BRPI0415308A - incorporação especìfica de local de aminoácidos redox ativos em proteìnas - Google Patents

incorporação especìfica de local de aminoácidos redox ativos em proteìnas

Info

Publication number
BRPI0415308A
BRPI0415308A BRPI0415308-1A BRPI0415308A BRPI0415308A BR PI0415308 A BRPI0415308 A BR PI0415308A BR PI0415308 A BRPI0415308 A BR PI0415308A BR PI0415308 A BRPI0415308 A BR PI0415308A
Authority
BR
Brazil
Prior art keywords
amino acids
proteins
active redox
redox amino
site
Prior art date
Application number
BRPI0415308-1A
Other languages
English (en)
Inventor
Lital Alfonta
Peter G Schultz
Zhiwen Zhang
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of BRPI0415308A publication Critical patent/BRPI0415308A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

"INCORPORAçãO ESPECìFICA DE LOCAL DE AMINOáCIDOS REDOX ATIVOS EM PROTEìNAS". São fornecidos composição e métodos de produzir componentes de maquinário biossintético de proteína que inclui RNAts ortogonais, aminoacil RNAt sintetases ortogonais e pares ortogonais de RNAts/sintetases que incorporam aminoácidos redox ativos em proteínas. Métodos para identificar estes pares ortogonais também são fornecidos junto com métodos de produzir proteínas com aminoácidos redox ativos usando estes pares ortogonais.
BRPI0415308-1A 2003-10-14 2004-10-13 incorporação especìfica de local de aminoácidos redox ativos em proteìnas BRPI0415308A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51153203P 2003-10-14 2003-10-14
PCT/US2004/034089 WO2005038002A2 (en) 2003-10-14 2004-10-13 Site-specific incorporation of redox active amino acids into proteins

Publications (1)

Publication Number Publication Date
BRPI0415308A true BRPI0415308A (pt) 2006-12-05

Family

ID=34465242

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415308-1A BRPI0415308A (pt) 2003-10-14 2004-10-13 incorporação especìfica de local de aminoácidos redox ativos em proteìnas

Country Status (14)

Country Link
US (5) US8008041B2 (pt)
EP (1) EP1687401B1 (pt)
JP (1) JP5657850B2 (pt)
CN (2) CN101532046A (pt)
AU (1) AU2004282577B2 (pt)
BR (1) BRPI0415308A (pt)
CA (1) CA2541166A1 (pt)
DK (1) DK1687401T3 (pt)
ES (1) ES2396712T3 (pt)
IL (3) IL174947A (pt)
MX (1) MXPA06004087A (pt)
PL (1) PL1687401T3 (pt)
PT (1) PT1687401E (pt)
WO (1) WO2005038002A2 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2464532T3 (es) * 2001-04-19 2014-06-03 The Scripps Research Institute Métodos y composiciones para la producción de pares ortogonales de ARNt-aminoacil-ARNt sintetasa
EP1558747B1 (en) * 2002-10-16 2009-10-14 The Scripps Research Institute Glycoprotein synthesis
JP5642916B2 (ja) * 2003-04-17 2014-12-17 ザ スクリプス リサーチ インスティテュート 真核遺伝コードの拡張
JP5275566B2 (ja) 2003-06-18 2013-08-28 ザ スクリプス リサーチ インスティチュート 反応性非天然アミノ酸遺伝コード付加
WO2005019415A2 (en) 2003-07-07 2005-03-03 The Scripps Research Institute Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof
CA2567624A1 (en) * 2004-05-25 2005-12-08 The Scripps Research Institute Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for crystal structure determination
DE102004031258A1 (de) * 2004-06-29 2006-02-09 Jennissen, Herbert P., Prof. Dr. Proteinhybride mit polyhydroxyaromatischen Aminosäure-Epitopen
EP1794312A4 (en) * 2004-09-22 2009-08-12 Scripps Research Inst LOCAL LABELING OF PROTEINS FOR NMR STUDIES
MX2007004892A (es) 2004-10-27 2007-08-16 Scripps Research Inst Componentes de traduccion ortogonales para la incorporacion in vivo de aminoacidos no naturales.
CA2624290A1 (en) * 2005-10-12 2007-04-26 Scripps Research Institute Selective posttranslational modification of phage-displayed polypeptides
WO2007092475A2 (en) * 2006-02-06 2007-08-16 Franklin And Marshall College Site-specific incorporation of fluorinated amino acids into proteins
MX2008011470A (es) 2006-03-09 2008-09-24 Scripps Research Inst Sistemas para la expresion de componentes de traduccion ortogonales en celulas huesped eubacterianas.
US7790847B2 (en) * 2006-03-16 2010-09-07 The Scripps Research Institute Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
US7807411B2 (en) * 2006-05-23 2010-10-05 The Scripps Research Institute Genetically encoded fluorescent coumarin amino acids
US8114627B2 (en) * 2006-09-21 2012-02-14 The Scripps Research Institute Genetically programmed expression of selectively sulfated proteins in eubacteria
CN101535338A (zh) 2006-10-18 2009-09-16 斯克利普斯研究院 在哺乳动物细胞中将非天然氨基酸遗传掺入蛋白质
WO2008137452A1 (en) * 2007-05-04 2008-11-13 Kenergy Royalty Company, Llc Implantable high efficiency digital stimulation device
EP2217707B1 (en) * 2007-10-25 2014-10-15 The Scripps Research Institute Genetic incorporation of 3-aminotyrosine into reductases
EP2220218A4 (en) * 2007-11-02 2010-12-08 Scripps Research Inst GENETICALLY ENCODED BORONATE AMINO ACID
US9150849B2 (en) 2007-11-02 2015-10-06 The Scripps Research Institute Directed evolution using proteins comprising unnatural amino acids
JP2011527886A (ja) 2007-12-11 2011-11-10 ザ スクリプス リサーチ インスティチュート メタノール資化性酵母ピキア・パストリスにおけるインビボ非天然アミノ酸発現
CA2712080A1 (en) * 2008-02-08 2009-08-13 The Scripps Research Institute Breaking immunological tolerance with a genetically encoded unnatural amino acid
WO2010077608A1 (en) * 2008-12-09 2010-07-08 Wilson-Cook Medical Inc. Apparatus and methods for controlled release of tacking devices
US20090197339A1 (en) * 2008-12-10 2009-08-06 The Scripps Research Institute In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris
EP2370473B1 (en) 2008-12-10 2016-05-11 The Scripps Research Institute Production of carrier-peptide conjugates using chemically reactive unnatural amino acids
EP2394323B1 (en) * 2009-02-04 2017-05-24 Ben-gurion University Of The Negev Research And Development Authority Systems and methods for bio-electricity production
US10233249B2 (en) 2013-03-19 2019-03-19 Beijing Shenogen Pharma Group Ltd. Antibodies and methods for treating estrogen receptor-associated diseases
US20150331624A1 (en) * 2014-05-19 2015-11-19 Kabushiki Kaisha Toshiba Host-controlled flash translation layer snapshot
KR101956042B1 (ko) * 2017-07-13 2019-03-08 서강대학교산학협력단 표적 단백질 내 l-디하이드록시페닐알라닌의 도입 방법
US12134725B2 (en) 2019-06-17 2024-11-05 Merck Patent Gmbh Liquid crystal-based light valve

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879905A (en) * 1996-08-29 1999-03-09 Massachusetts Institute Of Technology In vivo method of initiating protein synthesis with an amino acid other than methionine
ES2464532T3 (es) 2001-04-19 2014-06-03 The Scripps Research Institute Métodos y composiciones para la producción de pares ortogonales de ARNt-aminoacil-ARNt sintetasa
MXPA05003983A (es) 2002-10-16 2005-06-22 Scripps Research Inst Incorporacion en sitio especifico de cetoaminoacidos en proteinas.
EP1558747B1 (en) 2002-10-16 2009-10-14 The Scripps Research Institute Glycoprotein synthesis
EP1583816A4 (en) 2002-12-22 2007-06-13 Scripps Research Inst PROTEIN ARRAYS
JP5642916B2 (ja) 2003-04-17 2014-12-17 ザ スクリプス リサーチ インスティテュート 真核遺伝コードの拡張
JP5275566B2 (ja) 2003-06-18 2013-08-28 ザ スクリプス リサーチ インスティチュート 反応性非天然アミノ酸遺伝コード付加
WO2005019415A2 (en) 2003-07-07 2005-03-03 The Scripps Research Institute Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof
EP1704242A4 (en) 2003-07-07 2008-06-18 Scripps Research Inst COMPOSITIONS WITH PAIRS OF ORTHOGONAL LEUCYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF
WO2005007624A2 (en) 2003-07-07 2005-01-27 The Scripps Research Institute Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof

Also Published As

Publication number Publication date
WO2005038002A2 (en) 2005-04-28
ES2396712T3 (es) 2013-02-25
IL201705A0 (en) 2011-08-01
US20120100570A1 (en) 2012-04-26
US8008041B2 (en) 2011-08-30
US8114654B2 (en) 2012-02-14
US20110008782A1 (en) 2011-01-13
MXPA06004087A (es) 2006-06-27
WO2005038002A3 (en) 2006-11-23
US7494796B2 (en) 2009-02-24
AU2004282577A1 (en) 2005-04-28
US20070009990A1 (en) 2007-01-11
CN1942579B (zh) 2013-06-26
JP5657850B2 (ja) 2015-01-21
JP2007508034A (ja) 2007-04-05
AU2004282577B2 (en) 2009-10-29
US20050227318A1 (en) 2005-10-13
US9783798B2 (en) 2017-10-10
CN101532046A (zh) 2009-09-16
IL206889A0 (en) 2010-12-30
US7811801B2 (en) 2010-10-12
PT1687401E (pt) 2013-02-26
DK1687401T3 (da) 2013-02-04
CN1942579A (zh) 2007-04-04
IL174947A0 (en) 2006-08-20
US20090298124A1 (en) 2009-12-03
IL174947A (en) 2011-11-30
EP1687401B1 (en) 2012-11-21
CA2541166A1 (en) 2005-04-28
EP1687401A2 (en) 2006-08-09
PL1687401T3 (pl) 2013-04-30
EP1687401A4 (en) 2007-08-01

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.