BRPI0414580A - derivado do ácido fenilacético, processos para sua produção e uso - Google Patents
derivado do ácido fenilacético, processos para sua produção e usoInfo
- Publication number
- BRPI0414580A BRPI0414580A BRPI0414580-1A BRPI0414580A BRPI0414580A BR PI0414580 A BRPI0414580 A BR PI0414580A BR PI0414580 A BRPI0414580 A BR PI0414580A BR PI0414580 A BRPI0414580 A BR PI0414580A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- processes
- production
- acid derivative
- phenylacetic acid
- Prior art date
Links
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical class OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 abstract 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 230000001270 agonistic effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000037356 lipid metabolism Effects 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005750 substituted cyclic group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
"DERIVADO DO áCIDO FENILACéTICO, PROCESSOS PARA SUA PRODUçãO E USO". Descreve-se um composto representado pela fórmula geral (I): (I) (onde R¬ 1¬ e R¬ 2¬ representam cada qual, hidrogênio, C~ 1-8~ alquila, etc; R¬ 3¬ representa, ou C~ 1-8~ alquila opcionalmente substituído com 1-3 átomos de halogênio ou fenila; R¬ 4¬ representa hidrogênio etc.; R¬ 5¬ e R¬ 6¬ representam, cada qual, hidrogênio, C~ 1-8~ alquila, etc.; X representa enxofre, oxigênio, etc.; e o anel A representa um grupo cíclico opcionalmente substituído) ou um sal do mesmo. O composto representado pela fórmula geral (I) possui toxicidade extremamente baixa, sendo portanto, útil como um produto medicinal seguro. Ele possui atividade agonística para PPAR <sym>, sendo portanto, útil como um agente terapêutico preventivo e/ou terapêutico em doenças ocasionadas pelo metabolismo anormal de açúcar/lipídio, hipertensão, doenças circulatórias, etc.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003330616 | 2003-09-22 | ||
| JP2004231546 | 2004-08-06 | ||
| PCT/JP2004/014137 WO2005028453A1 (ja) | 2003-09-22 | 2004-09-21 | フェニル酢酸誘導体、その製造方法および用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0414580A true BRPI0414580A (pt) | 2006-11-07 |
Family
ID=34380351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0414580-1A BRPI0414580A (pt) | 2003-09-22 | 2004-09-21 | derivado do ácido fenilacético, processos para sua produção e uso |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7560475B2 (pt) |
| EP (1) | EP1666472B1 (pt) |
| JP (1) | JP4661595B2 (pt) |
| KR (1) | KR20060121884A (pt) |
| AU (1) | AU2004274337A1 (pt) |
| BR (1) | BRPI0414580A (pt) |
| CA (1) | CA2539554A1 (pt) |
| ES (1) | ES2390053T3 (pt) |
| IL (1) | IL174438A0 (pt) |
| MX (1) | MXPA06003205A (pt) |
| NO (1) | NO20061281L (pt) |
| NZ (1) | NZ546031A (pt) |
| RU (1) | RU2349587C2 (pt) |
| WO (1) | WO2005028453A1 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004076798A2 (en) | 2003-02-26 | 2004-09-10 | Enventure Global Technology | Apparatus for radially expanding and plastically deforming a tubular member |
| EP1940767A2 (en) * | 2005-09-07 | 2008-07-09 | Plexxikon, Inc. | Pparactive compounds |
| KR100806162B1 (ko) * | 2006-11-30 | 2008-02-22 | (주)아모레퍼시픽 | 식물유래 ＰＰＡＲｓ 활성물질을 함유하는 피부 외용제조성물 |
| US8367708B2 (en) | 2006-12-01 | 2013-02-05 | Msd K.K. | Phenyl-isoxazol-3-ol derivative |
| FR2910893A1 (fr) * | 2006-12-29 | 2008-07-04 | Genfit Sa | Derives de (phenylthiazolyl)-phenyl-propan-1-one et de (phenyloxazolyl)-phenyl-propan-1-one substitues, preparations et utilisations. |
| WO2011030104A1 (en) * | 2009-09-09 | 2011-03-17 | Rajiv Jalan | Phenylacetate and/or phenylbutyrate (not ornithine) for reducing portal blood pressure |
| CN102285933B (zh) | 2010-06-18 | 2016-03-09 | 浙江海正药业股份有限公司 | 一种对亚型过氧化物酶增殖物激活受体具有激动作用的化合物、其制备方法和应用 |
| RU2447082C1 (ru) * | 2011-01-19 | 2012-04-10 | Федеральное Государственное Бюджетное Учреждение "Научно-Исследовательский Институт Эпидемиологии И Микробиологии Имени Почетного Академика Н.Ф. Гамалеи" Министерства Здравоохранения И Социального Развития Российской Федерации | Способ стимуляции регенерации дефектов кожи и слизистых оболочек и лекарственное средство для его реализации |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW222626B (pt) * | 1991-07-22 | 1994-04-21 | Pfizer | |
| DE4427294C2 (de) | 1994-08-02 | 1996-08-22 | Kim Kyung Shin Dipl Designerin | Verfahren zur Herstellung von Schmuck-, Dekorations- und Kunstgegenständen aus einer Metallfolie oder aus einem Metallnetz mit unregelmäßig gefalteter Struktur |
| JPH09168441A (ja) | 1995-12-21 | 1997-06-30 | Elecom Kk | ラック |
| GB9606805D0 (en) | 1996-03-30 | 1996-06-05 | Glaxo Wellcome Inc | Medicaments |
| JP4345230B2 (ja) * | 1998-03-10 | 2009-10-14 | 小野薬品工業株式会社 | カルボン酸誘導体およびその誘導体を有効成分として含有する薬剤 |
| GB9914977D0 (en) | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
| DK1206457T3 (da) * | 1999-08-27 | 2004-02-16 | Lilly Co Eli | Biaryl-oxa(thia)zolderivater og deres anvendelse som modulatorer PPAP'ER |
| JP4148681B2 (ja) * | 2000-12-28 | 2008-09-10 | 武田薬品工業株式会社 | アルカン酸誘導体、その製造法および用途 |
| US20030092736A1 (en) * | 2001-05-30 | 2003-05-15 | Cheng Peter T. | Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method |
| JP2005529077A (ja) * | 2002-02-25 | 2005-09-29 | イーライ・リリー・アンド・カンパニー | ペルオキシソーム増殖因子活性化受容体調節物質 |
| DE60324898D1 (de) * | 2002-02-25 | 2009-01-08 | Lilly Co Eli | Modulatoren von peroxisome proliferator-aktivierten rezeptoren |
-
2004
- 2004-09-21 KR KR1020067005655A patent/KR20060121884A/ko not_active Withdrawn
- 2004-09-21 WO PCT/JP2004/014137 patent/WO2005028453A1/ja not_active Ceased
- 2004-09-21 NZ NZ546031A patent/NZ546031A/en unknown
- 2004-09-21 MX MXPA06003205A patent/MXPA06003205A/es unknown
- 2004-09-21 RU RU2006113612/04A patent/RU2349587C2/ru active
- 2004-09-21 EP EP04773449A patent/EP1666472B1/en not_active Expired - Lifetime
- 2004-09-21 BR BRPI0414580-1A patent/BRPI0414580A/pt not_active IP Right Cessation
- 2004-09-21 CA CA002539554A patent/CA2539554A1/en not_active Abandoned
- 2004-09-21 ES ES04773449T patent/ES2390053T3/es not_active Expired - Lifetime
- 2004-09-21 JP JP2005514140A patent/JP4661595B2/ja not_active Expired - Fee Related
- 2004-09-21 US US10/572,937 patent/US7560475B2/en not_active Expired - Fee Related
- 2004-09-21 AU AU2004274337A patent/AU2004274337A1/en not_active Abandoned
-
2006
- 2006-03-21 NO NO20061281A patent/NO20061281L/no not_active Application Discontinuation
- 2006-03-21 IL IL174438A patent/IL174438A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06003205A (es) | 2006-06-23 |
| NZ546031A (en) | 2009-03-31 |
| NO20061281L (no) | 2006-06-22 |
| EP1666472A4 (en) | 2009-05-13 |
| IL174438A0 (en) | 2006-08-01 |
| US20070105868A1 (en) | 2007-05-10 |
| US7560475B2 (en) | 2009-07-14 |
| AU2004274337A1 (en) | 2005-03-31 |
| RU2006113612A (ru) | 2007-10-27 |
| ES2390053T3 (es) | 2012-11-06 |
| EP1666472A1 (en) | 2006-06-07 |
| JPWO2005028453A1 (ja) | 2006-11-30 |
| EP1666472B1 (en) | 2012-08-01 |
| KR20060121884A (ko) | 2006-11-29 |
| CA2539554A1 (en) | 2005-03-31 |
| JP4661595B2 (ja) | 2011-03-30 |
| WO2005028453A1 (ja) | 2005-03-31 |
| RU2349587C2 (ru) | 2009-03-20 |
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