BRPI0415308A - incorporação especìfica de local de aminoácidos redox ativos em proteìnas - Google Patents

incorporação especìfica de local de aminoácidos redox ativos em proteìnas

Info

Publication number
BRPI0415308A
BRPI0415308A BRPI0415308-1A BRPI0415308A BRPI0415308A BR PI0415308 A BRPI0415308 A BR PI0415308A BR PI0415308 A BRPI0415308 A BR PI0415308A BR PI0415308 A BRPI0415308 A BR PI0415308A
Authority
BR
Brazil
Prior art keywords
amino acids
proteins
active redox
redox amino
site
Prior art date
Application number
BRPI0415308-1A
Other languages
English (en)
Inventor
Lital Alfonta
Peter G Schultz
Zhiwen Zhang
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of BRPI0415308A publication Critical patent/BRPI0415308A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

"INCORPORAçãO ESPECìFICA DE LOCAL DE AMINOáCIDOS REDOX ATIVOS EM PROTEìNAS". São fornecidos composição e métodos de produzir componentes de maquinário biossintético de proteína que inclui RNAts ortogonais, aminoacil RNAt sintetases ortogonais e pares ortogonais de RNAts/sintetases que incorporam aminoácidos redox ativos em proteínas. Métodos para identificar estes pares ortogonais também são fornecidos junto com métodos de produzir proteínas com aminoácidos redox ativos usando estes pares ortogonais.
BRPI0415308-1A 2003-10-14 2004-10-13 incorporação especìfica de local de aminoácidos redox ativos em proteìnas BRPI0415308A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51153203P 2003-10-14 2003-10-14
PCT/US2004/034089 WO2005038002A2 (en) 2003-10-14 2004-10-13 Site-specific incorporation of redox active amino acids into proteins

Publications (1)

Publication Number Publication Date
BRPI0415308A true BRPI0415308A (pt) 2006-12-05

Family

ID=34465242

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415308-1A BRPI0415308A (pt) 2003-10-14 2004-10-13 incorporação especìfica de local de aminoácidos redox ativos em proteìnas

Country Status (14)

Country Link
US (5) US7494796B2 (pt)
EP (1) EP1687401B1 (pt)
JP (1) JP5657850B2 (pt)
CN (2) CN1942579B (pt)
AU (1) AU2004282577B2 (pt)
BR (1) BRPI0415308A (pt)
CA (1) CA2541166A1 (pt)
DK (1) DK1687401T3 (pt)
ES (1) ES2396712T3 (pt)
IL (3) IL174947A (pt)
MX (1) MXPA06004087A (pt)
PL (1) PL1687401T3 (pt)
PT (1) PT1687401E (pt)
WO (1) WO2005038002A2 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002085923A2 (en) * 2001-04-19 2002-10-31 The Scripps Research Institute In vivo incorporation of unnatural amino acids
MXPA05003978A (es) * 2002-10-16 2005-06-22 Scripps Research Inst Sintesis de glicoproteinas.
JP5642916B2 (ja) 2003-04-17 2014-12-17 ザ スクリプス リサーチ インスティテュート 真核遺伝コードの拡張
EP2410331B1 (en) 2003-06-18 2015-09-23 The Scripps Research Institute Aminoacyl-tRNA synthetase for aminoacylation tRNA with unnatural amino acids
EP1649004A4 (en) * 2003-07-07 2008-04-09 Scripps Research Inst COMPOSITIONS WITH PAIRS OF ORTHOGONAL LYSYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF
JP2008500050A (ja) * 2004-05-25 2008-01-10 ザ スクリップス リサーチ インスティテュート 結晶構造決定のための重原子含有非天然アミノ酸の部位特異的蛋白質組込み
DE102004031258A1 (de) * 2004-06-29 2006-02-09 Jennissen, Herbert P., Prof. Dr. Proteinhybride mit polyhydroxyaromatischen Aminosäure-Epitopen
US20080171317A1 (en) * 2004-09-22 2008-07-17 The Scripps Research Institute Site-Specific Labeling of Proteins for Nmr Studies
CN101048506B (zh) 2004-10-27 2013-06-26 斯克利普斯研究院 体内掺入非天然氨基酸的正交翻译组分
BRPI0617191A2 (pt) * 2005-10-12 2011-07-19 Scripps Research Inst modificação pós-traducional de polipeptìdeos expressos em fagos
WO2007092475A2 (en) * 2006-02-06 2007-08-16 Franklin And Marshall College Site-specific incorporation of fluorinated amino acids into proteins
KR20080106430A (ko) * 2006-03-09 2008-12-05 더 스크립스 리서치 인스티튜트 진정 세균 숙주 세포 내에서의 직교형 번역 성분의 발현을 위한 시스템
WO2007109035A2 (en) 2006-03-16 2007-09-27 The Scripps Research Institute Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
AU2007267950B2 (en) * 2006-05-23 2012-08-16 The Scripps Research Institute Genetically encoded fluorescent coumarin amino acids
JP5385143B2 (ja) * 2006-09-21 2014-01-08 ザ スクリプス リサーチ インスティチュート 真正細菌における選択的に硫酸化された蛋白質の遺伝的にプログラムされた発現
WO2008073184A2 (en) 2006-10-18 2008-06-19 The Scripps Research Institute Genetic incorporation of unnatural amino acids into proteins in mammalian cells
WO2008137452A1 (en) * 2007-05-04 2008-11-13 Kenergy Royalty Company, Llc Implantable high efficiency digital stimulation device
US8673591B2 (en) 2007-10-25 2014-03-18 The Scripps Research Institute Genetic incorporation of 3-aminotyrosine into reductases
WO2009059056A2 (en) * 2007-11-02 2009-05-07 The Scripps Research Institute A genetically encoded boronate amino acid
JP5513398B2 (ja) * 2007-11-02 2014-06-04 ザ スクリプス リサーチ インスティチュート 非天然アミノ酸を含有する蛋白質を使用する指向的進化
CN101939410A (zh) 2007-12-11 2011-01-05 斯克利普斯研究院 甲基营养酵母菌巴斯德毕赤酵母中的体内非天然氨基酸表达
EP2249865A4 (en) * 2008-02-08 2012-04-04 Scripps Research Inst BREAKING IMMUNOLOGICAL TOLERANCE WITH A GENETICALLY ENCODED UNNATURAL AMINO ACID
JP2012511403A (ja) * 2008-12-09 2012-05-24 クック メディカル テクノロジーズ エルエルシー 鋲留め器具の制御放出のための装置と方法
US8609383B2 (en) 2008-12-10 2013-12-17 The Scripps Research Institute Production of carrier-peptide conjugates using chemically reactive unnatural amino acids
US20090197339A1 (en) * 2008-12-10 2009-08-06 The Scripps Research Institute In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris
WO2010089741A1 (en) * 2009-02-04 2010-08-12 Ben-Gurion University Of The Negev Research And Development Authority Systems and methods for bio-electricity production
JP6574754B2 (ja) 2013-03-19 2019-09-11 ベイジン シェノゲン ファーマ グループ リミテッド エストロゲン受容体関連疾患を処置するための抗体及び方法
US20150331624A1 (en) * 2014-05-19 2015-11-19 Kabushiki Kaisha Toshiba Host-controlled flash translation layer snapshot
KR101956042B1 (ko) * 2017-07-13 2019-03-08 서강대학교산학협력단 표적 단백질 내 l-디하이드록시페닐알라닌의 도입 방법
EP3983501B1 (en) 2019-06-17 2025-02-26 Merck Patent GmbH Liquid crystal-based light valve

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879905A (en) * 1996-08-29 1999-03-09 Massachusetts Institute Of Technology In vivo method of initiating protein synthesis with an amino acid other than methionine
WO2002085923A2 (en) 2001-04-19 2002-10-31 The Scripps Research Institute In vivo incorporation of unnatural amino acids
MXPA05003978A (es) 2002-10-16 2005-06-22 Scripps Research Inst Sintesis de glicoproteinas.
JP4444113B2 (ja) 2002-10-16 2010-03-31 ザ スクリップス リサーチ インスティテュート ケトアミノ酸の部位特異的蛋白質組込み方法
CA2508939A1 (en) 2002-12-22 2004-07-15 The Scripps Research Institute Protein arrays
JP5642916B2 (ja) 2003-04-17 2014-12-17 ザ スクリプス リサーチ インスティテュート 真核遺伝コードの拡張
EP2410331B1 (en) 2003-06-18 2015-09-23 The Scripps Research Institute Aminoacyl-tRNA synthetase for aminoacylation tRNA with unnatural amino acids
WO2005007624A2 (en) 2003-07-07 2005-01-27 The Scripps Research Institute Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof
EP1649004A4 (en) 2003-07-07 2008-04-09 Scripps Research Inst COMPOSITIONS WITH PAIRS OF ORTHOGONAL LYSYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF
US20060160175A1 (en) 2003-07-07 2006-07-20 The Scripps Research Institute Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof

Also Published As

Publication number Publication date
DK1687401T3 (da) 2013-02-04
ES2396712T3 (es) 2013-02-25
US20120100570A1 (en) 2012-04-26
AU2004282577B2 (en) 2009-10-29
PL1687401T3 (pl) 2013-04-30
IL174947A0 (en) 2006-08-20
CN101532046A (zh) 2009-09-16
US9783798B2 (en) 2017-10-10
CA2541166A1 (en) 2005-04-28
CN1942579A (zh) 2007-04-04
US8114654B2 (en) 2012-02-14
WO2005038002A2 (en) 2005-04-28
EP1687401B1 (en) 2012-11-21
US20050227318A1 (en) 2005-10-13
CN1942579B (zh) 2013-06-26
IL201705A0 (en) 2011-08-01
JP2007508034A (ja) 2007-04-05
US20090298124A1 (en) 2009-12-03
JP5657850B2 (ja) 2015-01-21
US20070009990A1 (en) 2007-01-11
IL206889A0 (en) 2010-12-30
WO2005038002A3 (en) 2006-11-23
EP1687401A2 (en) 2006-08-09
AU2004282577A1 (en) 2005-04-28
IL174947A (en) 2011-11-30
US7494796B2 (en) 2009-02-24
US8008041B2 (en) 2011-08-30
EP1687401A4 (en) 2007-08-01
PT1687401E (pt) 2013-02-26
US7811801B2 (en) 2010-10-12
US20110008782A1 (en) 2011-01-13
MXPA06004087A (es) 2006-06-27

Similar Documents

Publication Publication Date Title
BRPI0415308A (pt) incorporação especìfica de local de aminoácidos redox ativos em proteìnas
ATE541934T1 (de) Zusammensetzungen von aminoacyl-trna-synthetase und verwendungen davon
ATE526414T1 (de) Ortsspezifische einbindung von ketoaminosäuren in proteine
EP1704242A4 (en) COMPOSITIONS WITH PAIRS OF ORTHOGONAL LEUCYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF
WO2005007624A3 (en) Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof
DE602004027770D1 (de) Zusammensetzungen aus orthogonalen Lysyl-TRNA- und Aminoacyl-TRNA-Synthetasepaaren und deren Verwendung
MX2008002149A (es) Composiciones de arnt y sus usos.
IL158419A (en) Cell containing orthogonal trna synthase (ors) and orthogonal trna (otrna)
BRPI0411475A (pt) adições de código genético de aminoácido reativo não natural
WO2006034332A3 (en) In vivo incorporation of alkynyl amino acids into proteins in eubacteria
WO2007090198A3 (en) Fluorescent assays using orthogonal trna - aminoacyl synthetase pairs
BR0207775A (pt) Lipossomos anfotéricos métodos para carregamento dos mesmos com ingredientes ativos e sua utilização
IL196893A0 (en) Site specific incorporation of non-natural amino acids by vertebrate cells
WO2006034410A3 (en) Adding photoregulated amino acids to the genetic code
CY1112330T1 (el) Πρωτεϊνες συνδεσης gag
DE69942459D1 (de) Isolierte nukleinsäuremoleküle die t-zellen induzierbare faktoren kodieren (tif), kodierte proteine und ihre anwendung
WO2008030613A3 (en) Hybrid suppressor trna for vertebrate cells
ATE381623T1 (de) Verfahren zur expression von protein mit darin integrierter unnatürlicher aminosäure
BRPI0413880A (pt) compostos cicloalquilaminoácidos, processo para a obtenção dos mesmos
EA200300388A1 (ru) 1-аминоалкилциклогексаны в качестве трипаноцидных агентов
WO2002060941A3 (en) Fluorescent proteins
BRPI0408023A (pt) métodos para previnir gliconoilação de proteìnas
EA200200775A1 (ru) Псевдополиморф (-)-цис-2-(2-хлорфенил)-5,7-дигидрокси-8[4r-(3s-гидрокси-1-метил)пиперидинил]-4h-1-бензопиран-4-она

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.