BRPI0415348A - processo para preparação de 3beta-aminonortropanos n-substituìdos - Google Patents

processo para preparação de 3beta-aminonortropanos n-substituìdos

Info

Publication number
BRPI0415348A
BRPI0415348A BRPI0415348-0A BRPI0415348A BRPI0415348A BR PI0415348 A BRPI0415348 A BR PI0415348A BR PI0415348 A BRPI0415348 A BR PI0415348A BR PI0415348 A BRPI0415348 A BR PI0415348A
Authority
BR
Brazil
Prior art keywords
sup
aminonortropans
beta
preparing
formula
Prior art date
Application number
BRPI0415348-0A
Other languages
English (en)
Inventor
Rainer Sabotta
Hans-Peter Ignatow
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE200410013227 external-priority patent/DE102004013227A1/de
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BRPI0415348A publication Critical patent/BRPI0415348A/pt
Publication of BRPI0415348B1 publication Critical patent/BRPI0415348B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"PROCESSO PARA PREPARAçãO DE 3BETA-AMINONORTROPANOS N-SUBSTITUìDOS". A invenção refere-se a um processo para preparação de 3<225>aminonortropanos N-substituídos de fórmula I, na qual R1 apresenta o significado indicado nas reivindicações, em que, tautomeriza-se ou isomeriza-se e em seguida hidrolisa-se o respectivo 3-oxonortropano ou o respectivo 3<244>-aminonortropano, sendo que este é convertido com uma arilmetilamina ou um arilaldeído para formar as respectivas iminas. Além disso, a invenção refere-se aos novos compostos de fórmula V nos quais R¬ 1¬ e Ar apresentam os significados indicados nas reivindicações.
BRPI0415348-0A 2003-10-16 2004-10-05 3-beta-aminonortropanos N-substituídos e processo para preparação dos mesmos BRPI0415348B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10348112 2003-10-16
DE10348112.5 2003-10-16
DE200410013227 DE102004013227A1 (de) 2004-03-18 2004-03-18 Verfahren zur Herstellung von N-Substituierten 3-Beta-Aminonortropanen
DE102004013227.5 2004-03-18
PCT/EP2004/011094 WO2005037831A1 (de) 2003-10-16 2004-10-05 Verfahren zur herstellung von n-substituierten 3beta-aminonortropanen

Publications (2)

Publication Number Publication Date
BRPI0415348A true BRPI0415348A (pt) 2006-12-05
BRPI0415348B1 BRPI0415348B1 (pt) 2014-02-25

Family

ID=34466020

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415348-0A BRPI0415348B1 (pt) 2003-10-16 2004-10-05 3-beta-aminonortropanos N-substituídos e processo para preparação dos mesmos

Country Status (16)

Country Link
US (1) US7321042B2 (pt)
EP (1) EP1675851B1 (pt)
JP (1) JP4545152B2 (pt)
KR (1) KR101175603B1 (pt)
AT (1) ATE405563T1 (pt)
AU (1) AU2004281923B2 (pt)
BR (1) BRPI0415348B1 (pt)
CA (1) CA2542110C (pt)
DE (1) DE502004007915D1 (pt)
DK (1) DK1675851T3 (pt)
ES (1) ES2313058T3 (pt)
IL (1) IL174957A (pt)
MX (1) MXPA06004177A (pt)
NZ (1) NZ546916A (pt)
RU (1) RU2350614C2 (pt)
WO (1) WO2005037831A1 (pt)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01129571A (ja) * 1987-11-13 1989-05-22 Nec Corp ファクシミリ装置
GB9504060D0 (en) * 1995-03-01 1995-04-19 Smithkline Beecham Plc Novel process
FR2762316B1 (fr) * 1997-04-18 1999-12-17 Sanofi Synthelabo Derives de 5-aryl-3-(8-azabicyclo[3.2.1] octan-3-yl)-1,3,4- oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique
ES2278729T3 (es) 2000-03-06 2007-08-16 Acadia Pharmaceuticals Inc. Compuestos azaciclicos para usar en el tratamiento de enfermedades relacionadas con la serotonina.

Also Published As

Publication number Publication date
IL174957A (en) 2011-04-28
US20050096346A1 (en) 2005-05-05
JP2007523053A (ja) 2007-08-16
DE502004007915D1 (de) 2008-10-02
ES2313058T3 (es) 2009-03-01
EP1675851B1 (de) 2008-08-20
EP1675851A1 (de) 2006-07-05
KR20060100413A (ko) 2006-09-20
CA2542110A1 (en) 2005-04-28
CA2542110C (en) 2012-07-10
DK1675851T3 (da) 2008-11-24
BRPI0415348B1 (pt) 2014-02-25
WO2005037831A1 (de) 2005-04-28
AU2004281923A1 (en) 2005-04-28
US7321042B2 (en) 2008-01-22
AU2004281923B2 (en) 2011-01-20
RU2006116461A (ru) 2007-11-27
NZ546916A (en) 2010-01-29
KR101175603B1 (ko) 2012-08-22
JP4545152B2 (ja) 2010-09-15
IL174957A0 (en) 2006-08-20
MXPA06004177A (es) 2006-06-28
RU2350614C2 (ru) 2009-03-27
ATE405563T1 (de) 2008-09-15

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/10/2004, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 12A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.