BRPI0415421A - sulfoximine-substituted pyrimidines as cdk and / or vegf inhibitors, their preparation and their use as a medicament - Google Patents

sulfoximine-substituted pyrimidines as cdk and / or vegf inhibitors, their preparation and their use as a medicament

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Publication number
BRPI0415421A
BRPI0415421A BRPI0415421-5A BRPI0415421A BRPI0415421A BR PI0415421 A BRPI0415421 A BR PI0415421A BR PI0415421 A BRPI0415421 A BR PI0415421A BR PI0415421 A BRPI0415421 A BR PI0415421A
Authority
BR
Brazil
Prior art keywords
preparation
cdk
substituted pyrimidines
sulfoximine
medicament
Prior art date
Application number
BRPI0415421-5A
Other languages
Portuguese (pt)
Inventor
Ulrich Luecking
Martin Krueger
Rolf Jautelat
Gerhard Siemeister
Original Assignee
Schering Ag
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Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of BRPI0415421A publication Critical patent/BRPI0415421A/en

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A—HUMAN NECESSITIES
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

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Abstract

"PIRIMIDINAS SUBSTITUìDAS POR SULFóXIMINA COMO INIBIDORES DE CDK E/OU VEGF, SUA PREPARAçãO E SEU EMPREGO COMO MEDICAMENTO". Da presente invenção refere-se a um derivado de pirimidina de acordo com a fórmula I na qual o Q, R¬ 1¬, R¬ 2¬, R¬ 3¬, R¬ 4¬, R¬ 5¬, X, e m têm os significados contidos na descrições como cinases dependentes de inibidores de ciclina e receptores de tirosina quinase VEGF, cuja preparação assim como seu emprego como medicamento para tratamento de diversas doenças."Sulfoxime-Substituted Pyrimidines as CDK and / or VEGF Inhibitors, Their Preparation and Employment as a Drug". The present invention relates to a pyrimidine derivative according to formula I wherein Q, R¬1¬, R¬2¬, R¬3¬, R¬4¬, R¬5¬, X, have the meanings contained in the descriptions as cyclin inhibitor dependent kinases and VEGF tyrosine kinase receptors, the preparation of which as well as their use as a medicine for the treatment of various diseases.

BRPI0415421-5A 2003-10-16 2004-10-12 sulfoximine-substituted pyrimidines as cdk and / or vegf inhibitors, their preparation and their use as a medicament BRPI0415421A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10349423A DE10349423A1 (en) 2003-10-16 2003-10-16 Sulfoximine-substituted parimidines as CDK and / or VEGF inhibitors, their preparation and use as medicaments
PCT/EP2004/011661 WO2005037800A1 (en) 2003-10-16 2004-10-12 Sulfoximine-substituted pyrimidines for use as cdk and/or vegf inhibitors, the production thereof and their use as drugs

Publications (1)

Publication Number Publication Date
BRPI0415421A true BRPI0415421A (en) 2006-12-05

Family

ID=34442222

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415421-5A BRPI0415421A (en) 2003-10-16 2004-10-12 sulfoximine-substituted pyrimidines as cdk and / or vegf inhibitors, their preparation and their use as a medicament

Country Status (35)

Country Link
US (2) US8507510B2 (en)
EP (1) EP1673352B1 (en)
JP (1) JP4700006B2 (en)
KR (1) KR101117387B1 (en)
CN (1) CN1867553B (en)
AR (1) AR046119A1 (en)
AT (1) ATE427939T1 (en)
AU (1) AU2004281960B2 (en)
BR (1) BRPI0415421A (en)
CA (1) CA2542492C (en)
CR (1) CR8363A (en)
CY (1) CY1110058T1 (en)
DE (2) DE10349423A1 (en)
DK (1) DK1673352T3 (en)
EC (1) ECSP066568A (en)
ES (1) ES2324475T3 (en)
GT (1) GT200400206A (en)
HR (1) HRP20090348T1 (en)
IL (1) IL174952A (en)
JO (1) JO2534B1 (en)
ME (1) ME00158B (en)
MX (1) MXPA06004091A (en)
MY (1) MY140291A (en)
NO (1) NO337290B1 (en)
NZ (1) NZ546510A (en)
PE (1) PE20050907A1 (en)
PL (1) PL1673352T3 (en)
PT (1) PT1673352E (en)
RS (1) RS51657B (en)
RU (1) RU2410378C2 (en)
SI (1) SI1673352T1 (en)
TW (1) TWI347844B (en)
UA (1) UA86041C2 (en)
WO (1) WO2005037800A1 (en)
ZA (1) ZA200603885B (en)

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