BRPI0414272A - alvejamento de vasculatura tumoral usando l19 de anticorpo radiomarcado contra ed-b de fibronectina - Google Patents
alvejamento de vasculatura tumoral usando l19 de anticorpo radiomarcado contra ed-b de fibronectinaInfo
- Publication number
- BRPI0414272A BRPI0414272A BRPI0414272-1A BRPI0414272A BRPI0414272A BR PI0414272 A BRPI0414272 A BR PI0414272A BR PI0414272 A BRPI0414272 A BR PI0414272A BR PI0414272 A BRPI0414272 A BR PI0414272A
- Authority
- BR
- Brazil
- Prior art keywords
- domain
- antibody
- cdr1
- cdr2
- seq
- Prior art date
Links
- 102000016359 Fibronectins Human genes 0.000 title 1
- 108010067306 Fibronectins Proteins 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
- 210000005166 vasculature Anatomy 0.000 title 1
- 230000009870 specific binding Effects 0.000 abstract 4
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000027455 binding Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"ALVEJAMENTO DE VASCULATURA TUMORAL USANDO L19 DE ANTICORPO RADIOMARCADO CONTRA ED-B DE FIBRONECTINA". A presente invenção refere-se a um membro de ligação específico que liga o ED-B humano, em que o membro de ligação específico é marcado com um isótopo selecionado do grupo que consiste em 76Br, 77Br, 123I, 124I, 131I e 211At e compreende um sítio de ligação de antígeno que compreende um domínio de VH de anticorpo e um domínio de VL de anticorpo, em que o domínio de VH de anticorpo é selecionado do grupo que consiste no domínio de VH de L19, e um domínio de VH compreendendo um CDR1 de VH, uma CDR2 de VH e uma CDR3 de VH, em que a CDR3 de VH é a CDR3 de VH de L19 da SEQ ID NO. 3, a CDR1 de VH é opcionalmente CDR1 de VH de L19 da SEQ ID NO. 1 e a CDR2 de VH é opcionalmente CDR2 de VH de L19 da SEQ ID NO. 2; e em que o domínio de VL de anticorpo é opcionalmente selecionado do grupo que consiste no domínio de VL de L19, e um domínio de VL compreendendo uma CDR1 de VL, uma CDR2 de VL e uma CDR3 de VL, em que a CDR3 de VL é a CDR3 de VL de L19 da SEQ ID NO. 6, a CDR1 de VL é opcionalmente CDR1 de VL de L19 da SEQ ID NO. 4, e a CDR2 de VL é opcionalmente CDR2 de VL de L19 da SEO ID NO. 5; as seqüências de domínio de VH de L19 e de domínio de VL de L19 desndo descritas em Pini et al. (1998) J. Biol. Chem. 273: 2176921776; em que o membro de ligação específico compreende uma miniimunoglobulina compreendendo o dito domínio de VH de anticorpo e domínio de VL de anticorpo fundido com <sym>~ S2~-CH4 e dimerizado ou compreende uma molécula de anticorpo de IgG1 inteiro; também métodos e usos empregando um tal membro de ligação especificado.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50188103P | 2003-09-10 | 2003-09-10 | |
| EP03255633A EP1514561A1 (en) | 2003-09-10 | 2003-09-10 | Targeting of tumor vasculature using radiolabelled antibody L19 against fibronectin ED-B |
| PCT/EP2004/009733 WO2005023318A1 (en) | 2003-09-10 | 2004-09-01 | Targeting of tumor vasculature using radiolabelled antibody l19 against fibronectin ed-b |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0414272A true BRPI0414272A (pt) | 2006-11-07 |
Family
ID=34130349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0414272-1A BRPI0414272A (pt) | 2003-09-10 | 2004-09-01 | alvejamento de vasculatura tumoral usando l19 de anticorpo radiomarcado contra ed-b de fibronectina |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US20050074401A1 (pt) |
| EP (3) | EP1514561A1 (pt) |
| JP (1) | JP2007505065A (pt) |
| KR (1) | KR101129161B1 (pt) |
| CN (1) | CN100482285C (pt) |
| AT (1) | ATE499949T1 (pt) |
| AU (2) | AU2004269897B2 (pt) |
| BR (1) | BRPI0414272A (pt) |
| CA (1) | CA2536256C (pt) |
| CR (2) | CR8331A (pt) |
| DE (1) | DE602004031635D1 (pt) |
| DK (1) | DK1663320T3 (pt) |
| EA (1) | EA010653B1 (pt) |
| EC (1) | ECSP066499A (pt) |
| ES (1) | ES2361743T3 (pt) |
| IL (1) | IL173560A0 (pt) |
| ME (1) | MEP13108A (pt) |
| NO (1) | NO20061619L (pt) |
| NZ (1) | NZ545640A (pt) |
| PL (1) | PL1663320T3 (pt) |
| PT (1) | PT1663320E (pt) |
| RS (1) | RS20060176A (pt) |
| SG (1) | SG162760A1 (pt) |
| SI (1) | SI1663320T1 (pt) |
| UA (1) | UA89759C2 (pt) |
| WO (1) | WO2005023318A1 (pt) |
| ZA (1) | ZA200602014B (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003524018A (ja) * | 2000-02-24 | 2003-08-12 | アイトゲネーシシェ テクニシェ ホッホシューレ チューリッヒ | フィブロネクチンのｅｄ‐ｂドメインに特異的な抗体、前記抗体を含む複合体、および血管形成を検出および治療するためのその使用 |
| EP2174958A1 (en) * | 2002-03-11 | 2010-04-14 | Philogen S.p.A. | Antibodies derived from anti ed-b l19 and targeting tumor vasculature |
| US7785591B2 (en) | 2004-10-14 | 2010-08-31 | Morphosys Ag | Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies |
| ATE548052T1 (de) * | 2008-01-17 | 2012-03-15 | Philogen Spa | Kombination aus einem anti-edb-fibronectin- antikörper-il-2-fusionsprotein und einem b-zellen bindenden molekül, b-zellen-vorläufern und/oder deren krebserregendem gegenspieler |
| NZ610239A (en) | 2008-04-30 | 2014-11-28 | Immunogen Inc | Cross-linkers and their uses |
| AU2015202204A1 (en) * | 2008-04-30 | 2015-05-14 | Immunogen, Inc. | Cross-linkers and their uses |
| WO2011147762A2 (en) * | 2010-05-25 | 2011-12-01 | Bayer Pharma Aktiengesellschaft | Stabilized radiopharmaceutical composition |
| CN104395342B (zh) * | 2013-06-06 | 2017-07-04 | 合肥立方制药股份有限公司 | 人源抗纤连蛋白ed‑b结构域的抗体及其用途 |
| GB201621806D0 (en) | 2016-12-21 | 2017-02-01 | Philogen Spa | Immunocytokines with progressive activation mechanism |
| US10517238B2 (en) | 2017-09-18 | 2019-12-31 | Deere & Company | Implement optimization by automated adjustments |
| WO2020249757A1 (en) | 2019-06-14 | 2020-12-17 | Philogen S.P.A | Immunoconjugates comprising a single chain diabody and interleukin-15 or interleukin-15 and a sushi domain of interleukin-15 receptor alpha |
| JP7352040B2 (ja) | 2020-05-22 | 2023-09-27 | フィロジェン エッセ．ピー．アー． | 脳腫瘍の治療のためのＴＮＦα免疫コンジュゲート療法 |
| CN111808161A (zh) * | 2020-06-01 | 2020-10-23 | 北京大学 | 一种对生物化合物进行放射性标记的方法 |
| JP7690131B2 (ja) | 2022-01-04 | 2025-06-09 | フィロジェン ソチエタ ペル アツィオーニ | Ｉｌ－１２を含むイムノサイトカインとキナーゼ阻害剤の組合せ |
| WO2025061801A1 (en) | 2023-09-19 | 2025-03-27 | Philochem Ag | Therapeutic combination of an anti-edb fibronectin domain antibody il2 or il12 fusion protein and a lutetium-177 radioconjugate |
| WO2026003203A1 (en) | 2024-06-27 | 2026-01-02 | Philogen S.P.A. | Combination of an immunocytokine comprising targeted il2 and a jak inhibitor |
| CN119775344B (zh) * | 2024-12-31 | 2025-08-26 | 英科新创（苏州）生物科技有限公司 | 水溶性吖啶磺酰胺衍生物、制备方法、其应用及试剂盒 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US20030045681A1 (en) * | 1998-05-11 | 2003-03-06 | Anthony J. Zelano | Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis |
| JP2003524018A (ja) * | 2000-02-24 | 2003-08-12 | アイトゲネーシシェ テクニシェ ホッホシューレ チューリッヒ | フィブロネクチンのｅｄ‐ｂドメインに特異的な抗体、前記抗体を含む複合体、および血管形成を検出および治療するためのその使用 |
| AU2001239470A1 (en) | 2000-02-24 | 2001-09-03 | Philogen S.R.L. | Compositions and methods for treatment of angiogenesis in pathological lesions |
| WO2001096599A2 (en) * | 2000-06-15 | 2001-12-20 | Philogen S.R.L. | Methods for quantitative determination of b-fibronectin in biological fluids and tissues |
| MXPA04006517A (es) * | 2002-01-03 | 2005-03-31 | Schering Ag | Conjugados que comprenden un anticuerpo especifico para el dominio ed-b de fibronectina y sus usos para la deteccion y tratamiento de tumores. |
| EP2174958A1 (en) * | 2002-03-11 | 2010-04-14 | Philogen S.p.A. | Antibodies derived from anti ed-b l19 and targeting tumor vasculature |
-
2003
- 2003-09-10 EP EP03255633A patent/EP1514561A1/en not_active Withdrawn
-
2004
- 2004-09-01 EA EA200600494A patent/EA010653B1/ru not_active IP Right Cessation
- 2004-09-01 AT AT04764695T patent/ATE499949T1/de active
- 2004-09-01 DE DE602004031635T patent/DE602004031635D1/de not_active Expired - Lifetime
- 2004-09-01 JP JP2006525703A patent/JP2007505065A/ja active Pending
- 2004-09-01 CA CA2536256A patent/CA2536256C/en not_active Expired - Fee Related
- 2004-09-01 AU AU2004269897A patent/AU2004269897B2/en not_active Ceased
- 2004-09-01 PL PL04764695T patent/PL1663320T3/pl unknown
- 2004-09-01 SG SG201003976-6A patent/SG162760A1/en unknown
- 2004-09-01 SI SI200431651T patent/SI1663320T1/sl unknown
- 2004-09-01 WO PCT/EP2004/009733 patent/WO2005023318A1/en not_active Ceased
- 2004-09-01 ES ES04764695T patent/ES2361743T3/es not_active Expired - Lifetime
- 2004-09-01 RS YUP-2006/0176A patent/RS20060176A/sr unknown
- 2004-09-01 DK DK04764695.5T patent/DK1663320T3/da active
- 2004-09-01 UA UAA200603803A patent/UA89759C2/ru unknown
- 2004-09-01 CN CNB2004800260484A patent/CN100482285C/zh not_active Expired - Fee Related
- 2004-09-01 NZ NZ545640A patent/NZ545640A/xx unknown
- 2004-09-01 EP EP04764695A patent/EP1663320B1/en not_active Expired - Lifetime
- 2004-09-01 BR BRPI0414272-1A patent/BRPI0414272A/pt not_active IP Right Cessation
- 2004-09-01 ME MEP-131/08A patent/MEP13108A/xx unknown
- 2004-09-01 EP EP10008347A patent/EP2246070A2/en not_active Withdrawn
- 2004-09-01 KR KR1020067004816A patent/KR101129161B1/ko not_active Expired - Fee Related
- 2004-09-01 PT PT04764695T patent/PT1663320E/pt unknown
- 2004-09-10 US US10/937,882 patent/US20050074401A1/en not_active Abandoned
-
2006
- 2006-02-06 IL IL173560A patent/IL173560A0/en unknown
- 2006-03-09 ZA ZA200602014A patent/ZA200602014B/en unknown
- 2006-04-06 CR CR8331A patent/CR8331A/es unknown
- 2006-04-10 EC EC2006006499A patent/ECSP066499A/es unknown
- 2006-04-10 NO NO20061619A patent/NO20061619L/no not_active Application Discontinuation
-
2009
- 2009-01-08 US US12/350,346 patent/US20090214423A1/en not_active Abandoned
-
2010
- 2010-01-22 AU AU2010200271A patent/AU2010200271A1/en not_active Abandoned
-
2011
- 2011-03-24 CR CR20110168A patent/CR20110168A/es not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CR20110168A (es) | Reconocimiento dirigido de la vasculatura tumoral usando el anticuerpo l19 contra ed-b de fibronectina marcado radioactivamente (divisional solicitud 8331) | |
| JP7828375B2 (ja) | 標的分子に対する抗原結合コンストラクト | |
| Tang et al. | Imaging of HER2/neu-positive BT-474 human breast cancer xenografts in athymic mice using 111In-trastuzumab (Herceptin) Fab fragments | |
| HRP20120701T1 (hr) | Humana monoklonska protutijela protiv fukozil-gm1 i postupci za uporabu antifukozil-gm1 | |
| WO2007062245A3 (en) | Human monoclonal antibody human cd134 (ox40) and methods of making and using same | |
| PE20020871A1 (es) | Moleculas de enlace terapeuticas | |
| WO2006089133A3 (en) | Anti-cd19 antibodies and uses in oncology | |
| HRP20160270T1 (hr) | Monoklonska antitijela protiv glipikana-3 | |
| BR0306808A (pt) | Anticorpos monoclonais humanos contra cd30 | |
| AU2003219370B2 (en) | Antibodies derived rom anti ED-B L19 and targeting tumor vasculature | |
| MA28430B1 (fr) | Anticorps a madcam. | |
| NZ594466A (en) | Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and methods for using anti-PTK7 antibodies | |
| SG153825A1 (en) | Multivalent immunoglobulin-based bioactive assemblies | |
| WO2006121852A3 (en) | Anti-cd19 antibody therapy for autoimmune disease | |
| WO2006133450A3 (en) | Anti-cd19 antibody therapy for the transplantation | |
| CY1110033T1 (el) | Τεχνητα ανθρωπινα θεραπευτικα αντισωματα εναντια σε ισομορφες cd45 | |
| PE20121397A1 (es) | Anticuerpos especificos para cadherina-17 | |
| PT1299421E (pt) | Anticorpos para a mcp-1 humana | |
| ZA200508389B (en) | Humanized antibodies to interferon alpha receptor-1(IFNAR-1) | |
| WO2003055917A3 (en) | Conjugates comprising an antibody specific for the ed-b domain of fibronectin and their use for the detection and treatment of tumours | |
| Ma et al. | Radioimmunotherapy for model B cell malignancies using 90Y-labeled anti-CD19 and anti-CD20 monoclonal antibodies | |
| DK1411962T3 (da) | Terapi for pancreacancer med monoklonalt stof | |
| WO2000074729A3 (en) | Alpha or beta emitters to fragments in radioimmunotherapy | |
| Tang et al. | Construction and evaluation of the tumor imaging properties of 123I-labeled recombinant and enzymatically generated Fab fragments of the TAG-72 monoclonal antibody CC49 | |
| JP2007508352A5 (pt) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved |
Owner name: PHILOGEN S.P.A. (IT) , BAYER SCHERING PHARMA AKTIE Free format text: NOME ALTERADO DE: SCHERING AKTIENGESELLSCHAFT |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B25D | Requested change of name of applicant approved |
Owner name: PHILOGEN S.P.A. (IT) , BAYER PHARMA AKTIENGESELLSC |
|
| B25A | Requested transfer of rights approved |
Owner name: PHILOGEN S.P.A. (IT) |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |