BRPI0414849A - produto medicinal e método de revestimento biocompatìvel de produtos medicinais - Google Patents

produto medicinal e método de revestimento biocompatìvel de produtos medicinais

Info

Publication number
BRPI0414849A
BRPI0414849A BRPI0414849-5A BRPI0414849A BRPI0414849A BR PI0414849 A BRPI0414849 A BR PI0414849A BR PI0414849 A BRPI0414849 A BR PI0414849A BR PI0414849 A BRPI0414849 A BR PI0414849A
Authority
BR
Brazil
Prior art keywords
medicinal
biocompatibly
coating method
products
medical products
Prior art date
Application number
BRPI0414849-5A
Other languages
English (en)
Inventor
Roland Horres
Michael Hoffmann
Volker Faust
Erika Hoffmann
Donato Di Biase
Original Assignee
Hemoteq Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102004020856A external-priority patent/DE102004020856A1/de
Application filed by Hemoteq Gmbh filed Critical Hemoteq Gmbh
Publication of BRPI0414849A publication Critical patent/BRPI0414849A/pt
Publication of BRPI0414849B1 publication Critical patent/BRPI0414849B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D181/00—Coating compositions based on macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing sulfur, with or without nitrogen, oxygen, or carbon only; Coating compositions based on polysulfones; Coating compositions based on derivatives of such polymers
    • C09D181/06—Polysulfones; Polyethersulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/068—Use of macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

"PRODUTO MEDICINAL E MéTODO DE REVESTIMENTO BIOCOMPATìVEL DE PRODUTOS MEDICINAIS". A invenção se refere a produtos medicinais com pelo menos um revestimento de polissulfona biocompatível, bioestável por intermédio do qual a cinética de eluição do pelo menos um agente ativo incorporado e/ou depositado, antiproliferativo, antiinflamatório, antiflogístico e/ou antitrombótico pode ser controlada por intermédio da mistura de pelo menos um polímero hidrofílico em uma quantidade adequada e também uma separação local de diferentes agentes ativos e combinações de agentes ativos, respectivamente, pode ser obtida por intermédio do sistema de camada de polímeros bioestáveis, métodos de fabricação desses produtos medicinais assim como seu uso especificamente na forma de stents para a prevenção de restenose.
BRPI0414849A 2003-09-29 2004-09-29 produto medicinal e método de revestimento biocompatível de produtos medicinais BRPI0414849B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10345132 2003-09-29
US51629503P 2003-11-03 2003-11-03
DE102004020856A DE102004020856A1 (de) 2003-09-29 2004-04-28 Biokompatible, biostabile Beschichtung von medizinischen Oberflächen
US57158204P 2004-05-17 2004-05-17
PCT/DE2004/002184 WO2005032611A2 (de) 2003-09-29 2004-09-29 Biokompatible, biostabile beschichtung von medizinischen oberflächen

Publications (2)

Publication Number Publication Date
BRPI0414849A true BRPI0414849A (pt) 2006-11-21
BRPI0414849B1 BRPI0414849B1 (pt) 2017-05-16

Family

ID=34426957

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414849A BRPI0414849B1 (pt) 2003-09-29 2004-09-29 produto medicinal e método de revestimento biocompatível de produtos medicinais

Country Status (13)

Country Link
EP (1) EP1667743B1 (pt)
KR (1) KR100983440B1 (pt)
CN (1) CN101094698A (pt)
AT (1) ATE382377T1 (pt)
AU (1) AU2004277302B2 (pt)
BR (1) BRPI0414849B1 (pt)
CA (1) CA2540382C (pt)
DE (2) DE112004002385D2 (pt)
EA (1) EA011822B1 (pt)
ES (1) ES2304626T3 (pt)
NZ (1) NZ546068A (pt)
PL (1) PL1667743T3 (pt)
WO (1) WO2005032611A2 (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080008364A (ko) * 2005-05-05 2008-01-23 헤모텍 아게 관 스텐트의 전면 코팅
US9278161B2 (en) * 2005-09-28 2016-03-08 Atrium Medical Corporation Tissue-separating fatty acid adhesion barrier
US20070160641A1 (en) * 2006-01-12 2007-07-12 Eun-Hyun Jang Coated medical devices and methods of making the same
US20100063585A1 (en) * 2006-07-03 2010-03-11 Hemoteq Ag Manufacture, method and use of active substance-releasing medical products for permanently keeping blood vessels open
US20080172124A1 (en) * 2007-01-11 2008-07-17 Robert Lamar Bjork Multiple drug-eluting coronary artery stent for percutaneous coronary artery intervention
ES2393639T3 (es) 2007-01-21 2012-12-26 Hemoteq Ag Producto médico para tratar cierres de conductos corporales y prevención de nuevos cierres
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
JP2011509156A (ja) 2008-01-08 2011-03-24 イェール ユニバーシティ 血管移植片の開存性を促進するための組成物および方法
KR101792032B1 (ko) 2008-12-19 2017-11-02 백스터 인터내셔널 인코포레이티드 Ｔｆｐｉ 억제제 및 사용 방법
EP2944332B1 (en) 2009-07-10 2016-08-17 Boston Scientific Scimed, Inc. Use of nanocrystals for a drug delivery balloon
EP2453938B1 (en) 2009-07-17 2015-08-19 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
DK2547355T3 (en) 2010-03-19 2017-03-20 Baxalta GmbH TFPI INHIBITORS AND METHODS OF USE
EP2611476B1 (en) 2010-09-02 2016-08-10 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
JP5439551B2 (ja) * 2011-08-15 2014-03-12 一般財団法人川村理化学研究所 ブロック共重合体の塗膜
WO2013028208A1 (en) 2011-08-25 2013-02-28 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
CN102579579B (zh) * 2012-03-21 2013-10-16 张伟 一种肛周术后麻醉镇痛的药物组合物
CN102552405B (zh) * 2012-03-21 2013-10-16 张伟 一种肛周术后麻醉镇痛的药物组合物的制备方法
BR112014022435B1 (pt) 2012-03-21 2023-02-14 Takeda Pharmaceutical Company Limited Inibidores de tfpi e métodos de uso
US20170073401A1 (en) * 2014-05-02 2017-03-16 Research Institute At Nationwide Children's Hospital Compositions and methods for anti-lyst immunomodulation
WO2017100782A1 (en) 2015-12-11 2017-06-15 Research Institute At Nationwide Children's Hospital Systems and methods for optimized patent specific tissue engineering vascular grafts
CN107669380A (zh) * 2017-11-29 2018-02-09 成都创客之家科技有限公司 一种药物洗脱血管支架
CN107736958A (zh) * 2017-11-29 2018-02-27 成都创客之家科技有限公司 一种钛合金药物释放血管支架
CN107669381A (zh) * 2017-11-29 2018-02-09 成都创客之家科技有限公司 一种药物释放血管支架
CN107736960A (zh) * 2017-11-29 2018-02-27 成都创客之家科技有限公司 一种可显影载药钛合金支架
CN107736959A (zh) * 2017-11-29 2018-02-27 成都创客之家科技有限公司 一种可显影载药血管支架
CN108816689B (zh) * 2018-07-05 2020-07-07 四川大学 一种具有长效抗菌性能的超亲水涂层及其制备方法
CN108796491B (zh) * 2018-07-05 2019-07-09 四川大学 一种具有高耐腐蚀性和表面功能化的镁基金属转化涂层及其制备方法
RU2686747C1 (ru) * 2018-11-08 2019-04-30 Федеральное государственное бюджетное учреждение науки Институт металлургии и материаловедения им. А.А. Байкова Российской академии наук (ИМЕТ РАН) Способ получения биодеградируемого полимерного покрытия на основе полилактида на проволоке TiNbTaZr
CN109575727A (zh) * 2018-11-28 2019-04-05 浙江大学自贡创新中心 一种防滑涂料
CN109821076B (zh) * 2019-03-13 2021-05-07 陕西师范大学 一种抗凝抗感染的多功能涂层的制备方法及抗凝抗感染的多功能材料
CN113117154B (zh) * 2019-12-31 2022-10-21 东莞市先健医疗有限公司 亲水涂层溶液、其制备方法及涂覆该涂层溶液的医疗器械

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179757A (en) * 1972-02-22 1979-12-25 Owens-Illinois, Inc. Biocompatible articles having high permeability to gases derived from polysulfones
CA2294872A1 (en) * 1997-06-24 1998-12-30 Schering Aktiengesellschaft Stents that are coated with fluoroalkyl groups, processes for their production and their use for restenosis prophylaxis
US6348152B1 (en) * 1997-10-09 2002-02-19 Teijin Limited Medical material containing fluorinated polysulfone having excellent antithrombotic activity
WO2000021585A1 (en) * 1998-10-13 2000-04-20 Gambro Ab Biocompatible polymer film

Also Published As

Publication number Publication date
KR100983440B1 (ko) 2010-09-20
CA2540382A1 (en) 2005-04-14
AU2004277302B2 (en) 2010-08-26
ES2304626T3 (es) 2008-10-16
EP1667743A2 (de) 2006-06-14
EA011822B1 (ru) 2009-06-30
PL1667743T3 (pl) 2008-06-30
CN101094698A (zh) 2007-12-26
WO2005032611A2 (de) 2005-04-14
AU2004277302A1 (en) 2005-04-14
EA200600470A1 (ru) 2007-02-27
KR20060118438A (ko) 2006-11-23
NZ546068A (en) 2009-07-31
WO2005032611A3 (de) 2007-03-22
CA2540382C (en) 2012-03-06
BRPI0414849B1 (pt) 2017-05-16
DE502004005857D1 (de) 2008-02-14
EP1667743B1 (de) 2008-01-02
DE112004002385D2 (de) 2006-08-31
ATE382377T1 (de) 2008-01-15

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: HEMOTEQ AG (DE)

Free format text: NOME ALTERADO DE: HEMOTEQ GMBH.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B25E Requested change of name of applicant rejected

Owner name: HEMOTEQ AG (DE)

B25L Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B25B Requested transfer of rights rejected
B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 15A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2533 DE 23-07-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.