BRPI0609191B8 - métodos e compostos moduladores de receptor de androgênio - Google Patents

métodos e compostos moduladores de receptor de androgênio

Info

Publication number
BRPI0609191B8
BRPI0609191B8 BRPI0609191A BRPI0609191A BRPI0609191B8 BR PI0609191 B8 BRPI0609191 B8 BR PI0609191B8 BR PI0609191 A BRPI0609191 A BR PI0609191A BR PI0609191 A BRPI0609191 A BR PI0609191A BR PI0609191 B8 BRPI0609191 B8 BR PI0609191B8
Authority
BR
Brazil
Prior art keywords
compounds
androgen receptor
receptor modulating
methods
modulating methods
Prior art date
Application number
BRPI0609191A
Other languages
English (en)
Inventor
Pedram Bijan
A Van Oeveren Cornelis
Zhi Lin
Zhao Shuo
Shen Yixing
Original Assignee
Ligand Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ligand Pharm Inc filed Critical Ligand Pharm Inc
Publication of BRPI0609191A2 publication Critical patent/BRPI0609191A2/pt
Publication of BRPI0609191B1 publication Critical patent/BRPI0609191B1/pt
Publication of BRPI0609191B8 publication Critical patent/BRPI0609191B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

métodos e compostos moduladores de receptor de androgênio. são fornecidos aqui compostos que se ligam a receptores de androgênio e/ou modulam atividade de receptores de androgênio, e a métodos para fazer e utilizar tais compostos. são também fornecidas composições incluindo tais compostos e métodos para fazer e utilizar tais composições.
BRPI0609191A 2005-06-17 2006-06-12 métodos e compostos moduladores de receptor de androgênio BRPI0609191B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69189105P 2005-06-17 2005-06-17
US60/691,891 2005-06-17
PCT/US2006/023111 WO2006138347A2 (en) 2005-06-17 2006-06-12 Androgen receptor modulator compounds and methods

Publications (3)

Publication Number Publication Date
BRPI0609191A2 BRPI0609191A2 (pt) 2010-03-02
BRPI0609191B1 BRPI0609191B1 (pt) 2020-10-13
BRPI0609191B8 true BRPI0609191B8 (pt) 2021-05-25

Family

ID=37546607

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0609191A BRPI0609191B8 (pt) 2005-06-17 2006-06-12 métodos e compostos moduladores de receptor de androgênio

Country Status (14)

Country Link
US (2) US8193357B2 (pt)
EP (1) EP1891067B1 (pt)
JP (1) JP5199079B2 (pt)
KR (1) KR101293935B1 (pt)
CN (1) CN101137655A (pt)
AR (2) AR054783A1 (pt)
AU (1) AU2006259474B2 (pt)
BR (1) BRPI0609191B8 (pt)
CA (1) CA2598216C (pt)
IL (1) IL185003A (pt)
MX (1) MX2007009784A (pt)
NO (1) NO20074002L (pt)
NZ (1) NZ560354A (pt)
WO (1) WO2006138347A2 (pt)

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US8519158B2 (en) 2004-03-12 2013-08-27 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
BRPI0609191B8 (pt) 2005-06-17 2021-05-25 Ligand Pharm Inc métodos e compostos moduladores de receptor de androgênio
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WO2016022831A1 (en) 2014-08-06 2016-02-11 Xeris Pharmaceuticals, Inc. Syringes, kits, and methods for intracutaneous and/or subcutaneous injection of pastes
CN104856996B (zh) * 2015-04-27 2018-01-05 南京舒鹏生物科技有限公司 吡咯喹啉醌、其衍生物和/或盐新的药用用途以及药用组合物
US9649364B2 (en) 2015-09-25 2017-05-16 Xeris Pharmaceuticals, Inc. Methods for producing stable therapeutic formulations in aprotic polar solvents
US11590205B2 (en) 2015-09-25 2023-02-28 Xeris Pharmaceuticals, Inc. Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents
US11040973B2 (en) 2017-03-29 2021-06-22 Purdue Research Foundation Inhibitors of kinase networks and uses thereof
KR20240036128A (ko) 2017-06-02 2024-03-19 엑스에리스 파머수티클스, 인크. 침전 방지 저분자 약물 제제
WO2020214834A1 (en) 2019-04-19 2020-10-22 Ligand Pharmaceuticals Inc. Crystalline forms and methods of producing crystalline forms of a compound
WO2022006365A2 (en) * 2020-07-02 2022-01-06 Purdue Research Foundation Tetrahydro-3h-pyrazolo quinolone and tetrahydro-3h-pyrrolo[3,2-f]quinoline-containing compounds and uses thereof
TW202214632A (zh) * 2020-07-27 2022-04-16 大陸商江蘇恆瑞醫藥股份有限公司 吲哚稠環類衍生物、其製備方法及其在醫藥上的應用

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MX2007009784A (es) 2007-09-26
EP1891067B1 (en) 2016-01-13
NZ560354A (en) 2010-10-29
US20090030027A1 (en) 2009-01-29
CN101137655A (zh) 2008-03-05
NO20074002L (no) 2008-03-10
US8193357B2 (en) 2012-06-05
CA2598216A1 (en) 2006-12-28
EP1891067A2 (en) 2008-02-27
JP5199079B2 (ja) 2013-05-15
IL185003A0 (en) 2007-12-03
AR107862A2 (es) 2018-06-13
AU2006259474A1 (en) 2006-12-28
WO2006138347A3 (en) 2007-03-01
JP2008543857A (ja) 2008-12-04
US8580811B2 (en) 2013-11-12
BRPI0609191A2 (pt) 2010-03-02
CA2598216C (en) 2014-04-08
US20090264455A9 (en) 2009-10-22
KR20080020592A (ko) 2008-03-05
AR054783A1 (es) 2007-07-18
US20120165362A1 (en) 2012-06-28
AU2006259474B2 (en) 2011-10-27
BRPI0609191B1 (pt) 2020-10-13
WO2006138347A2 (en) 2006-12-28
IL185003A (en) 2015-06-30

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