BRPI0414423A - inibidores de pace4, suas composições farmacêuticas e respectivos usos - Google Patents

inibidores de pace4, suas composições farmacêuticas e respectivos usos

Info

Publication number
BRPI0414423A
BRPI0414423A BRPI0414423-6A BRPI0414423A BRPI0414423A BR PI0414423 A BRPI0414423 A BR PI0414423A BR PI0414423 A BRPI0414423 A BR PI0414423A BR PI0414423 A BRPI0414423 A BR PI0414423A
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
pace4 inhibitors
pace4
inhibitors
compositions
Prior art date
Application number
BRPI0414423-6A
Other languages
English (en)
Inventor
Anne-Marie Malfait
Micky D Tortorella
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BRPI0414423A publication Critical patent/BRPI0414423A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"INIBIDORES DE PACE4, SUAS COMPOSIçõES FARMACêUTICAS E RESPECTIVOS USOS". A presente invenção refere-se a métodos e composições para tratamento de artrite utilizando inibidores de PACE4.
BRPI0414423-6A 2003-09-16 2004-09-12 inibidores de pace4, suas composições farmacêuticas e respectivos usos BRPI0414423A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50319603P 2003-09-16 2003-09-16
PCT/IB2004/002948 WO2005025611A1 (en) 2003-09-16 2004-09-12 Inhibitors of pace4 for the treatment of arthritis

Publications (1)

Publication Number Publication Date
BRPI0414423A true BRPI0414423A (pt) 2006-11-14

Family

ID=34312434

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414423-6A BRPI0414423A (pt) 2003-09-16 2004-09-12 inibidores de pace4, suas composições farmacêuticas e respectivos usos

Country Status (7)

Country Link
US (1) US20050090466A1 (pt)
EP (1) EP1663300A1 (pt)
JP (1) JP2007505887A (pt)
BR (1) BRPI0414423A (pt)
CA (1) CA2539300A1 (pt)
MX (1) MXPA06002916A (pt)
WO (1) WO2005025611A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8658591B2 (en) 2008-07-11 2014-02-25 Robert Day Multi-LEU peptides and analogues thereof as selective PACE4 inhibitors and effective antiproliferative agents
US20130149295A1 (en) * 2010-05-12 2013-06-13 Martine Cohen-Solal Furin and biologically active derivatives thereof for use in the prevention or treatment of an inflammatory disease
WO2013029180A1 (en) 2011-09-02 2013-03-07 Socpra Sciences Santé Et Humaines S.E.C. Stable peptide-based pace4 inhibitors
WO2025097674A1 (zh) * 2023-11-08 2025-05-15 安炎达医药技术(广州)有限公司 一种新型pace4抑制剂及其在抗骨关节炎中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018159A2 (en) * 1992-03-09 1993-09-16 Chiron Corporation Compositions and methods for pace 4 and 4.1 gene and polypeptides in cells
US6506559B1 (en) * 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
EP1272630A2 (en) * 2000-03-16 2003-01-08 Genetica, Inc. Methods and compositions for rna interference
EP1409658A4 (en) * 2001-07-05 2006-08-23 Wyeth Corp Aggrecanase MOLECULES
GB0217136D0 (en) * 2002-07-24 2002-09-04 Renovo Ltd Wound healing & treatment of fibrosis
US20040086860A1 (en) * 2002-10-04 2004-05-06 Muhammad Sohail Methods of producing RNAs of defined length and sequence
US20040077082A1 (en) * 2002-10-18 2004-04-22 Koehn Richard K. RNA-based inhibitory oligonucleotides

Also Published As

Publication number Publication date
CA2539300A1 (en) 2005-03-24
JP2007505887A (ja) 2007-03-15
WO2005025611A1 (en) 2005-03-24
EP1663300A1 (en) 2006-06-07
US20050090466A1 (en) 2005-04-28
MXPA06002916A (es) 2006-05-31

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.