BRPI0415062A - processos para preparar um composto azabiciclo[3.1.0]hexano - Google Patents

processos para preparar um composto azabiciclo[3.1.0]hexano

Info

Publication number
BRPI0415062A
BRPI0415062A BRPI0415062-7A BRPI0415062A BRPI0415062A BR PI0415062 A BRPI0415062 A BR PI0415062A BR PI0415062 A BRPI0415062 A BR PI0415062A BR PI0415062 A BRPI0415062 A BR PI0415062A
Authority
BR
Brazil
Prior art keywords
preparing
processes
azabicyclo
hexane
hexane compound
Prior art date
Application number
BRPI0415062-7A
Other languages
English (en)
Inventor
John J Teixeira
Derek L Tickner
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BRPI0415062A publication Critical patent/BRPI0415062A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

"PROCESSOS PARA PREPARAR UM COMPOSTO AZABICICLO¢3.1.0!HEXANO, BEM COMO SEU SAL". A presente invenção rofere-se a um processo para preparar compostos de azabiciclo¢3.1.0!hexano que têm impurezas reduzidas relacionadas com o processo, por exemplo, derivados de 3-azabicicio¢3.1.0!hexano que têm níveis reduzidos de impurezas etéricas, por exemplo, THF.
BRPI0415062-7A 2003-10-06 2004-09-27 processos para preparar um composto azabiciclo[3.1.0]hexano BRPI0415062A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50908803P 2003-10-06 2003-10-06
PCT/IB2004/003158 WO2005033080A1 (en) 2003-10-06 2004-09-27 Process for preparing an azabicyclo[3.1.0]hexane compound

Publications (1)

Publication Number Publication Date
BRPI0415062A true BRPI0415062A (pt) 2006-11-28

Family

ID=34421799

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415062-7A BRPI0415062A (pt) 2003-10-06 2004-09-27 processos para preparar um composto azabiciclo[3.1.0]hexano

Country Status (16)

Country Link
US (1) US7153976B2 (pt)
EP (1) EP1678136A1 (pt)
JP (1) JP2007507484A (pt)
KR (1) KR100767895B1 (pt)
CN (1) CN1863772A (pt)
AR (1) AR046093A1 (pt)
AU (1) AU2004278159A1 (pt)
BR (1) BRPI0415062A (pt)
CA (1) CA2540637A1 (pt)
CO (1) CO5680415A2 (pt)
IL (1) IL174415A0 (pt)
MX (1) MXPA06003811A (pt)
NO (1) NO20061283L (pt)
RU (1) RU2006111094A (pt)
TW (1) TW200526578A (pt)
WO (1) WO2005033080A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA006708B1 (ru) * 2001-10-22 2006-02-24 Пфайзер Продактс Инк. Производные 3-азабицикло (3.1.0) гексана в качестве антагонистов опиоидного рецептора
KR101494067B1 (ko) 2004-03-05 2015-02-16 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 부작용을 최소화하면서 과지질혈증 및 과콜레스테롤혈증과 연관된 질환 또는 질병의 치료 방법
BR112013007566A2 (pt) 2010-09-28 2016-08-02 Panacea Biotec Ltd novos compostos bicíclicos
CN105764888B (zh) 2013-11-20 2018-04-06 株式会社三和化学研究所 一种新的3‑氮杂双环[3.1.0]己烷衍生物以及其医药用途
CN107428687B (zh) 2015-05-20 2021-06-11 宇部兴产株式会社 一种3-氮杂双环[3.1.0]己烷衍生物的盐的晶体以及其医药应用
CA3186856A1 (en) 2020-07-29 2022-02-03 Ruth NALLEN Lomitapide for use in methods of treating hyperlipidemia and hypercholesterolemia in pediatric patients
CN114057627B (zh) * 2022-01-18 2022-04-01 南京桦冠生物技术有限公司 一种丙型肝炎及新冠药物中间体及其盐的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB948730A (en) 1959-04-08 1964-02-05 Wellcome Found Substituted cyclopropanes and related compounds
US4231935A (en) 1975-07-31 1980-11-04 American Cyanamid Company 1-Phenyl-3-azabicyclo[3.1.0]hexanes
JPH08325228A (ja) * 1995-05-29 1996-12-10 Sumitomo Chem Co Ltd ビシクロヘキサンアミン誘導体の製造法
EA006708B1 (ru) * 2001-10-22 2006-02-24 Пфайзер Продактс Инк. Производные 3-азабицикло (3.1.0) гексана в качестве антагонистов опиоидного рецептора

Also Published As

Publication number Publication date
MXPA06003811A (es) 2006-06-14
AU2004278159A1 (en) 2005-04-14
NO20061283L (no) 2006-06-29
CA2540637A1 (en) 2005-04-14
KR20060085631A (ko) 2006-07-27
WO2005033080A1 (en) 2005-04-14
JP2007507484A (ja) 2007-03-29
RU2006111094A (ru) 2006-08-27
CN1863772A (zh) 2006-11-15
CO5680415A2 (es) 2006-09-29
US20050075387A1 (en) 2005-04-07
TW200526578A (en) 2005-08-16
AR046093A1 (es) 2005-11-23
EP1678136A1 (en) 2006-07-12
IL174415A0 (en) 2006-08-01
KR100767895B1 (ko) 2007-10-17
US7153976B2 (en) 2006-12-26

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 5A., 6A. E 7A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 5A, 6A E 7A ANUIDADES.