BRPI0414885A - método de fermentação para a preparação de testolactona por espécies fusarium - Google Patents

método de fermentação para a preparação de testolactona por espécies fusarium

Info

Publication number
BRPI0414885A
BRPI0414885A BRPI0414885-1A BRPI0414885A BRPI0414885A BR PI0414885 A BRPI0414885 A BR PI0414885A BR PI0414885 A BRPI0414885 A BR PI0414885A BR PI0414885 A BRPI0414885 A BR PI0414885A
Authority
BR
Brazil
Prior art keywords
fusarium species
preparation
fermentation method
testolactone
dione
Prior art date
Application number
BRPI0414885-1A
Other languages
English (en)
Inventor
Ivan Gale Gilbert
Michael Jon White
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of BRPI0414885A publication Critical patent/BRPI0414885A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/02—Dehydrogenating; Dehydroxylating
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/12—Acting on D ring
    • C12P33/16—Acting at 17 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/20—Preparation of steroids containing heterocyclic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)

Abstract

"MéTODO DE FERMENTAçãO PARA A PREPARAçãO DE TESTOLACTONA POR ESPéCIES FUSARIUM". A presente invenção refere-se a um método microbiano para a desidrogenação e oxidação completa de 4-androsten-3,17-diona para produzir 17<244>-oxo-D-homo-1,4-androstadieno-3,17-diona em elevado rendimento e elevadas concentrações de substrato através de espécies filamentosas de Fusarium.
BRPI0414885-1A 2003-09-29 2004-09-13 método de fermentação para a preparação de testolactona por espécies fusarium BRPI0414885A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50694503P 2003-09-29 2003-09-29
PCT/IB2004/002993 WO2005030977A1 (en) 2003-09-29 2004-09-13 Fermentation method for the preparation of testolactone by fusarium species

Publications (1)

Publication Number Publication Date
BRPI0414885A true BRPI0414885A (pt) 2006-12-12

Family

ID=34393204

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414885-1A BRPI0414885A (pt) 2003-09-29 2004-09-13 método de fermentação para a preparação de testolactona por espécies fusarium

Country Status (7)

Country Link
US (1) US20060292666A1 (pt)
EP (1) EP1670930A1 (pt)
JP (1) JP2007507219A (pt)
BR (1) BRPI0414885A (pt)
CA (1) CA2538098A1 (pt)
MX (1) MXPA06003504A (pt)
WO (1) WO2005030977A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019070087A1 (ko) * 2017-10-02 2019-04-11 한국생명공학연구원 푸사리세틴 화합물을 포함하는 피부 미백용 조성물
CN107974482A (zh) * 2017-12-14 2018-05-01 浙江仙琚制药股份有限公司 制备睾内酯及其衍生物的方法
CN108707553B (zh) * 2018-05-10 2020-10-16 上海师范大学 能够高效转化4ad特异性合成睾内酯酮和add的菌株及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB732557A (en) * 1951-07-27 1955-06-29 Squibb & Sons Inc Microbiological oxidation of steroids
DE956952C (de) * 1953-08-21 1957-01-24 Ciba Geigy Verfahren zur Herstellung von oxydierten Steroiden
US2823171A (en) * 1955-11-18 1958-02-11 Olin Mathieson Synthesis of steroids of the 1-dehydrotestololactone series
US4124607A (en) * 1977-04-15 1978-11-07 The Upjohn Company Preparation of sterol substrates for bioconversion
EP0578616A3 (en) * 1992-07-09 1994-06-01 Sandoz Ltd Cylosporin synthetase
PL207379B1 (pl) * 2002-02-01 2010-12-31 Organon Nv Sposób fermentacji kompozycji fitosteroli do androstadienodionu i Fusarium solani FMI 33

Also Published As

Publication number Publication date
WO2005030977A1 (en) 2005-04-07
US20060292666A1 (en) 2006-12-28
CA2538098A1 (en) 2005-04-07
EP1670930A1 (en) 2006-06-21
MXPA06003504A (es) 2006-06-08
JP2007507219A (ja) 2007-03-29

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A E 7AANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2112 DE 28/06/2011.