BRPI0414010A - uso de biotina ou de um derivado de biotina com a finalidade de clareamento da pele e para o trtamento de lentiginas senis - Google Patents
uso de biotina ou de um derivado de biotina com a finalidade de clareamento da pele e para o trtamento de lentiginas senisInfo
- Publication number
- BRPI0414010A BRPI0414010A BRPI0414010-9A BRPI0414010A BRPI0414010A BR PI0414010 A BRPI0414010 A BR PI0414010A BR PI0414010 A BRPI0414010 A BR PI0414010A BR PI0414010 A BRPI0414010 A BR PI0414010A
- Authority
- BR
- Brazil
- Prior art keywords
- biotin
- skin
- treatment
- skin whitening
- derivative
- Prior art date
Links
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 title abstract 5
- 229960002685 biotin Drugs 0.000 title abstract 3
- 235000020958 biotin Nutrition 0.000 title abstract 3
- 239000011616 biotin Substances 0.000 title abstract 3
- 206010024217 lentigo Diseases 0.000 title abstract 2
- 150000001615 biotins Chemical class 0.000 title 1
- 230000002087 whitening effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010040829 Skin discolouration Diseases 0.000 abstract 1
- -1 biotin compound Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 230000001777 nootropic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicinal Preparation (AREA)
Abstract
"USO DE BIOTINA OU DE UM DERIVADO DE BIOTINA COM A FINALIDADE DE CLAREAMENTO DA PELE E PARA O TRATAMENTO DE LENTIGINAS SENIS". A presente invenção refere-se ao uso de biotina isoladamente, preferencialmente, contudo, com vitamina C ou um derivado de vitamina C, para a preparação de uma composição cosmética ou de uma composição farmacêutica com a finalidade de clareamento da pele, para a eliminação de irregularidades na cor da pele e para o tratamento de lentiginas senis.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03018730 | 2003-08-26 | ||
| EP03018730.6 | 2003-08-26 | ||
| PCT/EP2004/009048 WO2005020877A2 (de) | 2003-08-26 | 2004-08-12 | Verwendung von biotin oder einem biotinderivat zur aufhellung der haut und behandlung von altersflecken |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0414010A true BRPI0414010A (pt) | 2006-10-24 |
| BRPI0414010B1 BRPI0414010B1 (pt) | 2021-03-16 |
Family
ID=34203219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0414010-9A BRPI0414010B1 (pt) | 2003-08-26 | 2004-08-12 | uso cosmético de biotina em conjunto com ascorbil fosfato de sódio ou um hidrato do mesmo para a produção de uma composição para clarear a pele, para corrigir irregularidades na cor da pele e/ou para tratar lentiginas senis |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20050048012A1 (pt) |
| EP (2) | EP1872772B1 (pt) |
| JP (1) | JP4755985B2 (pt) |
| KR (1) | KR101088604B1 (pt) |
| CN (1) | CN1842318B (pt) |
| AT (1) | ATE396695T1 (pt) |
| BR (1) | BRPI0414010B1 (pt) |
| DE (1) | DE502004007294D1 (pt) |
| ES (2) | ES2304161T3 (pt) |
| MX (1) | MXPA06000464A (pt) |
| PL (1) | PL1658039T3 (pt) |
| WO (1) | WO2005020877A2 (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007063224A (ja) * | 2005-09-01 | 2007-03-15 | Kobayashi Pharmaceut Co Ltd | チロシナーゼ活性阻害剤 |
| JP2007063223A (ja) * | 2005-09-01 | 2007-03-15 | Kobayashi Pharmaceut Co Ltd | しみ又はそばかす予防又は治療用経口組成物及び食品 |
| WO2007051596A1 (en) * | 2005-11-03 | 2007-05-10 | Dsm Ip Assets B.V. | Novel retinyl biotinates and use thereof |
| DE102006047157A1 (de) * | 2006-09-29 | 2008-04-03 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an 2-Isopropyl-5-Methyl-Cyclohexancarbonyl-D-Alaninmethylester und einem oder mehreren hautaufhellenden Wirkstoffen gegen unerwünschte Pigmentierung der Haut, insbesondere postinflammatorische Hyperpigmentierung |
| DE102006047156A1 (de) * | 2006-09-29 | 2008-04-03 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an 2-Isopropyl-5-Methyl-Cyclohexancarbonyl-D-Alaninethylester und einem oder mehreren hautaufhellenden Wirkstoffen gegen unerwünschte Pigmentierung der Haut, insbesondere postinflammatorische Hyperpigmentierung |
| FR2913198B1 (fr) * | 2007-03-01 | 2009-06-05 | Oreal | Utilisation cosmetique d'une association de biotine et de vitamine cg. |
| CN101631593B (zh) * | 2007-03-12 | 2014-08-13 | 帝斯曼知识产权资产管理有限公司 | 化妆品组合物 |
| US20100087498A1 (en) * | 2007-05-10 | 2010-04-08 | Regina Goralczyk | Use of biotin to prevent photoaging |
| DE102008008554A1 (de) * | 2008-02-12 | 2009-08-13 | Sebapharma Gmbh & Co. | Kosmetische oder medizinische Zubereitung enthaltend Biotin |
| JP2009256326A (ja) * | 2008-03-21 | 2009-11-05 | Kose Corp | 美白剤、及び皮膚外用剤 |
| WO2015195404A1 (en) | 2014-06-20 | 2015-12-23 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods for detection of an analyte by movement of tethered microparticles |
| WO2016205239A1 (en) | 2015-06-15 | 2016-12-22 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Non-hormonal mammalian sperm decoy contraception based on the n-terminus of the zp2 protein |
| US20170135969A1 (en) | 2015-11-12 | 2017-05-18 | Jds Therapeutics, Llc | Topical arginine-silicate-inositol for wound healing |
| AU2017318672B2 (en) * | 2016-09-01 | 2022-03-10 | Nutrition 21, Llc | Magnesium biotinate compositions and methods of use |
| CA3041059C (en) | 2016-10-21 | 2023-09-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Molecular nanotags |
| US10878941B2 (en) * | 2017-05-22 | 2020-12-29 | Zeyix Llc | Perpetual bioinformatics and virtual colorimeter expert system |
| WO2019133727A1 (en) | 2017-12-29 | 2019-07-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Universal influenza virus probe set for enrichment of any influenza virus nucleic acid |
| GB201800909D0 (en) * | 2018-01-19 | 2018-03-07 | Biocel Ltd | Compositions and methods relating to amnion |
| CN120360921A (zh) | 2018-03-23 | 2025-07-25 | 玫琳凯有限公司 | 局部用组合物和方法 |
| US11246886B2 (en) * | 2018-09-06 | 2022-02-15 | Nutrition 21, Llc | Treatment of autism and autism spectrum disorders with biotin compositions |
| WO2021127048A1 (en) | 2019-12-16 | 2021-06-24 | Nutrition 21, Llc | Methods of production of arginine-silicate complexes |
| WO2022056078A1 (en) | 2020-09-11 | 2022-03-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Rnase h-assisted detection assay for rna (radar) |
| CN114504549B (zh) * | 2022-02-24 | 2023-11-24 | 北京斯利安药业有限公司 | 生物素的水性凝胶剂及其制备方法和应用 |
| WO2024191684A1 (en) | 2023-03-10 | 2024-09-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Detection of hepatitis c virus ribonucleic acid from whole blood using reverse transcription loop-mediated isothermal amplification |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH656067A5 (de) * | 1981-12-10 | 1986-06-13 | Richardson Vicks Inc | Kosmetisches haarpflege- oder hautpflegemittel. |
| JPS6442414A (en) * | 1987-08-10 | 1989-02-14 | Kanebo Ltd | Skin-beautifying cosmetic |
| JPH02215707A (ja) * | 1989-02-15 | 1990-08-28 | Chisso Corp | 皮膚化粧料 |
| GB9006785D0 (en) * | 1990-03-27 | 1990-05-23 | Leung Lit Hung | Composition and methods for treatment of acne vulgaris and retardation of ageing |
| IT1254045B (it) * | 1991-12-31 | 1995-09-06 | Lifegroup Spa | Derivati idrosolubili della biotina e relative composizioni terapeutiche |
| DE4242876C2 (de) * | 1992-12-18 | 1997-11-27 | Beiersdorf Ag | Kosmetische und/oder dermatologische Zubereitungen zur kosmetischen und/oder dermatologischen Pflege der Haut und/oder der Hautanhangsgebilde |
| JPH0797322A (ja) * | 1993-09-29 | 1995-04-11 | Shiseido Co Ltd | 一重項酸素消去剤 |
| JPH07233046A (ja) * | 1993-12-28 | 1995-09-05 | Kose Corp | 外用剤 |
| DE4444238A1 (de) * | 1994-12-13 | 1996-06-20 | Beiersdorf Ag | Kosmetische oder dermatologische Wirkstoffkombinationen aus Zimtsäurederivaten und Flavonglycosiden |
| WO1997025883A1 (de) * | 1996-01-17 | 1997-07-24 | Friedrich Kisters | Aminosäuren-präparat zur haarwuchsförderung |
| DE19701651A1 (de) * | 1997-01-18 | 1998-07-23 | Rovi Gmbh Handelsgesellschaft | Wäßrige Zusammensetzung mit biotinhaltigen Liposomen |
| IN2000KO00299A (pt) * | 1999-05-28 | 2005-11-18 | Johnson & Johnson Consumer | |
| US6551604B1 (en) * | 1999-06-28 | 2003-04-22 | The Procter & Gamble Company | Skin care compositions |
| DE19941769A1 (de) * | 1999-09-02 | 2001-03-08 | Beiersdorf Ag | Wirkstoffkombinationen bzw. Addukte aus Biotin und/oder Biotinderivaten und Cyclodextrinen und Verwendung solcher Wirkstoffkombinationen in kosmetischen Zubereitungen |
| JP4786127B2 (ja) * | 2002-07-12 | 2011-10-05 | 任康 高田 | 色素沈着改善治療薬 |
| CN1816287A (zh) * | 2003-01-31 | 2006-08-09 | 宝洁公司 | 改善哺乳动物角质组织外观的方法 |
| EP1449514A1 (de) * | 2003-02-13 | 2004-08-25 | Beiersdorf AG | Hautpflegeprodukte mit Retinoiden, Ubichinonen sowie Biotin oder Carnitin |
-
2004
- 2004-04-28 US US10/833,983 patent/US20050048012A1/en not_active Abandoned
- 2004-08-12 CN CN200480024360XA patent/CN1842318B/zh not_active Expired - Lifetime
- 2004-08-12 EP EP07016471.0A patent/EP1872772B1/de not_active Expired - Lifetime
- 2004-08-12 JP JP2006524277A patent/JP4755985B2/ja not_active Expired - Lifetime
- 2004-08-12 WO PCT/EP2004/009048 patent/WO2005020877A2/de not_active Ceased
- 2004-08-12 BR BRPI0414010-9A patent/BRPI0414010B1/pt active IP Right Grant
- 2004-08-12 ES ES04764050T patent/ES2304161T3/es not_active Expired - Lifetime
- 2004-08-12 ES ES07016471.0T patent/ES2547852T3/es not_active Expired - Lifetime
- 2004-08-12 EP EP04764050A patent/EP1658039B1/de not_active Expired - Lifetime
- 2004-08-12 DE DE502004007294T patent/DE502004007294D1/de not_active Expired - Lifetime
- 2004-08-12 AT AT04764050T patent/ATE396695T1/de not_active IP Right Cessation
- 2004-08-12 KR KR1020067003887A patent/KR101088604B1/ko not_active Expired - Lifetime
- 2004-08-12 PL PL04764050T patent/PL1658039T3/pl unknown
- 2004-08-12 MX MXPA06000464A patent/MXPA06000464A/es unknown
- 2004-08-12 US US10/569,784 patent/US20070020206A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1872772A1 (de) | 2008-01-02 |
| JP4755985B2 (ja) | 2011-08-24 |
| EP1658039B1 (de) | 2008-05-28 |
| PL1658039T3 (pl) | 2008-10-31 |
| BRPI0414010B1 (pt) | 2021-03-16 |
| WO2005020877A2 (de) | 2005-03-10 |
| EP1872772B1 (de) | 2015-08-05 |
| JP2007503407A (ja) | 2007-02-22 |
| DE502004007294D1 (de) | 2008-07-10 |
| US20070020206A1 (en) | 2007-01-25 |
| CN1842318B (zh) | 2011-04-13 |
| ES2304161T3 (es) | 2008-09-16 |
| CN1842318A (zh) | 2006-10-04 |
| EP1658039A2 (de) | 2006-05-24 |
| MXPA06000464A (es) | 2006-04-11 |
| ES2547852T3 (es) | 2015-10-09 |
| US20050048012A1 (en) | 2005-03-03 |
| WO2005020877A3 (de) | 2005-07-14 |
| KR101088604B1 (ko) | 2011-11-30 |
| KR20060069472A (ko) | 2006-06-21 |
| ATE396695T1 (de) | 2008-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0414010A (pt) | uso de biotina ou de um derivado de biotina com a finalidade de clareamento da pele e para o trtamento de lentiginas senis | |
| US8568749B2 (en) | Systems and methods for skin rejuvenation | |
| WO2004068970A3 (en) | Means for improving the appearance of mammalian keratinous tissue | |
| BRPI0519195A2 (pt) | composiÇço de cuidado oral, e, mÉtodo para prevenir ou tratar cÁrie dental em um indivÍduo humano ou animal | |
| BRPI0416052A (pt) | composição para tratamento de pele contendo ácido deidro acético e ativos para tratamento de pele | |
| BRPI0408062A (pt) | regulação de tecido queratinoso de mamìferos usando composições com hexamidina | |
| DE59504241D1 (de) | Kombinationspräparat zur förderung des haarwachstums und ggf. des haut- und nagelwachstums sowie zur verhinderung bzw. zur beseitigung von haarausfall | |
| GB0420888D0 (en) | Compounds and uses | |
| AU2019204136B2 (en) | Compositions and methods for treating skin conditions using light and glucosamine hydrochloride | |
| Bellad et al. | Development ofcosmeceuticals | |
| WO2004071538A3 (en) | Topical delivery of cosmetic agents | |
| MXPA03010429A (es) | Producto topico con indicador visual. | |
| BR0306306A (pt) | Composição contendo extrato de matricária e uso desta | |
| EP1192949A4 (en) | PREVENTIVE OR THERAPEUTIC DRUGS FOR TREATING FIBROSIS AND CONTAINING CHYMASE INHIBITORS AS ACTIVE INGREDIENTS | |
| EP1074245A3 (en) | Composition using mineral salts for therapeutic treatment | |
| JP7214350B2 (ja) | 光及びポリカルボン酸を使用して皮膚疾患を治療するための組成物及び方法 | |
| MX2007014427A (es) | Regulacion del tejido queratinoso de mamiferos utilizando activos para el cuidado de la piel o el cabello. | |
| CA2494473A1 (en) | Stabilized protein compositions for topical administration and methods of making same | |
| TW201424764A (zh) | 膠原蛋白刺激物及其於處理皮膚之用途 | |
| BRPI0418764A (pt) | uso de espinosina ou um derivado ou sal da mesma fisiologicamente aceitável | |
| ES2169942T3 (es) | Uso de preparaciones topicas de trinitrato de glicerilo y lanolina para el tratamiento de la disfuncion erectil. | |
| BR0316029A (pt) | Combinação | |
| WO2007050423A3 (en) | Skin rejuvinating supplement | |
| RU2793250C2 (ru) | Композиция и способы лечения патологических состояний кожи; использование света и гидрохлорида глюкозамина | |
| DE602004030725D1 (de) | Dermatologische und/oder kosmetische zusammensetzung mit polypeptiden |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O ARTIGO 8O C/C 11 E 8O C/C 13 DA LPI. |
|
| B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Ipc: A61K 31/375 (2006.01), A61K 8/67 (2006.01), A61K 3 |
|
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/03/2021, OBSERVADAS AS CONDICOES LEGAIS. |