BRPI0414961A - processo de indução da diferenciação de células tronco em células do miocárdio - Google Patents

processo de indução da diferenciação de células tronco em células do miocárdio

Info

Publication number
BRPI0414961A
BRPI0414961A BRPI0414961-0A BRPI0414961A BRPI0414961A BR PI0414961 A BRPI0414961 A BR PI0414961A BR PI0414961 A BRPI0414961 A BR PI0414961A BR PI0414961 A BRPI0414961 A BR PI0414961A
Authority
BR
Brazil
Prior art keywords
stem cell
cell differentiation
myocardial cells
differentiation induction
induction process
Prior art date
Application number
BRPI0414961-0A
Other languages
English (en)
Inventor
Keiichi Fukuda
Shinsuke Yuasa
Hideyuki Okano
Takuya Shimazaki
Uichi Koshimizu
Tomofumi Tanaka
Keijiro Sugimura
Original Assignee
Keiichi Fukuda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Keiichi Fukuda filed Critical Keiichi Fukuda
Publication of BRPI0414961A publication Critical patent/BRPI0414961A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"PROCESSO DE INDUçãO DA DIFERENCIAçãO DE CéLULAS TRONCO EM CéLULAS DO MIOCáRDIO". Para um processo de indução da diferenciação de cardiomiócitos partindo de células tronco, é fornecido um processo para induzir eficientemente e seletivamente a diferenciação de cardiomiócitos através de um processo tal em que as células tronco são cultivadas para induzir a diferenciação em cardiomiócitos na presença de uma substância que inibe a sinalização de BMP.
BRPI0414961-0A 2003-10-03 2004-10-04 processo de indução da diferenciação de células tronco em células do miocárdio BRPI0414961A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003346248 2003-10-03
JP2004212255 2004-07-20
PCT/JP2004/014598 WO2005033298A1 (ja) 2003-10-03 2004-10-04 幹細胞から心筋細胞を分化誘導する方法

Publications (1)

Publication Number Publication Date
BRPI0414961A true BRPI0414961A (pt) 2006-11-07

Family

ID=34425354

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414961-0A BRPI0414961A (pt) 2003-10-03 2004-10-04 processo de indução da diferenciação de células tronco em células do miocárdio

Country Status (11)

Country Link
US (1) US7727762B2 (pt)
EP (1) EP1674562A4 (pt)
JP (1) JP4684108B2 (pt)
KR (1) KR101164104B1 (pt)
CN (2) CN103602633A (pt)
AU (1) AU2004278634B2 (pt)
BR (1) BRPI0414961A (pt)
CA (1) CA2540135C (pt)
IL (1) IL174606A (pt)
RU (1) RU2392315C2 (pt)
WO (1) WO2005033298A1 (pt)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US20030224345A1 (en) * 2001-08-24 2003-12-04 Advanced Cell Technology Screening assays for identifying differentiation-inducing agents and production of differentiated cells for cell therapy
US9074181B2 (en) 2005-06-22 2015-07-07 Asterias Biotherapeutics, Inc. Suspension culture of human embryonic stem cells
EP1739179A1 (en) * 2005-06-30 2007-01-03 Octapharma AG Serum-free stable transfection and production of recombinant human proteins in human cell lines
BRPI0710949A2 (pt) 2006-04-28 2012-03-06 Asubio Pharma Co., Ltd. Método para indução de diferenciação de células tronco pluripotentes em cardiomiócitos
EP2607477B1 (en) 2007-05-03 2020-09-23 The Brigham and Women's Hospital, Inc. Multipotent stem cells and uses thereof
US8574567B2 (en) 2007-05-03 2013-11-05 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
US8252583B2 (en) * 2007-06-07 2012-08-28 Keiichi Fukuda Method for inducing differentiation into cardiomyocytes using G-CSF
US8799249B2 (en) * 2007-06-08 2014-08-05 Yahoo! Inc. Method and system for rendering a collection of media items
WO2009017254A1 (ja) 2007-07-31 2009-02-05 Asubio Pharma Co., Ltd. 心筋細胞の細胞塊作製方法及び当該心筋細胞塊の用途
KR100937457B1 (ko) * 2007-08-10 2010-01-19 한국생명공학연구원 인간배아줄기세포와 인간배아종양세포를 심근세포 직계열로분화시키는 방법
US9962409B2 (en) 2007-10-01 2018-05-08 Vestion, Inc. Therapy using cardiac stem cells and mesenchymal stem cells
JP5453612B2 (ja) * 2007-12-06 2014-03-26 公益財団法人ヒューマンサイエンス振興財団 心筋細胞分化誘導促進剤及びその使用方法
JP5951254B2 (ja) 2008-03-17 2016-07-13 ザ スクリプス リサーチ インスティテュート 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法
WO2009154770A2 (en) * 2008-06-18 2009-12-23 The Texas A & M University System Mesenchymal stem cells, compositions, and methods for treatment of cardiac tissue damage
SG172160A1 (en) 2008-12-17 2011-07-28 Scripps Research Inst Generation and maintenance of stem cells
AU2010249821B2 (en) * 2009-05-20 2015-07-02 Cardio3 Biosciences Sa Method for determining the cardio-generative potential of mammalian cells
SG176806A1 (en) * 2009-07-09 2012-01-30 Centocor Ortho Biotech Inc Cardiac tissue-derived cells
MX389666B (es) 2009-10-16 2025-03-19 Scripps Research Inst Induccion de celulas pluripotentes.
EP3255142A1 (en) * 2009-10-19 2017-12-13 Cellular Dynamics International, Inc. Cardiomyocyte production
KR101168053B1 (ko) * 2009-11-06 2012-07-24 연세대학교 산학협력단 효율적이고 보편적인 전분화능 줄기세포의 신경세포 분화 유도방법
EP2511366A4 (en) * 2009-12-09 2014-04-30 Univ Kyoto NITROVINE MEDICINE FOR PROMOTING THE DIFFERENTIATION OF PLURIPOTENTAL STEM CELLS IN HEART MUSCLES
CA2800498C (en) 2010-03-31 2021-11-16 The Scripps Research Institute Reprogramming cells
AU2010355614B2 (en) * 2010-06-13 2015-07-02 Institute Of Biophysics, Chinese Academy Of Sciences Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof
WO2011159726A2 (en) 2010-06-14 2011-12-22 The Scripps Research Institute Reprogramming of cells to a new fate
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
JP5930205B2 (ja) * 2010-08-26 2016-06-08 国立大学法人京都大学 多能性幹細胞の心筋分化促進剤
KR101836850B1 (ko) * 2010-08-31 2018-03-09 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
US9181529B2 (en) 2010-10-19 2015-11-10 Cellular Dynamics International, Inc. Titration of differentiation medium components
US9732319B2 (en) 2010-12-22 2017-08-15 Fate Therapeutics, Inc. Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs
JP5840855B2 (ja) 2011-03-30 2016-01-06 学校法人東京女子医科大学 胚性幹細胞から心筋シートを製造する方法
CA2831609C (en) 2011-03-30 2019-06-11 Cellular Dynamics International, Inc. Priming of pluripotent stem cells for neural differentiation
JP6274510B2 (ja) 2012-01-27 2018-02-07 国立大学法人京都大学 多能性幹細胞の心筋分化誘導法
EP2826855B1 (en) * 2012-03-15 2018-08-29 iHeart Japan Corporation Myocardial sheet
CA2886396C (en) * 2012-07-23 2023-08-22 Institute Of Biophysics, Chinese Academy Of Sciences Method for inducing pluripotent stem cells to differentiate into ventricular cardiomyocytes in vitro
WO2014093051A2 (en) 2012-11-30 2014-06-19 Vestion, Inc. Cardiac stem cells and methods of identifying and using the same
JP6351567B2 (ja) 2013-03-08 2018-07-04 国立大学法人京都大学 Ｅｇｆ受容体阻害剤を含む多能性幹細胞の心筋分化促進剤
US9493742B2 (en) 2013-03-15 2016-11-15 Emory University Purification of cell mixtures using molecular beacons targeting cell specific RNA
KR101870174B1 (ko) 2013-05-31 2018-06-22 아이하트 재팬 가부시키가이샤 하이드로겔을 포함하는 적층화된 세포 시트
JP2016537414A (ja) * 2013-10-29 2016-12-01 ベスティオン、インク． 心臓神経堤細胞、及びその使用方法
CN120536341A (zh) 2014-03-04 2025-08-26 菲特治疗公司 改良的重编程方法和细胞培养平台
CA2943035A1 (en) * 2014-05-06 2015-11-12 F. Hoffmann-La Roche Ag Method for differentiation of pluripotent stem cells into cardiomyocytes
WO2015182765A1 (ja) 2014-05-30 2015-12-03 国立大学法人京都大学 低分子化合物を用いた多能性幹細胞の心筋分化誘導法
KR20160142587A (ko) * 2015-06-03 2016-12-13 서울대학교산학협력단 전기·기계적 자극을 가하여 줄기세포를 심근세포로 분화시키는 방법
CN117737124A (zh) 2015-10-16 2024-03-22 菲特治疗公司 用于诱导和维护基态多能性的平台
CA3040637C (en) * 2016-10-17 2023-02-28 Keio University Undifferentiated stem cell-removing agent, and method for removing undifferentiated stem cells
JP2018093823A (ja) 2016-12-15 2018-06-21 Ｈｅａｒｔｓｅｅｄ株式会社 未分化幹細胞除去剤及び未分化幹細胞除去方法
JP6909454B2 (ja) * 2017-01-26 2021-07-28 日本メナード化粧品株式会社 幹細胞の品質を評価する方法及び幹細胞の品質評価用キット
JP6978045B2 (ja) * 2017-10-03 2021-12-08 Ｈｅａｒｔｓｅｅｄ株式会社 未分化幹細胞を培養し心筋細胞を分化誘導するシステム及び心筋細胞の製造方法
CN111971392A (zh) * 2018-03-30 2020-11-20 国立大学法人京都大学 细胞的制造方法
JP7257698B2 (ja) 2018-03-30 2023-04-14 オリヅルセラピューティクス株式会社 複素環化合物
JP7344486B2 (ja) 2018-03-30 2023-09-14 国立大学法人京都大学 心筋細胞成熟促進剤
JP7436990B2 (ja) 2018-08-10 2024-02-22 国立大学法人京都大学 カチオン性脂質を用いた心筋細胞へのトランスフェクション方法
CN110907644B (zh) * 2019-12-11 2023-01-06 深圳市达科为生物工程有限公司 多种细胞鉴定试剂盒及操作方法
CN116113693A (zh) 2020-08-10 2023-05-12 谱系细胞疗法股份有限公司 用于胚胎干细胞扩增的组合物和方法
EP4678737A1 (en) 2023-03-03 2026-01-14 Kyoto University Method for producing primed pluripotent stem cells
GB202308408D0 (en) 2023-06-06 2023-07-19 Cambridge Entpr Ltd Stem cells based three-dimensional embryo model
WO2025089333A1 (ja) 2023-10-26 2025-05-01 公益財団法人京都大学ｉＰＳ細胞研究財団 細胞製造装置の包装体、細胞製造方法およびそのための管理システム
KR20260115082A (ko) 2023-12-04 2026-07-23 고에키자이단호진 교토다이가쿠 아이피에스 사이보겐큐자이단 인공 다능성 줄기세포의 제조 방법
CN117398427B (zh) * 2023-12-14 2024-02-27 再少年(北京)生物科技有限公司 包含iPS诱导定向分化成心肌细胞的药物组合在用于治疗心力衰竭中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1397646A (zh) * 2001-07-13 2003-02-19 上海杰隆生物工程股份有限公司 一种克隆心肌细胞、心脏组织及心脏的方法
US20030232430A1 (en) * 2001-11-26 2003-12-18 Advanced Cell Technology Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells
CN1164741C (zh) * 2002-12-30 2004-09-01 浙江大学 淫羊藿苷在诱导胚胎干细胞体外定向分化方面的用途

Also Published As

Publication number Publication date
AU2004278634A1 (en) 2005-04-14
KR101164104B1 (ko) 2012-07-12
AU2004278634B2 (en) 2009-10-01
RU2392315C2 (ru) 2010-06-20
EP1674562A1 (en) 2006-06-28
CN1863904A (zh) 2006-11-15
RU2006114832A (ru) 2007-11-10
KR20060080934A (ko) 2006-07-11
US20070134215A1 (en) 2007-06-14
CN1863904B (zh) 2014-05-28
EP1674562A4 (en) 2007-04-11
CA2540135A1 (en) 2005-04-14
WO2005033298A1 (ja) 2005-04-14
JPWO2005033298A1 (ja) 2006-12-14
US7727762B2 (en) 2010-06-01
IL174606A0 (en) 2006-08-20
JP4684108B2 (ja) 2011-05-18
IL174606A (en) 2011-07-31
CA2540135C (en) 2012-12-04
CN103602633A (zh) 2014-02-26

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B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
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Ipc: C12N 5/077 (2010.01)

B11T Dismissal of application maintained [chapter 11.20 patent gazette]