BRPI0414014A - métodos para distribuição intradérmica de agentes terapêuticos - Google Patents

métodos para distribuição intradérmica de agentes terapêuticos

Info

Publication number
BRPI0414014A
BRPI0414014A BRPI0414014-1A BRPI0414014A BRPI0414014A BR PI0414014 A BRPI0414014 A BR PI0414014A BR PI0414014 A BRPI0414014 A BR PI0414014A BR PI0414014 A BRPI0414014 A BR PI0414014A
Authority
BR
Brazil
Prior art keywords
methods
agents
therapeutic agents
present
delivery
Prior art date
Application number
BRPI0414014-1A
Other languages
English (en)
Inventor
Ronald J Pettis
Alfred Harvey
Robert Campbell
John Mikszta
John Brittingham
Original Assignee
Becton Dickinson Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson Co filed Critical Becton Dickinson Co
Publication of BRPI0414014A publication Critical patent/BRPI0414014A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"MéTODOS PARA DISTRIBUIçãO INTRADéRMICA DE AGENTES TERAPêUTICOS". A presente invenção refere-se a métodos e dispositivos para distribuição de um ou mais agentes biologicamente ativos, particularmente agentes terapêuticos, ao compartimento intradérmico da pele de um paciente. A presente invenção proporciona um método para distribuição de agentes biologicamente ativos, tais como agentes terapêuticos, através da vasculatura linfática acessada pela distribuição intradérmica. Agentes terapêuticos a serem distribuídos de acordo com a presente invenção incluem, mas sem limitação, agentes antineoplásicos, agentes quimioterapêuticos, anticorpos, antibióticos, agentes anti-angiogênese, e agentes imunoterapêuticos. Agentes terapêuticos distribuídos de acordo com a presente invenção têm biodisponibilidade aperfeiçoada, incluindo distribuição sistêmica aperfeiçoada e distribuição aperfeiçoada para tecidos particulares. Agentes terapêuticos distribuídos de acordo com os métodos da invenção têm uma utilidade clínica aperfeiçoada e eficácia terapêutica aperfeiçoada com relação a outros métodos de distribuição de drogas, incluindo distribuição intraperitonial, intramuscular e subcutânea. Os métodos da presente invenção proporcionam benefícios e aperfeiçoamentos com relação a métodos convencionais de distribuição de droga, incluindo dosagem moderada, eficácia da droga aumentada, efeitos colaterais reduzidos, potencial metastático reduzido e sobrevivência prolongada.
BRPI0414014-1A 2003-08-26 2004-06-14 métodos para distribuição intradérmica de agentes terapêuticos BRPI0414014A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49770203P 2003-08-26 2003-08-26
US55019704P 2004-03-03 2004-03-03
PCT/US2004/019118 WO2005023328A2 (en) 2003-08-26 2004-06-14 Methods for intradermal delivery of therapeutics agents

Publications (1)

Publication Number Publication Date
BRPI0414014A true BRPI0414014A (pt) 2006-10-24

Family

ID=34278560

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414014-1A BRPI0414014A (pt) 2003-08-26 2004-06-14 métodos para distribuição intradérmica de agentes terapêuticos

Country Status (8)

Country Link
US (1) US20050180952A1 (pt)
EP (1) EP1658078A4 (pt)
JP (1) JP2007503435A (pt)
AU (1) AU2004270113A1 (pt)
BR (1) BRPI0414014A (pt)
CA (1) CA2536669A1 (pt)
MX (1) MXPA06002159A (pt)
WO (1) WO2005023328A2 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0526849A (ja) * 1991-07-17 1993-02-02 Hitachi Building Syst Eng & Service Co Ltd 磁気探傷装置
JP2004531578A (ja) * 2001-06-29 2004-10-14 ベクトン・ディキンソン・アンド・カンパニー ワクチンおよび遺伝子治療剤のマイクロカニューレによる皮内送達
US20060018877A1 (en) * 2001-06-29 2006-01-26 Mikszta John A Intradermal delivery of vacccines and therapeutic agents
EP1635876A4 (en) * 2003-06-13 2009-05-06 Becton Dickinson Co IMPROVED INTRADERMAL ADMINISTRATION OF BIOACTIVE AGENTS
WO2005086773A2 (en) * 2004-03-08 2005-09-22 Becton Dickinson And Company A method for delivering therapeutic proteins to the intradermal compartment
WO2006031500A2 (en) 2004-09-10 2006-03-23 Becton, Dickinson And Company Reconstituting infusion device
US20070088414A1 (en) * 2005-05-25 2007-04-19 Campbell Robert L Particulate formulations for intradermal delivery of biologically active agents
KR100700869B1 (ko) * 2005-06-03 2007-03-29 재단법인 목암생명공학연구소 Ｐｔｈ, 완충제 및 안정제를 포함하는 안정한 ｐｔｈ조성물
GT200600397A (es) * 2005-09-07 2007-08-28 Formulas topicas conteniendo o-desmetil venlafaxina (odv) o sus sales
EP1999147A1 (en) * 2006-03-27 2008-12-10 Ablynx N.V. Medical delivery device for therapeutic proteins based on single domain antibodies
US8614192B2 (en) * 2006-07-28 2013-12-24 Leiden University Medical Center Method for treating ocular cancer
US7811254B2 (en) * 2006-10-18 2010-10-12 Meridian Medical Technologies, Inc. Autoinjector with needle depth adapter
WO2009062174A1 (en) * 2007-11-08 2009-05-14 University Of Utah Research Foundation Use of angiogenesis antagonists in conditions of abnormal venous proliferation
WO2010111533A2 (en) * 2009-03-25 2010-09-30 Kai Pharmaceuticals, Inc. Transdermal delivery of pkc modulatory peptides through microporated skin
US9345661B2 (en) * 2009-07-31 2016-05-24 Genentech, Inc. Subcutaneous anti-HER2 antibody formulations and uses thereof
AR078161A1 (es) 2009-09-11 2011-10-19 Hoffmann La Roche Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento.
ES2782999T3 (es) 2009-11-06 2020-09-16 Aerpio Therapeutics Inc Composiciones y métodos para tratar la colitis
US8814831B2 (en) * 2010-11-30 2014-08-26 Becton, Dickinson And Company Ballistic microneedle infusion device
US8784383B2 (en) * 2010-11-30 2014-07-22 Becton, Dickinson And Company Insulin pump dermal infusion set having partially integrated mechanized cannula insertion with disposable activation portion
MX343262B (es) 2011-10-27 2016-10-28 Kimberly Clark Co Administración transdérmica de agentes bioactivos de alta viscosidad.
CA2991455C (en) 2015-07-24 2023-10-10 Kimberly-Clark Worldwide, Inc. Methods for better delivery of active agents to tumors
PL3325081T3 (pl) 2015-07-24 2021-12-20 Sorrento Therapeutics, Inc. Sposoby dostarczania limfatycznego środków czynnych
IL249795B (en) * 2016-02-05 2020-01-30 Grifols Worldwide Operations Ltd Intradermal administration of an immunoglobulin preparation g
KR102168749B1 (ko) * 2017-11-17 2020-10-22 한양대학교 산학협력단 비강을 통한 뇌 약물 전달 장치 및 비강을 통한 뇌 약물 전달 방법
MX2020012789A (es) * 2018-05-31 2021-04-28 Sorrento Therapeutics Inc Métodos de suministro de fármacos dirigidos al sistema linfático.
US20220362530A1 (en) * 2019-09-23 2022-11-17 Aquavit Pharmaceuticals, Inc. Methods for treating neoplastic conditions of the skin
US11202753B1 (en) 2020-03-06 2021-12-21 Aquavit Pharmaceuticals, Inc. Systems and methods for generating immune responses in subjects using microchannel delivery devices

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2619962A (en) * 1948-02-19 1952-12-02 Res Foundation Vaccination appliance
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3914097A (en) * 1974-02-01 1975-10-21 Eastman Kodak Co Sheet guide and cooling apparatus
US4270537A (en) * 1979-11-19 1981-06-02 Romaine Richard A Automatic hypodermic syringe
IE53703B1 (en) * 1982-12-13 1989-01-18 Elan Corp Plc Drug delivery device
US4886499A (en) * 1986-12-18 1989-12-12 Hoffmann-La Roche Inc. Portable injection appliance
AU614092B2 (en) * 1987-09-11 1991-08-22 Paul Max Grinwald Improved method and apparatus for enhanced drug permeation of skin
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5098389A (en) * 1990-06-28 1992-03-24 Becton, Dickinson And Company Hypodermic needle assembly
TW279133B (pt) * 1990-12-13 1996-06-21 Elan Med Tech
US5156591A (en) * 1990-12-13 1992-10-20 S. I. Scientific Innovations Ltd. Skin electrode construction and transdermal drug delivery device utilizing same
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5527288A (en) * 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
SE9102652D0 (sv) * 1991-09-13 1991-09-13 Kabi Pharmacia Ab Injection needle arrangement
US5279552A (en) * 1993-01-11 1994-01-18 Anton Magnet Intradermal injection device
CA2132277C (en) * 1993-10-22 2005-05-10 Giorgio Cirelli Injection device
US5997501A (en) * 1993-11-18 1999-12-07 Elan Corporation, Plc Intradermal drug delivery device
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US5582591A (en) * 1994-09-02 1996-12-10 Delab Delivery of solid drug compositions
IE72524B1 (en) * 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
WO1996037155A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
US5801057A (en) * 1996-03-22 1998-09-01 Smart; Wilson H. Microsampling device and method of construction
CN1226180A (zh) * 1996-06-10 1999-08-18 伊兰股份有限公司 皮下注射流体的针头
US5871158A (en) * 1997-01-27 1999-02-16 The University Of Utah Research Foundation Methods for preparing devices having metallic hollow microchannels on planar substrate surfaces
US5928207A (en) * 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
US6977074B2 (en) * 1997-07-10 2005-12-20 Mannkind Corporation Method of inducing a CTL response
US6994851B1 (en) * 1997-07-10 2006-02-07 Mannkind Corporation Method of inducing a CTL response
US6007821A (en) * 1997-10-16 1999-12-28 Fordham University Method and compositions for the treatment of autoimmune disease using heat shock proteins
IE970782A1 (en) * 1997-10-22 1999-05-05 Elan Corp An improved automatic syringe
US6482176B1 (en) * 1997-11-27 2002-11-19 Disetronic Licensing Ag Method and device for controlling the introduction depth of an injection needle
IT1298087B1 (it) * 1998-01-08 1999-12-20 Fiderm S R L Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni
US5957895A (en) * 1998-02-20 1999-09-28 Becton Dickinson And Company Low-profile automatic injection device with self-emptying reservoir
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6423308B1 (en) * 1998-09-15 2002-07-23 Wyeth Treatment of Kaposi's sarcoma with IL-12
GB9827104D0 (en) * 1998-12-10 1999-02-03 Onyvax Ltd New cancer treatments
GB9827102D0 (en) * 1998-12-10 1999-02-03 Onyvax Ltd New cancer treatments
GB9827103D0 (en) * 1998-12-10 1999-02-03 Onyvax Ltd New cancer treatments
DE19934433A1 (de) * 1999-07-22 2001-01-25 Merck Patent Gmbh N-(Indolcarbonyl-)piperazinderivate
US6319224B1 (en) * 1999-08-20 2001-11-20 Bioject Medical Technologies Inc. Intradermal injection system for injecting DNA-based injectables into humans
US20020193740A1 (en) * 1999-10-14 2002-12-19 Alchas Paul G. Method of intradermally injecting substances
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US8465468B1 (en) * 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US20020183333A1 (en) * 2000-03-29 2002-12-05 Shah Sudhir V. Compositions and methods for chemotherapy having reduced nephrotoxicity
US6537242B1 (en) * 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
CA2444391A1 (en) * 2001-04-13 2002-10-24 Becton Dickinson And Company Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption
US20030073609A1 (en) * 2001-06-29 2003-04-17 Pinkerton Thomas C. Enhanced pharmacokinetic profile of intradermally delivered substances
US20050096331A1 (en) * 2001-12-21 2005-05-05 Das Saibal K. Novel compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them
EP1635876A4 (en) * 2003-06-13 2009-05-06 Becton Dickinson Co IMPROVED INTRADERMAL ADMINISTRATION OF BIOACTIVE AGENTS
US20050096332A1 (en) * 2003-10-30 2005-05-05 Boehringer Ingelheim International Gmbh Use of tyrosine kinase inhibitors for the treatment of inflammatory processes

Also Published As

Publication number Publication date
MXPA06002159A (es) 2006-05-22
US20050180952A1 (en) 2005-08-18
AU2004270113A1 (en) 2005-03-17
CA2536669A1 (en) 2005-03-17
WO2005023328A2 (en) 2005-03-17
JP2007503435A (ja) 2007-02-22
EP1658078A4 (en) 2009-05-06
WO2005023328A3 (en) 2005-11-10
EP1658078A2 (en) 2006-05-24

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.