BRPI0415022A - sais e polimorfos de um composto de indolinona substituìda com pirrol - Google Patents

sais e polimorfos de um composto de indolinona substituìda com pirrol

Info

Publication number
BRPI0415022A
BRPI0415022A BRPI0415022-8A BRPI0415022A BRPI0415022A BR PI0415022 A BRPI0415022 A BR PI0415022A BR PI0415022 A BRPI0415022 A BR PI0415022A BR PI0415022 A BRPI0415022 A BR PI0415022A
Authority
BR
Brazil
Prior art keywords
salts
pyrrol
polymorphs
indolinone compound
substituted indolinone
Prior art date
Application number
BRPI0415022-8A
Other languages
English (en)
Inventor
Andrei Blasko
Qingwu Jin
Qun Lu
Michael Anthony Mauragis
Dian Song
Brenda Sue Vonderwell
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of BRPI0415022A publication Critical patent/BRPI0415022A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

"SAIS E POLIMORFOS DE UM COMPOSTO DE INDOLINONA SUBSTITUìDA COM PIRROL". A invenção refere-se a sais não higroscópicos de 5-¢(Z)-(5-flúor-2-oxo-1,2-dihidro-3H-indol-3-ilideno)-metil!-N-¢(2)-2-hidr óxi-3-morfolin-4-ilpropil!-2,4-dimetil-1H-pirrol-3-carboxamida, tal como sais maleato, e para polimorfos cristalino destes sais. A invenção ainda se refere a composições farmacêuticas de sais de 5-¢(Z)-(5-flúor-2-oxo-1,2-dihidro-3H-indol-3-ilideno)metil!-N-(2S)-2-hidr óxi-3-morfolin-4-ilpropil!-2,4-dimetil-1H-pirrol-3-carboxamida, e a métodos de tratar distúrbios tal como câncer utilizando tais composições.
BRPI0415022-8A 2003-10-02 2004-09-20 sais e polimorfos de um composto de indolinona substituìda com pirrol BRPI0415022A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50810403P 2003-10-02 2003-10-02
PCT/IB2004/003070 WO2005033098A1 (en) 2003-10-02 2004-09-20 Salts and polymorphs of a pyrrole-substituted indolinone compound

Publications (1)

Publication Number Publication Date
BRPI0415022A true BRPI0415022A (pt) 2006-11-28

Family

ID=34421700

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415022-8A BRPI0415022A (pt) 2003-10-02 2004-09-20 sais e polimorfos de um composto de indolinona substituìda com pirrol

Country Status (25)

Country Link
US (1) US7247627B2 (pt)
EP (1) EP1670785B1 (pt)
JP (1) JP4933259B2 (pt)
KR (2) KR20080007520A (pt)
CN (1) CN100432072C (pt)
AR (1) AR047762A1 (pt)
AT (1) ATE473223T1 (pt)
AU (1) AU2004277464B2 (pt)
BR (1) BRPI0415022A (pt)
CA (1) CA2540639C (pt)
CY (1) CY1110771T1 (pt)
DE (1) DE602004028028D1 (pt)
DK (1) DK1670785T3 (pt)
ES (1) ES2348623T3 (pt)
IL (1) IL174414A (pt)
MX (1) MXPA06003661A (pt)
NO (1) NO20061246L (pt)
NZ (1) NZ546001A (pt)
PL (1) PL1670785T3 (pt)
PT (1) PT1670785E (pt)
RU (1) RU2319702C2 (pt)
SI (1) SI1670785T1 (pt)
TW (1) TW200524921A (pt)
WO (1) WO2005033098A1 (pt)
ZA (1) ZA200602691B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050182122A1 (en) * 2003-11-20 2005-08-18 Bello Carlo L. Method of treating abnormal cell growth using indolinone compounds
MX2007011767A (es) * 2005-03-23 2007-10-18 Pfizer Prod Inc Terapia de combinacion de anticuerpo anti-ctla4 e indolinona para el tratamiento del cancer.
KR20080040007A (ko) * 2005-09-20 2008-05-07 화이자 프로덕츠 인크. 티로신 키나제 억제제를 이용한 치료의 투여형 및 방법
CL2008000070A1 (es) * 2007-01-17 2008-07-25 Lg Life Sciences Ltd Monosal del acido maleico (3-[({1-[(2-amino-9h-purin-9-il)metil]ciclopropil}oxi)metil]-8,8-dimetil-3,7-dioxo-2,4,6-trioxa-3 lambda 5-fosfanon-1-il-pivalato; composicion farmaceutica que comprende a dicha monosal; y uso para el tratamiento del virus h
EP2130798B1 (en) * 2007-04-04 2018-05-16 Otsuka Chemical Co., Ltd. Potassium titanate, process for production of the same, friction materials, and resin compositions
PE20110292A1 (es) * 2008-09-17 2011-05-17 Novartis Ag Sales de n-[6-(cis-2,6-dimetil-morfolin-4-il)-piridin-3-il]-2-metil-4'-(trifluoro-metoxi)-[1,1'-bifenil]-3-carboxamida
RU2430361C1 (ru) * 2010-07-05 2011-09-27 Государственное образовательное учреждение высшего профессионального образования "Красноярский государственный медицинский университет им. В.Ф. Войно-Ясенецкого Министерства здравоохранения и социального развития Российской Федерации" Способ прогнозирования риска развития диабетической ретинопатии при сахарном диабете типа 2 у якутов
WO2012042421A1 (en) 2010-09-29 2012-04-05 Pfizer Inc. Method of treating abnormal cell growth
US9851313B2 (en) * 2015-03-03 2017-12-26 Panalytical B.V. Quantitative X-ray analysis—ratio correction

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1575936A3 (ru) * 1986-04-10 1990-06-30 Е.И.Дюпон Де Немур Энд Ко.(Фирма) Способ получени 3,3-дизамещенных индолин-2-ионов или их солей
US5534522A (en) * 1995-06-07 1996-07-09 Warner-Lambert Company (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent
DE19622489A1 (de) * 1996-06-05 1997-12-11 Hoechst Ag Salze des 3-(2-(4-(4-(Amino-imino-methyl)-phenyl)-4- methyl-2,5-dioxo-imidazolidin-1-yl)-acetylamino)-3- phenyl-propionsäure-ethylesters
JP3663382B2 (ja) * 2000-02-15 2005-06-22 スージェン・インコーポレーテッド ピロール置換２−インドリノン蛋白質キナーゼ阻害剤
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
CN100364991C (zh) 2001-08-15 2008-01-30 法玛西雅厄普约翰美国公司 2,4-二甲基-1h-吡咯-3-甲酰胺衍生物的苹果酸盐的晶体、其制备方法和其组合物
YU67702A (sh) 2001-09-28 2004-12-31 Pfizer Products Inc. Postupak za dobijanje alkansulfonil piridina
TWI259081B (en) * 2001-10-26 2006-08-01 Sugen Inc Treatment of acute myeloid leukemia with indolinone compounds
US7119209B2 (en) * 2002-02-15 2006-10-10 Pharmacia & Upjohn Company Process for preparing indolinone derivatives
TW200418836A (en) * 2002-09-10 2004-10-01 Pharmacia Italia Spa Formulations comprising an indolinone compound

Also Published As

Publication number Publication date
NO20061246L (no) 2006-03-29
DK1670785T3 (da) 2010-10-18
TW200524921A (en) 2005-08-01
RU2006110541A (ru) 2006-08-27
IL174414A (en) 2011-12-29
CA2540639A1 (en) 2005-04-14
DE602004028028D1 (de) 2010-08-19
CY1110771T1 (el) 2015-06-10
RU2319702C2 (ru) 2008-03-20
NZ546001A (en) 2009-09-25
WO2005033098A1 (en) 2005-04-14
ATE473223T1 (de) 2010-07-15
AU2004277464B2 (en) 2010-07-08
PT1670785E (pt) 2010-09-16
ZA200602691B (en) 2007-06-27
KR20080007520A (ko) 2008-01-21
AR047762A1 (es) 2006-02-22
MXPA06003661A (es) 2006-06-05
IL174414A0 (en) 2008-02-09
US7247627B2 (en) 2007-07-24
PL1670785T3 (pl) 2010-12-31
CN1863796A (zh) 2006-11-15
EP1670785B1 (en) 2010-07-07
HK1093068A1 (zh) 2007-02-23
JP2007507482A (ja) 2007-03-29
EP1670785A1 (en) 2006-06-21
WO2005033098A9 (en) 2006-05-26
JP4933259B2 (ja) 2012-05-16
AU2004277464A1 (en) 2005-04-14
CA2540639C (en) 2010-08-31
US20050118255A1 (en) 2005-06-02
CN100432072C (zh) 2008-11-12
ES2348623T3 (es) 2010-12-09
KR20060058728A (ko) 2006-05-30
SI1670785T1 (sl) 2010-10-29
WO2005033098A8 (en) 2006-04-20

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2167 DE 17/07/2012.