BRPI0413896A - processo de purificação - Google Patents
processo de purificaçãoInfo
- Publication number
- BRPI0413896A BRPI0413896A BRPI0413896-1A BRPI0413896A BRPI0413896A BR PI0413896 A BRPI0413896 A BR PI0413896A BR PI0413896 A BRPI0413896 A BR PI0413896A BR PI0413896 A BRPI0413896 A BR PI0413896A
- Authority
- BR
- Brazil
- Prior art keywords
- purification process
- acid addition
- addition salt
- free base
- distillation
- Prior art date
Links
- 238000000746 purification Methods 0.000 title abstract 3
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000012458 free base Substances 0.000 abstract 2
- 150000003839 salts Chemical group 0.000 abstract 2
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 abstract 2
- 229960002722 terbinafine Drugs 0.000 abstract 2
- 239000002585 base Substances 0.000 abstract 1
- 238000004821 distillation Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000000526 short-path distillation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/82—Purification; Separation; Stabilisation; Use of additives
- C07C209/84—Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/30—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the six-membered aromatic ring being part of a condensed ring system formed by two rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
"PROCESSO DE PURIFICAçãO". A presente invenção refere-se a um processo de purificação para a preparação da substância farmacêutica de alilamina terbinafina de fórmula (I) em forma de base livre ou em forma de sal de adição de ácido, por destilação de base de terbinafina bruta, de preferência por destilação de trajeto curto, por exemplo, a uma temperatura acima de 100<198>C e pressão reduzida, por exemplo, 0,2 mbar, e recuperação do produto purificado em forma de base livre ou de sal de adição de ácido.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0320312.2A GB0320312D0 (en) | 2003-08-29 | 2003-08-29 | Purification process |
| PCT/EP2004/009587 WO2005021483A2 (en) | 2003-08-29 | 2004-08-27 | Process for the purification of terbinafine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0413896A true BRPI0413896A (pt) | 2006-10-24 |
Family
ID=28686596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0413896-1A BRPI0413896A (pt) | 2003-08-29 | 2004-08-27 | processo de purificação |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US20060076227A1 (pt) |
| EP (1) | EP1694631A2 (pt) |
| JP (1) | JP5208416B2 (pt) |
| KR (2) | KR101233024B1 (pt) |
| CN (1) | CN100491334C (pt) |
| AR (1) | AR045506A1 (pt) |
| AU (1) | AU2004268051B2 (pt) |
| BR (1) | BRPI0413896A (pt) |
| CA (1) | CA2536498C (pt) |
| EC (1) | ECSP066382A (pt) |
| GB (1) | GB0320312D0 (pt) |
| IL (1) | IL173709A (pt) |
| IS (1) | IS8369A (pt) |
| MA (1) | MA28030A1 (pt) |
| MX (1) | MXPA06002348A (pt) |
| MY (1) | MY149357A (pt) |
| NO (1) | NO20061404L (pt) |
| NZ (1) | NZ545445A (pt) |
| PE (1) | PE20050873A1 (pt) |
| RU (1) | RU2367649C2 (pt) |
| SG (1) | SG145782A1 (pt) |
| TN (1) | TNSN06066A1 (pt) |
| TW (1) | TWI350829B (pt) |
| WO (1) | WO2005021483A2 (pt) |
| ZA (1) | ZA200601264B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0503942D0 (en) * | 2005-02-25 | 2005-04-06 | Novartis Ag | Purification process |
| EP1900378A1 (en) * | 2006-08-31 | 2008-03-19 | Novartis AG | Pharmaceutical compositions for the treatment of fungal infections |
| WO2010027468A1 (en) | 2008-09-05 | 2010-03-11 | Travanti Pharma Inc. | Iontophoretic drug delivery packaging |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2862103D1 (en) * | 1977-08-19 | 1982-11-18 | Sandoz Ag | Propenyl amines, processes for their production and pharmaceutical compositions containing them |
| US5132459A (en) * | 1979-08-22 | 1992-07-21 | Sandoz Ltd. | Propenylamines, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals |
| ATE10272T1 (de) | 1979-08-22 | 1984-11-15 | Sandoz Ag | Propenylamine, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zusammensetzungen und ihre verwendung als arzneimittel. |
| CS232849B1 (cs) * | 1983-05-04 | 1985-02-14 | Ladislav Kalvoda | Způsob přípravy honjugavaných eninů |
| RU2005717C1 (ru) * | 1989-02-17 | 1994-01-15 | Такеда кемикал-индастриз Лтд | Способ получения производных аралкиламинов или их кислотно-аддитивных солей |
| CH678527A5 (en) | 1989-06-22 | 1991-09-30 | Sandoz Ag | Trans(E)-N-(1-naphthyl:methyl)-heptenyl-amine prepn. - by simultaneously converting crude mixt. contg. cis and trans isomers to salt and precipitating trans isomer |
| JP3116364B2 (ja) | 1989-10-02 | 2000-12-11 | 萬有製薬株式会社 | エンイン誘導体の製造法 |
| NZ280065A (en) * | 1995-09-20 | 1998-04-27 | Apotex Inc | Preparation of n-alkyl-n-(1-naphthylmethyl)alk-2-en-4-ynylamine derivatives |
| US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| SK286804B6 (sk) | 1999-10-22 | 2009-05-07 | Richter Gedeon Vegy�Szeti Gy�R Rt. | Spôsob prípravy substituovaného derivátu alylamínu a jeho solí |
| GB2357762B (en) | 2000-03-13 | 2002-01-30 | Lundbeck & Co As H | Crystalline base of citalopram |
| ITMI20010421A1 (it) | 2001-03-01 | 2002-09-02 | Ausimont Spa | Membrane porose semipermeabili di fluoropolimeri semicristallini |
| ITMI20010430A1 (it) * | 2001-03-02 | 2002-09-02 | Dinamite Dipharma S P A In For | Metodo per la sintesi di terbinafina |
| KR100459275B1 (ko) | 2001-12-28 | 2004-12-03 | 주식회사유한양행 | 터비나핀 또는 그의 염산염의 제조방법 |
| ITMI20022534A1 (it) * | 2002-11-29 | 2004-05-30 | Dinamite Dipharma S P A | Procedimento per la preparazione di terbinafina mediante l'uso di platino come catalizzatore. |
| US20060004230A1 (en) * | 2004-06-30 | 2006-01-05 | Joseph Kaspi | Process for the preparation of terbinafine and salts thereof |
-
2003
- 2003-08-29 GB GBGB0320312.2A patent/GB0320312D0/en not_active Ceased
-
2004
- 2004-08-26 AR ARP040103068A patent/AR045506A1/es not_active Application Discontinuation
- 2004-08-27 JP JP2006524338A patent/JP5208416B2/ja not_active Expired - Fee Related
- 2004-08-27 MX MXPA06002348A patent/MXPA06002348A/es active IP Right Grant
- 2004-08-27 WO PCT/EP2004/009587 patent/WO2005021483A2/en not_active Ceased
- 2004-08-27 SG SG200806418-0A patent/SG145782A1/en unknown
- 2004-08-27 EP EP04764561A patent/EP1694631A2/en not_active Withdrawn
- 2004-08-27 BR BRPI0413896-1A patent/BRPI0413896A/pt not_active IP Right Cessation
- 2004-08-27 MY MYPI20043511A patent/MY149357A/en unknown
- 2004-08-27 KR KR1020067003979A patent/KR101233024B1/ko not_active Expired - Fee Related
- 2004-08-27 TW TW093125943A patent/TWI350829B/zh not_active IP Right Cessation
- 2004-08-27 NZ NZ545445A patent/NZ545445A/en not_active IP Right Cessation
- 2004-08-27 AU AU2004268051A patent/AU2004268051B2/en not_active Ceased
- 2004-08-27 CN CNB2004800249663A patent/CN100491334C/zh not_active Expired - Fee Related
- 2004-08-27 CA CA2536498A patent/CA2536498C/en not_active Expired - Fee Related
- 2004-08-27 RU RU2006109640/04A patent/RU2367649C2/ru not_active IP Right Cessation
- 2004-08-27 KR KR1020127012618A patent/KR20120054109A/ko not_active Withdrawn
- 2004-08-27 PE PE2004000823A patent/PE20050873A1/es not_active Application Discontinuation
- 2004-08-27 US US10/522,828 patent/US20060076227A1/en not_active Abandoned
-
2006
- 2006-02-13 IL IL173709A patent/IL173709A/en not_active IP Right Cessation
- 2006-02-13 ZA ZA200601264A patent/ZA200601264B/en unknown
- 2006-02-17 EC EC2006006382A patent/ECSP066382A/es unknown
- 2006-02-27 TN TNP2006000066A patent/TNSN06066A1/en unknown
- 2006-03-08 MA MA28862A patent/MA28030A1/fr unknown
- 2006-03-23 IS IS8369A patent/IS8369A/is unknown
- 2006-03-28 NO NO20061404A patent/NO20061404L/no not_active Application Discontinuation
-
2008
- 2008-11-14 US US12/291,863 patent/US7985323B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2268 DE 24/06/2014. |