BRPI0415123A - uso de l-butilftalida e respectiva composição farmacêutica - Google Patents

uso de l-butilftalida e respectiva composição farmacêutica

Info

Publication number
BRPI0415123A
BRPI0415123A BRPI0415123-2A BRPI0415123A BRPI0415123A BR PI0415123 A BRPI0415123 A BR PI0415123A BR PI0415123 A BRPI0415123 A BR PI0415123A BR PI0415123 A BRPI0415123 A BR PI0415123A
Authority
BR
Brazil
Prior art keywords
butylphthalide
pharmaceutical composition
butilftalide
medicaments
prevention
Prior art date
Application number
BRPI0415123-2A
Other languages
English (en)
Inventor
Yipu Feng
Xiaoliang Wang
Jinghua Yang
Ying Peng
Original Assignee
Shijiazhuang Pharma Group
Inst Materia Medica Cams
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shijiazhuang Pharma Group, Inst Materia Medica Cams filed Critical Shijiazhuang Pharma Group
Publication of BRPI0415123A publication Critical patent/BRPI0415123A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

"USO DE L-BUTILFTALIDA E RESPECTIVA COMPOSIçãO FARMACêUTICA". A presente invenção revela o uso de L-butilftaloida da fórmula (1) no fabrico de medicamentos para apreveenção e tratamento de infarto cerebral, especialmente induzido por isqueemia cerebral focal.
BRPI0415123-2A 2003-10-10 2004-09-29 uso de l-butilftalida e respectiva composição farmacêutica BRPI0415123A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNA2003101002222A CN1605336A (zh) 2003-10-10 2003-10-10 左旋丁基苯酞在制备预防和治疗脑梗塞的药物中的应用
PCT/CN2004/001123 WO2005034936A1 (en) 2003-10-10 2004-09-29 Use of l-butylphthalide in the manufacture of medicaments for prevention and treatment of cerebral infarct

Publications (1)

Publication Number Publication Date
BRPI0415123A true BRPI0415123A (pt) 2006-11-28

Family

ID=34427785

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415123-2A BRPI0415123A (pt) 2003-10-10 2004-09-29 uso de l-butilftalida e respectiva composição farmacêutica

Country Status (10)

Country Link
US (2) US20070112065A1 (pt)
EP (3) EP2974722A1 (pt)
JP (3) JP2007507436A (pt)
KR (1) KR100860703B1 (pt)
CN (3) CN1605336A (pt)
AU (1) AU2004279655B2 (pt)
BR (1) BRPI0415123A (pt)
CA (3) CA2549931A1 (pt)
RU (1) RU2336870C2 (pt)
WO (1) WO2005034936A1 (pt)

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CN1605336A (zh) 2003-10-10 2005-04-13 中国医学科学院药物研究所 左旋丁基苯酞在制备预防和治疗脑梗塞的药物中的应用
CN101627992B (zh) * 2004-01-20 2012-09-12 石药集团中奇制药技术（石家庄）有限公司 左旋丁苯酞在制备治疗脑卒中药物中的应用
CN1647796A (zh) * 2004-01-20 2005-08-03 中奇制药技术（石家庄）有限公司 左旋丁苯酞在制备预防和治疗脑缺血疾病药物中的应用
US8552058B2 (en) 2004-06-18 2013-10-08 CSPC Zhongqi Pharmaceutical Technology (Shijazhuang) Co., Ltd. Application of L-n-butylphthalide in preventing and treating dementia
CN100367951C (zh) * 2005-12-16 2008-02-13 石药集团恩必普药业有限公司 丁苯酞静脉乳剂及其应用
CA2851741C (en) * 2011-10-13 2016-08-23 Shijiazhuang Yiling Pharmaceutical Co., Ltd. Derivative of butylphthalide and preparation method and use thereof
CN106963757A (zh) * 2012-04-01 2017-07-21 石药集团恩必普药业有限公司 丁苯酞或其衍生物在制备治疗放射性脑损伤的药物中的应用
CN103505414B (zh) * 2012-06-28 2017-08-08 石药集团恩必普药业有限公司 丁苯酞滴鼻剂及其制备方法
CN103655555B (zh) * 2012-09-14 2018-08-28 中山大学 3-正丁基-异吲哚啉-1-酮在制备预防和治疗脑梗塞的药物中的应用
CN104224772A (zh) * 2013-06-13 2014-12-24 石药集团中奇制药技术（石家庄）有限公司 一种包含丁苯酞和冰片的药物组合物及其应用
CN109394724B (zh) * 2013-12-21 2021-07-30 石药集团恩必普药业有限公司 一种丁基苯酞液体硬胶囊制剂及其制备方法
CN104306372B (zh) * 2014-11-10 2018-05-08 石药集团恩必普药业有限公司 一种丁苯酞制剂组合物及其制备方法与用途
KR101749410B1 (ko) 2015-09-09 2017-06-21 충북대학교 산학협력단 불멸화 신경줄기세포를 유효성분으로 포함하는 뇌경색 또는 뇌졸중 예방 및 치료용 약제학적 조성물
CN108069942A (zh) * 2016-11-10 2018-05-25 四川大学 苯酞吡唑酮类偶联物、其制备方法和用途
WO2021074734A1 (en) 2019-10-14 2021-04-22 3M Innovative Properties Company Compositions comprising cyclic olefins and thermally conductive filler
WO2021084559A1 (en) * 2019-11-01 2021-05-06 Celagenex Research (India) Pvt. Ltd. Synergistic nutritional compositions for treating cerebrovascular diseases
KR102915528B1 (ko) 2019-12-20 2026-01-21 쓰리엠 이노베이티브 프로퍼티즈 캄파니 중합체 및 중합성 환형 올레핀을 포함하는 접착제 물품, 접착제 조성물 및 방법
CN118217279A (zh) * 2020-03-20 2024-06-21 石药集团恩必普药业有限公司 丁基苯酞及其衍生物的用途

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US6447814B1 (en) * 2001-08-28 2002-09-10 Yung Shin Pharma Ind. Co. Ltd. Chinese herbal composition for improving blood circulation and the method of preparing the same
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ATE489972T1 (de) * 2002-08-21 2010-12-15 Shijiazhuang Pharma Group Zhongqi Pharmaceutical Technology Shijiazhuang Co Ltd Einschlusskomplexe aus butylphthalid und cyclodextrin derivaten und verfahren zu deren herstellung
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Also Published As

Publication number Publication date
CN102008464A (zh) 2011-04-13
JP2011116781A (ja) 2011-06-16
RU2336870C2 (ru) 2008-10-27
AU2004279655B2 (en) 2008-09-25
US8598225B2 (en) 2013-12-03
KR20060085915A (ko) 2006-07-28
CA2902337A1 (en) 2005-04-21
WO2005034936A1 (en) 2005-04-21
EP1679070A4 (en) 2010-02-17
JP6027722B2 (ja) 2016-11-16
US20110082201A1 (en) 2011-04-07
CN102008464B (zh) 2012-08-29
CN1863523A (zh) 2006-11-15
RU2006115784A (ru) 2007-11-27
CA3028912A1 (en) 2005-04-21
JP2007507436A (ja) 2007-03-29
AU2004279655A1 (en) 2005-04-21
CN1605336A (zh) 2005-04-13
US20070112065A1 (en) 2007-05-17
KR100860703B1 (ko) 2008-09-26
JP2014205724A (ja) 2014-10-30
EP1679070A1 (en) 2006-07-12
EP2974722A1 (en) 2016-01-20
EP2689776A1 (en) 2014-01-29
CA2549931A1 (en) 2005-04-21

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8, 11, 13 E 25 DA LPI

B09B Patent application refused [chapter 9.2 patent gazette]