BRPI0413489A - composições polipeptìdicas de ligação a cd20 - Google Patents

composições polipeptìdicas de ligação a cd20

Info

Publication number
BRPI0413489A
BRPI0413489A BRPI0413489-3A BRPI0413489A BRPI0413489A BR PI0413489 A BRPI0413489 A BR PI0413489A BR PI0413489 A BRPI0413489 A BR PI0413489A BR PI0413489 A BRPI0413489 A BR PI0413489A
Authority
BR
Brazil
Prior art keywords
modified
chain variable
variable region
region polypeptide
seq
Prior art date
Application number
BRPI0413489-3A
Other languages
English (en)
Inventor
Francis J Carr
Stephen Williams
Stephen D Gillies
Original Assignee
Merck Patent Ges Mit Beschaenk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Ges Mit Beschaenk filed Critical Merck Patent Ges Mit Beschaenk
Publication of BRPI0413489A publication Critical patent/BRPI0413489A/pt
Publication of BRPI0413489B1 publication Critical patent/BRPI0413489B1/pt
Publication of BRPI0413489B8 publication Critical patent/BRPI0413489B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/80—Antibody or fragment thereof whose amino acid sequence is disclosed in whole or in part
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/801—Drug, bio-affecting and body treating compositions involving antibody or fragment thereof produced by recombinant dna technology

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"COMPOSIçõES POLIPEPTìDICAS DE LIGAçãO A CD20". A presente invenção refere-se a composições polipeptídicas que se ligam ao antígeno CD20, especialmente antígeno CD20 humano. As composições polipeptídicas têm a atividade biológica de anticorpos anti-CD20 conhecidos, tais como 2B8 ou Leu16, mas mostram uma imunogenicidade reduzida quando comparados às moléculas não modificadas. As composições polipeptídicas incluem anticorpos quiméricos, fragmentos de anticorpo e proteínas de fusão de um anticorpo ou fragmento de anticorpo com uma citocina.
BRPI0413489A 2003-08-14 2004-08-16 molécula de anticorpo anti-cd20 fusionada a il-2 e composição farmacêutica compreendendo a mesma BRPI0413489B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03018480 2003-08-14
US52017103P 2003-11-14 2003-11-14
PCT/EP2004/009033 WO2005016969A2 (en) 2003-08-14 2004-08-16 Cd20-binding polypeptide compositions

Publications (3)

Publication Number Publication Date
BRPI0413489A true BRPI0413489A (pt) 2006-10-17
BRPI0413489B1 BRPI0413489B1 (pt) 2019-12-03
BRPI0413489B8 BRPI0413489B8 (pt) 2021-05-25

Family

ID=37003287

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413489A BRPI0413489B8 (pt) 2003-08-14 2004-08-16 molécula de anticorpo anti-cd20 fusionada a il-2 e composição farmacêutica compreendendo a mesma

Country Status (18)

Country Link
US (2) US8147832B2 (pt)
EP (1) EP1654287B1 (pt)
JP (1) JP4787750B2 (pt)
KR (2) KR101209541B1 (pt)
CN (1) CN1835977B (pt)
AT (1) ATE476990T1 (pt)
AU (1) AU2004264372B2 (pt)
BR (1) BRPI0413489B8 (pt)
CA (1) CA2535515C (pt)
DK (1) DK1654287T3 (pt)
ES (1) ES2349781T3 (pt)
MX (1) MXPA06001664A (pt)
PL (1) PL1654287T3 (pt)
PT (1) PT1654287E (pt)
RU (1) RU2396279C2 (pt)
SI (1) SI1654287T1 (pt)
WO (1) WO2005016969A2 (pt)
ZA (1) ZA200602110B (pt)

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AU2004264372B2 (en) 2010-07-29
KR20060067956A (ko) 2006-06-20
KR101209541B1 (ko) 2012-12-13
US20050069545A1 (en) 2005-03-31
WO2005016969A3 (en) 2005-04-21
EP1654287A2 (en) 2006-05-10
US8337844B2 (en) 2012-12-25
EP1654287B1 (en) 2010-08-11
MXPA06001664A (es) 2006-04-28
WO2005016969A2 (en) 2005-02-24
JP4787750B2 (ja) 2011-10-05
RU2006107453A (ru) 2007-09-20
BRPI0413489B1 (pt) 2019-12-03
RU2396279C2 (ru) 2010-08-10
ZA200602110B (en) 2007-05-30
SI1654287T1 (sl) 2010-11-30
ATE476990T1 (de) 2010-08-15
PL1654287T3 (pl) 2010-12-31
CN1835977A (zh) 2006-09-20
CA2535515C (en) 2013-10-29
BRPI0413489B8 (pt) 2021-05-25
JP2007525202A (ja) 2007-09-06
KR20120101155A (ko) 2012-09-12
PT1654287E (pt) 2010-11-17
AU2004264372A1 (en) 2005-02-24
DK1654287T3 (da) 2010-10-25
US20120183545A1 (en) 2012-07-19
CA2535515A1 (en) 2005-02-24
CN1835977B (zh) 2012-10-31
ES2349781T3 (es) 2011-01-11
US8147832B2 (en) 2012-04-03

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