BRPI0415637A - derivados de sulfoalquil éter-alquil éter ciclodextrina - Google Patents

derivados de sulfoalquil éter-alquil éter ciclodextrina

Info

Publication number
BRPI0415637A
BRPI0415637A BRPI0415637-4A BRPI0415637A BRPI0415637A BR PI0415637 A BRPI0415637 A BR PI0415637A BR PI0415637 A BRPI0415637 A BR PI0415637A BR PI0415637 A BRPI0415637 A BR PI0415637A
Authority
BR
Brazil
Prior art keywords
sae
ether
cyclodextrin
membrane
alkyl
Prior art date
Application number
BRPI0415637-4A
Other languages
English (en)
Inventor
Valentino J Stella
Serena Tongiani
Original Assignee
Univ Kansas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kansas filed Critical Univ Kansas
Publication of BRPI0415637A publication Critical patent/BRPI0415637A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"DERIVADOS DE SULFOALQUIL éTER-ALQUIL éTER CICLODEXTRINA". A presente invenção refere-se a um derivado de sulfoalquil éter-alquil éter ciclodextrina (SAE-AE-CD) é provido. A SAE-AE-CD possui vantagens sobre derivados de SAE-CD e AE-CD conhecidos bem como outra ciclodextrina de origem ao ser mais solúvel em água e perturbar menos a membrana. A SAE-AE-CD inclui pelo menos um grupo sulfoalquil éter e pelo menos um grupo alquil éter mesmo que o grau de substituição para os grupos funcionais seja diferente. O grupo SAF funcional pode estar presente em excesso molar sobre o grupo funcional de AE e vice versa. O grau total de substituição da ciclodextrina, com relação a ambos grupos funcionais, pode ser variado de modo que uma maioria ou minoria das porções hidroxila da CD é derivatizada. O derivado de SAE-AE-CD pode ser usado para solubilizar compostos com solubilidade insuficiente em água. Em alguns casos, eles também solubilizam compostos em solução contra degracação ou solubilizam produtos de degradação formados durante a degradação. Ainda, SAE-AE-CD pode ser também usada para outros propósitos tal como agentes osmóticos, agentes usados para mascarar o gosto de drogas problemáticas. Surpreendentemente, embora AE-CDs sejam sabidas ser tóxicas ao perturbarem membrana, as SAE-AE-CDs perturbam menos a membrana e então têm maior segurança.
BRPI0415637-4A 2003-10-31 2004-10-29 derivados de sulfoalquil éter-alquil éter ciclodextrina BRPI0415637A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51602203P 2003-10-31 2003-10-31
PCT/US2004/036097 WO2005042584A2 (en) 2003-10-31 2004-10-29 Sulfoalkyl ether-alkyl ether cyclodextrin derivatives

Publications (1)

Publication Number Publication Date
BRPI0415637A true BRPI0415637A (pt) 2006-12-12

Family

ID=34549474

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415637-4A BRPI0415637A (pt) 2003-10-31 2004-10-29 derivados de sulfoalquil éter-alquil éter ciclodextrina

Country Status (10)

Country Link
US (1) US7625878B2 (pt)
EP (1) EP1678211A4 (pt)
JP (1) JP2007523887A (pt)
KR (1) KR20060096490A (pt)
CN (1) CN101039682A (pt)
AU (1) AU2004285032A1 (pt)
BR (1) BRPI0415637A (pt)
CA (1) CA2543443A1 (pt)
RU (1) RU2006118802A (pt)
WO (1) WO2005042584A2 (pt)

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AU2013201437B2 (en) * 2004-04-23 2015-09-03 Cydex Pharmaceuticals, Inc DPI formulation containing sulfoalkyl ether cyclodextrin
SI2952197T1 (sl) 2005-10-26 2017-09-29 Cydex Pharmaceuticals, Inc. Sestavki sulfoalkil eter ciklodekstrina in metode priprave le-tega
CN100503647C (zh) 2005-11-02 2009-06-24 南京师范大学 羟丙基-磺丁基-β-环糊精及其制备方法、分析方法以及在药学上的应用
CN100486645C (zh) * 2006-09-12 2009-05-13 南京师范大学 含有环糊精紫杉醇包合物的药物组合物及其制备方法
CN100411688C (zh) * 2006-09-12 2008-08-20 南京师范大学 含有环糊精/多烯紫杉醇包合物的药物组合物及其制备方法
US20090239942A1 (en) 2006-09-15 2009-09-24 Cloyd James C Topiramate Compositions and Methods of Making and Using the Same
ES2493641T3 (es) * 2007-06-28 2014-09-12 Cydex Pharmaceuticals, Inc. Administración nasal de soluciones acuosas de corticosteroides
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HUE063851T2 (hu) 2014-08-22 2024-02-28 Cydex Pharmaceuticals Inc Frakcionált alkilezett ciklodextrin készítmények és eljárás ezek elõállítására és alkalmazására
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WO2017007805A1 (en) 2015-07-09 2017-01-12 Gilead Sciences, Inc. Intravenous formulations of a late sodium current inhibitor
EP3359578A4 (en) * 2015-10-07 2019-05-15 UTI Limited Partnership MULTIFUNCTIONAL POLYANIONIC CYCLODEXTRINDDRIMERE
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Also Published As

Publication number Publication date
US7625878B2 (en) 2009-12-01
EP1678211A4 (en) 2008-04-02
WO2005042584A2 (en) 2005-05-12
AU2004285032A1 (en) 2005-05-12
RU2006118802A (ru) 2007-12-10
CN101039682A (zh) 2007-09-19
CA2543443A1 (en) 2005-05-12
KR20060096490A (ko) 2006-09-11
US20060258537A1 (en) 2006-11-16
EP1678211A2 (en) 2006-07-12
JP2007523887A (ja) 2007-08-23
WO2005042584A3 (en) 2007-06-07

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.