BRPI0415421A - pirimidinas substituìdas por sulfóximina como inibidores de cdk e/ou vegf, sua preparação e seu emprego como medicamento - Google Patents

pirimidinas substituìdas por sulfóximina como inibidores de cdk e/ou vegf, sua preparação e seu emprego como medicamento

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Publication number
BRPI0415421A
BRPI0415421A BRPI0415421-5A BRPI0415421A BRPI0415421A BR PI0415421 A BRPI0415421 A BR PI0415421A BR PI0415421 A BRPI0415421 A BR PI0415421A BR PI0415421 A BRPI0415421 A BR PI0415421A
Authority
BR
Brazil
Prior art keywords
preparation
cdk
substituted pyrimidines
sulfoximine
medicament
Prior art date
Application number
BRPI0415421-5A
Other languages
English (en)
Inventor
Ulrich Luecking
Martin Krueger
Rolf Jautelat
Gerhard Siemeister
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of BRPI0415421A publication Critical patent/BRPI0415421A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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Abstract

"PIRIMIDINAS SUBSTITUìDAS POR SULFóXIMINA COMO INIBIDORES DE CDK E/OU VEGF, SUA PREPARAçãO E SEU EMPREGO COMO MEDICAMENTO". Da presente invenção refere-se a um derivado de pirimidina de acordo com a fórmula I na qual o Q, R¬ 1¬, R¬ 2¬, R¬ 3¬, R¬ 4¬, R¬ 5¬, X, e m têm os significados contidos na descrições como cinases dependentes de inibidores de ciclina e receptores de tirosina quinase VEGF, cuja preparação assim como seu emprego como medicamento para tratamento de diversas doenças.
BRPI0415421-5A 2003-10-16 2004-10-12 pirimidinas substituìdas por sulfóximina como inibidores de cdk e/ou vegf, sua preparação e seu emprego como medicamento BRPI0415421A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10349423A DE10349423A1 (de) 2003-10-16 2003-10-16 Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
PCT/EP2004/011661 WO2005037800A1 (de) 2003-10-16 2004-10-12 Sulfoximinsubstituierte pyrimidine als cdk- und/oder vegf-inhibitoren, deren herstellung und verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
BRPI0415421A true BRPI0415421A (pt) 2006-12-05

Family

ID=34442222

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415421-5A BRPI0415421A (pt) 2003-10-16 2004-10-12 pirimidinas substituìdas por sulfóximina como inibidores de cdk e/ou vegf, sua preparação e seu emprego como medicamento

Country Status (35)

Country Link
US (2) US8507510B2 (pt)
EP (1) EP1673352B1 (pt)
JP (1) JP4700006B2 (pt)
KR (1) KR101117387B1 (pt)
CN (1) CN1867553B (pt)
AR (1) AR046119A1 (pt)
AT (1) ATE427939T1 (pt)
AU (1) AU2004281960B2 (pt)
BR (1) BRPI0415421A (pt)
CA (1) CA2542492C (pt)
CR (1) CR8363A (pt)
CY (1) CY1110058T1 (pt)
DE (2) DE10349423A1 (pt)
DK (1) DK1673352T3 (pt)
EC (1) ECSP066568A (pt)
ES (1) ES2324475T3 (pt)
GT (1) GT200400206A (pt)
HR (1) HRP20090348T1 (pt)
IL (1) IL174952A (pt)
JO (1) JO2534B1 (pt)
ME (1) ME00158B (pt)
MX (1) MXPA06004091A (pt)
MY (1) MY140291A (pt)
NO (1) NO337290B1 (pt)
NZ (1) NZ546510A (pt)
PE (1) PE20050907A1 (pt)
PL (1) PL1673352T3 (pt)
PT (1) PT1673352E (pt)
RS (1) RS51657B (pt)
RU (1) RU2410378C2 (pt)
SI (1) SI1673352T1 (pt)
TW (1) TWI347844B (pt)
UA (1) UA86041C2 (pt)
WO (1) WO2005037800A1 (pt)
ZA (1) ZA200603885B (pt)

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JP2005524672A (ja) 2002-03-09 2005-08-18 アストラゼネカ アクチボラグ Ｃｄｋ阻害活性を有するイミダゾリル置換ピリミジン誘導体
GB0205690D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
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GB0311276D0 (en) 2003-05-16 2003-06-18 Astrazeneca Ab Chemical compounds
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JP4886511B2 (ja) 2003-07-30 2012-02-29 ライジェル ファーマシューティカルズ， インコーポレイテッド ２，４−ピリミジンジアミン化合物による自己免疫疾患の治療または予防方法
DE10349423A1 (de) * 2003-10-16 2005-06-16 Schering Ag Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
JP4812763B2 (ja) 2004-05-18 2011-11-09 ライジェル ファーマシューティカルズ， インコーポレイテッド シクロアルキル置換ピリミジンジアミン化合物およびそれらの用途
GB2420559B (en) 2004-11-15 2008-08-06 Rigel Pharmaceuticals Inc Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses
CN101115761B (zh) 2005-01-19 2012-07-18 里格尔药品股份有限公司 2,4-嘧啶二胺化合物的前药及其应用
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EP1710246A1 (en) * 2005-04-08 2006-10-11 Schering Aktiengesellschaft Sulfoximine-pyrimidine Macrocycles and the salts thereof, a process for making them, and their pharmaceutical use against cancer
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BRPI0616722A2 (pt) 2005-09-30 2012-12-25 Astrazeneca Ab composto ou um sal farmaceuticamente aceitÁvel ou um Éster hidrolisÁvel in vivo do mesmo, processo para preparar o mesmo, composiÇço farmacÊutica, uso de um composto ou um sal farmaceuticamente aceitÁvel ou um Éster hidrolisÁvel in vivo do mesmo, e, mÉtodos para produzir um efeito anti-proliferaÇço celular e um efeito inibidor cdk2, para tratar cÂncer, e para tratar doenÇas
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
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