BRPI0415523A - derivados de 2-(4-sulfonilamino)-3-hidroxi-3,4-dihiro-2h-cromeno-6-i la substituìdos com amidometila, processo e produtos intermediários para a sua preparação e fármacos contendo estes compostos - Google Patents

derivados de 2-(4-sulfonilamino)-3-hidroxi-3,4-dihiro-2h-cromeno-6-i la substituìdos com amidometila, processo e produtos intermediários para a sua preparação e fármacos contendo estes compostos

Info

Publication number
BRPI0415523A
BRPI0415523A BRPI0415523-8A BRPI0415523A BRPI0415523A BR PI0415523 A BRPI0415523 A BR PI0415523A BR PI0415523 A BRPI0415523 A BR PI0415523A BR PI0415523 A BRPI0415523 A BR PI0415523A
Authority
BR
Brazil
Prior art keywords
compounds
preparation
chromen
hydroxy
dihiro
Prior art date
Application number
BRPI0415523-8A
Other languages
English (en)
Inventor
David Sykes
Brian Moloney
Lester Marrison
Dieter Ziegler
Michael Mlinaric
Christiane Boecker
Reinhard Brueckner
Michael Weske
Klaus Witte
Yvan Fischer
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of BRPI0415523A publication Critical patent/BRPI0415523A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE 2-(4-SULFONILAMINO)-3-HIDROXI-3,4-DIHIDRO-2H-CROMENO- 6-ILA SUBSTITUìDOS COM AMIDOMETILA, PROCESSO E PRODUTOS INTERMEDIáRIOS PARA A SUA PREPARAçãO E FáRMACOS CONTENDO ESTES COMPOSTOS". A presente invenção refere-se a compostos da fórmula geral I, onde R¬ 1¬, R¬ 2¬, R¬ 3¬, R¬ 4¬, R¬ 5¬ e R¬ 6¬ possuem os significados indicados na descrição, bem como um processo para a preparação destes compostos e produtos intermediários deste processo. Além disso, são indicados os medicamentos contendo compostos da fórmula I.
BRPI0415523-8A 2003-10-17 2004-10-14 derivados de 2-(4-sulfonilamino)-3-hidroxi-3,4-dihiro-2h-cromeno-6-i la substituìdos com amidometila, processo e produtos intermediários para a sua preparação e fármacos contendo estes compostos BRPI0415523A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10348298A DE10348298A1 (de) 2003-10-17 2003-10-17 Amidomethyl-substituierte 2-(4-Sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-ylderivade, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
PCT/EP2004/052539 WO2005037780A2 (de) 2003-10-17 2004-10-14 Amidomethyl-substituierte 2-(4-sulfonilamino)-3-hidroxy-3,4-dihydro-2h-chromen-6-yl-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
BRPI0415523A true BRPI0415523A (pt) 2006-12-26

Family

ID=34442032

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415523-8A BRPI0415523A (pt) 2003-10-17 2004-10-14 derivados de 2-(4-sulfonilamino)-3-hidroxi-3,4-dihiro-2h-cromeno-6-i la substituìdos com amidometila, processo e produtos intermediários para a sua preparação e fármacos contendo estes compostos

Country Status (24)

Country Link
EP (1) EP1678130B1 (pt)
JP (1) JP4791968B2 (pt)
KR (1) KR20060129170A (pt)
CN (1) CN100532375C (pt)
AR (1) AR046106A1 (pt)
AT (1) ATE405547T1 (pt)
AU (1) AU2004281195B2 (pt)
BR (1) BRPI0415523A (pt)
CA (1) CA2542813C (pt)
DE (3) DE10348298A1 (pt)
DK (1) DK1678130T3 (pt)
ES (1) ES2313126T3 (pt)
HR (1) HRP20080602T3 (pt)
IL (1) IL174950A (pt)
MX (1) MXPA06003958A (pt)
NO (1) NO20062202L (pt)
PL (1) PL1678130T3 (pt)
PT (1) PT1678130E (pt)
RU (1) RU2355685C2 (pt)
SI (1) SI1678130T1 (pt)
TW (1) TWI321564B (pt)
UA (1) UA82907C2 (pt)
WO (1) WO2005037780A2 (pt)
ZA (1) ZA200602788B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007011198A (es) * 2005-04-12 2007-10-17 Solvay Pharm Gmbh Derivados de los 2-(4-sulfonilamino)-3-3hidroxi-3,4-dihidro-2h- croman -6- ilo sustituidos con aminoalquil-amidometilo y medicamentos que contienen estos compuestos.
US7714150B2 (en) 2005-04-12 2010-05-11 Solvay Pharmaceuticals Gmbh Aminoalkyl-amidomethyl-substituted 2-(4-sulphonylamino)-3-hydroxy-3,4-dihydro-2H-chroman-6-yl derivatives
JP4943429B2 (ja) * 2005-07-22 2012-05-30 メルク・シャープ・エンド・ドーム・コーポレイション カリウムチャネル阻害剤
GB0525164D0 (en) 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
NO3175985T3 (pt) 2011-07-01 2018-04-28
WO2013112932A1 (en) 2012-01-27 2013-08-01 Gilead Sciences, Inc. Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
WO2014134419A1 (en) 2013-03-01 2014-09-04 Gilead Sciences, Inc. Use of ikach blockers for the treatment of cardiac diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK281507B6 (sk) * 1992-11-30 2001-04-09 Smithkline Beecham Plc Použitie benzopyránových analógov, benzopyránové analógy, spôsob ich prípravy a farmaceutický prostriedok s ich obsahom
DE19546736A1 (de) * 1995-12-14 1997-06-19 Hoechst Ag Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate
DE19742509A1 (de) * 1997-09-26 1999-04-01 Hoechst Marion Roussel De Gmbh Sulfonamid-substituierte Chromane, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen
EP1109544A4 (en) * 1998-09-01 2004-10-27 Bristol Myers Squibb Co POTASSIUM CHANNEL INHIBITORS AND THEIR METHOD OF USE
JP2000336085A (ja) * 1999-03-25 2000-12-05 Nissan Chem Ind Ltd クロマン誘導体
AU2830800A (en) * 1999-03-25 2000-10-16 Nissan Chemical Industries Ltd. Chroman derivatives
EP1240147A1 (en) * 1999-12-21 2002-09-18 Icagen, Inc. Potassium channel inhibitors

Also Published As

Publication number Publication date
DE502004007916D1 (de) 2008-10-02
CN1894233A (zh) 2007-01-10
JP4791968B2 (ja) 2011-10-12
PL1678130T3 (pl) 2009-01-30
NO20062202L (no) 2006-07-03
DE10348298A1 (de) 2005-05-19
EP1678130A2 (de) 2006-07-12
TW200523259A (en) 2005-07-16
AU2004281195A1 (en) 2005-04-28
RU2006116629A (ru) 2007-11-27
UA82907C2 (en) 2008-05-26
DE112004001659D2 (de) 2006-08-10
HRP20080602T3 (hr) 2008-12-31
HK1096960A1 (en) 2007-06-15
AU2004281195A2 (en) 2005-04-28
AR046106A1 (es) 2005-11-23
RU2355685C2 (ru) 2009-05-20
JP2007516235A (ja) 2007-06-21
DK1678130T3 (da) 2008-12-01
ES2313126T3 (es) 2009-03-01
KR20060129170A (ko) 2006-12-15
TWI321564B (en) 2010-03-11
PT1678130E (pt) 2008-10-08
EP1678130B1 (de) 2008-08-20
ZA200602788B (en) 2008-01-30
IL174950A0 (en) 2006-08-20
ATE405547T1 (de) 2008-09-15
CA2542813A1 (en) 2005-04-28
CA2542813C (en) 2011-08-30
WO2005037780A3 (de) 2007-10-18
AU2004281195B2 (en) 2010-12-16
MXPA06003958A (es) 2006-07-05
WO2005037780A2 (de) 2005-04-28
SI1678130T1 (sl) 2008-12-31
CN100532375C (zh) 2009-08-26
IL174950A (en) 2010-06-30

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Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 8A E 9A ANUIDADES.

B08I Publication cancelled [chapter 8.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2259 DE 22/04/2014 POR TER SIDO INDEVIDA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.