31
ZA200600584B (en) 2006-12-27
KR20060070541A (ko) 2006-06-23
DE602004013599D1 (de) 2008-06-19
PT1654280E (pt) 2008-08-18
AR045327A1 (es) 2005-10-26
MY141731A (en) 2010-06-15
JP4580928B2 (ja) 2010-11-17
JP2007526899A (ja) 2007-09-20
CA2534224C (en) 2012-03-27
IS2894B (is) 2014-09-15
WO2005014624A2 (en) 2005-02-17
SI1654280T1 (sl) 2008-10-31
HRP20080350T3 (en) 2008-08-31
EP1654280A2 (en) 2006-05-10
AU2004262570B2 (en) 2008-06-19
PL1654280T3 (pl) 2008-10-31
ECSP066352A (es) 2006-08-30
US20060258838A1 (en) 2006-11-16
GB0318682D0 (en) 2003-09-10
ATE394424T1 (de) 2008-05-15
TWI345570B (en) 2011-07-21
CY1108775T1 (el) 2014-04-09
WO2005014624A3 (en) 2005-09-22

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: PAGAR RESTAURACAO.

B08H Application fees: decision cancelled [chapter 8.8 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/12/2017, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 15A ANUIDADE.