BRPI0415308A - incorporação especìfica de local de aminoácidos redox ativos em proteìnas - Google Patents

incorporação especìfica de local de aminoácidos redox ativos em proteìnas

Info

Publication number
BRPI0415308A
BRPI0415308A BRPI0415308-1A BRPI0415308A BRPI0415308A BR PI0415308 A BRPI0415308 A BR PI0415308A BR PI0415308 A BRPI0415308 A BR PI0415308A BR PI0415308 A BRPI0415308 A BR PI0415308A
Authority
BR
Brazil
Prior art keywords
amino acids
proteins
active redox
redox amino
site
Prior art date
Application number
BRPI0415308-1A
Other languages
English (en)
Inventor
Lital Alfonta
Peter G Schultz
Zhiwen Zhang
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of BRPI0415308A publication Critical patent/BRPI0415308A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

"INCORPORAçãO ESPECìFICA DE LOCAL DE AMINOáCIDOS REDOX ATIVOS EM PROTEìNAS". São fornecidos composição e métodos de produzir componentes de maquinário biossintético de proteína que inclui RNAts ortogonais, aminoacil RNAt sintetases ortogonais e pares ortogonais de RNAts/sintetases que incorporam aminoácidos redox ativos em proteínas. Métodos para identificar estes pares ortogonais também são fornecidos junto com métodos de produzir proteínas com aminoácidos redox ativos usando estes pares ortogonais.
BRPI0415308-1A 2003-10-14 2004-10-13 incorporação especìfica de local de aminoácidos redox ativos em proteìnas BRPI0415308A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51153203P 2003-10-14 2003-10-14
PCT/US2004/034089 WO2005038002A2 (en) 2003-10-14 2004-10-13 Site-specific incorporation of redox active amino acids into proteins

Publications (1)

Publication Number Publication Date
BRPI0415308A true BRPI0415308A (pt) 2006-12-05

Family

ID=34465242

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415308-1A BRPI0415308A (pt) 2003-10-14 2004-10-13 incorporação especìfica de local de aminoácidos redox ativos em proteìnas

Country Status (14)

Country Link
US (5) US7494796B2 (pt)
EP (1) EP1687401B1 (pt)
JP (1) JP5657850B2 (pt)
CN (2) CN1942579B (pt)
AU (1) AU2004282577B2 (pt)
BR (1) BRPI0415308A (pt)
CA (1) CA2541166A1 (pt)
DK (1) DK1687401T3 (pt)
ES (1) ES2396712T3 (pt)
IL (3) IL174947A (pt)
MX (1) MXPA06004087A (pt)
PL (1) PL1687401T3 (pt)
PT (1) PT1687401E (pt)
WO (1) WO2005038002A2 (pt)

Families Citing this family (30)

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DK2128246T3 (da) * 2001-04-19 2014-05-12 Univ California Fremgangsmåder og sammensætninger til fremstilling af ortogonale tRNA-aminoacyl-tRNA-syntetasepar.
ES2333422T3 (es) * 2002-10-16 2010-02-22 The Scripps Research Institute Sintesis de glicoproteinas.
US7618775B2 (en) * 2003-04-17 2009-11-17 The Scripps Research Institute Expanding the eukaryotic genetic code
EP2793027B1 (en) 2003-06-18 2019-11-13 The Scripps Research Institute Unnatural reactive amino acid genetic code additions
PT1914314E (pt) 2003-07-07 2010-09-08 Scripps Research Inst Composições de pares ortogonais de lisil-arnt e aminoacil-arnt-sintetase e suas utilizações
AU2005248392A1 (en) * 2004-05-25 2005-12-08 Irm, Llc Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for crystal structure determination
DE102004031258A1 (de) * 2004-06-29 2006-02-09 Jennissen, Herbert P., Prof. Dr. Proteinhybride mit polyhydroxyaromatischen Aminosäure-Epitopen
EP1794312A4 (en) * 2004-09-22 2009-08-12 Scripps Research Inst LOCAL LABELING OF PROTEINS FOR NMR STUDIES
CN102827827B (zh) 2004-10-27 2014-10-29 斯克利普斯研究院 体内掺入非天然氨基酸的正交翻译组分
WO2007047301A2 (en) * 2005-10-12 2007-04-26 The Scripps Research Institute Selective posttranslational modification of phage-displayed polypeptides
US7776535B2 (en) * 2006-02-06 2010-08-17 Franklin And Marshall College Site-specific incorporation of fluorinated amino acids into proteins
MX2008011470A (es) 2006-03-09 2008-09-24 Scripps Research Inst Sistemas para la expresion de componentes de traduccion ortogonales en celulas huesped eubacterianas.
KR20080113226A (ko) * 2006-03-16 2008-12-29 더 스크립스 리서치 인스티튜트 비천연 아미노산 페닐셀레노시스테인을 함유하는 단백질의 유전자적으로 프로그램된 발현
EP2018429A4 (en) * 2006-05-23 2010-07-14 Scrips Res Inst GENETICALLY ENCODED FLUORESCENT CUMARIN AMINO ACIDS
WO2008036392A2 (en) * 2006-09-21 2008-03-27 The Scripps Research Institute Genetically programmed expression of selectively sulfated proteins in eubacteria
AU2007333010A1 (en) 2006-10-18 2008-06-19 The Scripps Research Institute Genetic incorporation of unnatural amino acids into proteins in mammalian cells
WO2008137452A1 (en) * 2007-05-04 2008-11-13 Kenergy Royalty Company, Llc Implantable high efficiency digital stimulation device
US20090208994A1 (en) * 2007-10-25 2009-08-20 The Scripps Research Institute Genetic incorporation of 3-aminotyrosine into reductases
MX2010004807A (es) * 2007-11-02 2010-08-02 Scripss Res Inst Evolucion dirigida utilizando proteinas que comprenden aminoacidos no naturales.
US20090148887A1 (en) * 2007-11-02 2009-06-11 The Scripps Research Institute Genetically encoded boronate amino acid
CN105647824A (zh) * 2007-12-11 2016-06-08 斯克利普斯研究院 甲基营养酵母菌巴斯德毕赤酵母中的体内非天然氨基酸表达
US8318172B2 (en) * 2008-02-08 2012-11-27 The Scripps Research Institute Breaking immunological tolerance with a genetically encoded unnatural amino acid
JP2012511403A (ja) * 2008-12-09 2012-05-24 クック メディカル テクノロジーズ エルエルシー 鋲留め器具の制御放出のための装置と方法
US20090197339A1 (en) * 2008-12-10 2009-08-06 The Scripps Research Institute In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris
EP2370473B1 (en) 2008-12-10 2016-05-11 The Scripps Research Institute Production of carrier-peptide conjugates using chemically reactive unnatural amino acids
US9017978B2 (en) * 2009-02-04 2015-04-28 Bengurion University Of The Negev Research And Development Authority Systems and method for bio-electricity production
JP6574754B2 (ja) 2013-03-19 2019-09-11 ベイジン シェノゲン ファーマ グループ リミテッド エストロゲン受容体関連疾患を処置するための抗体及び方法
US20150331624A1 (en) * 2014-05-19 2015-11-19 Kabushiki Kaisha Toshiba Host-controlled flash translation layer snapshot
KR101956042B1 (ko) * 2017-07-13 2019-03-08 서강대학교산학협력단 표적 단백질 내 l-디하이드록시페닐알라닌의 도입 방법
WO2020254219A1 (en) 2019-06-17 2020-12-24 Merck Patent Gmbh Liquid crystal-based light valve

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879905A (en) * 1996-08-29 1999-03-09 Massachusetts Institute Of Technology In vivo method of initiating protein synthesis with an amino acid other than methionine
DK2128246T3 (da) * 2001-04-19 2014-05-12 Univ California Fremgangsmåder og sammensætninger til fremstilling af ortogonale tRNA-aminoacyl-tRNA-syntetasepar.
MXPA05003983A (es) 2002-10-16 2005-06-22 Scripps Research Inst Incorporacion en sitio especifico de cetoaminoacidos en proteinas.
ES2333422T3 (es) 2002-10-16 2010-02-22 The Scripps Research Institute Sintesis de glicoproteinas.
CA2508939A1 (en) 2002-12-22 2004-07-15 The Scripps Research Institute Protein arrays
US7618775B2 (en) 2003-04-17 2009-11-17 The Scripps Research Institute Expanding the eukaryotic genetic code
EP2793027B1 (en) 2003-06-18 2019-11-13 The Scripps Research Institute Unnatural reactive amino acid genetic code additions
PT1914314E (pt) 2003-07-07 2010-09-08 Scripps Research Inst Composições de pares ortogonais de lisil-arnt e aminoacil-arnt-sintetase e suas utilizações
WO2005007870A2 (en) 2003-07-07 2005-01-27 The Scripps Research Institute COMPOSITIONS OF ORTHOGONAL LEUCYL-tRNA AND AMINOACYL-tRNA SYNTHETASE PAIRS AND USES THEREOF
EP1658366A4 (en) 2003-07-07 2006-08-09 Scripps Research Inst COMPOSITIONS OF ORTHOGONAL GLUTAMYL-TRNA AND AMINOACYL-TRNA-SYNTHETASEPAARES AND THEIR USES

Also Published As

Publication number Publication date
WO2005038002A3 (en) 2006-11-23
WO2005038002A2 (en) 2005-04-28
US8008041B2 (en) 2011-08-30
EP1687401A4 (en) 2007-08-01
PL1687401T3 (pl) 2013-04-30
PT1687401E (pt) 2013-02-26
US20120100570A1 (en) 2012-04-26
US8114654B2 (en) 2012-02-14
JP2007508034A (ja) 2007-04-05
JP5657850B2 (ja) 2015-01-21
IL174947A (en) 2011-11-30
US20090298124A1 (en) 2009-12-03
AU2004282577B2 (en) 2009-10-29
CN101532046A (zh) 2009-09-16
US7494796B2 (en) 2009-02-24
EP1687401B1 (en) 2012-11-21
CN1942579B (zh) 2013-06-26
IL174947A0 (en) 2006-08-20
US9783798B2 (en) 2017-10-10
US20050227318A1 (en) 2005-10-13
EP1687401A2 (en) 2006-08-09
IL206889A0 (en) 2010-12-30
US7811801B2 (en) 2010-10-12
IL201705A0 (en) 2011-08-01
MXPA06004087A (es) 2006-06-27
AU2004282577A1 (en) 2005-04-28
DK1687401T3 (da) 2013-02-04
CA2541166A1 (en) 2005-04-28
US20070009990A1 (en) 2007-01-11
US20110008782A1 (en) 2011-01-13
CN1942579A (zh) 2007-04-04
ES2396712T3 (es) 2013-02-25

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.